COPG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPG2_HUMAN
• UniProt AC: Q9UBF2
• Protein Name: Coatomer subunit gamma-2
• Gene Name: COPG2
• Organism: Homo sapiens (Human).
• Sequence Length: 871
• Subcellular Localization: Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasm
• Protein Description: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)..
• Protein Sequence: MIKKFDKKDEESGSGSNPFQHLEKSAVLQEARIFNETPINPRRCLHILTKILYLLNQGEHFGTTEATEAFFAMTRLFQSNDQTLRRMCYLTIKEMATISEDVIIVTSSLTKDMTGKEDVYRGPAIRALCRITDGTMLQAIERYMKQAIVDKVSSVSSSALVSSLHMMKISYDVVKRWINEAQEAASSDNIMVQYHALGVLYHLRKNDRLAVSKMLNKFTKSGLKSQFAYCMLIRIASRLLKETEDGHESPLFDFIESCLRNKHEMVIYEAASAIIHLPNCTARELAPAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTACNLDLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALCQKYPRKHSVMMTFLSNMLRDDGGFEYKRAIVDCIISIVEENPESKEAGLAHLCEFIEDCEHTVLATKILHLLGKEGPRTPVPSKYIRFIFNRVVLENEAVRAAAVSALAKFGAQNESLLPSILVLLQRCMMDTDDEVRDRATFYLNVLQQRQMALNATYIFNGLTVSVPGMEKALHQYTLEPSEKPFDMKSIPLAMAPVFEQKAEITLVATKPEKLAPSRQDIFQEQLAAIPEFLNIGPLFKSSEPVQLTEAETEYFVRCIKHMFTNHIVFQFDCTNTLNDQLLEKVTVQMEPSDSYEVLSCIPAPSLPYNQPGICYTLVRLPDDDPTAVAGSFSCTMKFTVRDCDPNTGVPDEDGYDDEYVLEDLEVTVSDHIQKVLKPNFAAAWEEVGDTFEKEETFALSSTKTLEEAVNNIITFLGMQPCERSDKVPENKNSHSLYLAGIFRGGYDLLVRSRLALADGVTMQVTVRSKERTPVDVILASVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	FDKKDEESGSGSNPF CCCCCCCCCCCCCHH	35.89	20873877
14	Phosphorylation	KKDEESGSGSNPFQH CCCCCCCCCCCHHHH	48.61	20873877
16	Phosphorylation	DEESGSGSNPFQHLE CCCCCCCCCHHHHHH	42.92	23186163
25	Phosphorylation	PFQHLEKSAVLQEAR HHHHHHHHHHHHHHH	17.77	22199227
32	Methylation	SAVLQEARIFNETPI HHHHHHHHHHCCCCC	33.02	-
67	Phosphorylation	HFGTTEATEAFFAMT CCCCHHHHHHHHHHH	22.93	-
83	Phosphorylation	LFQSNDQTLRRMCYL HHHCCHHHHHHHHHH	25.70	25599653
89	Phosphorylation	QTLRRMCYLTIKEMA HHHHHHHHHHHHHHC	9.50	29116813
99	Phosphorylation	IKEMATISEDVIIVT HHHHCCCCCCEEEEE	24.32	-
106	Phosphorylation	SEDVIIVTSSLTKDM CCCEEEEECCCCCCC	11.37	-
107	Phosphorylation	EDVIIVTSSLTKDMT CCEEEEECCCCCCCC	16.68	-
108	Phosphorylation	DVIIVTSSLTKDMTG CEEEEECCCCCCCCC	30.60	-
110	Phosphorylation	IIVTSSLTKDMTGKE EEEECCCCCCCCCCC	27.26	-
114	Phosphorylation	SSLTKDMTGKEDVYR CCCCCCCCCCCCHHC	56.06	-
136	Sulfoxidation	CRITDGTMLQAIERY HHCCCCHHHHHHHHH	2.98	21406390
143	Phosphorylation	MLQAIERYMKQAIVD HHHHHHHHHHHHHHH	8.89	27251275
145	Methylation	QAIERYMKQAIVDKV HHHHHHHHHHHHHHH	27.87	-
