dbPTM

BAZ1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BAZ1B_HUMAN
UniProt AC	Q9UIG0
Protein Name	Tyrosine-protein kinase BAZ1B
Gene Name	BAZ1B
Organism	Homo sapiens (Human).
Sequence Length	1483
Subcellular Localization	Nucleus . Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA.
Protein Description	Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication..
Protein Sequence	MAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFEVGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKKPGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYKENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLERLEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVKSRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSIDYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEKRYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDEEKKMVEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAPPVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDVITHPMDFQTVQNKCSCGSYRSVQEFLTDMKQVFTNAEVYNCRGSHVLSCMVKTEQCLVALLHKHLPGHPYVRRKRKKFPDRLAEDEGDSEPEAVGQSRGRRQKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Acetylation	MAPLLGRKPFPLVKP CCCCCCCCCCCCCCC	49.57	26051181
8	Ubiquitination	MAPLLGRKPFPLVKP CCCCCCCCCCCCCCC	49.57	23000965
14	Acetylation	RKPFPLVKPLPGEEP CCCCCCCCCCCCCCC	48.82	26051181
14	Ubiquitination	RKPFPLVKPLPGEEP CCCCCCCCCCCCCCC	48.82	23000965
45	Phosphorylation	YEARLERYSERIWTC HHHHHHHHHHCEEEE	12.90	23312004
46	Phosphorylation	EARLERYSERIWTCK HHHHHHHHHCEEEEC	26.98	23312004
53	Ubiquitination	SERIWTCKSTGSSQL HHCEEEECCCCCCCC	43.61	29967540
54	Phosphorylation	ERIWTCKSTGSSQLT HCEEEECCCCCCCCC	39.90	23312004
55	Phosphorylation	RIWTCKSTGSSQLTH CEEEECCCCCCCCCC	26.95	23312004
57	Phosphorylation	WTCKSTGSSQLTHKE EEECCCCCCCCCCHH	18.26	23312004
58	Phosphorylation	TCKSTGSSQLTHKEA EECCCCCCCCCCHHH	30.47	25159151
61	Phosphorylation	STGSSQLTHKEAWEE CCCCCCCCCHHHHHH	24.22	23312004
63	Ubiquitination	GSSQLTHKEAWEEEQ CCCCCCCHHHHHHHH	43.84	29967540
77	Ubiquitination	QEVAELLKEEFPAWY HHHHHHHHHHCHHHH	68.75	29967540
126	Acetylation	ECDFEVGKEKMLKVK CCCCCCCCCCEEEEE	60.38	26051181
126	Ubiquitination	ECDFEVGKEKMLKVK CCCCCCCCCCEEEEE	60.38	33845483
128	Ubiquitination	DFEVGKEKMLKVKIV CCCCCCCCEEEEEEE	53.68	-
136	Ubiquitination	MLKVKIVKIHPLEKV EEEEEEEEEEECHHC	38.48	29967540
142	Acetylation	VKIHPLEKVDEEATE EEEEECHHCCHHHHH	63.77	26051181
