ELK4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELK4_HUMAN
• UniProt AC: P28324
• Protein Name: ETS domain-containing protein Elk-4
• Gene Name: ELK4
• Organism: Homo sapiens (Human).
• Sequence Length: 431
• Subcellular Localization: Nucleus.
• Protein Description: Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously..
• Protein Sequence: MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARLWGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYPEILNMDPMTVGRIEGDCESLNFSEVSSSSKDVENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNVKLFKLIKTENPAEKLAEKKSPQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSSEETIQALETLVSPKLPSLEAPTSASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHPDIDTDIDSVASQPMELPENLSLEPKDQDSVLLEKDKVNNSSRSKKPKGLELAPTLVITSSDPSPLGILSPSLPTASLTPAFFSQTPIILTPSPLLSSIHFWSTLSPVAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPSTPGPFSPDLQKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	KNKPNMNYDKLSRAL CCCCCCCHHHHHHHH	12.04	20049867
107	Phosphorylation	RIEGDCESLNFSEVS EEECCHHHCCHHHHC	34.64	-
111	Phosphorylation	DCESLNFSEVSSSSK CHHHCCHHHHCCCCC	35.69	27251275
114	Phosphorylation	SLNFSEVSSSSKDVE HCCHHHHCCCCCCHH	22.05	27251275
125	Acetylation	KDVENGGKDKPPQPG CCHHCCCCCCCCCCC	65.07	26051181
135	Phosphorylation	PPQPGAKTSSRNDYI CCCCCCCCCCCCCCC	31.25	-
137	Phosphorylation	QPGAKTSSRNDYIHS CCCCCCCCCCCCCCC	40.09	-
164	Sumoylation	SSNVKLFKLIKTENP CCCEEEEEEEECCCH	60.79	-
164	Sumoylation	SSNVKLFKLIKTENP CCCEEEEEEEECCCH	60.79	-
167	Sumoylation	VKLFKLIKTENPAEK EEEEEEEECCCHHHH	61.29	-
167	Sumoylation	VKLFKLIKTENPAEK EEEEEEEECCCHHHH	61.29	28112733
178	Ubiquitination	PAEKLAEKKSPQEPT HHHHHHHCCCCCCCC	53.60	-
180	Phosphorylation	EKLAEKKSPQEPTPS HHHHHCCCCCCCCCC	42.77	30266825
185	Phosphorylation	KKSPQEPTPSVIKFV CCCCCCCCCCCEEEE	27.69	23403867
187	Phosphorylation	SPQEPTPSVIKFVTT CCCCCCCCCEEEEEC	38.66	23403867
193	Phosphorylation	PSVIKFVTTPSKKPP CCCEEEEECCCCCCC	35.80	27251275
194	Phosphorylation	SVIKFVTTPSKKPPV CCEEEEECCCCCCCC	21.91	29396449
207	Phosphorylation	PVEPVAATISIGPSI CCCCEEEEEEECCCC	12.91	27080861
209	Phosphorylation	EPVAATISIGPSISP CCEEEEEEECCCCCC	19.69	27080861
213	Phosphorylation	ATISIGPSISPSSEE EEEEECCCCCCCHHH	30.41	30108239
215	Phosphorylation	ISIGPSISPSSEETI EEECCCCCCCHHHHH	24.06	25159151
217	Phosphorylation	IGPSISPSSEETIQA ECCCCCCCHHHHHHH	43.52	26657352
218	Phosphorylation	GPSISPSSEETIQAL CCCCCCCHHHHHHHH	42.72	30108239
221	Phosphorylation	ISPSSEETIQALETL CCCCHHHHHHHHHHH	17.84	30108239
227	Phosphorylation	ETIQALETLVSPKLP HHHHHHHHHHCCCCC	33.05	27080861
230	Phosphorylation	QALETLVSPKLPSLE HHHHHHHCCCCCCCC	21.30	25159151
235	O-linked_Glycosylation	LVSPKLPSLEAPTSA HHCCCCCCCCCCCCC	49.64	OGP
305	Phosphorylation	LEPKDQDSVLLEKDK CCCCCCCCEEEEECC	14.72	25159151
310	Ubiquitination	QDSVLLEKDKVNNSS CCCEEEEECCCCCCC	63.92	-
316	Phosphorylation	EKDKVNNSSRSKKPK EECCCCCCCCCCCCC	23.17	21712546
320	Acetylation	VNNSSRSKKPKGLEL CCCCCCCCCCCCCCC	72.49	7926731
378	Phosphorylation	LSSIHFWSTLSPVAP HHHHHHHHCCCCCCC	20.66	26074081
379	Phosphorylation	SSIHFWSTLSPVAPL HHHHHHHCCCCCCCC	23.11	26074081
381	Phosphorylation	IHFWSTLSPVAPLSP HHHHHCCCCCCCCCH	19.88	26074081
385 (in isoform 2)	Phosphorylation	-	33.34	27174698
386 (in isoform 2)	Phosphorylation	-	7.45	27174698
387	Phosphorylation	LSPVAPLSPARLQGA CCCCCCCCHHHHCCC	18.56	26074081
419	Phosphorylation	LSGLDGPSTPGPFSP ECCCCCCCCCCCCCC	53.41	-
420	Phosphorylation	SGLDGPSTPGPFSPD CCCCCCCCCCCCCCC	35.08	-
425	Phosphorylation	PSTPGPFSPDLQKT- CCCCCCCCCCCCCC-	22.19	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
194	T	Phosphorylation	Kinase	CDK2	P24941	PSP
361	T	Phosphorylation	Kinase	MAPK8	P45983	GPS
366	T	Phosphorylation	Kinase	MAPK8	P45983	GPS
381	S	Phosphorylation	Kinase	ERK1	P27361	PSP
381	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
381	S	Phosphorylation	Kinase	P38A	Q16539	PSP
387	S	Phosphorylation	Kinase	CDK2	P24941	PSP
387	S	Phosphorylation	Kinase	ERK1	P27361	PSP
387	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
387	S	Phosphorylation	Kinase	P38A	Q16539	PSP
420	T	Phosphorylation	Kinase	MAPK8	P45983	GPS
425	S	Phosphorylation	Kinase	MAPK8	P45983	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELK4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELK4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRF_HUMAN	SRF	physical	11406578
SIR7_HUMAN	SIRT7	physical	28655758

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.