ZN316_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN316_HUMAN
• UniProt AC: A6NFI3
• Protein Name: Zinc finger protein 316
• Gene Name: ZNF316
• Organism: Homo sapiens (Human).
• Sequence Length: 1004
• Subcellular Localization: Nucleus.
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MAALHTTPDSPAAQLERAEDGSECDPDQEEEEEEEEKGEEVQEVEEEEEEIVVEEEEEGVAEVVQDAQVEAVAEVEVEADVEEEDVKEVLAEEECPALGTQERLSRGGDAKSPVLQEKGLQASRAPATPRDEDLEEEEEEEEDEDEDDLLTAGCQELVTFEDVAVYFSLEEWERLEADQRGLYQEVMQENYGILVSLGYPIPKPDLIFRLEQGEEPWVPDSPRPEEGDIVTGVYTGAWFWTDDIEDHEEEDDEDFLAEVAEEENEPPGLWSAAYGVGDVPGTWGPDDSDSAQTPEGWGPDPGGLGVLADGSEAKPFLPGREPGANLLSPWAFPAAVAPPAGRPETTCDVCGKVFPHRSRLAKHQRYHAAVKPFGCEECGKGFVYRSHLAIHQRTHTGEKPFPCPDCGKRFVYKSHLVTHRRIHTGERPYRCAFCGAGFGRRSYLVTHQRTHTGERPYPCSHCGRSFSQSSALARHQAVHTADRPHCCPDCGQAFRLRADFQRHRRGGGCAEAGGDGPRREPGETAAAAGPEDTDPGPEGSEVGEADGEAEAAAEEREEAAVAAPTPSGKVDPAPERRFLELGNGLGEGEGPSSHPLGFHFPVHPKSWLHPDSFPILGLPDFRERLPVDGRPLPAPLGGPLSLVEGTGLACDPFGGGGAAGGGGGLRAFGPAIGGLLAEPAPAALAEEESPWICSDCGKTFGRRAALAKHQRYHAGERPHRCADCGKSFVYGSHLARHRRTHTGERPFPCPECGARFARGSHLAAHVRGHTGEKPFVCGVCGAGFSRRAHLTAHGRAHTGERPYACGECGRRFGQSAALTRHQWAHAEEKPHRCPDCGKGFGHSSDFKRHRRTHTGEKPFRCADCGRGFAQRSNLAKHRRGHTGERPFPCPECGKRFSQRSVLVTHQRTHTGERPYACANCGRRFSQSSHLLTHMKTHRGATAAPGSGSAPAPAPKPEAAAKGPSSAGPGERGSALLEFAGGTSFGSEHQAAFAGPSGAYREGVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAALHTTPD ------CCCCCCCCC	29.99	19369195
6	Phosphorylation	--MAALHTTPDSPAA --CCCCCCCCCCHHH	40.65	30266825
7	Phosphorylation	-MAALHTTPDSPAAQ -CCCCCCCCCCHHHH	17.85	30266825
10	Phosphorylation	ALHTTPDSPAAQLER CCCCCCCCHHHHHHC	20.03	29255136
22	Phosphorylation	LERAEDGSECDPDQE HHCCCCCCCCCCCHH	47.58	27732954
100	Phosphorylation	EECPALGTQERLSRG HCCCCCCCHHHHHCC	28.27	25849741
105	Phosphorylation	LGTQERLSRGGDAKS CCCHHHHHCCCCCCC	34.79	25849741
112	Phosphorylation	SRGGDAKSPVLQEKG HCCCCCCCHHHHHHC	23.20	29255136
123	Phosphorylation	QEKGLQASRAPATPR HHHCCCCCCCCCCCC	18.93	26074081
128	Phosphorylation	QASRAPATPRDEDLE CCCCCCCCCCCCCHH	20.14	27362937
328	Phosphorylation	EPGANLLSPWAFPAA CCCCCCCCCCCCCCC	22.89	25159151
371	Acetylation	QRYHAAVKPFGCEEC HHHCEECCCCCCCCC	29.87	26051181
394	Phosphorylation	HLAIHQRTHTGEKPF EEEEECCCCCCCCCC	19.74	-
396	Phosphorylation	AIHQRTHTGEKPFPC EEECCCCCCCCCCCC	46.56	29214152
399	Acetylation	QRTHTGEKPFPCPDC CCCCCCCCCCCCCCC	53.99	7428687
424	Phosphorylation	VTHRRIHTGERPYRC EECCEECCCCCCEEE	38.06	21857030