142	Ubiquitination	VKIHPLEKVDEEATE EEEEECHHCCHHHHH	63.77	33845483
148	Phosphorylation	EKVDEEATEKKSDGA HHCCHHHHHCCCCCC	52.17	30576142
150	Ubiquitination	VDEEATEKKSDGACD CCHHHHHCCCCCCCC	53.90	33845483
151	Acetylation	DEEATEKKSDGACDS CHHHHHCCCCCCCCC	47.77	7408827
152	Phosphorylation	EEATEKKSDGACDSP HHHHHCCCCCCCCCC	52.96	22167270
158	Phosphorylation	KSDGACDSPSSDKEN CCCCCCCCCCCCCCC	26.94	22167270
160	Phosphorylation	DGACDSPSSDKENSS CCCCCCCCCCCCCHH	55.94	22167270
161	Phosphorylation	GACDSPSSDKENSSQ CCCCCCCCCCCCHHH	56.96	22167270
163	Acetylation	CDSPSSDKENSSQIA CCCCCCCCCCHHHHH	61.82	25953088
166	Phosphorylation	PSSDKENSSQIAQDH CCCCCCCHHHHHHHH	25.39	22167270
167	Phosphorylation	SSDKENSSQIAQDHQ CCCCCCHHHHHHHHH	36.87	17525332
175	"N6,N6-dimethyllysine"	QIAQDHQKKETVVKE HHHHHHHHHHHEECC	49.51	-
175	Acetylation	QIAQDHQKKETVVKE HHHHHHHHHHHEECC	49.51	7408839
175	Methylation	QIAQDHQKKETVVKE HHHHHHHHHHHEECC	49.51	-
181	"N6,N6-dimethyllysine"	QKKETVVKEDEGRRE HHHHHEECCCCCCHH	55.93	-
181	Methylation	QKKETVVKEDEGRRE HHHHHEECCCCCCHH	55.93	-
189	Phosphorylation	EDEGRRESINDRARR CCCCCHHHHHHHHHC	25.53	23401153
197	Phosphorylation	INDRARRSPRKLPTS HHHHHHCCCCCCCCC	24.41	25159151
203	Phosphorylation	RSPRKLPTSLKKGER CCCCCCCCCCCCCCC	58.07	30266825
204	Phosphorylation	SPRKLPTSLKKGERK CCCCCCCCCCCCCCC	35.93	30266825
207	Ubiquitination	KLPTSLKKGERKWAP CCCCCCCCCCCCCCC	71.89	24816145
216	Acetylation	ERKWAPPKFLPHKYD CCCCCCCCCCCCCCE	59.48	26051181
221	Acetylation	PPKFLPHKYDVKLQN CCCCCCCCCEEECCC	41.00	26051181
221	Ubiquitination	PPKFLPHKYDVKLQN CCCCCCCCCEEECCC	41.00	29967540
222	Phosphorylation	PKFLPHKYDVKLQNE CCCCCCCCEEECCCC	23.96	-
225	Sumoylation	LPHKYDVKLQNEDKI CCCCCEEECCCCCCC	41.27	-
225	Sumoylation	LPHKYDVKLQNEDKI CCCCCEEECCCCCCC	41.27	-
225	Ubiquitination	LPHKYDVKLQNEDKI CCCCCEEECCCCCCC	41.27	33845483
231	Acetylation	VKLQNEDKIISNVPA EECCCCCCCCCCCCH	35.44	25953088
231	Ubiquitination	VKLQNEDKIISNVPA EECCCCCCCCCCCCH	35.44	33845483
234	Phosphorylation	QNEDKIISNVPADSL CCCCCCCCCCCHHHH	34.94	-
240	Phosphorylation	ISNVPADSLIRTERP CCCCCHHHHHCCCCC	28.00	24719451
250	Acetylation	RTERPPNKEIVRYFI CCCCCCCHHHHHHHH	55.37	26051181
250	Ubiquitination	RTERPPNKEIVRYFI CCCCCCCHHHHHHHH	55.37	24816145
266	Phosphorylation	HNALRAGTGENAPWV HCCHHCCCCCCCCCE	40.10	20068231
280	Acetylation	VVEDELVKKYSLPSK EECHHHHHHCCCCCC	59.63	26051181
