dbPTM

FRYL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FRYL_HUMAN
UniProt AC	O94915
Protein Name	Protein furry homolog-like
Gene Name	FRYL
Organism	Homo sapiens (Human).
Sequence Length	3013
Subcellular Localization
Protein Description	Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator..
Protein Sequence	MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTEDESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVRKKFVTELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPVAAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLKNKDPKMSRVALESLYRLLWVYVIRIKCESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVGKSTKTFTINPERMNIGLRVFLVIADSLQQKDGEPPMPTTGVILPSGNTLRVKKIFLNKTLTDEEAKVIGMSVYYPQVRKALDSILRHLDKEVGRPMCMTSVQMSNKEPEDMITGERKPKIDLFRTCIAAIPRLIPDGMSRTDLIELLARLTIHMDEELRALAFNTLQALMLDFPDWREDVLSGFVYFIVREVTDVHPTLLDNAVKMLVQLINQWKQAAQMHNKNQDTQHGVANGASHPPPLERSPYSNVFHVVEGFALVILCSSRPATRRLAVSVLREIRALFALLEIPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLYCPSSIDLQTLAEWNSSPISHQFDVISPSHIWIFAHVTQGQDPWIISLSSFLKQENLPKHCSTAVSYAWMFAYTRLQLLSPQVDINSPINAKKVNTTTSSDSYIGLWRNYLILCCSAATSSSSTSAGSVRCSPPETLASTPDSGYSIDSKIIGIPSPSSLFKHIVPMMRSESMEITESLVLGLGRTNPGAFRELIEELHPIIKEALERRPENMKRRRRRDILRVQLVRIFELLADAGVISHSASGGLDNETHFLNNTLLEYVDLTRQLLEAENEKDSDTLKDIRCHFSALVANIIQNVPVHQRRSIFPQQSLRHSLFMLFSHWAGPFSIMFTPLDRYSDRNMQINRHQYCALKAMSAVLCCGPVADNVGLSSDGYLYKWLDNILDSLDKKVHQLGCEAVTLLLELNPDQSNLMYWAVDRCYTGSGRVAAGCFKAIANVFQNRDYQCDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKMFRYAHKLEVQRTDGVLSQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQRIQTAHPAGRQVMLHYLLPWMNNIELVDLKPLPTARRHDEDEDDSLKDRELMVTSRRWLRGEGWGSPQATAMVLNNLMYMTAKYGDELAWSEVENVWTTLADGWPKNLKIILHFLISICGVNSEPSLLPYVKKVIVYLGRDKTMQLLEELVSELQLTDPVSSGVTHMDNPPYYRITSSYKIPSVTSGTTSSSNTMVAPTDGNPDNKPIKENIEESYVHLDIYSGLNSHLNRQHHRLESRYSSSSGGSYEEEKSDSMPLYSNWRLKVMEHNQGEPLPFPPAGGCWSPLVDYVPETSSPGLPLHRCNIAVILLTDLIIDHSVKVEWGSYLHLLLHAIFIGFDHCHPEVYEHCKRLLLHLLIVMGPNSNIRTVASVLLRNKEFNEPRVLTVKQVAHLDYNFTAGINDFIPDYQPSPMTDSGLSSSSTSSSISLGNNSAAISHLHTTILNEVDISVEQDGKVKTLMEFITSRKRGPLWNHEDVSAKNPSIKSAEQLTTFLKHVVSVFKQSSSEGIHLEHHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLTATTLSDVLSRLVETVGDPGEDAQGFVIELLLTLESAIDTLAETMKHYDLLSALSQTSYHDPIMGNKYAANRKSTGQLNLSTSPINSSSYLGYNSNARSNSLRLSLIGDRRGDRRRSNTLDIMDGRINHSSSLARTRSLSSLREKGMYDVQSTTEPTNLMATIFWIAASLLESDYEYEYLLALRLLNKLLIHLPLDKSESREKIENVQSKLKWTNFPGLQQLFLKGFTSASTQEMTVHLLSKLISVSKHTLVDPSQLSGFPLNILCLLPHLIQHFDSPTQFCKETASRIAKVCAEEKCPTLVNLAHMMSLYSTHTYSRDCSNWINVVCRYLHDSFSDTTFNLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPAKQFNLEIIKIIGKYVQSPYWKEALNILKLVVSRSASLVVPSDIPKTYGGDTGSPEISFTKIFNNVSKELPGKTLDFHFDISETPIIGNKYGDQHSAAGRNGKPKVIAVTRSTSSTSSGSNSNALVPVSWKRPQLSQRRTREKLMNVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTTEDINQEEEVAVEDNSSEQQFGVFKDFDFLDVELEDAEGESMDNFNWGVRRRSLDSIDKGDTPSLQEYQCSSSTPSLNLTNQEDTDESSEEEAALTASQILSRTQMLNSDSATDETIPDHPDLLLQSEDSTGSITTEEVLQIRDETPTLEASLDNANSRLPEDTTSVLKEEHVTTFEDEGSYIIQEQQESLVCQGILDLEETEMPEPLAPESYPESVCEEDVTLALKELDERCEEEEADFSGLSSQDEEEQDGFPEVQTSPLPSPFLSAIIAAFQPVAYDDEEEAWRCHVNQMLSDTDGSSAVFTFHVFSRLFQTIQRKFGEITNEAVSFLGDSLQRIGTKFKSSLEVMMLCSECPTVFVDAETLMSCGLLETLKFGVLELQEHLDTYNVKREAAEQWLDDCKRTFGAKEDMYRINTDAQQMEILAELELCRRLYKLHFQLLLLFQAYCKLINQVNTIKNEAEVINMSEELAQLESILKEAESASENEEIDISKAAQTTIETAIHSLIETLKNKEFISAVAQVKAFRSLWPSDIFGSCEDDPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANYKLMELNLEIRESLRMVQSYQLLAQAKPMGNMVSTGF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSNITIDPD ------CCCCEECCC	48.52	-
11	Ubiquitination	ITIDPDVKPGEYVIK CEECCCCCCCHHHHH	55.47	-
42	Ubiquitination	VMAEPLEKLLSRSLQ EECHHHHHHHHHHHH	63.51	-
92	Phosphorylation	QNGTEDESYEYRPRS HCCCCCCCCCCCCCC	35.27	25106551
93	Phosphorylation	NGTEDESYEYRPRSS CCCCCCCCCCCCCCC	18.22	25839225
95	Phosphorylation	TEDESYEYRPRSSTK CCCCCCCCCCCCCCC	20.06	22817900
100	Phosphorylation	YEYRPRSSTKSKGDE CCCCCCCCCCCCCCH	40.93	22817900
101	Phosphorylation	EYRPRSSTKSKGDEQ CCCCCCCCCCCCCHH	40.35	22817900
103	Phosphorylation	RPRSSTKSKGDEQQR CCCCCCCCCCCHHHH	41.79	-
104	Ubiquitination	PRSSTKSKGDEQQRE CCCCCCCCCCHHHHH	72.45	-
165	Phosphorylation	HFKHKEGYSGTNTGN HHCCCCCCCCCCCCC	12.67	26074081
166	Phosphorylation	FKHKEGYSGTNTGNV HCCCCCCCCCCCCCE	50.42	26074081
168	Phosphorylation	HKEGYSGTNTGNVHI CCCCCCCCCCCCEEE	24.54	26074081
170	Phosphorylation	EGYSGTNTGNVHIIA CCCCCCCCCCEEEEH	29.94	26074081
180	Phosphorylation	VHIIADLYAEVIGVL EEEEHHHHHHHHHHH	10.98	26074081
204	Ubiquitination	KKFVTELKELRQKEQ HHHHHHHHHHHHHCC	48.77	-
360	Phosphorylation	RVALESLYRLLWVYV HHHHHHHHHHHHHHH	14.43	-
384	Phosphorylation	VTQSRLMSIVSALFP CCHHHHHHHHHHHCC	25.16	-
392	Ubiquitination	IVSALFPKGSRSVVP HHHHHCCCCCCCCCC	63.28	21906983
392 (in isoform 1)	Ubiquitination	-	63.28	21890473
392 (in isoform 2)	Ubiquitination	-	63.28	21906983
432	Phosphorylation	EIIFDLLSVGKSTKT HHHHHHHHCCCCCCE	35.80	29083192
479	Phosphorylation	TTGVILPSGNTLRVK CCEEECCCCCEEEEE	41.03	30576142