429	Phosphorylation	IHTGERPYRCAFCGA ECCCCCCEEECCCCC	25.25	28555341
442	Phosphorylation	GAGFGRRSYLVTHQR CCCCCCCEEEEEECC	22.81	28555341
467	Phosphorylation	SHCGRSFSQSSALAR CCCCCCCCHHHHHHH	30.33	28857561
480	Phosphorylation	ARHQAVHTADRPHCC HHHHHHHHCCCCCCC	24.53	28555341
533	Phosphorylation	AAAGPEDTDPGPEGS HHCCCCCCCCCCCCC	42.29	29255136
540	Phosphorylation	TDPGPEGSEVGEADG CCCCCCCCCCCCCCC	27.70	25849741
565	Phosphorylation	EAAVAAPTPSGKVDP HHHHHCCCCCCCCCC	25.92	29255136
567	Phosphorylation	AVAAPTPSGKVDPAP HHHCCCCCCCCCCCC	54.44	29255136
727	Phosphorylation	RCADCGKSFVYGSHL CCCCCCCCHHCCHHH	12.77	28555341
732	Phosphorylation	GKSFVYGSHLARHRR CCCHHCCHHHHHCCC	9.53	28555341
740	Phosphorylation	HLARHRRTHTGERPF HHHHCCCCCCCCCCC	24.60	23532336
742	Phosphorylation	ARHRRTHTGERPFPC HHCCCCCCCCCCCCC	39.87	29214152
760	Phosphorylation	GARFARGSHLAAHVR CCCCCCCCCHHHHHC	15.13	28555341
770	Phosphorylation	AAHVRGHTGEKPFVC HHHHCCCCCCCCEEE	50.27	29214152
798	Phosphorylation	TAHGRAHTGERPYAC ECCCCCCCCCCCCCC	39.49	28985074
829	Sumoylation	QWAHAEEKPHRCPDC HHHHHHCCCCCCCCC	37.31	28112733
844	Phosphorylation	GKGFGHSSDFKRHRR CCCCCCCHHHHHHCC	41.20	28555341
852	Phosphorylation	DFKRHRRTHTGEKPF HHHHHCCCCCCCCCC	24.60	-
854	Phosphorylation	KRHRRTHTGEKPFRC HHHCCCCCCCCCCCC	46.56	29496963
857	Ubiquitination	RRTHTGEKPFRCADC CCCCCCCCCCCCCCC	51.29	-
882	Phosphorylation	AKHRRGHTGERPFPC HHHCCCCCCCCCCCC	43.49	25159151
908	Phosphorylation	VLVTHQRTHTGERPY EEEEECCCCCCCCCE	19.74	29759185
910	Phosphorylation	VTHQRTHTGERPYAC EEECCCCCCCCCEEE	39.87	29759185
925	Phosphorylation	ANCGRRFSQSSHLLT CCCCCCCCHHHHHHH	27.60	23312004
927	Phosphorylation	CGRRFSQSSHLLTHM CCCCCCHHHHHHHHC	20.66	23312004
928	Phosphorylation	GRRFSQSSHLLTHMK CCCCCHHHHHHHHCH	15.54	23312004
946	Phosphorylation	GATAAPGSGSAPAPA CCCCCCCCCCCCCCC	28.63	23532336
948	Phosphorylation	TAAPGSGSAPAPAPK CCCCCCCCCCCCCCC	32.54	23532336
955	Acetylation	SAPAPAPKPEAAAKG CCCCCCCCHHHHHCC	58.56	26051181
955	Sumoylation	SAPAPAPKPEAAAKG CCCCCCCCHHHHHCC	58.56	28112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN316_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN316_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN316_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN316_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY.
PubMed: 19369195

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112, AND MASSSPECTROMETRY.
PubMed: 18669648