dbPTM

WDR46_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WDR46_HUMAN
UniProt AC	O15213
Protein Name	WD repeat-containing protein 46
Gene Name	WDR46
Organism	Homo sapiens (Human).
Sequence Length	610
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus..
Protein Sequence	METAPKPGKDVPPKKDKLQTKRKKPRRYWEEETVPTTAGASPGPPRNKKNRELRPQRPKNAYILKKSRISKKPQVPKKPREWKNPESQRGLSGTQDPFPGPAPVPVEVVQKFCRIDKSRKLPHSKAKTRSRLEVAEAEEEETSIKAARSELLLAEEPGFLEGEDGEDTAKICQADIVEAVDIASAAKHFDLNLRQFGPYRLNYSRTGRHLAFGGRRGHVAALDWVTKKLMCEINVMEAVRDIRFLHSEALLAVAQNRWLHIYDNQGIELHCIRRCDRVTRLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGHSNGTVSLWSPAMKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRGTYQPLSTRTLPHGAGHLAFSQRGLLVAGMGDVVNIWAGQGKASPPSLEQPYLTHRLSGPVHGLQFCPFEDVLGVGHTGGITSMLVPGAGEPNFDGLESNPYRSRKQRQEWEVKALLEKVPAELICLDPRALAEVDVISLEQGKKEQIERLGYDPQAKAPFQPKPKQKGRSSTASLVKRKRKVMDEEHRDKVRQSLQQQHHKEAKAKPTGARPSALDRFVR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----METAPKPGKD -----CCCCCCCCCC	47.14	20860994
33	Phosphorylation	RRYWEEETVPTTAGA CCCCCCCCCCCCCCC	34.76	30266825
36	Phosphorylation	WEEETVPTTAGASPG CCCCCCCCCCCCCCC	25.58	30266825
37	Phosphorylation	EEETVPTTAGASPGP CCCCCCCCCCCCCCC	19.61	30266825
41	Phosphorylation	VPTTAGASPGPPRNK CCCCCCCCCCCCCCC	29.49	25159151
111	Acetylation	VPVEVVQKFCRIDKS CCHHHHHHHHCCCCC	34.52	26051181
124	Phosphorylation	KSRKLPHSKAKTRSR CCCCCCCCCCCHHHH	32.16	20068231
145	Ubiquitination	EEEETSIKAARSELL HHHHHHHHHHHHHHH	35.44	-
149	Phosphorylation	TSIKAARSELLLAEE HHHHHHHHHHHHCCC	28.06	30624053
168	Phosphorylation	EGEDGEDTAKICQAD CCCCCCHHHHHHHHH	26.08	20860994
216	Methylation	HLAFGGRRGHVAALD CCEECCCCCHHHHHH	42.73	115919993
227	2-Hydroxyisobutyrylation	AALDWVTKKLMCEIN HHHHHHHHHHHHHHH	34.00	-
389	Methylation	QLKIFDLRGTYQPLS EEEEEECCCCCCCCC	36.93	115919997
436	Phosphorylation	QGKASPPSLEQPYLT CCCCCCCCCCCCCCH	48.17	28985074
503	Ubiquitination	QRQEWEVKALLEKVP HHHHHHHHHHHHHCC	23.08	-
508	Ubiquitination	EVKALLEKVPAELIC HHHHHHHHCCHHHEE	54.19	-
528	Phosphorylation	LAEVDVISLEQGKKE HCCCCEEEHHCCCHH	26.21	27050516
533	Sumoylation	VISLEQGKKEQIERL EEEHHCCCHHHHHHH	53.48	-
533	Ubiquitination	VISLEQGKKEQIERL EEEHHCCCHHHHHHH	53.48	-
533	Sumoylation	VISLEQGKKEQIERL EEEHHCCCHHHHHHH	53.48	-
533	Acetylation	VISLEQGKKEQIERL EEEHHCCCHHHHHHH	53.48	26051181
560	Phosphorylation	KPKQKGRSSTASLVK CCCCCCCCCHHHHHH	40.48	19691289
561	Phosphorylation	PKQKGRSSTASLVKR CCCCCCCCHHHHHHH	26.99	19691289
562	Phosphorylation	KQKGRSSTASLVKRK CCCCCCCHHHHHHHH	22.85	20860994
564	Phosphorylation	KGRSSTASLVKRKRK CCCCCHHHHHHHHHH	33.51	25159151
567	2-Hydroxyisobutyrylation	SSTASLVKRKRKVMD CCHHHHHHHHHHHCC	58.45	-
567	Acetylation	SSTASLVKRKRKVMD CCHHHHHHHHHHHCC	58.45	25953088
598	Phosphorylation	KEAKAKPTGARPSAL HHHHCCCCCCCCHHH	42.65	20860994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WDR46_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WDR46_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WDR46_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PUM3_HUMAN	KIAA0020	physical	26344197
RRP7A_HUMAN	RRP7A	physical	28514442
