dbPTM

PHRF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PHRF1_HUMAN
UniProt AC	Q9P1Y6
Protein Name	PHD and RING finger domain-containing protein 1
Gene Name	PHRF1
Organism	Homo sapiens (Human).
Sequence Length	1649
Subcellular Localization
Protein Description
Protein Sequence	MDDDSLDELVARSPGPDGHPQVGPADPAGDFEESSVGSSGDSGDDSDSEHGDGTDGEDEGASEEEDLEDRSGSEDSEDDGETLLEVAGTQGKLEAAGSFNSDDDAESCPICLNAFRDQAVGTPENCAHYFCLDCIVEWSKNANSCPVDRTLFKCICIRAQFGGKILRKIPVENTKASEEEEDPTFCEVCGRSDREDRLLLCDGCDAGYHMECLDPPLQEVPVDEWFCPECAAPGVVLAADAGPVSEEEVSLLLADVVPTTSRLRPRAGRTRAIARTRQSERVRATVNRNRISTARRVQHTPGRLGSSLLDEAIEAVATGLSTAVYQRPLTPRTPARRKRKTRRRKKVPGRKKTPSGPSAKSKSSATRSKKRQHRVKKRRGKKVKSEATTRSRIARTLGLRRPVHSSCIPSVLKPVEPSLGLLRADIGAASLSLFGDPYELDPFDSSEELSANPLSPLSAKRRALSRSALQSHQPVARPVSVGLSRRRLPAAVPEPDLEEEPVPDLLGSILSGQSLLMLGSSDVIIHRDGSLSAKRAAPVSFQRNSGSLSRGEEGFKGCLQPRALPSGSPAQGPSGNRPQSTGLSCQGRSRTPARTAGAPVRLDLPAAPGAVQARNLSNGSVPGFRQSHSPWFNGTNKHTLPLASAASKISSRDSKPPCRSVVPGPPLKPAPRRTDISELPRIPKIRRDDGGGRRDAAPAHGQSIEIPSACISRLTGREGTGQPGRGTRAESEASSRVPREPGVHTGSSRPPAPSSHGSLAPLGPSRGKGVGSTFESFRINIPGNMAHSSQLSSPGFCNTFRPVDDKEQRKENPSPLFSIKKTKQLRSEVYDPSDPTGSDSSAPGSSPERSGPGLLPSEITRTISINSPKAQTVQAVRCVTSYTVESIFGTEPEPPLGPSSAMSKLRGAVAAEGASDTEREEPTESQGLAARLRRPSPPEPWDEEDGASCSTFFGSEERTVTCVTVVEPEAPPSPDVLQAATHRVVELRPPSRSRSTSSSRSRKKAKRKRVSREHGRTRSGTRSESRDRSSRSASPSVGEERPRRQRSKAKSRRSSSDRSSSRERAKRKKAKDKSREHRRGPWGHSRRTSRSRSGSPGSSSYEHYESRKKKKRRSASRPRGRECSPTSSLERLCRHKHQRERSHERPDRKESVAWPRDRRKRRSRSPSSEHRAREHRRPRSREKWPQTRSHSPERKGAVREASPAPLAQGEPGREDLPTRLPALGEAHVSPEVATADKAPLQAPPVLEVAAECEPDDLDLDYGDSVEAGHVFDDFSSDAVFIQLDDMSSPPSPESTDSSPERDFPLKPALPPASLAVAAIQREVSLMHDEDPSQPPPLPEGTQEPHLLRPDAAEKAEAPSSPDVAPAGKEDSPSASGRVQEAARPEEVVSQTPLLRSRALVKRVTWNLQESESSAPAEDRAPRAPLHRPQKPREGAWDMEDVAPTGVRQVFSELPFPSHVLPEPGFPDTDPSQVYSPGLPPAPAQPSSIPPCALVSQPTVQFILQGSLPLVGCGAAQTLAPVPAALTPASEPASQATAASNSEEKTPAPRLAAEKTKKEEYMKKLHMQERAVEEVKLAIKPFYQKREVTKEEYKDILRKAVQKICHSKSGEINPVKVANLVKAYVDKYRHMRRHKKPEAGEEPPTQGAEG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MDDDSLDELVAR ---CCCCHHHHHHHC	44.72	29255136
5 (in isoform 3)	Phosphorylation	-	44.72	-
13	Phosphorylation	LDELVARSPGPDGHP HHHHHHCCCCCCCCC	25.19	26074081
42	Phosphorylation	SVGSSGDSGDDSDSE CCCCCCCCCCCCCCC	47.88	22468782
54	Phosphorylation	DSEHGDGTDGEDEGA CCCCCCCCCCCCCCC	45.64	22468782
71	Phosphorylation	EEDLEDRSGSEDSED HHCCCCCCCCCCCCC	60.02	25850435
71 (in isoform 3)	Phosphorylation	-	60.02	-
73	Phosphorylation	DLEDRSGSEDSEDDG CCCCCCCCCCCCCHH	39.20	25850435
73 (in isoform 3)	Phosphorylation	-	39.20	-
