dbPTM

SIR7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SIR7_HUMAN
UniProt AC	Q9NRC8
Protein Name	NAD-dependent protein deacetylase sirtuin-7
Gene Name	SIRT7
Organism	Homo sapiens (Human).
Sequence Length	400
Subcellular Localization	Cytoplasm. Nucleus, nucleolus. Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.
Protein Description	NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation..
Protein Sequence	MAAGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESADLVTELQGRSRRREGLKRRQEEVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCVPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMAELGLEIPAYSRWQDPIFSLATPLRAGEEGSHSRKSLCRSREEAPPGDRGAPLSSAPILGGWFGRGCTKRTKRKKVT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8 (in isoform 3)	Phosphorylation	-	47.80	28674419
11	Methylation	GGLSRSERKAAERVR CCCCHHHHHHHHHHH	34.85	115388867
94	Phosphorylation	GKVRELASAVRNAKY HHHHHHHHHHHHCCE	39.66	20860994
101	Phosphorylation	SAVRNAKYLVVYTGA HHHHHCCEEEEEECC	11.43	28122231
105	Phosphorylation	NAKYLVVYTGAGIST HCCEEEEEECCCCHH	7.62	28122231
106	Phosphorylation	AKYLVVYTGAGISTA CCEEEEEECCCCHHH	14.67	28122231
111	Phosphorylation	VYTGAGISTAASIPD EEECCCCHHHHCCCC	15.86	28122231
112	Phosphorylation	YTGAGISTAASIPDY EECCCCHHHHCCCCC	25.07	28122231
115	Phosphorylation	AGISTAASIPDYRGP CCCHHHHCCCCCCCC	31.99	28122231
131	Ubiquitination	GVWTLLQKGRSVSAA CHHHHHHCCCCCCHH	57.15	-
153	Phosphorylation	TLTHMSITRLHEQKL CCCCCCHHHHHHHHH	21.63	-
196	Phosphorylation	NMYIEVCTSCVPNRE CEEEEECCCCCCCCC	30.27	29759185
214	Phosphorylation	VFDVTERTALHRHQT EEECCCCHHHHCCCC	27.60	28258704
342	O-linked_Glycosylation	RWQDPIFSLATPLRA CCCCCCHHHCCCCCC	20.15	29351928
345	O-linked_Glycosylation	DPIFSLATPLRAGEE CCCHHHCCCCCCCCC	28.31	29351928
359	Phosphorylation	EGSHSRKSLCRSREE CCCCCCHHHHCCCCC	31.43	-
363	Phosphorylation	SRKSLCRSREEAPPG CCHHHHCCCCCCCCC	42.94	-
388	Methylation	ILGGWFGRGCTKRTK CCCCCCCCCCCCCCC	27.78	24129315

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
153	T	Phosphorylation	Kinase	AMPKA1	Q13131	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
388	R	Acetylation	24129315
Methylation at Arg-388 by PRMT6 inhibits the H3K18Ac histone deacetylase activity, promoting mitochondria biogenesis and maintaining mitochondria respiration.
388	R	Methylation	24129315
Methylation at Arg-388 by PRMT6 inhibits the H3K18Ac histone deacetylase activity, promoting mitochondria biogenesis and maintaining mitochondria respiration.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SIR7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBF1_HUMAN	UBTF	physical	19174463
RPA1_HUMAN	POLR1A	physical	16618798
H31_HUMAN	HIST1H3A	physical	16618798
H2B2E_HUMAN	HIST2H2BE	physical	16618798
H2A2C_HUMAN	HIST2H2AC	physical	16618798
FLNA_HUMAN	FLNA	physical	22586326
KI67_HUMAN	MKI67	physical	22586326
FAS_HUMAN	FASN	physical	22586326
PRKDC_HUMAN	PRKDC	physical	22586326
MYH9_HUMAN	MYH9	physical	22586326
USP9X_HUMAN	USP9X	physical	22586326
DYHC1_HUMAN	DYNC1H1	physical	22586326
EPIPL_HUMAN	EPPK1	physical	22586326
DESP_HUMAN	DSP	physical	22586326
U520_HUMAN	SNRNP200	physical	22586326
CLH1_HUMAN	CLTC	physical	22586326
PRP8_HUMAN	PRPF8	physical	22586326
PLEC_HUMAN	PLEC	physical	22586326
RRP5_HUMAN	PDCD11	physical	22586326
MBB1A_HUMAN	MYBBP1A	physical	22586326
TBA1C_HUMAN	TUBA1C	physical	22586326
DDX21_HUMAN	DDX21	physical	22586326