145	Acetylation	QAIERYMKQAIVDKV HHHHHHHHHHHHHHH	27.87	25953088
145	Malonylation	QAIERYMKQAIVDKV HHHHHHHHHHHHHHH	27.87	26320211
145	Ubiquitination	QAIERYMKQAIVDKV HHHHHHHHHHHHHHH	27.87	-
153	Phosphorylation	QAIVDKVSSVSSSAL HHHHHHHHCCCHHHH	30.66	27251275
154	Phosphorylation	AIVDKVSSVSSSALV HHHHHHHCCCHHHHH	29.07	27251275
156	Phosphorylation	VDKVSSVSSSALVSS HHHHHCCCHHHHHHH	22.11	27251275
157	Phosphorylation	DKVSSVSSSALVSSL HHHHCCCHHHHHHHH	19.92	27251275
158	Phosphorylation	KVSSVSSSALVSSLH HHHCCCHHHHHHHHH	20.37	27251275
201	Phosphorylation	YHALGVLYHLRKNDR HHHHHHHHHHHHCCH	9.08	20068231
213	Acetylation	NDRLAVSKMLNKFTK CCHHHHHHHHHHHHH	40.59	25953088
229	Phosphorylation	GLKSQFAYCMLIRIA CHHHHHHHHHHHHHH	4.62	-
249	Phosphorylation	ETEDGHESPLFDFIE HCCCCCCCHHHHHHH	22.64	18452278
257	Phosphorylation	PLFDFIESCLRNKHE HHHHHHHHHHCCCCH	17.40	18452278
290	Phosphorylation	RELAPAVSVLQLFCS HHHHHHHHHHHHHHC	21.15	24719451
296	Glutathionylation	VSVLQLFCSSPKPAL HHHHHHHHCCCCHHH	5.53	22555962
296	S-nitrosocysteine	VSVLQLFCSSPKPAL HHHHHHHHCCCCHHH	5.53	-
296	S-nitrosylation	VSVLQLFCSSPKPAL HHHHHHHHCCCCHHH	5.53	19483679
297	Phosphorylation	SVLQLFCSSPKPALR HHHHHHHCCCCHHHH	42.20	28348404
298	Phosphorylation	VLQLFCSSPKPALRY HHHHHHCCCCHHHHH	37.82	28348404
305	Phosphorylation	SPKPALRYAAVRTLN CCCHHHHHHHHHHHH	10.36	22210691
310	Phosphorylation	LRYAAVRTLNKVAMK HHHHHHHHHHHHHHH	28.25	28857561
313	Acetylation	AAVRTLNKVAMKHPS HHHHHHHHHHHHCCC	34.19	27452117
317	Acetylation	TLNKVAMKHPSAVTA HHHHHHHHCCCHHCC	42.50	26051181
320	Phosphorylation	KVAMKHPSAVTACNL HHHHHCCCHHCCCCC	34.78	-
325	S-nitrosylation	HPSAVTACNLDLENL CCCHHCCCCCCHHHH	3.67	19483679
325	Glutathionylation	HPSAVTACNLDLENL CCCHHCCCCCCHHHH	3.67	22555962
325	S-nitrosocysteine	HPSAVTACNLDLENL CCCHHCCCCCCHHHH	3.67	-
339	Phosphorylation	LITDSNRSIATLAIT HHCCCCHHHHHHHHH	22.33	21712546
350	Ubiquitination	LAITTLLKTGSESSV HHHHHHHHHCCHHHH	54.69	-
366	Phosphorylation	RLMKQISSFVSEISD HHHHHHHHHHHHCCH	31.15	-
414	Ubiquitination	DDGGFEYKRAIVDCI CCCCCCHHHHHHHHH	28.31	-
420	Glutathionylation	YKRAIVDCIISIVEE HHHHHHHHHHHHHHH	1.74	22555962
461	Ubiquitination	KILHLLGKEGPRTPV HHHHHHCCCCCCCCC	60.51	21890473
461	Ubiquitination	KILHLLGKEGPRTPV HHHHHHCCCCCCCCC	60.51	21890473
471	Acetylation	PRTPVPSKYIRFIFN CCCCCCHHHHHHHHH	38.33	25953088
471	Ubiquitination	PRTPVPSKYIRFIFN CCCCCCHHHHHHHHH	38.33	-
