CILP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CILP2_HUMAN
• UniProt AC: Q8IUL8
• Protein Name: Cartilage intermediate layer protein 2
• Gene Name: CILP2
• Organism: Homo sapiens (Human).
• Sequence Length: 1156
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: May play a role in cartilage scaffolding..
• Protein Sequence: MASLLPLLCLCVVAAHLAGARDATPTEEPMATALGLERRSVYTGQPSPALEDWEEASEWTSWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTDWALPSAVGERVHLNPTRGFWCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPGCSLDTCECPDHILLGSVVTPSGQPLLGARVSLRDQPGTVATSDAHGTFRVPGVCADSRANIRAQMDGFSAGEAQAQANGSISVVTIILDKLEKPYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGYGAHLELRGLRPDQAGIYHCKAWNEAGAVRSGTARLTVLAPGQPACDPRPREYLIKLPEDCGQPGSGPAYLDVGLCPDTRCPSLAGSSPRCGDASSRCCSVRRLERREIHCPGYVLPVKVVAECGCQKCLPPRGLVRGRVVAADSGEPLRFARILLGQEPIGFTAYQGDFTIEVPPSTQRLVVTFVDPSGEFMDAVRVLPFDPRGAGVYHEVKAMRKKAPVILHTSQSNTIPLGELEDEAPLGELVLPSGAFRRADGKPYSGPVEARVTFVDPRDLTSAASAPSDLRFVDSDGELAPLRTYGMFSVDLRAPGSAEQLQVGPVAVRVAASQIHMPGHVEALKLWSLNPETGLWEEESGFRREGSSGPRVRREERVFLVGNVEIRERRLFNLDVPERRRCFVKVRAYANDKFTPSEQVEGVVVTLVNLEPAPGFSANPRAWGRFDSAVTGPNGACLPAFCDADRPDAYTALVTATLGGEELEPAPSLPRPLPATVGVTQPYLDRLGYRRTDHDDPAFKRNGFRINLAKPRPGDPAEANGPVYPWRSLRECQGAPVTASHFRFARVEADKYEYNVVPFREGTPASWTGDLLAWWPNPQEFRACFLKVKIQGPQEYMVRSHNAGGSHPRTRGQLYGLRDARSVRDPERPGTSAACVEFKCSGMLFDQRQVDRTLVTIMPQGSCRRVAVNGLLRDYLTRHPPPVPAEDPAAFSMLAPLDPLGHNYGVYTVTDQSPRLAKEIAIGRCFDGSSDGFSREMKADAGTAVTFQCREPPAGRPSLFQRLLESPATALGDIRREMSEAAQAQARASGPLRTRRGRVRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
236	O-linked_Glycosylation	SLRDQPGTVATSDAH ECCCCCCCEEEECCC	17.41	55835807
276	N-linked_Glycosylation	GEAQAQANGSISVVT HHHHHHHCCCEEEEE	32.44	UniProtKB CARBOHYD
308	N-linked_Glycosylation	RVREAGQNVTFCCKA HHHHCCCCEEEEEEC	33.60	UniProtKB CARBOHYD
318	Phosphorylation	FCCKASGTPMPKKYS EEEECCCCCCCCEEC	17.58	27794612
329	N-linked_Glycosylation	KKYSWFHNGTLLDRR CEECEEECCEEECCC	35.35	UniProtKB CARBOHYD
376	Phosphorylation	RSGTARLTVLAPGQP CCCEEEEEEECCCCC	14.12	24667141
434	Phosphorylation	SPRCGDASSRCCSVR CCCCCCHHHHCCCCE	24.05	-
435	Phosphorylation	PRCGDASSRCCSVRR CCCCCHHHHCCCCEE	30.93	-
484	Phosphorylation	GRVVAADSGEPLRFA CEEEEECCCCCCHHH	40.09	-
567	Phosphorylation	VILHTSQSNTIPLGE EEEEECCCCEEECCC	35.39	22210691
569	Phosphorylation	LHTSQSNTIPLGELE EEECCCCEEECCCCC	29.26	22210691
703	Phosphorylation	GFRREGSSGPRVRRE CCCCCCCCCCCCCCH	64.77	-
951	Phosphorylation	KIQGPQEYMVRSHNA EECCCCEEEEEECCC	8.82	22817900
970	Phosphorylation	PRTRGQLYGLRDARS CCCHHCCCCCCCCCC	13.26	22817900
1089	Phosphorylation	DGSSDGFSREMKADA CCCCCCCCCEEECCC	32.62	-
1098	Phosphorylation	EMKADAGTAVTFQCR EEECCCCEEEEEEEC	21.48	28509920
1101	Phosphorylation	ADAGTAVTFQCREPP CCCCEEEEEEECCCC	12.91	28509920

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CILP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CILP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CILP2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CILP2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.