HEAT1_HUMAN	HEATR1	physical	22586326
TBB4A_HUMAN	TUBB4A	physical	22586326
NUMA1_HUMAN	NUMA1	physical	22586326
FLNB_HUMAN	FLNB	physical	22586326
RBP2_HUMAN	RANBP2	physical	22586326
SPTN1_HUMAN	SPTAN1	physical	22586326
ACTN4_HUMAN	ACTN4	physical	22586326
TLN1_HUMAN	TLN1	physical	22586326
TERA_HUMAN	VCP	physical	22586326
SPTB2_HUMAN	SPTBN1	physical	22586326
PABP1_HUMAN	PABPC1	physical	22586326
HNRL1_HUMAN	HNRNPUL1	physical	22586326
UTP20_HUMAN	UTP20	physical	22586326
MYH10_HUMAN	MYH10	physical	22586326
NOP2_HUMAN	NOP2	physical	22586326
RENT1_HUMAN	UPF1	physical	22586326
TPR_HUMAN	TPR	physical	22586326
GCN1_HUMAN	GCN1L1	physical	22586326
SC16A_HUMAN	SEC16A	physical	22586326
FLNC_HUMAN	FLNC	physical	22586326
IQGA1_HUMAN	IQGAP1	physical	22586326
UBR4_HUMAN	UBR4	physical	22586326
RL4_HUMAN	RPL4	physical	22586326
PYR1_HUMAN	CAD	physical	22586326
PRC2C_HUMAN	PRRC2C	physical	22586326
MDN1_HUMAN	MDN1	physical	22586326
GANAB_HUMAN	GANAB	physical	22586326
ACTN1_HUMAN	ACTN1	physical	22586326
PDIA4_HUMAN	PDIA4	physical	22586326
SF3B1_HUMAN	SF3B1	physical	22586326
PABP4_HUMAN	PABPC4	physical	22586326
H2B1L_HUMAN	HIST1H2BL	physical	22586326
DHX30_HUMAN	DHX30	physical	22586326
RPB1_HUMAN	POLR2A	physical	22586326
HUWE1_HUMAN	HUWE1	physical	22586326
NUCL_HUMAN	NCL	physical	22586326
HYOU1_HUMAN	HYOU1	physical	22586326
LMNA_HUMAN	LMNA	physical	22586326
IMB1_HUMAN	KPNB1	physical	22586326
H2B1J_HUMAN	HIST1H2BJ	physical	22586326
RLA0_HUMAN	RPLP0	physical	22586326
DDB1_HUMAN	DDB1	physical	22586326
MOV10_HUMAN	MOV10	physical	22586326
TCPB_HUMAN	CCT2	physical	22586326
ACINU_HUMAN	ACIN1	physical	22586326
ACLY_HUMAN	ACLY	physical	22586326
CNOT1_HUMAN	CNOT1	physical	22586326
BAZ1B_HUMAN	BAZ1B	physical	22586326
GRP75_HUMAN	HSPA9	physical	22586326
RRP12_HUMAN	RRP12	physical	22586326
NAT10_HUMAN	NAT10	physical	22586326
AT1A1_HUMAN	ATP1A1	physical	22586326
RL6_HUMAN	RPL6	physical	22586326
DHX15_HUMAN	DHX15	physical	22586326
RACK1_HUMAN	GNB2L1	physical	22586326
TCPG_HUMAN	CCT3	physical	22586326
SPB1_HUMAN	FTSJ3	physical	22586326
RL1D1_HUMAN	RSL1D1	physical	22586326
RL3_HUMAN	RPL3	physical	22586326
NU205_HUMAN	NUP205	physical	22586326
MDC1_HUMAN	MDC1	physical	22586326
NOP58_HUMAN	NOP58	physical	22586326
YTDC2_HUMAN	YTHDC2	physical	22586326
COPA_HUMAN	COPA	physical	22586326
IF4A1_HUMAN	EIF4A1	physical	22586326
XRCC6_HUMAN	XRCC6	physical	22586326
BMS1_HUMAN	BMS1	physical	22586326
TBL3_HUMAN	TBL3	physical	22586326
IF4G1_HUMAN	EIF4G1	physical	22586326
HSP72_HUMAN	HSPA2	physical	22586326
PELP1_HUMAN	PELP1	physical	22586326
H14_HUMAN	HIST1H1E	physical	22586326
RL5_HUMAN	RPL5	physical	22586326
AT2A2_HUMAN	ATP2A2	physical	22586326
SON_HUMAN	SON	physical	22586326
WDR36_HUMAN	WDR36	physical	22586326
NOG1_HUMAN	GTPBP4	physical	22586326
NU214_HUMAN	NUP214	physical	22586326
EDC4_HUMAN	EDC4	physical	22586326
RBM28_HUMAN	RBM28	physical	22586326
IF2B3_HUMAN	IGF2BP3	physical	22586326
LPPRC_HUMAN	LRPPRC	physical	22586326
DDX27_HUMAN	DDX27	physical	22586326
NVL_HUMAN	NVL	physical	22586326
PESC_HUMAN	PES1	physical	22586326
SF3B2_HUMAN	SF3B2	physical	22586326
H2AX_HUMAN	H2AFX	physical	22586326
HNRPF_HUMAN	HNRNPF	physical	22586326
PHIP_HUMAN	PHIP	physical	22586326
MYO1B_HUMAN	MYO1B	physical	22586326
MYH14_HUMAN	MYH14	physical	22586326
NPA1P_HUMAN	URB1	physical	22586326
CEBPZ_HUMAN	CEBPZ	physical	22586326
CHD4_HUMAN	CHD4	physical	22586326