482	Phosphorylation	VILPSGNTLRVKKIF EECCCCCEEEEEEEE	21.33	30576142
492	Acetylation	VKKIFLNKTLTDEEA EEEEEECCCCCHHHH	47.24	19813103
492	Ubiquitination	VKKIFLNKTLTDEEA EEEEEECCCCCHHHH	47.24	-
500	Ubiquitination	TLTDEEAKVIGMSVY CCCHHHHHHHCEECC	37.35	21906983
500 (in isoform 1)	Ubiquitination	-	37.35	21890473
500 (in isoform 2)	Ubiquitination	-	37.35	21906983
517	Phosphorylation	QVRKALDSILRHLDK HHHHHHHHHHHHHHH	25.11	24719451
538	Phosphorylation	CMTSVQMSNKEPEDM CCCCEECCCCCCHHH	27.88	-
540	Acetylation	TSVQMSNKEPEDMIT CCEECCCCCCHHHCC	68.30	7672045
547	Phosphorylation	KEPEDMITGERKPKI CCCHHHCCCCCCCCH	26.76	-
627	O-linked_Glycosylation	YFIVREVTDVHPTLL HHHEEECCCCCHHHH	27.79	29351928
632	O-linked_Glycosylation	EVTDVHPTLLDNAVK ECCCCCHHHHHHHHH	25.69	29351928
708	Phosphorylation	ATRRLAVSVLREIRA HHHHHHHHHHHHHHH	15.15	20860994
804	Phosphorylation	GQDPWIISLSSFLKQ CCCCEEEEHHHHHHH	17.05	20068231
806	Phosphorylation	DPWIISLSSFLKQEN CCEEEEHHHHHHHCC	16.56	20068231
807	Phosphorylation	PWIISLSSFLKQENL CEEEEHHHHHHHCCC	39.63	20068231
819	Phosphorylation	ENLPKHCSTAVSYAW CCCCHHHHHHHHHHH	21.08	27251275
837	Phosphorylation	YTRLQLLSPQVDINS HHHHHHHCCCCCCCC	23.14	29255136
844	Phosphorylation	SPQVDINSPINAKKV CCCCCCCCCCCCCCC	27.73	30266825
849	Ubiquitination	INSPINAKKVNTTTS CCCCCCCCCCCCCCC	53.41	21906983
849 (in isoform 1)	Ubiquitination	-	53.41	21890473
849 (in isoform 2)	Ubiquitination	-	53.41	21906983
853	Phosphorylation	INAKKVNTTTSSDSY CCCCCCCCCCCCCCC	34.14	29759185
854	Phosphorylation	NAKKVNTTTSSDSYI CCCCCCCCCCCCCCC	21.34	29759185
855	Phosphorylation	AKKVNTTTSSDSYIG CCCCCCCCCCCCCCC	24.97	27732954
856	Phosphorylation	KKVNTTTSSDSYIGL CCCCCCCCCCCCCCC	30.01	27732954
857	Phosphorylation	KVNTTTSSDSYIGLW CCCCCCCCCCCCCCC	28.60	27732954
859	Phosphorylation	NTTTSSDSYIGLWRN CCCCCCCCCCCCCCC	22.16	29759185
860	Phosphorylation	TTTSSDSYIGLWRNY CCCCCCCCCCCCCCE	12.19	29759185
867	Phosphorylation	YIGLWRNYLILCCSA CCCCCCCEEEEHHHC	6.12	30576142
879	Phosphorylation	CSAATSSSSTSAGSV HHCCCCCCCCCCCCC	37.09	30576142
882	Phosphorylation	ATSSSSTSAGSVRCS CCCCCCCCCCCCCCC	32.36	30576142
889	Phosphorylation	SAGSVRCSPPETLAS CCCCCCCCCCHHHCC	32.69	28985074
893	Phosphorylation	VRCSPPETLASTPDS CCCCCCHHHCCCCCC	33.14	21815630
896	Phosphorylation	SPPETLASTPDSGYS CCCHHHCCCCCCCCC	43.52	27080861
897	Phosphorylation	PPETLASTPDSGYSI CCHHHCCCCCCCCCC	26.05	29449344
900	Phosphorylation	TLASTPDSGYSIDSK HHCCCCCCCCCCCCE	40.61	27080861