472	Phosphorylation	RTPVPSKYIRFIFNR CCCCCHHHHHHHHHH	11.15	-
504	Phosphorylation	KFGAQNESLLPSILV HCCCCCCCHHHHHHH	42.63	23401153
508	Phosphorylation	QNESLLPSILVLLQR CCCCHHHHHHHHHHH	28.64	23401153
529	Phosphorylation	DEVRDRATFYLNVLQ HHHHHHHHHHHHHHH	17.44	26074081
531	Phosphorylation	VRDRATFYLNVLQQR HHHHHHHHHHHHHHH	7.94	26074081
545	Phosphorylation	RQMALNATYIFNGLT HHHHHCCEEEECCEE	18.97	26074081
546	Phosphorylation	QMALNATYIFNGLTV HHHHCCEEEECCEEE	10.91	26074081
552	Phosphorylation	TYIFNGLTVSVPGME EEEECCEEEECCCHH	16.48	26074081
554	Phosphorylation	IFNGLTVSVPGMEKA EECCEEEECCCHHHH	19.84	26074081
572	Ubiquitination	YTLEPSEKPFDMKSI CCCCCCCCCCCCCCC	56.15	21890473
572	Ubiquitination	YTLEPSEKPFDMKSI CCCCCCCCCCCCCCC	56.15	21890473
576	Sulfoxidation	PSEKPFDMKSIPLAM CCCCCCCCCCCCCCH	3.62	30846556
583	Sulfoxidation	MKSIPLAMAPVFEQK CCCCCCCHHHHCCCC	5.96	21406390
594	Phosphorylation	FEQKAEITLVATKPE CCCCEEEEEEECCHH	13.49	-
599	Ubiquitination	EITLVATKPEKLAPS EEEEEECCHHHCCCC	41.25	-
630	Phosphorylation	NIGPLFKSSEPVQLT CCCCCCCCCCCEECC	32.38	20068231
631	Phosphorylation	IGPLFKSSEPVQLTE CCCCCCCCCCEECCH	46.65	20068231
637	Phosphorylation	SSEPVQLTEAETEYF CCCCEECCHHHHHHH	18.96	20068231
641	Phosphorylation	VQLTEAETEYFVRCI EECCHHHHHHHHHHH	42.93	20068231
643	Phosphorylation	LTEAETEYFVRCIKH CCHHHHHHHHHHHHH	18.13	20068231
715	Phosphorylation	RLPDDDPTAVAGSFS ECCCCCCCCCCEEEE	40.53	21406692
720	Phosphorylation	DPTAVAGSFSCTMKF CCCCCCEEEEEEEEE	12.30	21406692
722	Phosphorylation	TAVAGSFSCTMKFTV CCCCEEEEEEEEEEE	15.46	21406692
724	Phosphorylation	VAGSFSCTMKFTVRD CCEEEEEEEEEEEEC	23.38	21406692
826	Phosphorylation	NKNSHSLYLAGIFRG CCCCCCCHHHHHHHC	9.49	25839225
835	Phosphorylation	AGIFRGGYDLLVRSR HHHHHCCHHHHHHHH	13.27	-
850	Phosphorylation	LALADGVTMQVTVRS HHHCCCCEEEEEECC	13.86	29759185
854	Phosphorylation	DGVTMQVTVRSKERT CCCEEEEEECCCCCC	8.03	29759185
857	Phosphorylation	TMQVTVRSKERTPVD EEEEEECCCCCCCCE	34.24	18491316

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPG2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COPA_HUMAN	COPA	physical	14729954
COPB_HUMAN	COPB1	physical	14729954
COPB2_HUMAN	COPB2	physical	14729954
COPG2_HUMAN	COPG2	physical	14729954
COPD_HUMAN	ARCN1	physical	14729954
COPG1_HUMAN	COPG1	physical	22939629
COPZ1_HUMAN	COPZ1	physical	22939629
NDUB8_HUMAN	NDUFB8	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.