280	Ubiquitination	VVEDELVKKYSLPSK EECHHHHHHCCCCCC	59.63	29967540
281	Ubiquitination	VEDELVKKYSLPSKF ECHHHHHHCCCCCCH	32.37	-
282	Phosphorylation	EDELVKKYSLPSKFS CHHHHHHCCCCCCHH	15.10	-
283	Phosphorylation	DELVKKYSLPSKFSD HHHHHHCCCCCCHHH	42.56	19691289
286	Phosphorylation	VKKYSLPSKFSDFLL HHHCCCCCCHHHHHC	52.18	24719451
287	Ubiquitination	KKYSLPSKFSDFLLD HHCCCCCCHHHHHCC	47.12	-
289	Phosphorylation	YSLPSKFSDFLLDPY CCCCCCHHHHHCCHH	31.05	20068231
296	Phosphorylation	SDFLLDPYKYMTLNP HHHHCCHHHCCCCCC	17.89	26074081
297	Acetylation	DFLLDPYKYMTLNPS HHHCCHHHCCCCCCC	33.65	11688637
297	Ubiquitination	DFLLDPYKYMTLNPS HHHCCHHHCCCCCCC	33.65	23000965
297 (in isoform 1)	Ubiquitination	-	33.65	21890473
297 (in isoform 2)	Ubiquitination	-	33.65	21890473
298	Phosphorylation	FLLDPYKYMTLNPST HHCCHHHCCCCCCCC	6.89	26074081
300	Phosphorylation	LDPYKYMTLNPSTKR CCHHHCCCCCCCCCC	21.94	26074081
304	Phosphorylation	KYMTLNPSTKRKNTG HCCCCCCCCCCCCCC	45.55	23401153
305	Phosphorylation	YMTLNPSTKRKNTGS CCCCCCCCCCCCCCC	35.80	23401153
306	Acetylation	MTLNPSTKRKNTGSP CCCCCCCCCCCCCCC	66.76	25953088
306	Ubiquitination	MTLNPSTKRKNTGSP CCCCCCCCCCCCCCC	66.76	23000965
308	Ubiquitination	LNPSTKRKNTGSPDR CCCCCCCCCCCCCCC	61.49	23000965
310	Phosphorylation	PSTKRKNTGSPDRKP CCCCCCCCCCCCCCC	41.91	26074081
312	Phosphorylation	TKRKNTGSPDRKPSK CCCCCCCCCCCCCCC	22.91	25159151
316	Ubiquitination	NTGSPDRKPSKKSKT CCCCCCCCCCCCCCC	62.11	23000965
318	Phosphorylation	GSPDRKPSKKSKTDN CCCCCCCCCCCCCCC	56.61	28176443
319	Ubiquitination	SPDRKPSKKSKTDNS CCCCCCCCCCCCCCC	70.37	23000965
320	Ubiquitination	PDRKPSKKSKTDNSS CCCCCCCCCCCCCCC	62.62	23000965
321	Phosphorylation	DRKPSKKSKTDNSSL CCCCCCCCCCCCCCC	44.52	26055452
322	Ubiquitination	RKPSKKSKTDNSSLS CCCCCCCCCCCCCCC	69.63	23000965
323	Phosphorylation	KPSKKSKTDNSSLSS CCCCCCCCCCCCCCC	47.72	26055452
326	Phosphorylation	KKSKTDNSSLSSPLN CCCCCCCCCCCCCCC	35.15	25159151
327	Phosphorylation	KSKTDNSSLSSPLNP CCCCCCCCCCCCCCH	38.23	25159151
329	Phosphorylation	KTDNSSLSSPLNPKL CCCCCCCCCCCCHHH	31.68	30266825
330	Phosphorylation	TDNSSLSSPLNPKLW CCCCCCCCCCCHHHE	38.40	23401153
335	Acetylation	LSSPLNPKLWCHVHL CCCCCCHHHEEEEEE	54.25	25953088
335	Ubiquitination	LSSPLNPKLWCHVHL CCCCCCHHHEEEEEE	54.25	23000965
343	Ubiquitination	LWCHVHLKKSLSGSP HEEEEEEEHHHCCCC	25.99	29967540
344	Methylation	WCHVHLKKSLSGSPL EEEEEEEHHHCCCCC	64.09	115978471