902	Phosphorylation	ASTPDSGYSIDSKII CCCCCCCCCCCCEEC	13.35	27080861
916	Phosphorylation	IGIPSPSSLFKHIVP CCCCCHHHHHHHHHH	41.01	24719451
960	Ubiquitination	EELHPIIKEALERRP HHHHHHHHHHHHHCC	37.34	-
1068	Phosphorylation	RSIFPQQSLRHSLFM CCCCCCCHHHHHHHH	23.32	24702127
1085	Phosphorylation	SHWAGPFSIMFTPLD HCCCCCCEEEEECHH	19.10	-
1094	Phosphorylation	MFTPLDRYSDRNMQI EEECHHHCCCCCCCC	18.00	29083192
1095	Phosphorylation	FTPLDRYSDRNMQIN EECHHHCCCCCCCCC	30.87	29083192
1146	Ubiquitination	NILDSLDKKVHQLGC HHHHHHHHHHHHHHH	63.09	-
1224	Phosphorylation	ADSSRSIYEVAMQLL HCCCCCHHHHHHHHH	12.95	-
1244	Ubiquitination	KMFRYAHKLEVQRTD HHHHHHHHCCEECCC	37.86	-
1337	Phosphorylation	HDEDEDDSLKDRELM CCCCCCCCCHHHHHH	50.03	29255136
1339	Ubiquitination	EDEDDSLKDRELMVT CCCCCCCHHHHHHHE	59.70	-
1358	Phosphorylation	LRGEGWGSPQATAMV HCCCCCCCHHHHHHH	13.82	20860994
1475	Phosphorylation	TSSYKIPSVTSGTTS CCCEECCCCCCCCCC	41.31	27732954
1477	Phosphorylation	SYKIPSVTSGTTSSS CEECCCCCCCCCCCC	26.27	27732954
1478	Phosphorylation	YKIPSVTSGTTSSSN EECCCCCCCCCCCCC	31.80	30576142
1480	Phosphorylation	IPSVTSGTTSSSNTM CCCCCCCCCCCCCCE	24.23	30576142
1481	Phosphorylation	PSVTSGTTSSSNTMV CCCCCCCCCCCCCEE	30.09	30576142
1482	Phosphorylation	SVTSGTTSSSNTMVA CCCCCCCCCCCCEEC	31.44	30576142
1483	Phosphorylation	VTSGTTSSSNTMVAP CCCCCCCCCCCEECC	26.05	30576142
1484	Phosphorylation	TSGTTSSSNTMVAPT CCCCCCCCCCEECCC	35.77	30576142
1486	Phosphorylation	GTTSSSNTMVAPTDG CCCCCCCCEECCCCC	18.25	30576142
1514	Phosphorylation	SYVHLDIYSGLNSHL HHEEEHHHHHHHHHH	9.06	25884760
1530	Phosphorylation	RQHHRLESRYSSSSG HHHHHHHHHCCCCCC	40.90	28450419
1532	Phosphorylation	HHRLESRYSSSSGGS HHHHHHHCCCCCCCC	23.37	28450419
1533	Phosphorylation	HRLESRYSSSSGGSY HHHHHHCCCCCCCCC	23.72	29507054
1534	Phosphorylation	RLESRYSSSSGGSYE HHHHHCCCCCCCCCC	21.42	28450419
1535	Phosphorylation	LESRYSSSSGGSYEE HHHHCCCCCCCCCCC	27.36	28450419
1536	Phosphorylation	ESRYSSSSGGSYEEE HHHCCCCCCCCCCCC	49.47	21815630
1539	Phosphorylation	YSSSSGGSYEEEKSD CCCCCCCCCCCCCCC	32.66	21815630
1540	Phosphorylation	SSSSGGSYEEEKSDS CCCCCCCCCCCCCCC	30.54	28450419
1545	Phosphorylation	GSYEEEKSDSMPLYS CCCCCCCCCCCCCCC	37.89	21601212
1551	Phosphorylation	KSDSMPLYSNWRLKV CCCCCCCCCCCEEEE	8.29	23186163
1552	Phosphorylation	SDSMPLYSNWRLKVM CCCCCCCCCCEEEEE	37.28	24719451
1664	Phosphorylation	SNIRTVASVLLRNKE CCHHHHHHHHHHCCC	14.68	28348404
1761	Ubiquitination	MEFITSRKRGPLWNH HHHHHCCCCCCCCCC	62.57	-