76	Phosphorylation	DRSGSEDSEDDGETL CCCCCCCCCCHHHHH	38.58	25850435
76 (in isoform 3)	Phosphorylation	-	38.58	-
82	Phosphorylation	DSEDDGETLLEVAGT CCCCHHHHHHHHHCC	42.02	27732954
98	Phosphorylation	GKLEAAGSFNSDDDA CEEEECCCCCCCCCH	19.27	22617229
98 (in isoform 3)	Phosphorylation	-	19.27	-
101	Phosphorylation	EAAGSFNSDDDAESC EECCCCCCCCCHHHC	40.17	22617229
101 (in isoform 3)	Phosphorylation	-	40.17	24719451
107	Phosphorylation	NSDDDAESCPICLNA CCCCCHHHCCCCHHH	27.24	30108239
153	Ubiquitination	PVDRTLFKCICIRAQ CCCHHHHHHHHHHHH	26.29	-
164	Ubiquitination	IRAQFGGKILRKIPV HHHHHCCEEEEECCC	38.66	-
168	Ubiquitination	FGGKILRKIPVENTK HCCEEEEECCCCCCC	48.17	-
174	Phosphorylation	RKIPVENTKASEEEE EECCCCCCCCCCCCC	17.93	30624053
175	Ubiquitination	KIPVENTKASEEEED ECCCCCCCCCCCCCC	62.59	-
177	Phosphorylation	PVENTKASEEEEDPT CCCCCCCCCCCCCCC	47.28	28464451
177 (in isoform 3)	Phosphorylation	-	47.28	24719451
184	Phosphorylation	SEEEEDPTFCEVCGR CCCCCCCCCHHHCCC	53.92	28464451
192	Phosphorylation	FCEVCGRSDREDRLL CHHHCCCCCCCCCEE	26.72	-
276	Phosphorylation	RTRAIARTRQSERVR CCHHHHHHHHHHHHH	24.84	27174698
279	Phosphorylation	AIARTRQSERVRATV HHHHHHHHHHHHHHH	24.87	27174698
285	Phosphorylation	QSERVRATVNRNRIS HHHHHHHHHCCCHHH	14.03	27174698
300	Phosphorylation	TARRVQHTPGRLGSS HHHHHCCCCCCCCHH	15.45	25599653
306	Phosphorylation	HTPGRLGSSLLDEAI CCCCCCCHHHHHHHH	23.54	23090842
307	Phosphorylation	TPGRLGSSLLDEAIE CCCCCCHHHHHHHHH	31.02	22115753
318	Phosphorylation	EAIEAVATGLSTAVY HHHHHHHHCCCHHHH	31.86	23090842
321	Phosphorylation	EAVATGLSTAVYQRP HHHHHCCCHHHHCCC	18.70	23090842
321 (in isoform 3)	Phosphorylation	-	18.70	27251275
322	Phosphorylation	AVATGLSTAVYQRPL HHHHCCCHHHHCCCC	25.78	29496963
325	Phosphorylation	TGLSTAVYQRPLTPR HCCCHHHHCCCCCCC	9.06	22617229
330	Phosphorylation	AVYQRPLTPRTPARR HHHCCCCCCCCHHHH	17.26	22617229
330 (in isoform 3)	Phosphorylation	-	17.26	24719451
333	Phosphorylation	QRPLTPRTPARRKRK CCCCCCCCHHHHHCC	23.62	22617229
353	Phosphorylation	KVPGRKKTPSGPSAK CCCCCCCCCCCCCCC	26.23	28985074
355	Phosphorylation	PGRKKTPSGPSAKSK CCCCCCCCCCCCCCC	69.44	21964256
358	Phosphorylation	KKTPSGPSAKSKSSA CCCCCCCCCCCCCCC	52.43	21964256
361	Phosphorylation	PSGPSAKSKSSATRS CCCCCCCCCCCCCHH	37.17	23312004
363	Phosphorylation	GPSAKSKSSATRSKK CCCCCCCCCCCHHHH	32.09	23312004
364	Phosphorylation	PSAKSKSSATRSKKR CCCCCCCCCCHHHHH	37.08	23312004
366	Phosphorylation	AKSKSSATRSKKRQH CCCCCCCCHHHHHHH	37.11	-
418	Phosphorylation	VLKPVEPSLGLLRAD HCCCCCCCCCHHHHC	22.89	22167270
430	Phosphorylation	RADIGAASLSLFGDP HHCCCCHHHHHHCCC	20.25	28176443
