P5CS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P5CS_HUMAN
• UniProt AC: P54886
• Protein Name: Delta-1-pyrroline-5-carboxylate synthase
• Gene Name: ALDH18A1
• Organism: Homo sapiens (Human).
• Sequence Length: 795
• Subcellular Localization: Mitochondrion inner membrane .
• Protein Description: Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine..
• Protein Sequence: MLSQVYRCGFQPFNQHLLPWVKCTTVFRSHCIQPSVIRHVRSWSNIPFITVPLSRTHGKSFAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAVAFGKQRLRHEILLSQSVRQALHSGQNQLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSICAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPAEPNSDLQGVNVISVKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTKSRVGMGGMEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAGPTVEQQGEMARSGGRMLATLEPEQRAEIIHHLADLLTDQRDEILLANKKDLEEAEGRLAAPLLKRLSLSTSKLNSLAIGLRQIAASSQDSVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQVAALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGVKEAVQLVNTREEVEDLCRLDKMIDLIIPRGSSQLVRDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYLTFSPSEVKSLRTEYGDLELCIEVVDNVQDAIDHIHKYGSSHTDVIVTEDENTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGKDHVVSDFSEHGSLKYLHENLPIPQRNTN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Ubiquitination	TVFRSHCIQPSVIRH HHHHHHCCCHHHHHH	5.89	24816145
38	Ubiquitination	CIQPSVIRHVRSWSN CCCHHHHHHCCCCCC	21.79	23503661
59	2-Hydroxyisobutyrylation	PLSRTHGKSFAHRSE ECCCCCCCCCCCHHH	34.49	-
59	Acetylation	PLSRTHGKSFAHRSE ECCCCCCCCCCCHHH	34.49	26210075
71	Ubiquitination	RSELKHAKRIVVKLG HHHHHHHHHHEEECC	42.23	24816145
79	Phosphorylation	RIVVKLGSAVVTRGD HHEEECCCEEEECCC	28.46	30108239
83	Phosphorylation	KLGSAVVTRGDECGL ECCCEEEECCCHHHH	23.49	23312004
88	Ubiquitination	VVTRGDECGLALGRL EEECCCHHHHHHHHH	6.87	22817900
97	Phosphorylation	LALGRLASIVEQVSV HHHHHHHHHHHHHHH	31.58	20068231
99	Ubiquitination	LGRLASIVEQVSVLQ HHHHHHHHHHHHHHH	3.79	23503661
101	Ubiquitination	RLASIVEQVSVLQNQ HHHHHHHHHHHHHHC	23.14	23503661
103	Phosphorylation	ASIVEQVSVLQNQGR HHHHHHHHHHHHCCC	19.46	20068231
116	Phosphorylation	GREMMLVTSGAVAFG CCEEEEEEECHHHHC	19.92	24144214
117	Phosphorylation	REMMLVTSGAVAFGK CEEEEEEECHHHHCH	19.78	113311063
124	Acetylation	SGAVAFGKQRLRHEI ECHHHHCHHHHHHHH	26.28	26051181
124	Malonylation	SGAVAFGKQRLRHEI ECHHHHCHHHHHHHH	26.28	26320211
124	Methylation	SGAVAFGKQRLRHEI ECHHHHCHHHHHHHH	26.28	-
133	Ubiquitination	RLRHEILLSQSVRQA HHHHHHHHCHHHHHH	5.56	24816145
134	Phosphorylation	LRHEILLSQSVRQAL HHHHHHHCHHHHHHH	19.57	27080861
135	Ubiquitination	RHEILLSQSVRQALH HHHHHHCHHHHHHHH	46.01	22817900
136	Phosphorylation	HEILLSQSVRQALHS HHHHHCHHHHHHHHC	18.85	27080861
136	Ubiquitination	HEILLSQSVRQALHS HHHHHCHHHHHHHHC	18.85	22817900
