VWCE_HUMAN - dbPTM
VWCE_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VWCE_HUMAN
UniProt AC Q96DN2
Protein Name von Willebrand factor C and EGF domain-containing protein
Gene Name VWCE
Organism Homo sapiens (Human).
Sequence Length 955
Subcellular Localization Secreted . According to PubMed:16496348 is localized in the cytoplasm.
Protein Description May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma..
Protein Sequence MWAGLLLRAACVALLLPGAPARGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEESTM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25PhosphorylationGAPARGYTGRKPPGH
CCCCCCCCCCCCCCC		33.0827282143
197PhosphorylationCQQRCKNSIGSYKCS
HHHHHHHCCCCCCCC		17.5224719451
200PhosphorylationRCKNSIGSYKCSCRT
HHHHCCCCCCCCCCC		21.54-
201PhosphorylationCKNSIGSYKCSCRTG
HHHCCCCCCCCCCCC		15.7124719451
204PhosphorylationSIGSYKCSCRTGFHL
CCCCCCCCCCCCEEE		11.50-
272O-linked_GlycosylationPKAVLAPSAILQPRQ
CHHHHCCHHHCCCCC		23.49OGP
320PhosphorylationVRTTRLPSPTPRLPT
CCCCCCCCCCCCCCC		46.1028188228
322PhosphorylationTTRLPSPTPRLPTSS
CCCCCCCCCCCCCCC		25.9423403867
370PhosphorylationEVMGTPSSPRGPESP
EECCCCCCCCCCCCC		21.5924719451
431PhosphorylationACSHPIPSRDGGCCP
HHCCCCCCCCCCCCC		43.66-
439PhosphorylationRDGGCCPSCTGCFHS
CCCCCCCCCCCCCCC		15.47-
441PhosphorylationGGCCPSCTGCFHSGV
CCCCCCCCCCCCCCE		41.12-
446PhosphorylationSCTGCFHSGVVRAEG
CCCCCCCCCEEECCC		17.03-
462N-linked_GlycosylationVFSPPNENCTVCVCL
CCCCCCCCCEEEEEE		33.14UniProtKB CARBOHYD
472N-linked_GlycosylationVCVCLAGNVSCISPE
EEEEECCCEEEECCC		19.54UniProtKB CARBOHYD
756O-linked_GlycosylationLEEKQGLSPHGNVAF
HHHHCCCCCCCCEEE		22.98OGP
764O-linked_GlycosylationPHGNVAFSKAGRSLH
CCCCEEECCCCCCCC		16.32OGP
774PhosphorylationGRSLHGDTEAPVNCS
CCCCCCCCCCCCCCC		38.3422210691
816O-linked_GlycosylationKTQTLPTSPAGAHGP
CCCCCCCCCCCCCCC		15.71OGP
816PhosphorylationKTQTLPTSPAGAHGP
CCCCCCCCCCCCCCC		15.7128857561
825PhosphorylationAGAHGPHSLALGLTA
CCCCCCCCEEEEEEE		20.6228857561
831PhosphorylationHSLALGLTATFPGEP
CCEEEEEEEECCCCC		23.1228857561
833PhosphorylationLALGLTATFPGEPGA
EEEEEEEECCCCCCC		25.7328857561
833O-linked_GlycosylationLALGLTATFPGEPGA
EEEEEEEECCCCCCC		25.73OGP
845PhosphorylationPGASPRLSPGPSTPP
CCCCCCCCCCCCCCC		29.1422964224
849PhosphorylationPRLSPGPSTPPGAPT
CCCCCCCCCCCCCCC		60.5022964224
861O-linked_GlycosylationAPTLPLASPGAPQPP
CCCCCCCCCCCCCCC		31.39OGP
861PhosphorylationAPTLPLASPGAPQPP
CCCCCCCCCCCCCCC		31.3922964224
871PhosphorylationAPQPPPVTPERSFSA
CCCCCCCCCCCCCCC		25.8030257219
877O-linked_GlycosylationVTPERSFSASGAQIV
CCCCCCCCCCCCEEC		23.83OGP
879O-linked_GlycosylationPERSFSASGAQIVSR
CCCCCCCCCCEECCC		33.2055825747
885O-linked_GlycosylationASGAQIVSRWPPLPG
CCCCEECCCCCCCCC		30.2055825751
911O-linked_GlycosylationMDPSPSKTPITLLGP
CCCCCCCCCCEEECC		25.02OGP
929PhosphorylationSPTTSRLSTALAATT
CCCCCHHHHHHHHCC		15.5519690332
929O-linked_GlycosylationSPTTSRLSTALAATT
CCCCCHHHHHHHHCC		15.55OGP
930PhosphorylationPTTSRLSTALAATTH
CCCCHHHHHHHHCCC		30.2219690332