432	Phosphorylation	DIGAASLSLFGDPYE CCCCHHHHHHCCCCC	21.11	28176443
438	Phosphorylation	LSLFGDPYELDPFDS HHHHCCCCCCCCCCC	33.59	28176443
445	Phosphorylation	YELDPFDSSEELSAN CCCCCCCCCCCCCCC	39.77	20068231
446	Phosphorylation	ELDPFDSSEELSANP CCCCCCCCCCCCCCC	36.61	28464451
450	Phosphorylation	FDSSEELSANPLSPL CCCCCCCCCCCCCHH	29.31	28176443
455	Phosphorylation	ELSANPLSPLSAKRR CCCCCCCCHHHHHHH	25.67	28464451
458	Phosphorylation	ANPLSPLSAKRRALS CCCCCHHHHHHHHHH	34.82	20068231
465	Phosphorylation	SAKRRALSRSALQSH HHHHHHHHHHHHHHC	24.17	-
467	Phosphorylation	KRRALSRSALQSHQP HHHHHHHHHHHHCCC	29.92	-
480	Phosphorylation	QPVARPVSVGLSRRR CCCCCCCCCCCCCCC	17.10	-
484	Phosphorylation	RPVSVGLSRRRLPAA CCCCCCCCCCCCCCC	20.15	23312004
544 (in isoform 3)	Phosphorylation	-	39.68	24719451
545	Phosphorylation	PVSFQRNSGSLSRGE CCEEECCCCCCCCCC	31.76	20068231
547	Phosphorylation	SFQRNSGSLSRGEEG EEECCCCCCCCCCCC	24.00	20068231
548 (in isoform 3)	Phosphorylation	-	4.64	-
549	Phosphorylation	QRNSGSLSRGEEGFK ECCCCCCCCCCCCCC	39.68	20068231
556	Methylation	SRGEEGFKGCLQPRA CCCCCCCCCCCCCCC	60.62	82984871
556	Ubiquitination	SRGEEGFKGCLQPRA CCCCCCCCCCCCCCC	60.62	-
565 (in isoform 3)	Phosphorylation	-	35.34	24719451
566	Phosphorylation	LQPRALPSGSPAQGP CCCCCCCCCCCCCCC	53.40	26552605
568	Phosphorylation	PRALPSGSPAQGPSG CCCCCCCCCCCCCCC	22.77	28985074
574	Phosphorylation	GSPAQGPSGNRPQST CCCCCCCCCCCCCCC	56.37	28985074
580	Phosphorylation	PSGNRPQSTGLSCQG CCCCCCCCCCCCCCC	27.42	25599653
581	Phosphorylation	SGNRPQSTGLSCQGR CCCCCCCCCCCCCCC	36.57	26552605
584	Phosphorylation	RPQSTGLSCQGRSRT CCCCCCCCCCCCCCC	13.02	25599653
589	Phosphorylation	GLSCQGRSRTPARTA CCCCCCCCCCCCCCC	47.53	20860994
591	Phosphorylation	SCQGRSRTPARTAGA CCCCCCCCCCCCCCC	23.65	20860994
627	Phosphorylation	SVPGFRQSHSPWFNG CCCCCCCCCCCCCCC	22.98	27251275
628 (in isoform 3)	Phosphorylation	-	29.55	27251275
629	Phosphorylation	PGFRQSHSPWFNGTN CCCCCCCCCCCCCCC	29.13	27251275
639	Phosphorylation	FNGTNKHTLPLASAA CCCCCCCCCCHHHHH	31.51	-
668	Acetylation	VVPGPPLKPAPRRTD CCCCCCCCCCCCCCC	44.93	25953088
668	Ubiquitination	VVPGPPLKPAPRRTD CCCCCCCCCCCCCCC	44.93	-
703	Phosphorylation	AAPAHGQSIEIPSAC CCCCCCCCCCCCHHH	27.12	28555341
725	Methylation	EGTGQPGRGTRAESE CCCCCCCCCCCCCHH	50.41	80700737
726 (in isoform 3)	Phosphorylation	-	26.01	24719451
727	Phosphorylation	TGQPGRGTRAESEAS CCCCCCCCCCCHHHH	25.91	24719451
731	Phosphorylation	GRGTRAESEASSRVP CCCCCCCHHHHCCCC	37.16	30387612
749	Methylation	GVHTGSSRPPAPSSH CCCCCCCCCCCCCCC	42.81	115487493
768	Sumoylation	PLGPSRGKGVGSTFE CCCCCCCCCCCCCCC	49.68	-