HNRPQ_HUMAN	SYNCRIP	physical	22586326
RBMX_HUMAN	RBMX	physical	22586326
SND1_HUMAN	SND1	physical	22586326
ZFR_HUMAN	ZFR	physical	22586326
ROA3_HUMAN	HNRNPA3	physical	22586326
UT14A_HUMAN	UTP14A	physical	22586326
SMHD1_HUMAN	SMCHD1	physical	22586326
TCPE_HUMAN	CCT5	physical	22586326
TF3C1_HUMAN	GTF3C1	physical	22586326
DDX18_HUMAN	DDX18	physical	22586326
AHNK_HUMAN	AHNAK	physical	22586326
RSSA_HUMAN	RPSA	physical	22586326
YLPM1_HUMAN	YLPM1	physical	22586326
RL7A_HUMAN	RPL7A	physical	22586326
RS4X_HUMAN	RPS4X	physical	22586326
UBR5_HUMAN	UBR5	physical	22586326
ACACA_HUMAN	ACACA	physical	22586326
MYO1C_HUMAN	MYO1C	physical	22586326
SUGP2_HUMAN	SUGP2	physical	22586326
WDR3_HUMAN	WDR3	physical	22586326
RS2_HUMAN	RPS2	physical	22586326
PRC2A_HUMAN	PRRC2A	physical	22586326
TRIPC_HUMAN	TRIP12	physical	22586326
NOL6_HUMAN	NOL6	physical	22586326
NEST_HUMAN	NES	physical	22586326
SPT6H_HUMAN	SUPT6H	physical	22586326
ILF2_HUMAN	ILF2	physical	22586326
NU153_HUMAN	NUP153	physical	22586326
CKAP5_HUMAN	CKAP5	physical	22586326
LARP1_HUMAN	LARP1	physical	22586326
PWP2_HUMAN	PWP2	physical	22586326
NU155_HUMAN	NUP155	physical	22586326
DDX24_HUMAN	DDX24	physical	22586326
FINC_HUMAN	FN1	physical	22586326
NOC2L_HUMAN	NOC2L	physical	22586326
BOP1_HUMAN	BOP1	physical	22586326
PO210_HUMAN	NUP210	physical	22586326
FBRL_HUMAN	FBL	physical	22586326
CCAR2_HUMAN	CCAR2	physical	22586326
ZN638_HUMAN	ZNF638	physical	22586326
F120A_HUMAN	FAM120A	physical	22586326
MACF1_HUMAN	MACF1	physical	22586326
HERC2_HUMAN	HERC2	physical	22586326
DOCK7_HUMAN	DOCK7	physical	22586326
ANKH1_HUMAN	ANKHD1	physical	22586326
RBP56_HUMAN	TAF15	physical	22586326
XRN2_HUMAN	XRN2	physical	22586326
UGGG1_HUMAN	UGGT1	physical	22586326
RL7_HUMAN	RPL7	physical	22586326
SFPQ_HUMAN	SFPQ	physical	22586326
XRCC5_HUMAN	XRCC5	physical	22586326
PUM3_HUMAN	KIAA0020	physical	22586326
DICER_HUMAN	DICER1	physical	22586326
TEX10_HUMAN	TEX10	physical	22586326
MINT_HUMAN	SPEN	physical	22586326
NOL11_HUMAN	NOL11	physical	22586326
HSP74_HUMAN	HSPA4	physical	22586326
PAIRB_HUMAN	SERBP1	physical	22586326
RAD50_HUMAN	RAD50	physical	22586326
GNL3_HUMAN	GNL3	physical	22586326
TOP1_HUMAN	TOP1	physical	22586326
H13_HUMAN	HIST1H1D	physical	22586326
FUS_HUMAN	FUS	physical	22586326
SPT5H_HUMAN	SUPT5H	physical	22586326
MCM6_HUMAN	MCM6	physical	22586326
FRYL_HUMAN	FRYL	physical	22586326
SRRM2_HUMAN	SRRM2	physical	22586326
WDR46_HUMAN	WDR46	physical	22586326
TDIF2_HUMAN	DNTTIP2	physical	22586326
RS3A_HUMAN	RPS3A	physical	22586326
ECHA_HUMAN	HADHA	physical	22586326
MK67I_HUMAN	NIFK	physical	22586326
PFKAP_HUMAN	PFKP	physical	22586326
PSA_HUMAN	NPEPPS	physical	22586326
STRBP_HUMAN	STRBP	physical	22586326
ZO1_HUMAN	TJP1	physical	22586326
MAP1B_HUMAN	MAP1B	physical	22586326
LAS1L_HUMAN	LAS1L	physical	22586326
LMNB2_HUMAN	LMNB2	physical	22586326
ASCC3_HUMAN	ASCC3	physical	22586326
ZCCHV_HUMAN	ZC3HAV1	physical	22586326
WDR75_HUMAN	WDR75	physical	22586326
SR140_HUMAN	U2SURP	physical	22586326
VIGLN_HUMAN	HDLBP	physical	22586326
MCM5_HUMAN	MCM5	physical	22586326
NU160_HUMAN	NUP160	physical	22586326
ELYS_HUMAN	AHCTF1	physical	22586326
NKRF_HUMAN	NKRF	physical	22586326
RL10A_HUMAN	RPL10A	physical	22586326
ELAV1_HUMAN	ELAVL1	physical	22586326
PDIA1_HUMAN	P4HB	physical	22586326
MIC60_HUMAN	IMMT	physical	22586326
RL14_HUMAN	RPL14	physical	22586326
PGK1_HUMAN	PGK1	physical	22586326
VIR_HUMAN	KIAA1429	physical	22586326