143	Phosphorylation	SVRQALHSGQNQLKE HHHHHHHCCCHHHHH	42.81	37604049
145	Ubiquitination	RQALHSGQNQLKEMA HHHHHCCCHHHHHCH	37.19	23503661
149	Acetylation	HSGQNQLKEMAIPVL HCCCHHHHHCHHHHH	35.36	26051181
149	Ubiquitination	HSGQNQLKEMAIPVL HCCCHHHHHCHHHHH	35.36	23503661
149 (in isoform 2)	Ubiquitination	-	35.36	-
151	Sulfoxidation	GQNQLKEMAIPVLEA CCHHHHHCHHHHHHH	3.81	21406390
187	Ubiquitination	YSICAAQILVTNLDF HHHHHHHHHHHCCCC	2.61	22817900
189	Ubiquitination	ICAAQILVTNLDFHD HHHHHHHHHCCCCCC	3.40	22817900
196	Ubiquitination	VTNLDFHDEQKRRNL HHCCCCCCHHHHHCC	61.08	23503661
197	Ubiquitination	TNLDFHDEQKRRNLN HCCCCCCHHHHHCCC	49.81	24816145
198	Ubiquitination	NLDFHDEQKRRNLNG CCCCCCHHHHHCCCC	51.09	23503661
200	Ubiquitination	DFHDEQKRRNLNGTL CCCCHHHHHCCCCHH	32.20	23503661
202	Ubiquitination	HDEQKRRNLNGTLHE CCHHHHHCCCCHHHH	41.72	23503661
209	Ubiquitination	NLNGTLHELLRMNIV CCCCHHHHHHHCCCE	53.24	24816145
212	Methylation	GTLHELLRMNIVPIV CHHHHHHHCCCEEEE	28.82	-
212	Ubiquitination	GTLHELLRMNIVPIV CHHHHHHHCCCEEEE	28.82	27667366
234	Ubiquitination	PPAEPNSDLQGVNVI CCCCCCCCCCCCEEE	50.04	22817900
235	Ubiquitination	PAEPNSDLQGVNVIS CCCCCCCCCCCEEEE	4.85	22817900
236	Ubiquitination	AEPNSDLQGVNVISV CCCCCCCCCCEEEEE	59.80	22817900
237	Ubiquitination	EPNSDLQGVNVISVK CCCCCCCCCEEEEEC	21.92	22817900
244	Ubiquitination	GVNVISVKDNDSLAA CCEEEEECCCCHHHH	43.98	24816145
246	Ubiquitination	NVISVKDNDSLAARL EEEEECCCCHHHHHH	34.74	23503661
248	Phosphorylation	ISVKDNDSLAARLAV EEECCCCHHHHHHHH	26.60	22210691
258	Sumoylation	ARLAVEMKTDLLIVL HHHHHHHCCCEEEEE	25.94	-
258	Sumoylation	ARLAVEMKTDLLIVL HHHHHHHCCCEEEEE	25.94	17000644
265	Ubiquitination	KTDLLIVLSDVEGLF CCCEEEEECCCCCCC	2.61	22817900
266	Phosphorylation	TDLLIVLSDVEGLFD CCEEEEECCCCCCCC	28.81	22210691
276	Ubiquitination	EGLFDSPPGSDDAKL CCCCCCCCCCCCCEE	59.89	23503661
278	Ubiquitination	LFDSPPGSDDAKLID CCCCCCCCCCCEEEE	37.78	23503661
295	Ubiquitination	YPGDQQSVTFGTKSR CCCCCCEEEECCCCC	4.46	23503661
296	Ubiquitination	PGDQQSVTFGTKSRV CCCCCEEEECCCCCC	22.92	24816145
297	Ubiquitination	GDQQSVTFGTKSRVG CCCCEEEECCCCCCC	12.55	23503661
298	Ubiquitination	DQQSVTFGTKSRVGM CCCEEEECCCCCCCC	23.91	22817900
298 (in isoform 2)	Ubiquitination	-	23.91	21890473
300	Ubiquitination	QSVTFGTKSRVGMGG CEEEECCCCCCCCCH	36.32	21906983
300 (in isoform 1)	Ubiquitination	-	36.32	21890473
309	Ubiquitination	RVGMGGMEAKVKAAL CCCCCHHHHHHHHHH	48.92	23503661
309 (in isoform 2)	Ubiquitination	-	48.92	-
311	Malonylation	GMGGMEAKVKAALWA CCCHHHHHHHHHHHH	30.84	26320211
311	Succinylation	GMGGMEAKVKAALWA CCCHHHHHHHHHHHH	30.84	-
311	Succinylation	GMGGMEAKVKAALWA CCCHHHHHHHHHHHH	30.84	-
311	Ubiquitination	GMGGMEAKVKAALWA CCCHHHHHHHHHHHH	30.84	27667366
312	Ubiquitination	MGGMEAKVKAALWAL CCHHHHHHHHHHHHH	7.03	22817900
313	Ubiquitination	GGMEAKVKAALWALQ CHHHHHHHHHHHHHH	27.51	27667366