768	Sumoylation	PLGPSRGKGVGSTFE CCCCCCCCCCCCCCC	49.68	-
768	Ubiquitination	PLGPSRGKGVGSTFE CCCCCCCCCCCCCCC	49.68	-
772	Phosphorylation	SRGKGVGSTFESFRI CCCCCCCCCCCEEEE	27.76	28555341
776	Phosphorylation	GVGSTFESFRINIPG CCCCCCCEEEEECCC	18.68	-
791 (in isoform 3)	Phosphorylation	-	6.22	24719451
792	Phosphorylation	MAHSSQLSSPGFCNT CCCHHHCCCCCCCCC	27.18	25159151
792 (in isoform 3)	Phosphorylation	-	27.18	27251275
793	Phosphorylation	AHSSQLSSPGFCNTF CCHHHCCCCCCCCCC	37.32	25159151
799	Phosphorylation	SSPGFCNTFRPVDDK CCCCCCCCCCCCCCH	23.39	28555341
813 (in isoform 3)	Phosphorylation	-	38.11	24719451
814	Phosphorylation	EQRKENPSPLFSIKK HHHCCCCCCCCCCHH	45.90	29255136
818	Phosphorylation	ENPSPLFSIKKTKQL CCCCCCCCCHHCHHH	40.98	30266825
820	Acetylation	PSPLFSIKKTKQLRS CCCCCCCHHCHHHHC	53.87	25953088
821	Ubiquitination	SPLFSIKKTKQLRSE CCCCCCHHCHHHHCC	60.32	-
822	Phosphorylation	PLFSIKKTKQLRSEV CCCCCHHCHHHHCCC	21.01	26657352
827	Phosphorylation	KKTKQLRSEVYDPSD HHCHHHHCCCCCCCC	39.75	27732954
830	Phosphorylation	KQLRSEVYDPSDPTG HHHHCCCCCCCCCCC	20.34	24275569
833	Phosphorylation	RSEVYDPSDPTGSDS HCCCCCCCCCCCCCC	54.01	29978859
836	Phosphorylation	VYDPSDPTGSDSSAP CCCCCCCCCCCCCCC	55.07	28450419
838	Phosphorylation	DPSDPTGSDSSAPGS CCCCCCCCCCCCCCC	36.48	28450419
839 (in isoform 3)	Phosphorylation	-	48.21	27251275
840	Phosphorylation	SDPTGSDSSAPGSSP CCCCCCCCCCCCCCC	30.05	30108239
840 (in isoform 3)	Phosphorylation	-	30.05	27251275
841	Phosphorylation	DPTGSDSSAPGSSPE CCCCCCCCCCCCCCC	43.40	23401153
844 (in isoform 3)	Phosphorylation	-	40.24	24719451
845	Phosphorylation	SDSSAPGSSPERSGP CCCCCCCCCCCCCCC	41.48	30631047
845 (in isoform 3)	Phosphorylation	-	41.48	27251275
846	Phosphorylation	DSSAPGSSPERSGPG CCCCCCCCCCCCCCC	36.37	28355574
850	Phosphorylation	PGSSPERSGPGLLPS CCCCCCCCCCCCCCH	47.91	29255136
857	Phosphorylation	SGPGLLPSEITRTIS CCCCCCCHHEEEEEE	41.42	28450419
860	O-linked_Glycosylation	GLLPSEITRTISINS CCCCHHEEEEEECCC	20.08	30379171
860	Phosphorylation	GLLPSEITRTISINS CCCCHHEEEEEECCC	20.08	28450419
862	Phosphorylation	LPSEITRTISINSPK CCHHEEEEEECCCCC	15.49	30266825
863 (in isoform 3)	Phosphorylation	-	3.33	24719451
864	Phosphorylation	SEITRTISINSPKAQ HHEEEEEECCCCCCC	18.33	30266825
866 (in isoform 3)	Phosphorylation	-	45.53	24719451
867	Phosphorylation	TRTISINSPKAQTVQ EEEEECCCCCCCCEE	26.55	25159151
869	Ubiquitination	TISINSPKAQTVQAV EEECCCCCCCCEEEE	53.61	-
872	Phosphorylation	INSPKAQTVQAVRCV CCCCCCCCEEEEEEE	21.31	27486199
914 (in isoform 3)	Phosphorylation	-	8.85	24719451
915	Phosphorylation	AVAAEGASDTEREEP HHHHCCCCCCCCCCC	56.79	29255136