1779	Ubiquitination	SAKNPSIKSAEQLTT CCCCCCCCCHHHHHH	48.20	-
1786	Phosphorylation	KSAEQLTTFLKHVVS CCHHHHHHHHHHHHH	35.25	20058876
1789	Acetylation	EQLTTFLKHVVSVFK HHHHHHHHHHHHHHH	30.11	7668087
1793	Phosphorylation	TFLKHVVSVFKQSSS HHHHHHHHHHHHCCC	22.28	20058876
1796	Acetylation	KHVVSVFKQSSSEGI HHHHHHHHHCCCCCC	47.30	7668097
1837	Ubiquitination	FQIFRALKQPLTATT HHHHHHHCCCCCHHH	49.21	-
1895	Phosphorylation	YDLLSALSQTSYHDP HHHHHHHHCCCCCCC	31.00	28555341
1897	Phosphorylation	LLSALSQTSYHDPIM HHHHHHCCCCCCCCC	28.07	-
1898	Phosphorylation	LSALSQTSYHDPIMG HHHHHCCCCCCCCCC	16.91	28555341
1899	Phosphorylation	SALSQTSYHDPIMGN HHHHCCCCCCCCCCC	17.40	-
1908	Phosphorylation	DPIMGNKYAANRKST CCCCCCCCCCCCCCC	18.23	28464451
1913	Ubiquitination	NKYAANRKSTGQLNL CCCCCCCCCCCCCCC	52.77	-
1914	Phosphorylation	KYAANRKSTGQLNLS CCCCCCCCCCCCCCC	34.24	23401153
1915	Phosphorylation	YAANRKSTGQLNLST CCCCCCCCCCCCCCC	31.79	30278072
1921	Phosphorylation	STGQLNLSTSPINSS CCCCCCCCCCCCCCC	26.26	30278072
1922	Phosphorylation	TGQLNLSTSPINSSS CCCCCCCCCCCCCCH	41.51	30278072
1923	Phosphorylation	GQLNLSTSPINSSSY CCCCCCCCCCCCCHH	22.02	27273156
1927	Phosphorylation	LSTSPINSSSYLGYN CCCCCCCCCHHCCCC	22.75	23927012
1928	Phosphorylation	STSPINSSSYLGYNS CCCCCCCCHHCCCCC	20.65	23927012
1929	Phosphorylation	TSPINSSSYLGYNSN CCCCCCCHHCCCCCC	24.97	23927012
1930	Phosphorylation	SPINSSSYLGYNSNA CCCCCCHHCCCCCCC	13.19	23403867
1933	Phosphorylation	NSSSYLGYNSNARSN CCCHHCCCCCCCCCC	16.90	23403867
1935	Phosphorylation	SSYLGYNSNARSNSL CHHCCCCCCCCCCCE	24.31	23927012
1939	Phosphorylation	GYNSNARSNSLRLSL CCCCCCCCCCEEEEE	28.49	22617229
1941	Phosphorylation	NSNARSNSLRLSLIG CCCCCCCCEEEEECC	19.00	23401153
1943	Methylation	NARSNSLRLSLIGDR CCCCCCEEEEECCCC	23.27	-
1945	Phosphorylation	RSNSLRLSLIGDRRG CCCCEEEEECCCCCC	16.11	30266825
1957	Phosphorylation	RRGDRRRSNTLDIMD CCCCCCCCCCEECCC	32.15	23927012
1959	Phosphorylation	GDRRRSNTLDIMDGR CCCCCCCCEECCCCC	27.36	29255136
1970	Phosphorylation	MDGRINHSSSLARTR CCCCCCCCHHHHHHC	19.68	28176443
1971	Phosphorylation	DGRINHSSSLARTRS CCCCCCCHHHHHHCC	23.09	23401153
1972	Phosphorylation	GRINHSSSLARTRSL CCCCCCHHHHHHCCH	29.12	27273156
1976	Phosphorylation	HSSSLARTRSLSSLR CCHHHHHHCCHHHHH	21.00	23403867
1978	Phosphorylation	SSLARTRSLSSLREK HHHHHHCCHHHHHHC	31.80	23401153
1980	Phosphorylation	LARTRSLSSLREKGM HHHHCCHHHHHHCCC	28.68	30266825
1981	Phosphorylation	ARTRSLSSLREKGMY HHHCCHHHHHHCCCC	36.42	30266825