XPO1_HUMAN	XPO1	physical	22586326
NOP14_HUMAN	NOP14	physical	22586326
HP1B3_HUMAN	HP1BP3	physical	22586326
SK2L2_HUMAN	SKIV2L2	physical	22586326
SYAC_HUMAN	AARS	physical	22586326
CPSF1_HUMAN	CPSF1	physical	22586326
HELZ2_HUMAN	HELZ2	physical	22586326
BRX1_HUMAN	BRIX1	physical	22586326
DHX57_HUMAN	DHX57	physical	22586326
NOC3L_HUMAN	NOC3L	physical	22586326
EXOSX_HUMAN	EXOSC10	physical	22586326
NU133_HUMAN	NUP133	physical	22586326
GAPD1_HUMAN	GAPVD1	physical	22586326
SMCA4_HUMAN	SMARCA4	physical	22586326
HCFC1_HUMAN	HCFC1	physical	22586326
ANR17_HUMAN	ANKRD17	physical	22586326
URB2_HUMAN	URB2	physical	22586326
F208B_HUMAN	FAM208B	physical	22586326
COPB_HUMAN	COPB1	physical	22586326
PSMD1_HUMAN	PSMD1	physical	22586326
RS6_HUMAN	RPS6	physical	22586326
PSMD2_HUMAN	PSMD2	physical	22586326
GDIB_HUMAN	GDI2	physical	22586326
BIRC6_HUMAN	BIRC6	physical	22586326
TP53B_HUMAN	TP53BP1	physical	22586326
KMT2A_HUMAN	KMT2A	physical	22586326
RAGP1_HUMAN	RANGAP1	physical	22586326
EBP2_HUMAN	EBNA1BP2	physical	22586326
RRP1B_HUMAN	RRP1B	physical	22586326
NDUS1_HUMAN	NDUFS1	physical	22586326
NUP93_HUMAN	NUP93	physical	22586326
NPM_HUMAN	NPM1	physical	22586326
MCM4_HUMAN	MCM4	physical	22586326
XRN1_HUMAN	XRN1	physical	22586326
TRRAP_HUMAN	TRRAP	physical	22586326
RSF1_HUMAN	RSF1	physical	22586326
RIF1_HUMAN	RIF1	physical	22586326
WDR43_HUMAN	WDR43	physical	22586326
IF2B2_HUMAN	IGF2BP2	physical	22586326
EIF3L_HUMAN	EIF3L	physical	22586326
SRSF4_HUMAN	SRSF4	physical	22586326
FMR1_HUMAN	FMR1	physical	22586326
CALX_HUMAN	CANX	physical	22586326
RAI1_HUMAN	RAI1	physical	22586326
FXR2_HUMAN	FXR2	physical	22586326
MOES_HUMAN	MSN	physical	22586326
ATAD2_HUMAN	ATAD2	physical	22586326
UBP7_HUMAN	USP7	physical	22586326
ZO2_HUMAN	TJP2	physical	22586326
MPRI_HUMAN	IGF2R	physical	22586326
DDX54_HUMAN	DDX54	physical	22586326
DDX10_HUMAN	DDX10	physical	22586326
PININ_HUMAN	PNN	physical	22586326
RLA2_HUMAN	RPLP2	physical	22586326
RL30_HUMAN	RPL30	physical	22586326
G3BP1_HUMAN	G3BP1	physical	22586326
ZN512_HUMAN	ZNF512	physical	22586326
RS5_HUMAN	RPS5	physical	22586326
RL15_HUMAN	RPL15	physical	22586326
CALR_HUMAN	CALR	physical	22586326
KCRB_HUMAN	CKB	physical	22586326
CUL9_HUMAN	CUL9	physical	22586326
NIPBL_HUMAN	NIPBL	physical	22586326
KRI1_HUMAN	KRI1	physical	22586326
SYNC_HUMAN	NARS	physical	22586326
NCBP1_HUMAN	NCBP1	physical	22586326
XPO2_HUMAN	CSE1L	physical	22586326
CHD1_HUMAN	CHD1	physical	22586326
COIL_HUMAN	COIL	physical	22586326
IF4G3_HUMAN	EIF4G3	physical	22586326
GEMI5_HUMAN	GEMIN5	physical	22586326
XPO5_HUMAN	XPO5	physical	22586326
EIF3D_HUMAN	EIF3D	physical	22586326
NU107_HUMAN	NUP107	physical	22586326
SMRC2_HUMAN	SMARCC2	physical	22586326
EFTU_HUMAN	TUFM	physical	22586326
SF3A1_HUMAN	SF3A1	physical	22586326
GTF2I_HUMAN	GTF2I	physical	22586326
THOC2_HUMAN	THOC2	physical	22586326
ATX2L_HUMAN	ATXN2L	physical	22586326
E41L2_HUMAN	EPB41L2	physical	22586326
SNUT1_HUMAN	SART1	physical	22586326
SLTM_HUMAN	SLTM	physical	22586326
RS14_HUMAN	RPS14	physical	22586326
RS7_HUMAN	RPS7	physical	22586326
SRSF3_HUMAN	SRSF3	physical	22586326
RS16_HUMAN	RPS16	physical	22586326
MSH6_HUMAN	MSH6	physical	22586326
DNMT1_HUMAN	DNMT1	physical	22586326
MYCB2_HUMAN	MYCBP2	physical	22586326
CHD8_HUMAN	CHD8	physical	22586326
MTMR5_HUMAN	SBF1	physical	22586326
BYST_HUMAN	BYSL	physical	22586326
MPP10_HUMAN	MPHOSPH10	physical	22586326