344	Ubiquitination	WCHVHLKKSLSGSPL EEEEEEEHHHCCCCC	64.09	29967540
345	Phosphorylation	CHVHLKKSLSGSPLK EEEEEEHHHCCCCCC	26.61	23927012
347	Phosphorylation	VHLKKSLSGSPLKVK EEEEHHHCCCCCCCC	44.29	22167270
349	Phosphorylation	LKKSLSGSPLKVKNS EEHHHCCCCCCCCCC	24.55	22167270
352	Ubiquitination	SLSGSPLKVKNSKNS HHCCCCCCCCCCCCC	55.32	32015554
359	Phosphorylation	KVKNSKNSKSPEEHL CCCCCCCCCCHHHHH	37.94	22167270
361	Phosphorylation	KNSKNSKSPEEHLEE CCCCCCCCHHHHHHH	37.05	29255136
374	Phosphorylation	EEMMKMMSPNKLHTN HHHHHHHCCCCCCCC	23.09	27134283
380	Phosphorylation	MSPNKLHTNFHIPKK HCCCCCCCCCCCCCC	50.44	20068231
386	Ubiquitination	HTNFHIPKKGPPAKK CCCCCCCCCCCCCCC	70.52	29967540
409	Acetylation	LKAKGRSKGILNGQK CCCCCCCCCCCCCCC	48.92	71341
416	Acetylation	KGILNGQKSTGNSKS CCCCCCCCCCCCCCC	51.92	71345
421	Phosphorylation	GQKSTGNSKSPKKGL CCCCCCCCCCCCCCC	35.54	29888752
423	Phosphorylation	KSTGNSKSPKKGLKT CCCCCCCCCCCCCCC	41.60	24719451
426	Acetylation	GNSKSPKKGLKTPKT CCCCCCCCCCCCCCH	73.24	19608861
429	Acetylation	KSPKKGLKTPKTKMK CCCCCCCCCCCHHHH	72.02	26210075
430	Phosphorylation	SPKKGLKTPKTKMKQ CCCCCCCCCCHHHHH	34.75	24719451
432	Acetylation	KKGLKTPKTKMKQMT CCCCCCCCHHHHHHH	67.04	26210075
439	Phosphorylation	KTKMKQMTLLDMAKG CHHHHHHHHHHHHHC	22.98	29396449
445	Ubiquitination	MTLLDMAKGTQKMTR HHHHHHHHCCHHHCC	56.72	29967540
447	Phosphorylation	LLDMAKGTQKMTRAP HHHHHHCCHHHCCCC	25.06	29396449
449	Acetylation	DMAKGTQKMTRAPRN HHHHCCHHHCCCCCC	41.92	11791593
451	Phosphorylation	AKGTQKMTRAPRNSG HHCCHHHCCCCCCCC	30.62	-
457	Phosphorylation	MTRAPRNSGGTPRTS HCCCCCCCCCCCCCC	39.62	28102081
460	Phosphorylation	APRNSGGTPRTSSKP CCCCCCCCCCCCCCC	17.08	28102081
465	Phosphorylation	GGTPRTSSKPHKHLP CCCCCCCCCCCCCCC	49.98	-
483	Ubiquitination	LHLIAYYKENKDRED HHHHHHHHHCCCHHH	41.98	23000965
486	Ubiquitination	IAYYKENKDREDKRS HHHHHHCCCHHHHHH	60.29	23000965
496	Phosphorylation	EDKRSALSCVISKTA HHHHHHHHHHHHHHH	13.17	24667141
501	Acetylation	ALSCVISKTARLLSS HHHHHHHHHHHHCCH	34.77	25953088
501	Malonylation	ALSCVISKTARLLSS HHHHHHHHHHHHCCH	34.77	26320211
501	Ubiquitination	ALSCVISKTARLLSS HHHHHHHHHHHHCCH	34.77	23000965
507	Phosphorylation	SKTARLLSSEDRARL HHHHHHCCHHHHHCC	35.95	20873877
508	Phosphorylation	KTARLLSSEDRARLP HHHHHCCHHHHHCCH	43.41	19691289
526	Phosphorylation	RSLVQKRYELLEHKK HHHHHHHHHHHHHHH	20.26	28152594
532	2-Hydroxyisobutyrylation	RYELLEHKKRWASMS HHHHHHHHHHHHCCC	34.36	-