2085	Phosphorylation	HLLSKLISVSKHTLV HHHHHHHHCCCCCCC	30.67	24719451
2156	Phosphorylation	SLYSTHTYSRDCSNW HHHCCCCCCCCHHHH	8.29	-
2157	Phosphorylation	LYSTHTYSRDCSNWI HHCCCCCCCCHHHHH	23.85	-
2232	Ubiquitination	EIIKIIGKYVQSPYW HHHHHHHHHHCCHHH	31.66	21890473
2232 (in isoform 1)	Ubiquitination	-	31.66	21890473
2233	Phosphorylation	IIKIIGKYVQSPYWK HHHHHHHHHCCHHHH	9.86	25262027
2236	Phosphorylation	IIGKYVQSPYWKEAL HHHHHHCCHHHHHHH	15.20	25262027
2238	Phosphorylation	GKYVQSPYWKEALNI HHHHCCHHHHHHHHH	34.07	25262027
2240	Ubiquitination	YVQSPYWKEALNILK HHCCHHHHHHHHHHH	27.54	21890473
2240 (in isoform 1)	Ubiquitination	-	27.54	21890473
2240 (in isoform 2)	Ubiquitination	-	27.54	21906983
2251	Phosphorylation	NILKLVVSRSASLVV HHHHHHHCCCCCEEC	17.03	24719451
2264	Ubiquitination	VVPSDIPKTYGGDTG ECCCCCCCCCCCCCC	55.50	-
2265	Phosphorylation	VPSDIPKTYGGDTGS CCCCCCCCCCCCCCC	23.26	23403867
2266	Phosphorylation	PSDIPKTYGGDTGSP CCCCCCCCCCCCCCC	25.82	23403867
2270	Phosphorylation	PKTYGGDTGSPEISF CCCCCCCCCCCCCCH	42.72	30266825
2272	Phosphorylation	TYGGDTGSPEISFTK CCCCCCCCCCCCHHH	22.81	25159151
2276	Phosphorylation	DTGSPEISFTKIFNN CCCCCCCCHHHHHCC	25.79	30266825
2278	Phosphorylation	GSPEISFTKIFNNVS CCCCCCHHHHHCCCC	19.21	30266825
2279	Ubiquitination	SPEISFTKIFNNVSK CCCCCHHHHHCCCCC	43.20	21890473
2279 (in isoform 1)	Ubiquitination	-	43.20	21890473
2286	Ubiquitination	KIFNNVSKELPGKTL HHHCCCCCCCCCCEE	60.01	-
2309	Phosphorylation	TPIIGNKYGDQHSAA CCCCCCCCCCCCCCC	29.90	-
2314	Phosphorylation	NKYGDQHSAAGRNGK CCCCCCCCCCCCCCC	17.74	-
2328	Phosphorylation	KPKVIAVTRSTSSTS CCEEEEEEECCCCCC	15.18	29514088
2330	Phosphorylation	KVIAVTRSTSSTSSG EEEEEEECCCCCCCC	24.23	25159151
2331	Phosphorylation	VIAVTRSTSSTSSGS EEEEEECCCCCCCCC	24.33	25159151
2332	Phosphorylation	IAVTRSTSSTSSGSN EEEEECCCCCCCCCC	32.63	25159151
2333	Phosphorylation	AVTRSTSSTSSGSNS EEEECCCCCCCCCCC	32.18	28102081
2334	Phosphorylation	VTRSTSSTSSGSNSN EEECCCCCCCCCCCC	27.03	28102081
2335	Phosphorylation	TRSTSSTSSGSNSNA EECCCCCCCCCCCCC	34.35	28102081
2336	Phosphorylation	RSTSSTSSGSNSNAL ECCCCCCCCCCCCCE	46.45	22617229
2338	Phosphorylation	TSSTSSGSNSNALVP CCCCCCCCCCCCEEE	38.75	22617229
2340	Phosphorylation	STSSGSNSNALVPVS CCCCCCCCCCEEECC	25.77	22617229
2347	Phosphorylation	SNALVPVSWKRPQLS CCCEEECCCCCCCHH	22.32	23403867
2380	Phosphorylation	SGLPKNPSVVFSSNE CCCCCCCCEEECCCC	40.06	26074081
2384	Phosphorylation	KNPSVVFSSNEDLEV CCCCEEECCCCCCCC	22.20	26074081