322	Ubiquitination	ALWALQGGTSVVIAN HHHHHHCCEEEEEEC	11.23	23503661
338	Ubiquitination	THPKVSGHVITDIVE CCCCCCCEEEEEHHC	10.57	24816145
345	Ubiquitination	HVITDIVEGKKVGTF EEEEEHHCCCEEEEE	66.68	22817900
345 (in isoform 2)	Ubiquitination	-	66.68	21890473
346	Ubiquitination	VITDIVEGKKVGTFF EEEEHHCCCEEEEEC	24.96	22817900
346 (in isoform 2)	Ubiquitination	-	24.96	-
347	2-Hydroxyisobutyrylation	ITDIVEGKKVGTFFS EEEHHCCCEEEEECC	30.68	-
347	Acetylation	ITDIVEGKKVGTFFS EEEHHCCCEEEEECC	30.68	23236377
347	Malonylation	ITDIVEGKKVGTFFS EEEHHCCCEEEEECC	30.68	26320211
347	Succinylation	ITDIVEGKKVGTFFS EEEHHCCCEEEEECC	30.68	-
347	Succinylation	ITDIVEGKKVGTFFS EEEHHCCCEEEEECC	30.68	-
347	Ubiquitination	ITDIVEGKKVGTFFS EEEHHCCCEEEEECC	30.68	22817900
347 (in isoform 1)	Ubiquitination	-	30.68	21890473
348	2-Hydroxyisobutyrylation	TDIVEGKKVGTFFSE EEHHCCCEEEEECCC	57.67	-
348	Malonylation	TDIVEGKKVGTFFSE EEHHCCCEEEEECCC	57.67	26320211
348	Ubiquitination	TDIVEGKKVGTFFSE EEHHCCCEEEEECCC	57.67	22817900
355	Ubiquitination	KVGTFFSEVKPAGPT EEEEECCCCCCCCCC	49.78	23503661
355 (in isoform 2)	Ubiquitination	-	49.78	-
357	Acetylation	GTFFSEVKPAGPTVE EEECCCCCCCCCCHH	25.71	26051181
357	Ubiquitination	GTFFSEVKPAGPTVE EEECCCCCCCCCCHH	25.71	23503661
373	Ubiquitination	QGEMARSGGRMLATL HHHHHHHCCCEEEEC	23.36	23503661
374	Ubiquitination	GEMARSGGRMLATLE HHHHHHCCCEEEECC	17.05	24816145
376	Sulfoxidation	MARSGGRMLATLEPE HHHHCCCEEEECCHH	3.18	21406390
389	Ubiquitination	PEQRAEIIHHLADLL HHHHHHHHHHHHHHH	0.95	27667366
393	Ubiquitination	AEIIHHLADLLTDQR HHHHHHHHHHHHHCH	10.88	24816145
406	Ubiquitination	QRDEILLANKKDLEE CHHHHHHCCHHHHHH	23.50	23503661
406 (in isoform 2)	Ubiquitination	-	23.50	-
407	Ubiquitination	RDEILLANKKDLEEA HHHHHHCCHHHHHHH	52.45	24816145
408	2-Hydroxyisobutyrylation	DEILLANKKDLEEAE HHHHHCCHHHHHHHC	41.90	-
408	Acetylation	DEILLANKKDLEEAE HHHHHCCHHHHHHHC	41.90	26051181
408	Ubiquitination	DEILLANKKDLEEAE HHHHHCCHHHHHHHC	41.90	23503661
409	Acetylation	EILLANKKDLEEAEG HHHHCCHHHHHHHCH	68.31	7406521
409	Malonylation	EILLANKKDLEEAEG HHHHCCHHHHHHHCH	68.31	26320211
409	Ubiquitination	EILLANKKDLEEAEG HHHHCCHHHHHHHCH	68.31	24816145
422	Ubiquitination	EGRLAAPLLKRLSLS CHHHHHHHHHHHCCC	8.26	27667366
422 (in isoform 2)	Ubiquitination	-	8.26	21890473
424	Acetylation	RLAAPLLKRLSLSTS HHHHHHHHHHCCCHH	60.00	25953088
424	Malonylation	RLAAPLLKRLSLSTS HHHHHHHHHHCCCHH	60.00	26320211
424	Ubiquitination	RLAAPLLKRLSLSTS HHHHHHHHHHCCCHH	60.00	27667366
424 (in isoform 1)	Ubiquitination	-	60.00	21890473
427	Phosphorylation	APLLKRLSLSTSKLN HHHHHHHCCCHHHHH	25.06	25849741
429	Phosphorylation	LLKRLSLSTSKLNSL HHHHHCCCHHHHHHH	27.53	25159151
430	Phosphorylation	LKRLSLSTSKLNSLA HHHHCCCHHHHHHHH	34.86	29396449