532	Ubiquitination	RYELLEHKKRWASMS HHHHHHHHHHHHCCC	34.36	29967540
537	Phosphorylation	EHKKRWASMSEEQRK HHHHHHHCCCHHHHH	18.84	28555341
539	Phosphorylation	KKRWASMSEEQRKEY HHHHHCCCHHHHHHH	35.17	29083192
546	Phosphorylation	SEEQRKEYLKKKREE CHHHHHHHHHHHHHH	27.19	29083192
549	Ubiquitination	QRKEYLKKKREELKK HHHHHHHHHHHHHHH	55.24	24816145
561	Ubiquitination	LKKKLKEKAKERREK HHHHHHHHHHHHHHH	64.27	24816145
588	Acetylation	EDQELTGKNLPAFRL HCCCCCCCCCCCEEE	50.50	26051181
588	Ubiquitination	EDQELTGKNLPAFRL HCCCCCCCCCCCEEE	50.50	22817900
588 (in isoform 1)	Ubiquitination	-	50.50	21890473
588 (in isoform 2)	Ubiquitination	-	50.50	21890473
699	Phosphorylation	VRLCLRRSDVQEESE HHHHHHCCCCCHHHC	35.38	30278072
705	Phosphorylation	RSDVQEESEGSDTDD CCCCCHHHCCCCCCC	46.64	29255136
708	Phosphorylation	VQEESEGSDTDDNKD CCHHHCCCCCCCCCC	33.03	29255136
710	Phosphorylation	EESEGSDTDDNKDSA HHHCCCCCCCCCCCH	47.12	29255136
716	Phosphorylation	DTDDNKDSAAFEDNE CCCCCCCCHHHCCCH	24.09	30278072
759	Phosphorylation	LCHRILMTYSVQDHM HHHHHHHHHCHHHHH	14.81	-
760	Phosphorylation	CHRILMTYSVQDHME HHHHHHHHCHHHHHH	7.90	-
774 (in isoform 2)	Ubiquitination	-	15.57	21890473
778	Ubiquitination	QMSAELWKERLAVLK HHHHHHHHHHHHHHH	45.65	21890473
778 (in isoform 1)	Ubiquitination	-	45.65	21890473
790	Ubiquitination	VLKEENDKKRAEKQK HHHHHHHHHHHHHHH	56.60	24816145
810	Acetylation	AKNKENGKVENGLGK HHHHHCCCCCCCCCC	58.94	30584253
817	Acetylation	KVENGLGKTDRKKEI CCCCCCCCCCCCHHH	52.90	23749302
826	Sumoylation	DRKKEIVKFEPQVDT CCCHHHEEECCCCCC	50.07	-
826	Sumoylation	DRKKEIVKFEPQVDT CCCHHHEEECCCCCC	50.07	25114211
826	Ubiquitination	DRKKEIVKFEPQVDT CCCHHHEEECCCCCC	50.07	24816145
833	Phosphorylation	KFEPQVDTEAEDMIS EECCCCCCCHHHHHH	37.93	30266825
840	Phosphorylation	TEAEDMISAVKSRRL CCHHHHHHHHHHHHH	22.00	-
843	Acetylation	EDMISAVKSRRLLAI HHHHHHHHHHHHHHH	37.65	25953088
843	Ubiquitination	EDMISAVKSRRLLAI HHHHHHHHHHHHHHH	37.65	32015554
844	Phosphorylation	DMISAVKSRRLLAIQ HHHHHHHHHHHHHHH	18.94	-
853	Sumoylation	RLLAIQAKKEREIQE HHHHHHHHHHHHHHH	38.50	-
853	2-Hydroxyisobutyrylation	RLLAIQAKKEREIQE HHHHHHHHHHHHHHH	38.50	-
853	Acetylation	RLLAIQAKKEREIQE HHHHHHHHHHHHHHH	38.50	25953088
853	Sumoylation	RLLAIQAKKEREIQE HHHHHHHHHHHHHHH	38.50	28112733
853	Ubiquitination	RLLAIQAKKEREIQE HHHHHHHHHHHHHHH	38.50	29967540
854	Ubiquitination	LLAIQAKKEREIQER HHHHHHHHHHHHHHH	66.09	-
