| UniProt ID | POMT2_HUMAN | |
|---|---|---|
| UniProt AC | Q9UKY4 | |
| Protein Name | Protein O-mannosyl-transferase 2 | |
| Gene Name | POMT2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 750 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.. | |
| Protein Sequence | MPPATGGGLAESELRPRRGRCGPQAARAAGRDVAAEAVARSPKRPAWGSRRFEAVGWWALLALVTLLSFATRFHRLDEPPHICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDKYEHHSYMGMRGFCAFLGSWLVPFAYLTVLDLSKSLSAALLTAALLTFDTGCLTLSQYILLDPILMFFIMAAMLSMVKYNSCADRPFSAPWWFWLSLTGVSLAGALGVKFVGLFIILQVGLNTIADLWYLFGDLSLSLVTVGKHLTARVLCLIVLPLALYTATFAVHFMVLSKSGPGDGFFSSAFQARLSGNNLHNASIPEHLAYGSVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLHKDYNNLWIIKKHNTNSDPLDPSFPVEFVRHGDIIRLEHKETSRNLHSHYHEAPMTRKHYQVTGYGINGTGDSNDFWRIEVVNRKFGNRIKVLRSRIRFIHLVTGCVLGSSGKVLPKWGWEQLEVTCTPYLKETLNSIWNVEDHINPKLPNISLDVLQPSFPEILLESHMVMIRGNSGLKPKDNEFTSKPWHWPINYQGLRFSGVNDTDFRVYLLGNPVVWWLNLLSIALYLLSGSIIAVAMQRGARLPAEVAGLSQVLLRGGGQVLLGWTLHYFPFFLMGRVLYFHHYFPAMLFSSMLTGILWDTLLRLCAWGLASWPLARGIHVAGILSLLLGTAYSFYLFHPLAYGMVGPLAQDPQSPMAGLRWLDSWDF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 41 | Phosphorylation | AAEAVARSPKRPAWG HHHHHHCCCCCCCCC | 25.65 | 28355574 | |
| 94 | Phosphorylation | THFGKMGSYYINRTF CCCCCCCCEEECCEE | 15.97 | - | |
| 95 | Phosphorylation | HFGKMGSYYINRTFF CCCCCCCEEECCEEE | 11.57 | - | |
| 96 | Phosphorylation | FGKMGSYYINRTFFF CCCCCCEEECCEEEE | 8.07 | - | |
| 98 | N-linked_Glycosylation | KMGSYYINRTFFFDV CCCCEEECCEEEEEE | 22.33 | UniProtKB CARBOHYD | |
| 330 | N-linked_Glycosylation | LSGNNLHNASIPEHL HCCCCCCCCCCCHHH | 38.25 | UniProtKB CARBOHYD | |
| 376 | Phosphorylation | RQQQVTTYLHKDYNN CHHHHHEEECCCCCC | 9.46 | 25627689 | |
| 419 | Phosphorylation | IRLEHKETSRNLHSH EEEEEHHHHCCCHHH | 37.48 | - | |
| 420 | Phosphorylation | RLEHKETSRNLHSHY EEEEHHHHCCCHHHC | 21.91 | - | |
| 425 | Phosphorylation | ETSRNLHSHYHEAPM HHHCCCHHHCCCCCC | 28.98 | - | |
| 445 | N-linked_Glycosylation | QVTGYGINGTGDSND EEEEEECCCCCCCCC | 37.30 | UniProtKB CARBOHYD | |
| 528 | N-linked_Glycosylation | HINPKLPNISLDVLQ CCCCCCCCCCEEHHC | 47.09 | UniProtKB CARBOHYD | |
| 583 | N-linked_Glycosylation | GLRFSGVNDTDFRVY CEEEECCCCCCEEEE | 50.41 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of POMT2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of POMT2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of POMT2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of POMT2_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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