ZSWM8_HUMAN	ZSWIM8	physical	22586326
PRC2B_HUMAN	PRRC2B	physical	22586326
RS15_HUMAN	RPS15	physical	22586326
COPG1_HUMAN	COPG1	physical	22586326
RL9_HUMAN	RPL9	physical	22586326
PP1A_HUMAN	PPP1CA	physical	22586326
THOC4_HUMAN	ALYREF	physical	22586326
COPB2_HUMAN	COPB2	physical	22586326
RL23A_HUMAN	RPL23A	physical	22586326
PUR4_HUMAN	PFAS	physical	22586326
NSUN2_HUMAN	NSUN2	physical	22586326
DYST_HUMAN	DST	physical	22586326
PLSL_HUMAN	LCP1	physical	22586326
NOG2_HUMAN	GNL2	physical	22586326
BLM_HUMAN	BLM	physical	22586326
ZN318_HUMAN	ZNF318	physical	22586326
SYNE2_HUMAN	SYNE2	physical	22586326
SCAFB_HUMAN	SCAF11	physical	22586326
ANXA1_HUMAN	ANXA1	physical	22586326
ATD3A_HUMAN	ATAD3A	physical	22586326
RL8_HUMAN	RPL8	physical	22586326
PP1G_HUMAN	PPP1CC	physical	22586326
RBM15_HUMAN	RBM15	physical	22586326
PUR9_HUMAN	ATIC	physical	22586326
IPO5_HUMAN	IPO5	physical	22586326
UBP2L_HUMAN	UBAP2L	physical	22586326
BAZ2A_HUMAN	BAZ2A	physical	22586326
PHF3_HUMAN	PHF3	physical	22586326
DDX31_HUMAN	DDX31	physical	22586326
PCM1_HUMAN	PCM1	physical	22586326
NUP98_HUMAN	NUP98	physical	22586326
UTP6_HUMAN	UTP6	physical	22586326
ECM29_HUMAN	KIAA0368	physical	22586326
PPM1G_HUMAN	PPM1G	physical	22586326
RL10_HUMAN	RPL10	physical	22586326
P53_HUMAN	TP53	physical	22586326
PRP6_HUMAN	PRPF6	physical	22586326
SERPH_HUMAN	SERPINH1	physical	22586326
PP1B_HUMAN	PPP1CB	physical	22586326
RL19_HUMAN	RPL19	physical	22586326
SMC4_HUMAN	SMC4	physical	22586326
CUL4B_HUMAN	CUL4B	physical	22586326
RBM39_HUMAN	RBM39	physical	22586326
KIF14_HUMAN	KIF14	physical	22586326
PP6R3_HUMAN	PPP6R3	physical	22586326
COPG2_HUMAN	COPG2	physical	22586326
UTRO_HUMAN	UTRN	physical	22586326
UTP18_HUMAN	UTP18	physical	22586326
GEMI4_HUMAN	GEMIN4	physical	22586326
WDR12_HUMAN	WDR12	physical	22586326
SMU1_HUMAN	SMU1	physical	22586326
ARP3_HUMAN	ACTR3	physical	22586326
CE170_HUMAN	CEP170	physical	22586326
RS12_HUMAN	RPS12	physical	22586326
SART3_HUMAN	SART3	physical	22586326
NUP88_HUMAN	NUP88	physical	22586326
TPP2_HUMAN	TPP2	physical	22586326
AP2B1_HUMAN	AP2B1	physical	22586326
CSDE1_HUMAN	CSDE1	physical	22586326
P5CS_HUMAN	ALDH18A1	physical	22586326
KINH_HUMAN	KIF5B	physical	22586326
DDX42_HUMAN	DDX42	physical	22586326
FUBP2_HUMAN	KHSRP	physical	22586326
NFM_HUMAN	NEFM	physical	22586326
HECD1_HUMAN	HECTD1	physical	22586326
HERC5_HUMAN	HERC5	physical	22586326
OASL_HUMAN	OASL	physical	22586326
UTP4_HUMAN	CIRH1A	physical	22586326
TSR1_HUMAN	TSR1	physical	22586326
UTP15_HUMAN	UTP15	physical	22586326
RBM25_HUMAN	RBM25	physical	22586326
POP1_HUMAN	POP1	physical	22586326
ZC11A_HUMAN	ZC3H11A	physical	22586326
SC24C_HUMAN	SEC24C	physical	22586326
RPN2_HUMAN	RPN2	physical	22586326
ELP1_HUMAN	IKBKAP	physical	22586326
C1TM_HUMAN	MTHFD1L	physical	22586326
2AAA_HUMAN	PPP2R1A	physical	22586326
RL18A_HUMAN	RPL18A	physical	22586326
RL26_HUMAN	RPL26	physical	22586326
PUR2_HUMAN	GART	physical	22586326
ABCF1_HUMAN	ABCF1	physical	22586326
U2AF2_HUMAN	U2AF2	physical	22586326
DHX8_HUMAN	DHX8	physical	22586326
DDX52_HUMAN	DDX52	physical	22586326
SRSF5_HUMAN	SRSF5	physical	22586326
NOC4L_HUMAN	NOC4L	physical	22586326
RL21_HUMAN	RPL21	physical	22586326
AP1B1_HUMAN	AP1B1	physical	22586326
NU188_HUMAN	NUP188	physical	22586326
STAU1_HUMAN	STAU1	physical	22586326
FXR1_HUMAN	FXR1	physical	22586326
RINI_HUMAN	RNH1	physical	22586326
VDAC1_HUMAN	VDAC1	physical	22586326