864	Acetylation	EIQEREMKVKLERQA HHHHHHHHHHHHHHH	31.31	19821681
885	Acetylation	KHKAAAEKAFQEGIA HHHHHHHHHHHHHHH	50.18	25953088
885	Ubiquitination	KHKAAAEKAFQEGIA HHHHHHHHHHHHHHH	50.18	-
893	Acetylation	AFQEGIAKAKLVMRR HHHHHHHHHEEEEEC	44.10	25953088
893	Ubiquitination	AFQEGIAKAKLVMRR HHHHHHHHHEEEEEC	44.10	29967540
932	Phosphorylation	EKGWVHDSIDYRFNH ECCCCCCCCCCCCCC	11.50	-
935	Phosphorylation	WVHDSIDYRFNHHCK CCCCCCCCCCCCCCC	18.55	-
942	Acetylation	YRFNHHCKDHTVSGD CCCCCCCCCCCCCCC	48.46	26051181
942	Ubiquitination	YRFNHHCKDHTVSGD CCCCCCCCCCCCCCC	48.46	33845483
945	Phosphorylation	NHHCKDHTVSGDEDY CCCCCCCCCCCCCCC	26.88	23401153
947	Phosphorylation	HCKDHTVSGDEDYCP CCCCCCCCCCCCCCC	41.50	29255136
952	Phosphorylation	TVSGDEDYCPRSKKA CCCCCCCCCCHHHCC	11.42	29255136
963	Acetylation	SKKANLGKNASMNTQ HHCCCCCCCCCCCCC	53.13	26051181
966	Phosphorylation	ANLGKNASMNTQHGT CCCCCCCCCCCCCCC	23.20	29214152
969	Phosphorylation	GKNASMNTQHGTATE CCCCCCCCCCCCEEE	17.19	21712546
973	Phosphorylation	SMNTQHGTATEVAVE CCCCCCCCEEEEEEE	28.43	21712546
983	Phosphorylation	EVAVETTTPKQGQNL EEEEEECCCCCCCEE	35.59	-
1025	Phosphorylation	KERLEKRYQDIIHSI HHHHHHHHHHHHHHH	22.93	28152594
1043	Acetylation	RKPNLGLKSCDGNQE CCCCCCCCCCCCCHH	47.44	26051181
1043	Sumoylation	RKPNLGLKSCDGNQE CCCCCCCCCCCCCHH	47.44	28112733
1043	Ubiquitination	RKPNLGLKSCDGNQE CCCCCCCCCCCCCHH	47.44	-
1045	Glutathionylation	PNLGLKSCDGNQELL CCCCCCCCCCCHHHH	8.10	22555962
1064 (in isoform 2)	Ubiquitination	-	36.77	21890473
1068	Ubiquitination	EVATRLQKGGLGYVE HHHHHHHHCCCCCCE	60.58	22817900
1068 (in isoform 1)	Ubiquitination	-	60.58	21890473
1078	Phosphorylation	LGYVEETSEFEARVI CCCCEECCCEEEEEE	43.50	-
1089	Sumoylation	ARVISLEKLKDFGEC EEEEEHHHHCCHHHH	67.16	-
1089	Sumoylation	ARVISLEKLKDFGEC EEEEEHHHHCCHHHH	67.16	28112733
1089	Ubiquitination	ARVISLEKLKDFGEC EEEEEHHHHCCHHHH	67.16	23000965
1091	Ubiquitination	VISLEKLKDFGECVI EEEHHHHCCHHHHHH	63.18	23000965
1107	Sumoylation	LQASVIKKFLQGFMA HHHHHHHHHHHHHCC	39.93	-
1107	Sumoylation	LQASVIKKFLQGFMA HHHHHHHHHHHHHCC	39.93	28112733
1116	Acetylation	LQGFMAPKQKRRKLQ HHHHCCCHHHHHHCC	59.94	7465925
1118	Acetylation	GFMAPKQKRRKLQSE HHCCCHHHHHHCCCC	61.36	7465937
1124	Phosphorylation	QKRRKLQSEDSAKTE HHHHHCCCCCCCCHH	54.53	25627689
1127	Phosphorylation	RKLQSEDSAKTEEVD HHCCCCCCCCHHHCH	27.84	25159151