431	Phosphorylation	KRLSLSTSKLNSLAI HHHCCCHHHHHHHHH	31.60	29396449
431	Ubiquitination	KRLSLSTSKLNSLAI HHHCCCHHHHHHHHH	31.60	33845483
432	Ubiquitination	RLSLSTSKLNSLAIG HHCCCHHHHHHHHHH	52.34	-
437	Ubiquitination	TSKLNSLAIGLRQIA HHHHHHHHHHHHHHH	8.14	24816145
439	Ubiquitination	KLNSLAIGLRQIAAS HHHHHHHHHHHHHHC	14.81	24816145
446	Phosphorylation	GLRQIAASSQDSVGR HHHHHHHCCCCHHHH	21.36	20068231
447	Phosphorylation	LRQIAASSQDSVGRV HHHHHHCCCCHHHHH	33.03	20071362
450	Phosphorylation	IAASSQDSVGRVLRR HHHCCCCHHHHHHHH	20.87	20068231
450	Ubiquitination	IAASSQDSVGRVLRR HHHCCCCHHHHHHHH	20.87	21890473
492	Ubiquitination	DCLPQVAALAIASGN CCHHHHHHHHHHCCC	9.93	24816145
494	Ubiquitination	LPQVAALAIASGNGL HHHHHHHHHHCCCCE	7.20	24816145
515	Ubiquitination	EAAHSNRILHLLTQE HHHHHHHHHHHHHHH	3.13	24816145
530	Ubiquitination	ALSIHGVKEAVQLVN HHHHCCHHHHHHHHC	44.54	33845483
532	Ubiquitination	SIHGVKEAVQLVNTR HHCCHHHHHHHHCCH	6.66	33845483
538	Phosphorylation	EAVQLVNTREEVEDL HHHHHHCCHHHHHHH	31.79	20860994
548	Ubiquitination	EVEDLCRLDKMIDLI HHHHHHHHHHHHHEE	7.87	24816145
549	Ubiquitination	VEDLCRLDKMIDLII HHHHHHHHHHHHEEE	21.08	21890473
550	2-Hydroxyisobutyrylation	EDLCRLDKMIDLIIP HHHHHHHHHHHEEEC	42.20	-
550	Acetylation	EDLCRLDKMIDLIIP HHHHHHHHHHHEEEC	42.20	26051181
550	Succinylation	EDLCRLDKMIDLIIP HHHHHHHHHHHEEEC	42.20	-
550	Succinylation	EDLCRLDKMIDLIIP HHHHHHHHHHHEEEC	42.20	-
550	Ubiquitination	EDLCRLDKMIDLIIP HHHHHHHHHHHEEEC	42.20	24816145
551	Ubiquitination	DLCRLDKMIDLIIPR HHHHHHHHHHEEECC	2.62	21890473
555	Ubiquitination	LDKMIDLIIPRGSSQ HHHHHHEEECCCCHH	3.46	23503661
569	Ubiquitination	QLVRDIQKAAKGIPV HHHHHHHHHHCCCCC	51.12	29967540
570	Ubiquitination	LVRDIQKAAKGIPVM HHHHHHHHHCCCCCC	9.68	24816145
572	Malonylation	RDIQKAAKGIPVMGH HHHHHHHCCCCCCCC	63.33	26320211
580	Phosphorylation	GIPVMGHSEGICHMY CCCCCCCCCCEEEEE	31.61	26126808
587	Phosphorylation	SEGICHMYVDSEASV CCCEEEEECCCCCCH	4.21	26126808
603	Ubiquitination	KVTRLVRDSKCEYPA HHHHHHHCCCCCCHH	44.99	24816145
605	Ubiquitination	TRLVRDSKCEYPAAC HHHHHCCCCCCHHHH	35.06	24816145
606	S-nitrosocysteine	RLVRDSKCEYPAACN HHHHCCCCCCHHHHH	7.59	-
606	S-nitrosylation	RLVRDSKCEYPAACN HHHHCCCCCCHHHHH	7.59	19483679
608	Ubiquitination	VRDSKCEYPAACNAL HHCCCCCCHHHHHHH	13.98	33845483
612	S-nitrosocysteine	KCEYPAACNALETLL CCCCHHHHHHHHHHH	3.12	-
612	S-nitrosylation	KCEYPAACNALETLL CCCCHHHHHHHHHHH	3.12	19483679
627	Ubiquitination	IHRDLLRTPLFDQII HCHHHHCCHHHHHHH	25.06	21890473
641	Ubiquitination	IDMLRVEQVKIHAGP HHHHHHEEEEECCCC	38.66	33845483
643	Acetylation	MLRVEQVKIHAGPKF HHHHEEEEECCCCCC	28.59	25953088
643	Ubiquitination	MLRVEQVKIHAGPKF HHHHEEEEECCCCCC	28.59	33845483
648	Ubiquitination	QVKIHAGPKFASYLT EEEECCCCCCHHHEE	29.40	23503661
649	Acetylation	VKIHAGPKFASYLTF EEECCCCCCHHHEEE	53.28	71329