916 (in isoform 3)	Phosphorylation	-	52.64	24719451
917	Phosphorylation	AAEGASDTEREEPTE HHCCCCCCCCCCCCH	34.15	29255136
923	Phosphorylation	DTEREEPTESQGLAA CCCCCCCCHHHCHHH	52.10	29255136
924 (in isoform 3)	Phosphorylation	-	52.35	-
925	Phosphorylation	EREEPTESQGLAARL CCCCCCHHHCHHHHH	31.84	17525332
935 (in isoform 3)	Phosphorylation	-	44.76	24719451
936	Phosphorylation	AARLRRPSPPEPWDE HHHHCCCCCCCCCCC	51.80	22167270
947 (in isoform 3)	Phosphorylation	-	21.49	24719451
948	Phosphorylation	WDEEDGASCSTFFGS CCCCCCCCCCHHCCC	17.71	23927012
949 (in isoform 3)	Phosphorylation	-	4.38	-
950	Phosphorylation	EEDGASCSTFFGSEE CCCCCCCCHHCCCCC	26.25	23927012
950 (in isoform 3)	Phosphorylation	-	26.25	-
951	Phosphorylation	EDGASCSTFFGSEER CCCCCCCHHCCCCCE	27.58	23927012
955	Phosphorylation	SCSTFFGSEERTVTC CCCHHCCCCCEEEEE	31.00	23927012
959	Phosphorylation	FFGSEERTVTCVTVV HCCCCCEEEEEEEEE	24.36	24732914
961	Phosphorylation	GSEERTVTCVTVVEP CCCCEEEEEEEEECC	10.72	27987026
964	Phosphorylation	ERTVTCVTVVEPEAP CEEEEEEEEECCCCC	22.45	22167270
972 (in isoform 3)	Phosphorylation	-	66.59	24719451
973	Phosphorylation	VEPEAPPSPDVLQAA ECCCCCCCHHHHHHH	32.45	29255136
980 (in isoform 3)	Phosphorylation	-	7.32	-
981	Phosphorylation	PDVLQAATHRVVELR HHHHHHHCEEEEECC	17.15	22167270
990 (in isoform 3)	Phosphorylation	-	35.62	24719451
991	Phosphorylation	VVELRPPSRSRSTSS EEECCCCCCCCCCCC	45.64	30266825
993	Phosphorylation	ELRPPSRSRSTSSSR ECCCCCCCCCCCCHH	34.61	30266825
997	Phosphorylation	PSRSRSTSSSRSRKK CCCCCCCCCHHHHHH	27.80	24260401
998	Phosphorylation	SRSRSTSSSRSRKKA CCCCCCCCHHHHHHH	29.83	24260401
1029	Phosphorylation	RSESRDRSSRSASPS CCCCCCCCCCCCCCC	34.10	24260401
1031 (in isoform 3)	Phosphorylation	-	37.17	27251275
1032	Phosphorylation	SRDRSSRSASPSVGE CCCCCCCCCCCCCCC	34.74	23401153
1033 (in isoform 3)	Phosphorylation	-	25.09	24719451
1034	Phosphorylation	DRSSRSASPSVGEER CCCCCCCCCCCCCCC	20.96	29255136
1036	Phosphorylation	SSRSASPSVGEERPR CCCCCCCCCCCCCHH	40.01	20363803
1060	Phosphorylation	RSSSDRSSSRERAKR HCCCCHHHHHHHHHH	34.02	23401153
1091	Phosphorylation	HSRRTSRSRSGSPGS CCCCCCCCCCCCCCC	30.48	23663014
1092 (in isoform 3)	Phosphorylation	-	43.88	24719451
1093	Phosphorylation	RRTSRSRSGSPGSSS CCCCCCCCCCCCCCC	44.89	23927012
1094 (in isoform 3)	Phosphorylation	-	36.43	27251275
1095	Phosphorylation	TSRSRSGSPGSSSYE CCCCCCCCCCCCCHH	27.60	23927012
1098	Phosphorylation	SRSGSPGSSSYEHYE CCCCCCCCCCHHHHH	21.35	23927012
1099	Phosphorylation	RSGSPGSSSYEHYES CCCCCCCCCHHHHHH	42.74	23927012
1100	Phosphorylation	SGSPGSSSYEHYESR CCCCCCCCHHHHHHH	35.92	23663014
