EID2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EID2_HUMAN
• UniProt AC: Q8N6I1
• Protein Name: EP300-interacting inhibitor of differentiation 2
• Gene Name: EID2 {ECO:0000312|EMBL:AAH30137.3}
• Organism: Homo sapiens (Human).
• Sequence Length: 236
• Subcellular Localization: Nucleus .
• Protein Description: Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex..
• Protein Sequence: MSKLPADSSVPQTGAANGDRDVPQAEVGRGRREPAPAQPEEAGEGAMAAARGGPVPAAREGRMAAARAAPAAAARGAPVAAAALARAAAAGRESPAAAAAREARMAEVARLLGEPVDEEGPEGRPRSRHGNGGLAALPYLRLRHPLSVLGINYQQFLRHYLENYPIAPGRIQELEERRRRFVEACRAREAAFDAEYQRNPHRVDLDILTFTIALTASEVINPLIEELGCDKFINRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSKLPADSS ------CCCCCCCCC	42.79	23403867
9	Phosphorylation	SKLPADSSVPQTGAA CCCCCCCCCCCCCCC	38.06	23403867
47	Sulfoxidation	EEAGEGAMAAARGGP HHHCHHHHHHHHCCC	3.71	21406390
51	Methylation	EGAMAAARGGPVPAA HHHHHHHHCCCCCHH	45.97	-
59	Methylation	GGPVPAAREGRMAAA CCCCCHHHHHHHHHH	49.35	-
75	Methylation	AAPAAAARGAPVAAA HHHHHHHCCHHHHHH	36.76	24129315
94	Phosphorylation	AAAAGRESPAAAAAR HHHCCCCCHHHHHHH	20.62	-
160	Phosphorylation	YQQFLRHYLENYPIA HHHHHHHHHHHCCCC	14.85	24719451
196	Phosphorylation	EAAFDAEYQRNPHRV HHHHCHHHHHCCCCC	17.94	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EID2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EID2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EID2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMAD2_HUMAN	SMAD2	physical	14612439
SMAD3_HUMAN	SMAD3	physical	14612439
SMAD4_HUMAN	SMAD4	physical	14612439
HDAC2_HUMAN	HDAC2	physical	12586827
EID3_HUMAN	EID3	physical	15970276

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.