ANM5_HUMAN	PRMT5	physical	22586326
DPYL2_HUMAN	DPYSL2	physical	22586326
TB182_HUMAN	TNKS1BP1	physical	22586326
CHD2_HUMAN	CHD2	physical	22586326
RBM34_HUMAN	RBM34	physical	22586326
MRT4_HUMAN	MRTO4	physical	22586326
NFL_HUMAN	NEFL	physical	22586326
STML2_HUMAN	STOML2	physical	22586326
AINX_HUMAN	INA	physical	22586326
PRDX4_HUMAN	PRDX4	physical	22586326
GFPT1_HUMAN	GFPT1	physical	22586326
IRS4_HUMAN	IRS4	physical	22586326
RRS1_HUMAN	RRS1	physical	22586326
UBP47_HUMAN	USP47	physical	22586326
DHX37_HUMAN	DHX37	physical	22586326
CTCF_HUMAN	CTCF	physical	22586326
SNX9_HUMAN	SNX9	physical	22586326
SMCA2_HUMAN	SMARCA2	physical	22586326
BPTF_HUMAN	BPTF	physical	22586326
ACSL3_HUMAN	ACSL3	physical	22586326
WDR18_HUMAN	WDR18	physical	22586326
KIF1A_HUMAN	KIF1A	physical	22586326
TTC37_HUMAN	TTC37	physical	22586326
SYK_HUMAN	KARS	physical	22586326
NOL10_HUMAN	NOL10	physical	22586326
FSCN1_HUMAN	FSCN1	physical	22586326
INCE_HUMAN	INCENP	physical	22586326
PR40A_HUMAN	PRPF40A	physical	22586326
NXF1_HUMAN	NXF1	physical	22586326
SNW1_HUMAN	SNW1	physical	22586326
IF2P_HUMAN	EIF5B	physical	22586326
AATF_HUMAN	AATF	physical	22586326
PLOD1_HUMAN	PLOD1	physical	22586326
SOGA1_HUMAN	SOGA1	physical	22586326
GANP_HUMAN	MCM3AP	physical	22586326
PRP4B_HUMAN	PRPF4B	physical	22586326
IF6_HUMAN	EIF6	physical	22586326
RRP1_HUMAN	RRP1	physical	22586326
KIF23_HUMAN	KIF23	physical	22586326
CAPR1_HUMAN	CAPRIN1	physical	22586326
RS19_HUMAN	RPS19	physical	22586326
DNJA1_HUMAN	DNAJA1	physical	22586326
SYF1_HUMAN	XAB2	physical	22586326
CHERP_HUMAN	CHERP	physical	22586326
RTCB_HUMAN	RTCB	physical	22586326
SC23A_HUMAN	SEC23A	physical	22586326
E41L3_HUMAN	EPB41L3	physical	22586326
U3IP2_HUMAN	RRP9	physical	22586326
ZC3HE_HUMAN	ZC3H14	physical	22586326
NF1_HUMAN	NF1	physical	22586326
DDX56_HUMAN	DDX56	physical	22586326
ESF1_HUMAN	ESF1	physical	22586326
CCD86_HUMAN	CCDC86	physical	22586326
RS10_HUMAN	RPS10	physical	22586326
GLYR1_HUMAN	GLYR1	physical	22586326
SRP68_HUMAN	SRP68	physical	22586326
RS26_HUMAN	RPS26	physical	22586326
MYEF2_HUMAN	MYEF2	physical	22586326
GSTP1_HUMAN	GSTP1	physical	22586326
ZMYM3_HUMAN	ZMYM3	physical	22586326
SDHA_HUMAN	SDHA	physical	22586326
LKHA4_HUMAN	LTA4H	physical	22586326
IPO7_HUMAN	IPO7	physical	22586326
STAG2_HUMAN	STAG2	physical	22586326
H11_HUMAN	HIST1H1A	physical	22586326
RCL1_HUMAN	RCL1	physical	22586326
CENPF_HUMAN	CENPF	physical	22586326
ZCHC3_HUMAN	ZCCHC3	physical	22586326
CO5A1_HUMAN	COL5A1	physical	22586326
DCA13_HUMAN	DCAF13	physical	22586326
CTNA1_HUMAN	CTNNA1	physical	22586326
UBP24_HUMAN	USP24	physical	22586326
AFAD_HUMAN	MLLT4	physical	22586326
KRR1_HUMAN	KRR1	physical	22586326
NSA2_HUMAN	NSA2	physical	22586326
SRPK1_HUMAN	SRPK1	physical	22586326
CSK21_HUMAN	CSNK2A1	physical	22586326
NOP53_HUMAN	GLTSCR2	physical	22586326
MTA2_HUMAN	MTA2	physical	22586326
AQR_HUMAN	AQR	physical	22586326
RS23_HUMAN	RPS23	physical	22586326
TCOF_HUMAN	TCOF1	physical	22586326
PUR6_HUMAN	PAICS	physical	22586326
PRS7_HUMAN	PSMC2	physical	22586326
PRP16_HUMAN	DHX38	physical	22586326
PB1_HUMAN	PBRM1	physical	22586326
TNPO1_HUMAN	TNPO1	physical	22586326
VINC_HUMAN	VCL	physical	22586326
ADNP_HUMAN	ADNP	physical	22586326
ARF3_HUMAN	ARF3	physical	22586326
REXO4_HUMAN	REXO4	physical	22586326
DHX36_HUMAN	DHX36	physical	22586326
CUL7_HUMAN	CUL7	physical	22586326
MED12_HUMAN	MED12	physical	22586326
MYO5A_HUMAN	MYO5A	physical	22586326