1101	Phosphorylation	GSPGSSSYEHYESRK CCCCCCCHHHHHHHH	14.52	23663014
1104	Phosphorylation	GSSSYEHYESRKKKK CCCCHHHHHHHHHHH	12.03	23663014
1106	Phosphorylation	SSYEHYESRKKKKRR CCHHHHHHHHHHHCH	42.08	23663014
1123 (in isoform 3)	Phosphorylation	-	5.94	24719451
1124	Phosphorylation	RPRGRECSPTSSLER CCCCCCCCCCHHHHH	26.85	29255136
1126	Phosphorylation	RGRECSPTSSLERLC CCCCCCCCHHHHHHH	18.04	23401153
1126 (in isoform 3)	Phosphorylation	-	18.04	-
1127	Phosphorylation	GRECSPTSSLERLCR CCCCCCCHHHHHHHH	35.99	30266825
1127 (in isoform 3)	Phosphorylation	-	35.99	-
1128	Phosphorylation	RECSPTSSLERLCRH CCCCCCHHHHHHHHH	36.41	29255136
1142	Phosphorylation	HKHQRERSHERPDRK HHHHHHHHCCCCCHH	25.58	23312004
1150 (in isoform 3)	Phosphorylation	-	51.87	27251275
1151	Phosphorylation	ERPDRKESVAWPRDR CCCCHHHCCCCCHHH	21.85	28555341
1163	Phosphorylation	RDRRKRRSRSPSSEH HHHHHHHCCCCCHHH	40.94	30576142
1165	Phosphorylation	RRKRRSRSPSSEHRA HHHHHCCCCCHHHHH	30.31	30576142
1167	Phosphorylation	KRRSRSPSSEHRARE HHHCCCCCHHHHHHH	49.99	30576142
1168	Phosphorylation	RRSRSPSSEHRAREH HHCCCCCHHHHHHHH	40.58	30576142
1180	Phosphorylation	REHRRPRSREKWPQT HHHCCCCCHHHCCCC	47.69	28152594
1187	Phosphorylation	SREKWPQTRSHSPER CHHHCCCCCCCCHHH	30.02	28152594
1188	Methylation	REKWPQTRSHSPERK HHHCCCCCCCCHHHC	27.42	115389073
1189	Phosphorylation	EKWPQTRSHSPERKG HHCCCCCCCCHHHCC	31.53	23898821
1191	Phosphorylation	WPQTRSHSPERKGAV CCCCCCCCHHHCCCC	29.69	29743597
1201 (in isoform 3)	Phosphorylation	-	15.39	24719451
1202	Phosphorylation	KGAVREASPAPLAQG CCCCCCCCCCCCCCC	19.49	19664994
1218	Phosphorylation	PGREDLPTRLPALGE CCCCCCCCCCCCCCC	52.73	23927012
1228 (in isoform 3)	Phosphorylation	-	15.28	24719451
1229	Phosphorylation	ALGEAHVSPEVATAD CCCCCCCCHHHCCCC	12.89	29255136
1234	Phosphorylation	HVSPEVATADKAPLQ CCCHHHCCCCCCCCC	40.33	23927012
1323 (in isoform 3)	Phosphorylation	-	6.08	27251275
1324	Phosphorylation	AAIQREVSLMHDEDP HHHHHHHHHCCCCCC	18.41	29449344
1341	Phosphorylation	PPPLPEGTQEPHLLR CCCCCCCCCCCCCCC	28.26	26074081
1358 (in isoform 3)	Phosphorylation	-	27.18	24719451
1359	Phosphorylation	AEKAEAPSSPDVAPA HHHCCCCCCCCCCCC	62.64	29255136
1359 (in isoform 3)	Phosphorylation	-	62.64	24719451
1360	Phosphorylation	EKAEAPSSPDVAPAG HHCCCCCCCCCCCCC	24.86	29255136
1370 (in isoform 3)	Phosphorylation	-	70.14	24719451
1371	Phosphorylation	APAGKEDSPSASGRV CCCCCCCCCCCCCCC	23.11	29255136
1373	Phosphorylation	AGKEDSPSASGRVQE CCCCCCCCCCCCCCH	38.73	30266825
1375	Phosphorylation	KEDSPSASGRVQEAA CCCCCCCCCCCCHHC	31.31	30266825