930O-linked_GlycosylationPTTSRLSTALAATTH
CCCCHHHHHHHHCCC		30.22OGP
935PhosphorylationLSTALAATTHPGPQQ
HHHHHHHCCCCCCCC		21.7429978859
935O-linked_GlycosylationLSTALAATTHPGPQQ
HHHHHHHCCCCCCCC		21.74OGP
936O-linked_GlycosylationSTALAATTHPGPQQP
HHHHHHCCCCCCCCC		22.73OGP
936PhosphorylationSTALAATTHPGPQQP
HHHHHHCCCCCCCCC		22.7329978859
948PhosphorylationQQPPVGASRGEESTM
CCCCCCCCCCCCCCC		34.5829978859
948O-linked_GlycosylationQQPPVGASRGEESTM
CCCCCCCCCCCCCCC		34.58OGP
953PhosphorylationGASRGEESTM-----
CCCCCCCCCC-----		26.0129978859
954PhosphorylationASRGEESTM------
CCCCCCCCC------		30.1329978859
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VWCE_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VWCE_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VWCE_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZN444_HUMANZNF444physical
28514442
ZN747_HUMANZNF747physical
28514442
ZN669_HUMANZNF669physical
28514442
ZN764_HUMANZNF764physical
28514442
KPTN_HUMANKPTNphysical
28514442
ZN664_HUMANZNF664physical
28514442
ITFG2_HUMANITFG2physical
28514442
ZN627_HUMANZNF627physical
28514442
ZN620_HUMANZNF620physical
28514442
FIZ1_HUMANFIZ1physical
28514442
ZNF77_HUMANZNF77physical
28514442
TTLL5_HUMANTTLL5physical
28514442
ZSC21_HUMANZSCAN21physical
28514442
ZNF74_HUMANZNF74physical
28514442
ZN302_HUMANZNF302physical
28514442
CILP2_HUMANCILP2physical
28514442
ZN460_HUMANZNF460physical
28514442
ZBTB9_HUMANZBTB9physical
28514442
ZNF8_HUMANZNF8physical
28514442
EGFL7_HUMANEGFL7physical
28514442
ZN696_HUMANZNF696physical
28514442
ZN358_HUMANZNF358physical
28514442
KAISO_HUMANZBTB33physical
28514442
ZN316_HUMANZNF316physical
28514442
COQA1_HUMANCOL26A1physical
28514442
DPA1_HUMANHLA-DPA1physical
28514442
OZF_HUMANZNF146physical
28514442
CBX4_HUMANCBX4physical
28514442
Z324A_HUMANZNF324physical
28514442
CERK1_HUMANCERKphysical
28514442
LTBP1_HUMANLTBP1physical
28514442
E4F1_HUMANE4F1physical
28514442
ZKSC1_HUMANZKSCAN1physical
28514442
RPOM_HUMANPOLRMTphysical
28514442
SQSTM_HUMANSQSTM1physical
28514442
PIGA_HUMANPIGAphysical
28514442
ZN430_HUMANZNF430physical
28514442
DPB1_HUMANHLA-DPB1physical
28514442
POMT2_HUMANPOMT2physical
28514442
TIMP3_HUMANTIMP3physical
28514442
EMIL3_HUMANEMILIN3physical
28514442
CTU1_HUMANCTU1physical
28514442
NUFP2_HUMANNUFIP2physical
28514442
RUSD4_HUMANRPUSD4physical
28514442
POMT1_HUMANPOMT1physical
28514442
BCD1_HUMANZNHIT6physical
28514442
GRP78_HUMANHSPA5physical
28514442
TM160_HUMANTMEM160physical
28514442
TSR3_HUMANTSR3physical
28514442
LTBP4_HUMANLTBP4physical
28514442
FBN2_HUMANFBN2physical
28514442
FBX21_HUMANFBXO21physical
28514442
RECQ4_HUMANRECQL4physical
28514442
IDE_HUMANIDEphysical
28514442
LAMB2_HUMANLAMB2physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VWCE_HUMAN

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Related Literatures of Post-Translational Modification

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