ZNF74_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZNF74_HUMAN
• UniProt AC: Q16587
• Protein Name: Zinc finger protein 74
• Gene Name: ZNF74
• Organism: Homo sapiens (Human).
• Sequence Length: 644
• Subcellular Localization: Nucleus.
• Protein Description: May play a role in RNA metabolism..
• Protein Sequence: MEIPAPEPEKTALSSQDPALSLKENLEDISGWGLPEARSKESVSFKDVAVDFTQEEWGQLDSPQRALYRDVMLENYQNLLALGPPLHKPDVISHLERGEEPWSMQREVPRGPCPEWELKAVPSQQQGICKEEPAQEPIMERPLGGAQAWGRQAGALQRSQAAPWAPAPAMVWDVPVEEFPLRCPLFAQQRVPEGGPLLDTRKNVQATEGRTKAPARLCAGENASTPSEPEKFPQVRRQRGAGAGEGEFVCGECGKAFRQSSSLTLHRRWHSREKAYKCDECGKAFTWSTNLLEHRRIHTGEKPFFCGECGKAFSCHSSLNVHQRIHTGERPYKCSACEKAFSCSSLLSMHLRVHTGEKPYRCGECGKAFNQRTHLTRHHRIHTGEKPYQCGSCGKAFTCHSSLTVHEKIHSGDKPFKCSDCEKAFNSRSRLTLHQRTHTGEKPFKCADCGKGFSCHAYLLVHRRIHSGEKPFKCNECGKAFSSHAYLIVHRRIHTGEKPFDCSQCWKAFSCHSSLIVHQRIHTGEKPYKCSECGRAFSQNHCLIKHQKIHSGEKSFKCEKCGEMFNWSSHLTEHQRLHSEGKPLAIQFNKHLLSTYYVPGSLLGAGDAGLRDVDPIDALDVAKLLCVVPPRAGRNFSLGSKPRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	SSQDPALSLKENLED CCCCCCHHHHHHHHH	39.23	24719451
23	Ubiquitination	QDPALSLKENLEDIS CCCCHHHHHHHHHHC	40.98	-
44	Phosphorylation	ARSKESVSFKDVAVD HHCCCCCCHHHEEEE	35.54	24719451
55 (in isoform 5)	Phosphorylation	-	53.30	30631047
56 (in isoform 5)	Phosphorylation	-	47.27	30631047
62	Phosphorylation	EEWGQLDSPQRALYR HHHHCCCCHHHHHHH	31.37	27251275
68 (in isoform 5)	Phosphorylation	-	12.09	30631047
79 (in isoform 5)	Phosphorylation	-	1.42	28102081
155 (in isoform 5)	Phosphorylation	-	11.97	25954137
161 (in isoform 5)	Phosphorylation	-	19.42	25954137
163 (in isoform 5)	Phosphorylation	-	30.67	25954137
231	Ubiquitination	STPSEPEKFPQVRRQ CCCCCCCCCHHHHHH	73.41	-
327	Phosphorylation	NVHQRIHTGERPYKC CCCCCCCCCCCCCCC	38.06	24719451
342	Phosphorylation	SACEKAFSCSSLLSM CCCCHHHCCHHHHHC	20.25	-
344	Phosphorylation	CEKAFSCSSLLSMHL CCHHHCCHHHHHCCE	23.87	29759185
345	Phosphorylation	EKAFSCSSLLSMHLR CHHHCCHHHHHCCEE	37.34	29759185
348	Phosphorylation	FSCSSLLSMHLRVHT HCCHHHHHCCEEECC	14.95	29759185
355	Phosphorylation	SMHLRVHTGEKPYRC HCCEEECCCCCCEEC	44.15	-
358	Ubiquitination	LRVHTGEKPYRCGEC EEECCCCCCEECCCC	49.01	-
383	Phosphorylation	TRHHRIHTGEKPYQC CCCCCCCCCCCCEEC	44.67	28111955
414	Acetylation	EKIHSGDKPFKCSDC CHHHCCCCCEECCHH	56.74	25953088
437	Phosphorylation	RLTLHQRTHTGEKPF CEEEECCCCCCCCCE	19.74	23312004
439	Phosphorylation	TLHQRTHTGEKPFKC EEECCCCCCCCCEEC	46.56	29496963
467	Phosphorylation	LVHRRIHSGEKPFKC EECCCCCCCCCCEEC	46.40	23917254
523	Phosphorylation	IVHQRIHTGEKPYKC EEEEEEECCCCCEEC	44.67	29496963
528	Phosphorylation	IHTGEKPYKCSECGR EECCCCCEECCCCCC	35.38	-
554	Acetylation	QKIHSGEKSFKCEKC CEECCCCCEEECCCC	65.79	7468575
557	Acetylation	HSGEKSFKCEKCGEM CCCCCEEECCCCHHC	48.88	7468583
582	Sumoylation	QRLHSEGKPLAIQFN HHHHCCCCCEEEEEC	32.57	28112733
637	Phosphorylation	PRAGRNFSLGSKPRN CCCCCCCCCCCCCCC	35.06	-
640	Phosphorylation	GRNFSLGSKPRN--- CCCCCCCCCCCC---	44.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZNF74_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZNF74_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZNF74_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIF1B_HUMAN	TRIM28	physical	12684500
RPB1_HUMAN	POLR2A	physical	9346935

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.