1129	Sumoylation	LQSEDSAKTEEVDEE CCCCCCCCHHHCHHH	61.49	-
1129	Acetylation	LQSEDSAKTEEVDEE CCCCCCCCHHHCHHH	61.49	26051181
1129	Sumoylation	LQSEDSAKTEEVDEE CCCCCCCCHHHCHHH	61.49	-
1147	Phosphorylation	VEEAKVASALEKWKT HHHHHHHHHHHHHHH	36.05	22817900
1151	Ubiquitination	KVASALEKWKTAIRE HHHHHHHHHHHHHHH	55.64	-
1192	Ubiquitination	ARCKVCRKKGEDDKL CCCCCCCCCCCCCCE	61.06	22505724
1193	Ubiquitination	RCKVCRKKGEDDKLI CCCCCCCCCCCCCEE	48.45	22505724
1198	Ubiquitination	RKKGEDDKLILCDEC CCCCCCCCEEEECCC	50.15	22505724
1207	Ubiquitination	ILCDECNKAFHLFCL EEECCCHHHHHHHHH	65.18	22505724
1249	Phosphorylation	GRNYTEESASEDSED CCCCCCCCCCCCCCC	30.75	25137130
1251	Phosphorylation	NYTEESASEDSEDDE CCCCCCCCCCCCCCC	51.74	25137130
1254	Phosphorylation	EESASEDSEDDESDE CCCCCCCCCCCCCCH	38.58	25137130
1259	Phosphorylation	EDSEDDESDEEEEEE CCCCCCCCCHHHHHH	58.26	25137130
1291	Acetylation	PRKTIRGKHSVIPPA CCCCCCCCCCCCCHH	23.90	26051181
1291	Ubiquitination	PRKTIRGKHSVIPPA CCCCCCCCCCCCCHH	23.90	29967540
1293	Phosphorylation	KTIRGKHSVIPPAAR CCCCCCCCCCCHHHH	25.81	28555341
1315	Phosphorylation	KPHSTRRSQPKAPPV CCCCCCCCCCCCCCC	47.76	23401153
1318	Ubiquitination	STRRSQPKAPPVDDA CCCCCCCCCCCCCHH	66.92	29967540
1331 (in isoform 2)	Ubiquitination	-	3.33	21890473
1334	Phosphorylation	VDELVLQTKRSSRRQ HHHHHHHHHHHHHHH	25.02	23312004
1335	Acetylation	DELVLQTKRSSRRQS HHHHHHHHHHHHHHH	37.00	23954790
1335	Ubiquitination	DELVLQTKRSSRRQS HHHHHHHHHHHHHHH	37.00	22817900
1335 (in isoform 1)	Ubiquitination	-	37.00	21890473
1337	Phosphorylation	LVLQTKRSSRRQSLE HHHHHHHHHHHHHHH	29.74	21406692
1338	Phosphorylation	VLQTKRSSRRQSLEL HHHHHHHHHHHHHHH	35.20	21406692
1342	Phosphorylation	KRSSRRQSLELQKCE HHHHHHHHHHHHHHH	23.23	29255136
1347	Ubiquitination	RQSLELQKCEEILHK HHHHHHHHHHHHHHH	57.13	29967540
1354	Acetylation	KCEEILHKIVKYRFS HHHHHHHHHHHHHCC	45.83	26051181
1354	Ubiquitination	KCEEILHKIVKYRFS HHHHHHHHHHHHHCC	45.83	29967540
1358	Phosphorylation	ILHKIVKYRFSWPFR HHHHHHHHHCCCCCC	13.14	22210691
1361	Phosphorylation	KIVKYRFSWPFREPV HHHHHHCCCCCCCCC	25.49	22210691
1369	Phosphorylation	WPFREPVTRDEAEDY CCCCCCCCHHHHHHH	43.02	27642862
1376	Phosphorylation	TRDEAEDYYDVITHP CHHHHHHHHHCCCCC	7.96	28796482
1377	Phosphorylation	RDEAEDYYDVITHPM HHHHHHHHHCCCCCC	18.96	28796482
1381	Phosphorylation	EDYYDVITHPMDFQT HHHHHCCCCCCCHHH	21.56	22210691
1388	Phosphorylation	THPMDFQTVQNKCSC CCCCCHHHHCCCCCC	24.85	22210691