ITPR3_HUMAN	ITPR3	physical	22586326
DIDO1_HUMAN	DIDO1	physical	22586326
RL38_HUMAN	RPL38	physical	22586326
PWP1_HUMAN	PWP1	physical	22586326
SRP72_HUMAN	SRP72	physical	22586326
NOL9_HUMAN	NOL9	physical	22586326
TF3C3_HUMAN	GTF3C3	physical	22586326
SEC13_HUMAN	SEC13	physical	22586326
PTCD3_HUMAN	PTCD3	physical	22586326
MTOR_HUMAN	MTOR	physical	22586326
CBX3_HUMAN	CBX3	physical	22586326
PHRF1_HUMAN	PHRF1	physical	22586326
INT1_HUMAN	INTS1	physical	22586326
RS24_HUMAN	RPS24	physical	22586326
POGZ_HUMAN	POGZ	physical	22586326
CRNL1_HUMAN	CRNKL1	physical	22586326
SYWC_HUMAN	WARS	physical	22586326
CAN1_HUMAN	CAPN1	physical	22586326
DDX46_HUMAN	DDX46	physical	22586326
LA_HUMAN	SSB	physical	22586326
THIL_HUMAN	ACAT1	physical	22586326
FANCI_HUMAN	FANCI	physical	22586326
PRS6A_HUMAN	PSMC3	physical	22586326
MRE11_HUMAN	MRE11A	physical	22586326
GDIA_HUMAN	GDI1	physical	22586326
RBBP4_HUMAN	RBBP4	physical	22586326
CMC2_HUMAN	SLC25A13	physical	22586326
RPF2_HUMAN	RPF2	physical	22586326
RRP7A_HUMAN	RRP7A	physical	22586326
PUM1_HUMAN	PUM1	physical	22586326
ZCH18_HUMAN	ZC3H18	physical	22586326
DIEXF_HUMAN	DIEXF	physical	22586326
CHD7_HUMAN	CHD7	physical	22586326
MYO1D_HUMAN	MYO1D	physical	22586326
UBP34_HUMAN	USP34	physical	22586326
ARP2_HUMAN	ACTR2	physical	22586326
TCF20_HUMAN	TCF20	physical	22586326
CSK22_HUMAN	CSNK2A2	physical	22586326
SPTN2_HUMAN	SPTBN2	physical	22586326
SRRM1_HUMAN	SRRM1	physical	22586326
PARN_HUMAN	PARN	physical	22586326
CPSF3_HUMAN	CPSF3	physical	22586326
SKIV2_HUMAN	SKIV2L	physical	22586326
PSD12_HUMAN	PSMD12	physical	22586326
RU17_HUMAN	SNRNP70	physical	22586326
MAK16_HUMAN	MAK16	physical	22586326
ZC3HD_HUMAN	ZC3H13	physical	22586326
OSBL8_HUMAN	OSBPL8	physical	22586326
MAP4_HUMAN	MAP4	physical	22586326
IPO4_HUMAN	IPO4	physical	22586326
RPOM_HUMAN	POLRMT	physical	22586326
CND1_HUMAN	NCAPD2	physical	22586326
RPA1_HUMAN	POLR1A	physical	22586326
NOLC1_HUMAN	NOLC1	physical	22586326
RBBP7_HUMAN	RBBP7	physical	22586326
PDS5A_HUMAN	PDS5A	physical	22586326
IMDH2_HUMAN	IMPDH2	physical	22586326
DHX16_HUMAN	DHX16	physical	22586326
HXK1_HUMAN	HK1	physical	22586326
OAT_HUMAN	OAT	physical	22586326
LONM_HUMAN	LONP1	physical	22586326
NSD2_HUMAN	WHSC1	physical	22586326
RLA1_HUMAN	RPLP1	physical	22586326
NSD1_HUMAN	NSD1	physical	22586326
RRP8_HUMAN	RRP8	physical	22586326
DDX20_HUMAN	DDX20	physical	22586326
GGYF2_HUMAN	GIGYF2	physical	22586326
ABCE1_HUMAN	ABCE1	physical	22586326
LARP7_HUMAN	LARP7	physical	22586326
KDM1A_HUMAN	KDM1A	physical	22586326
RBM6_HUMAN	RBM6	physical	22586326
SMRC1_HUMAN	SMARCC1	physical	22586326
ANXA6_HUMAN	ANXA6	physical	22586326
EIF3I_HUMAN	EIF3I	physical	22586326
ATD2B_HUMAN	ATAD2B	physical	22586326
EIF3E_HUMAN	EIF3E	physical	22586326
SC23B_HUMAN	SEC23B	physical	22586326
PDIP3_HUMAN	POLDIP3	physical	22586326
LAR4B_HUMAN	LARP4B	physical	22586326
LARP4_HUMAN	LARP4	physical	22586326
CING_HUMAN	CGN	physical	22586326
PPCE_HUMAN	PREP	physical	22586326
DYN2_HUMAN	DNM2	physical	22586326
PUF60_HUMAN	PUF60	physical	22586326
PYGB_HUMAN	PYGB	physical	22586326
FUBP3_HUMAN	FUBP3	physical	22586326
SYIM_HUMAN	IARS2	physical	22586326
UBP5_HUMAN	USP5	physical	22586326
DLDH_HUMAN	DLD	physical	22586326
RAD21_HUMAN	RAD21	physical	22586326
PNPH_HUMAN	PNP	physical	22586326
PDC6I_HUMAN	PDCD6IP	physical	22586326
H1X_HUMAN	H1FX	physical	22586326
ZBT11_HUMAN	ZBTB11	physical	22586326