650	Ubiquitination	KIHAGPKFASYLTFS EECCCCCCHHHEEEC	6.50	23503661
652	Phosphorylation	HAGPKFASYLTFSPS CCCCCCHHHEEECHH	24.65	26074081
653	Phosphorylation	AGPKFASYLTFSPSE CCCCCHHHEEECHHH	13.31	26074081
654	Ubiquitination	GPKFASYLTFSPSEV CCCCHHHEEECHHHH	3.45	23503661
655	Phosphorylation	PKFASYLTFSPSEVK CCCHHHEEECHHHHH	17.52	26074081
656	Ubiquitination	KFASYLTFSPSEVKS CCHHHEEECHHHHHH	10.50	23503661
657	Phosphorylation	FASYLTFSPSEVKSL CHHHEEECHHHHHHH	23.45	25159151
659	Phosphorylation	SYLTFSPSEVKSLRT HHEEECHHHHHHHHH	54.55	26074081
660	Ubiquitination	YLTFSPSEVKSLRTE HEEECHHHHHHHHHH	58.30	21890473
660 (in isoform 2)	Ubiquitination	-	58.30	21890473
662	Ubiquitination	TFSPSEVKSLRTEYG EECHHHHHHHHHHCC	39.46	22817900
662 (in isoform 1)	Ubiquitination	-	39.46	21890473
668	Ubiquitination	VKSLRTEYGDLELCI HHHHHHHCCCHHHHH	18.48	29967540
670	Ubiquitination	SLRTEYGDLELCIEV HHHHHCCCHHHHHHH	35.75	29967540
725	Phosphorylation	CVFWNASTRFSDGYR EEEEECCCCCCCCCC	33.07	46161911
726	Ubiquitination	VFWNASTRFSDGYRF EEEECCCCCCCCCCC	26.95	23503661
732	Ubiquitination	TRFSDGYRFGLGAEV CCCCCCCCCCCCCEE	25.37	23503661
746	Ubiquitination	VGISTSRIHARGPVG EEECCCCCCCCCCCC	2.74	29967540
749	Methylation	STSRIHARGPVGLEG CCCCCCCCCCCCHHH	35.47	-
759	Phosphorylation	VGLEGLLTTKWLLRG CCHHHHHHHHHHHCC	31.22	21712546
759	Ubiquitination	VGLEGLLTTKWLLRG CCHHHHHHHHHHHCC	31.22	23503661
761	Ubiquitination	LEGLLTTKWLLRGKD HHHHHHHHHHHCCCC	30.52	23503661
765	Ubiquitination	LTTKWLLRGKDHVVS HHHHHHHCCCCCCCC	48.20	23503661
765 (in isoform 2)	Ubiquitination	-	48.20	-
767	Acetylation	TKWLLRGKDHVVSDF HHHHHCCCCCCCCCC	37.92	26051181
767	Malonylation	TKWLLRGKDHVVSDF HHHHHCCCCCCCCCC	37.92	26320211
767	Succinylation	TKWLLRGKDHVVSDF HHHHHCCCCCCCCCC	37.92	27452117
767	Ubiquitination	TKWLLRGKDHVVSDF HHHHHCCCCCCCCCC	37.92	23503661
772	Phosphorylation	RGKDHVVSDFSEHGS CCCCCCCCCCCCCCC	31.67	20068231
775	Phosphorylation	DHVVSDFSEHGSLKY CCCCCCCCCCCCHHH	33.40	27080861
779	Phosphorylation	SDFSEHGSLKYLHEN CCCCCCCCHHHHHHC	24.48	30108239
779	Ubiquitination	SDFSEHGSLKYLHEN CCCCCCCCHHHHHHC	24.48	29967540
781	Ubiquitination	FSEHGSLKYLHENLP CCCCCCHHHHHHCCC	47.68	29967540
782	Phosphorylation	SEHGSLKYLHENLPI CCCCCHHHHHHCCCC	20.70	28270605
794	Phosphorylation	LPIPQRNTN------ CCCCCCCCC------	44.48	28270605

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P5CS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P5CS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P5CS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIM13_HUMAN	TIMM13	physical	22939629
ATRAP_HUMAN	AGTRAP	physical	25416956
CKLF5_HUMAN	CMTM5	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 219150: Cutis laxa, autosomal recessive, 3A (ARCL3A)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.