LTK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LTK_HUMAN
• UniProt AC: P29376
• Protein Name: Leukocyte tyrosine kinase receptor
• Gene Name: LTK
• Organism: Homo sapiens (Human).
• Sequence Length: 864
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport..
• Protein Sequence: MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGCSEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	AGAILCSSPGSQETF CCHHCCCCCCCHHHH	32.08	24850871
27	Phosphorylation	SSPGSQETFLRSSPL CCCCCHHHHHHCCCC	21.97	24850871
40	Phosphorylation	PLPLASPSPRDPKVS CCCCCCCCCCCCCCC	30.03	17081983
257	N-linked_Glycosylation	ASPEKLENRSEAPGS CCHHHHCCCCCCCCC	64.31	UniProtKB CARBOHYD
259	Phosphorylation	PEKLENRSEAPGSGG HHHHCCCCCCCCCCC	50.09	-
380	N-linked_Glycosylation	VEIRRHLNCSHCPLR EEEHHHCCCCCCCCC	21.08	UniProtKB CARBOHYD
412	N-linked_Glycosylation	GMELAVDNVTCMDLH CCEEEEECEEEECCC	25.13	UniProtKB CARBOHYD
475	Phosphorylation	ELSKLRTSAIRTAPN HHHHHHHHHHHCCCC	18.44	-
580	Phosphorylation	IVRCVGLSLRATPRL HHHHHHCCCCCCCCE	15.18	28348404
600	Phosphorylation	MSGGDMKSFLRHSRP HHCCCHHHHHHHCCC	23.91	24719451
672	Phosphorylation	FGMARDIYRASYYRR CHHHHHHHHHHHHHC	12.38	22817900
676	Phosphorylation	RDIYRASYYRRGDRA HHHHHHHHHHCCCCC	10.45	22817900
677	Phosphorylation	DIYRASYYRRGDRAL HHHHHHHHHCCCCCE	7.43	22817900
753	Phosphorylation	RGCPGPVYRIMTQCW CCCCCHHHHHHHHHH	9.50	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LTK_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LTK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LTK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLCG1_HUMAN	PLCG1	physical	8084603
P85A_HUMAN	PIK3R1	physical	8084603
CBL_HUMAN	CBL	physical	9223670
EGFR_HUMAN	EGFR	physical	7650032
SHC1_HUMAN	SHC1	physical	7650032
DUS6_HUMAN	DUSP6	physical	28065597
MTMRE_HUMAN	MTMR14	physical	28065597

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-672; TYR-676 ANDTYR-677, AND MASS SPECTROMETRY.
PubMed: 18083107