ZCHC8_HUMAN	ZCCHC8	physical	22586326
UBP11_HUMAN	USP11	physical	22586326
RED_HUMAN	IK	physical	22586326
ASNS_HUMAN	ASNS	physical	22586326
UBE2O_HUMAN	UBE2O	physical	22586326
SYMPK_HUMAN	SYMPK	physical	22586326
RECQ1_HUMAN	RECQL	physical	22586326
NCKP1_HUMAN	NCKAP1	physical	22586326
HDAC2_HUMAN	HDAC2	physical	22586326
ODP2_HUMAN	DLAT	physical	22586326
CLU_HUMAN	CLUH	physical	22586326
ANR28_HUMAN	ANKRD28	physical	22586326
NUFP2_HUMAN	NUFIP2	physical	22586326
WDR6_HUMAN	WDR6	physical	22586326
AMPB_HUMAN	RNPEP	physical	22586326
RFC1_HUMAN	RFC1	physical	22586326
DDX51_HUMAN	DDX51	physical	22586326
PGAM5_HUMAN	PGAM5	physical	22586326
NNTM_HUMAN	NNT	physical	22586326
RCC2_HUMAN	RCC2	physical	22586326
MAOM_HUMAN	ME2	physical	22586326
PRS8_HUMAN	PSMC5	physical	22586326
DDX23_HUMAN	DDX23	physical	22586326
UBF1_HUMAN	UBTF	physical	22586326
FKBP4_HUMAN	FKBP4	physical	22586326
TUT7_HUMAN	ZCCHC6	physical	22586326
ANR52_HUMAN	ANKRD52	physical	22586326
DPOE1_HUMAN	POLE	physical	22586326
NLE1_HUMAN	NLE1	physical	22586326
PDS5B_HUMAN	PDS5B	physical	22586326
NP1L1_HUMAN	NAP1L1	physical	22586326
EWS_HUMAN	EWSR1	physical	22586326
CCAR1_HUMAN	CCAR1	physical	22586326
LRC47_HUMAN	LRRC47	physical	22586326
TTF1_HUMAN	TTF1	physical	22586326
APC1_HUMAN	ANAPC1	physical	22586326
DPOLA_HUMAN	POLA1	physical	22586326
QCR2_HUMAN	UQCRC2	physical	22586326
JIP4_HUMAN	SPAG9	physical	22586326
XPOT_HUMAN	XPOT	physical	22586326
ODPA_HUMAN	PDHA1	physical	22586326
PGAM1_HUMAN	PGAM1	physical	22586326
PCNT_HUMAN	PCNT	physical	22586326
PRKRA_HUMAN	PRKRA	physical	22586326
ARI1A_HUMAN	ARID1A	physical	22586326
MSH2_HUMAN	MSH2	physical	22586326
SRSF2_HUMAN	SRSF2	physical	22586326
GUAA_HUMAN	GMPS	physical	22586326
QCR1_HUMAN	UQCRC1	physical	22586326
BEND3_HUMAN	BEND3	physical	22586326
KIF4A_HUMAN	KIF4A	physical	22586326
TTL12_HUMAN	TTLL12	physical	22586326
PYGL_HUMAN	PYGL	physical	22586326
CAP1_HUMAN	CAP1	physical	22586326
SURF6_HUMAN	SURF6	physical	22586326
PNPT1_HUMAN	PNPT1	physical	22586326
ANX11_HUMAN	ANXA11	physical	22586326
GDIR1_HUMAN	ARHGDIA	physical	22586326
MVP_HUMAN	MVP	physical	22586326
ATM_HUMAN	ATM	physical	22586326
NAA15_HUMAN	NAA15	physical	22586326
RRP44_HUMAN	DIS3	physical	22586326
S10A8_HUMAN	S100A8	physical	22586326
TGM3_HUMAN	TGM3	physical	22586326
FUMH_HUMAN	FH	physical	22586326
XPO7_HUMAN	XPO7	physical	22586326
TRFL_HUMAN	LTF	physical	22586326
A4_HUMAN	APP	physical	21832049
DDB1_HUMAN	DDB1	physical	24703702
DCAF1_HUMAN	VPRBP	physical	24703702
UBP7_HUMAN	USP7	physical	28655758
XRCC6_HUMAN	XRCC6	physical	28655758
MBB1A_HUMAN	MYBBP1A	physical	28655758
SIR1_HUMAN	SIRT1	physical	28655758
DDB1_HUMAN	DDB1	physical	28655758
HERC5_HUMAN	HERC5	physical	28655758
PSME2_HUMAN	PSME2	physical	28655758
CDK9_HUMAN	CDK9	physical	28655758
FOXO1_HUMAN	FOXO1	physical	28655758
DDB1_HUMAN	DDB1	physical	28886238
CSN4_HUMAN	COPS4	physical	28886238
UB2R2_HUMAN	UBE2R2	physical	28886238
MEP50_HUMAN	WDR77	physical	28886238
RBBP7_HUMAN	RBBP7	physical	28886238
DCA11_HUMAN	DCAF11	physical	28886238
DCAF5_HUMAN	DCAF5	physical	28886238
DCAF7_HUMAN	DCAF7	physical	28886238
CUL4B_HUMAN	CUL4B	physical	28886238
CSN5_HUMAN	COPS5	physical	28886238
CUL4A_HUMAN	CUL4A	physical	28886238

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SIR7_HUMAN

Related Literatures of Post-Translational Modification

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