2385	Phosphorylation	NPSVVFSSNEDLEVG CCCEEECCCCCCCCC	32.54	26074081
2417	Phosphorylation	EVAVEDNSSEQQFGV CEECCCCCCCCEEEE	47.80	26074081
2418	Phosphorylation	VAVEDNSSEQQFGVF EECCCCCCCCEEEEE	45.75	26074081
2454	Phosphorylation	NWGVRRRSLDSIDKG CCCCCHHHHCCCCCC	34.42	20164059
2457	Phosphorylation	VRRRSLDSIDKGDTP CCHHHHCCCCCCCCC	37.67	20363803
2465	Phosphorylation	IDKGDTPSLQEYQCS CCCCCCCCCCEEECC	44.79	27362937
2497	Phosphorylation	SEEEAALTASQILSR HHHHHHHHHHHHHHH	21.38	26074081
2499	Phosphorylation	EEAALTASQILSRTQ HHHHHHHHHHHHHHH	16.71	26074081
2547	Phosphorylation	VLQIRDETPTLEASL HHHHHCCCCCHHHHH	26.34	23401153
2549	Phosphorylation	QIRDETPTLEASLDN HHHCCCCCHHHHHCC	44.65	30266825
2553	Phosphorylation	ETPTLEASLDNANSR CCCCHHHHHCCCCCC	27.21	21815630
2565	Phosphorylation	NSRLPEDTTSVLKEE CCCCCCCHHHHHHHH	21.22	25850435
2566	Phosphorylation	SRLPEDTTSVLKEEH CCCCCCHHHHHHHHC	29.21	25850435
2567	Phosphorylation	RLPEDTTSVLKEEHV CCCCCHHHHHHHHCC	27.78	21815630
2792	Ubiquitination	HLDTYNVKREAAEQW HHHHCCCCHHHHHHH	40.66	-
2806	Phosphorylation	WLDDCKRTFGAKEDM HHHHHHHHHCCCHHH	16.35	20068231
2814	Phosphorylation	FGAKEDMYRINTDAQ HCCCHHHEECCCCHH	22.21	-
2877	Phosphorylation	EELAQLESILKEAES HHHHHHHHHHHHHHH	41.64	24719451
2915	Ubiquitination	LIETLKNKEFISAVA HHHHHCCHHHHHHHH	53.03	-
2989	Phosphorylation	LNLEIRESLRMVQSY HCHHHHHHHHHHHHH	16.07	21406692
2995	Phosphorylation	ESLRMVQSYQLLAQA HHHHHHHHHHHHHHC	11.93	21406692
2996	Phosphorylation	SLRMVQSYQLLAQAK HHHHHHHHHHHHHCC	6.01	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FRYL_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FRYL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FRYL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PELI2_HUMAN	PELI2	physical	21988832
ABCF1_HUMAN	ABCF1	physical	22863883
FRY_HUMAN	FRY	physical	28514442
HOME1_HUMAN	HOMER1	physical	28514442
FLNC_HUMAN	FLNC	physical	28514442
RN138_HUMAN	RNF138	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FRYL_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1914; SER-1935;SER-1941; SER-1957; THR-1959 AND SER-2272, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2272, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-844; THR-1959 ANDSER-2272, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-844 AND SER-2272, ANDMASS SPECTROMETRY.	18691976 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2272, AND MASSSPECTROMETRY.	16964243 [Abstract]