1388 (in isoform 3)	Phosphorylation	-	3.87	-
1389	Phosphorylation	ARPEEVVSQTPLLRS CCHHHHHCCCHHHHH	33.25	17525332
1390 (in isoform 3)	Phosphorylation	-	35.21	27251275
1391	Phosphorylation	PEEVVSQTPLLRSRA HHHHHCCCHHHHHHH	14.38	25850435
1403 (in isoform 3)	Phosphorylation	-	6.35	27251275
1404	Phosphorylation	RALVKRVTWNLQESE HHHHHHHHCCCCCCC	16.81	10997877
1410	Phosphorylation	VTWNLQESESSAPAE HHCCCCCCCCCCCHH	29.80	29978859
1430	Acetylation	APLHRPQKPREGAWD CCCCCCCCCCCCCCC	49.04	25953088
1563	Acetylation	KKEEYMKKLHMQERA HHHHHHHHHHHHHHH	27.39	7704555
1575	Ubiquitination	ERAVEEVKLAIKPFY HHHHHHHHHHHHHHH	35.17	-
1578	Ubiquitination	VEEVKLAIKPFYQKR HHHHHHHHHHHHHCC	9.37	21890473
1579	Ubiquitination	EEVKLAIKPFYQKRE HHHHHHHHHHHHCCC	24.38	21890473
1579	Ubiquitination	EEVKLAIKPFYQKRE HHHHHHHHHHHHCCC	24.38	21890473
1579 (in isoform 1)	Ubiquitination	-	24.38	21890473
1588	Phosphorylation	FYQKREVTKEEYKDI HHHCCCCCHHHHHHH	28.16	-
1589	Acetylation	YQKREVTKEEYKDIL HHCCCCCHHHHHHHH	54.44	20167786
1593	Acetylation	EVTKEEYKDILRKAV CCCHHHHHHHHHHHH	41.39	20167786
1593	Ubiquitination	EVTKEEYKDILRKAV CCCHHHHHHHHHHHH	41.39	-
1607	Ubiquitination	VQKICHSKSGEINPV HHHHHHCCCCCCCHH	38.52	-
1608	Phosphorylation	QKICHSKSGEINPVK HHHHHCCCCCCCHHH	44.68	22496350
1615	Malonylation	SGEINPVKVANLVKA CCCCCHHHHHHHHHH	36.57	26320211
1615	Ubiquitination	SGEINPVKVANLVKA CCCCCHHHHHHHHHH	36.57	-
1626	Acetylation	LVKAYVDKYRHMRRH HHHHHHHHHHHHHHC	33.85	30591301
1626	Malonylation	LVKAYVDKYRHMRRH HHHHHHHHHHHHHHC	33.85	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PHRF1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PHRF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PHRF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H31T_HUMAN	HIST3H3	physical	25855964
NBN_HUMAN	NBN	physical	25855964
XRCC6_HUMAN	XRCC6	physical	25855964
XRCC5_HUMAN	XRCC5	physical	25855964

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PHRF1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-330; SER-915; THR-917;SER-936; SER-1359; SER-1360; SER-1371 AND THR-1404, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-864; SER-867; SER-1124;SER-1127; SER-1128 AND SER-1202, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-973, AND MASSSPECTROMETRY.	18220336 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-915; THR-917; SER-925AND SER-1389, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-991; SER-1093; SER-1095;SER-1124 AND SER-1202, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-846 AND SER-1202, ANDMASS SPECTROMETRY.	15302935 [Abstract]