1431	Acetylation	HVLSCMVKTEQCLVA CHHHHEECHHHHHHH	21.33	26051181
1435	Glutathionylation	CMVKTEQCLVALLHK HEECHHHHHHHHHHH	2.41	22555962
1442	Acetylation	CLVALLHKHLPGHPY HHHHHHHHHCCCCHH	46.97	26051181
1449	Phosphorylation	KHLPGHPYVRRKRKK HHCCCCHHHHCCCCC	10.83	28258704
1468	Phosphorylation	LAEDEGDSEPEAVGQ HCCCCCCCCHHHHCC	66.94	29255136
1476	Phosphorylation	EPEAVGQSRGRRQKK CHHHHCCCCCCCCCC	30.67	23927012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
158	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
158	S	Phosphorylation	Kinase	MAPK9	P45984	GPS
158	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BAZ1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BAZ1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMCA5_HUMAN	SMARCA5	physical	16603771
ERCC6_HUMAN	ERCC6	physical	16603771
SF3B1_HUMAN	SF3B1	physical	16603771
RHD_HUMAN	RHD	physical	16603771
DEK_HUMAN	DEK	physical	16603771
MBB1A_HUMAN	MYBBP1A	physical	16603771
MYO1C_HUMAN	MYO1C	physical	16603771
VDR_HUMAN	VDR	physical	17250953
SMCA5_HUMAN	SMARCA5	physical	22939629
SMRC2_HUMAN	SMARCC2	physical	22939629
TOP2B_HUMAN	TOP2B	physical	22939629
SMRC1_HUMAN	SMARCC1	physical	22939629
SMCA4_HUMAN	SMARCA4	physical	22939629
MBD3_HUMAN	MBD3	physical	22939629
SMRD2_HUMAN	SMARCD2	physical	22939629
SRRM2_HUMAN	SRRM2	physical	22939629
SMCA5_HUMAN	SMARCA5	physical	23555303
MYO1C_HUMAN	MYO1C	physical	23555303

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BAZ1B_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-426, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-705; SER-1315 ANDSER-1468, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330 AND SER-1468, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330; SER-345; SER-347;SER-349; SER-361; SER-374; SER-699; SER-705; SER-708; SER-716;SER-947; SER-1315; SER-1342 AND SER-1468, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1468, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330; SER-347; SER-349;SER-508; SER-1342 AND SER-1468, AND MASS SPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-705 AND SER-1468, ANDMASS SPECTROMETRY.	16565220 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189; SER-361; SER-1147;SER-1342 AND SER-1468, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-705; SER-708 ANDSER-1468, AND MASS SPECTROMETRY.	15302935 [Abstract]