FBX21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX21_HUMAN
• UniProt AC: O94952
• Protein Name: F-box only protein 21
• Gene Name: FBXO21
• Organism: Homo sapiens (Human).
• Sequence Length: 628
• Protein Description: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
• Protein Sequence: MAAAAVDSAMEVVPALAEEAAPEVAGLSCLVNLPGEVLEYILCCGSLTAADIGRVSSTCRRLRELCQSSGKVWKEQFRVRWPSLMKHYSPTDYVNWLEEYKVRQKAGLEARKIVASFSKRFFSEHVPCNGFSDIENLEGPEIFFEDELVCILNMEGRKALTWKYYAKKILYYLRQQKILNNLKAFLQQPDDYESYLEGAVYIDQYCNPLSDISLKDIQAQIDSIVELVCKTLRGINSRHPSLAFKAGESSMIMEIELQSQVLDAMNYVLYDQLKFKGNRMDYYNALNLYMHQVLIRRTGIPISMSLLYLTIARQLGVPLEPVNFPSHFLLRWCQGAEGATLDIFDYIYIDAFGKGKQLTVKECEYLIGQHVTAALYGVVNVKKVLQRMVGNLLSLGKREGIDQSYQLLRDSLDLYLAMYPDQVQLLLLQARLYFHLGIWPEKSFCLVLKVLDILQHIQTLDPGQHGAVGYLVQHTLEHIERKKEEVGVEVKLRSDEKHRDVCYSIGLIMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHGHHQPFYNVLVEDGSCRYAAQENLEYNVEPQEISHPDVGRYFSEFTGTHYIPNAELEIRYPEDLEFVYETVQNIYSAKKENIDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	Ubiquitination	QSSGKVWKEQFRVRW HHCCCHHHHHHHCCC	44.62	-
83	Phosphorylation	QFRVRWPSLMKHYSP HHHCCCHHHHHHCCC	33.85	28348404
101	Ubiquitination	VNWLEEYKVRQKAGL HHHHHHHHHHHHCCC	33.93	21906983
101 (in isoform 2)	Ubiquitination	-	33.93	21906983
101 (in isoform 1)	Ubiquitination	-	33.93	21906983
116	Phosphorylation	EARKIVASFSKRFFS HHHHHHHHHHHHHHC	21.11	26552605
118	Phosphorylation	RKIVASFSKRFFSEH HHHHHHHHHHHHCCC	22.04	23401153
249	Phosphorylation	LAFKAGESSMIMEIE HEHHCCCCCEEEEEE	25.04	25002506
250	Phosphorylation	AFKAGESSMIMEIEL EHHCCCCCEEEEEEH	14.18	25002506
259	Phosphorylation	IMEIELQSQVLDAMN EEEEEHHHHHHHHHH	34.58	25002506
267	Phosphorylation	QVLDAMNYVLYDQLK HHHHHHHHHHHHCCC	4.44	25002506
270	Phosphorylation	DAMNYVLYDQLKFKG HHHHHHHHHCCCCCC	7.50	25002506
365	Phosphorylation	LTVKECEYLIGQHVT EEHHHHHHHHHHHHH	18.44	-
376	Phosphorylation	QHVTAALYGVVNVKK HHHHHHHHHHHCHHH	11.80	-
397	Ubiquitination	GNLLSLGKREGIDQS HHHHHHHHHCCCCHH	53.20	2190698
397 (in isoform 1)	Ubiquitination	-	53.20	21906983
397 (in isoform 2)	Ubiquitination	-	53.20	21906983
452	Phosphorylation	CLVLKVLDILQHIQT HHHHHHHHHHHHHHH	42.41	20068231
459	Phosphorylation	DILQHIQTLDPGQHG HHHHHHHHCCCCCCC	32.31	20068231
482	Ubiquitination	TLEHIERKKEEVGVE HHHHHHHHHHHHCCE	52.31	-
483	Ubiquitination	LEHIERKKEEVGVEV HHHHHHHHHHHCCEE	66.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX21_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EID1_HUMAN	EID1	physical	26085330
CUL1_HUMAN	CUL1	physical	26085330
RBX1_HUMAN	RBX1	physical	26085330
EID1_HUMAN	EID1	physical	26631746
CUL1_HUMAN	CUL1	physical	26631746
SKP1_HUMAN	SKP1	physical	26631746
EID2_HUMAN	EID2	physical	26631746

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.