NOL6_HUMAN	NOL6	physical	28514442
LIN41_HUMAN	TRIM71	physical	28514442
ZN317_HUMAN	ZNF317	physical	28514442
H1T_HUMAN	HIST1H1T	physical	28514442
ZFP37_HUMAN	ZFP37	physical	28514442
NSD2_HUMAN	WHSC1	physical	28514442
SPB1_HUMAN	FTSJ3	physical	28514442
RENT1_HUMAN	UPF1	physical	28514442
WDR43_HUMAN	WDR43	physical	28514442
GLYR1_HUMAN	GLYR1	physical	28514442
TTF1_HUMAN	TTF1	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
BUD13_HUMAN	BUD13	physical	28514442
NOG2_HUMAN	GNL2	physical	28514442
ZN668_HUMAN	ZNF668	physical	28514442
BRX1_HUMAN	BRIX1	physical	28514442
ZN184_HUMAN	ZNF184	physical	28514442
STAU2_HUMAN	STAU2	physical	28514442
DDX31_HUMAN	DDX31	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
CC137_HUMAN	CCDC137	physical	28514442
RBM34_HUMAN	RBM34	physical	28514442
ELAV2_HUMAN	ELAVL2	physical	28514442
RS3A_HUMAN	RPS3A	physical	28514442
RBM28_HUMAN	RBM28	physical	28514442
ZN777_HUMAN	ZNF777	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
STAU1_HUMAN	STAU1	physical	28514442
ZKSC8_HUMAN	ZKSCAN8	physical	28514442
RBMX2_HUMAN	RBMX2	physical	28514442
RRP8_HUMAN	RRP8	physical	28514442
DDX24_HUMAN	DDX24	physical	28514442
DDX27_HUMAN	DDX27	physical	28514442
NOP2_HUMAN	NOP2	physical	28514442
NOC3L_HUMAN	NOC3L	physical	28514442
NMNA1_HUMAN	NMNAT1	physical	28514442
DKC1_HUMAN	DKC1	physical	28514442
IMP4_HUMAN	IMP4	physical	28514442
ZCCHV_HUMAN	ZC3HAV1	physical	28514442
PK1IP_HUMAN	PAK1IP1	physical	28514442
KNOP1_HUMAN	KNOP1	physical	28514442
RBM5_HUMAN	RBM5	physical	28514442
ZN483_HUMAN	ZNF483	physical	28514442
CDK13_HUMAN	CDK13	physical	28514442
REXO4_HUMAN	REXO4	physical	28514442
RS13_HUMAN	RPS13	physical	28514442
ZNF22_HUMAN	ZNF22	physical	28514442
RRP15_HUMAN	RRP15	physical	28514442
RL32_HUMAN	RPL32	physical	28514442
DCAF1_HUMAN	VPRBP	physical	28514442
PRKRA_HUMAN	PRKRA	physical	28514442
ZN629_HUMAN	ZNF629	physical	28514442
DDX10_HUMAN	DDX10	physical	28514442
GAR1_HUMAN	GAR1	physical	28514442
RRS1_HUMAN	RRS1	physical	28514442
DDX21_HUMAN	DDX21	physical	28514442
RL37A_HUMAN	RPL37A	physical	28514442
NUCL_HUMAN	NCL	physical	28514442
POP1_HUMAN	POP1	physical	28514442
BOP1_HUMAN	BOP1	physical	28514442
ZN512_HUMAN	ZNF512	physical	28514442
NSA2_HUMAN	NSA2	physical	28514442
LAR1B_HUMAN	LARP1B	physical	28514442
RLP24_HUMAN	RSL24D1	physical	28514442
PURA_HUMAN	PURA	physical	28514442
PAPD5_HUMAN	PAPD5	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
ZN770_HUMAN	ZNF770	physical	28514442
CEBPZ_HUMAN	CEBPZ	physical	28514442
DDX56_HUMAN	DDX56	physical	28514442
NOL10_HUMAN	NOL10	physical	28514442
EBP2_HUMAN	EBNA1BP2	physical	28514442
RSBN1_HUMAN	RSBN1	physical	28514442
SAS10_HUMAN	UTP3	physical	28514442
YTDC2_HUMAN	YTHDC2	physical	28514442
ZCHC3_HUMAN	ZCCHC3	physical	28514442
SRP72_HUMAN	SRP72	physical	28514442
HP1B3_HUMAN	HP1BP3	physical	28514442
RL10A_HUMAN	RPL10A	physical	28514442
NGDN_HUMAN	NGDN	physical	28514442
TRBP2_HUMAN	TARBP2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WDR46_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-561, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, AND MASSSPECTROMETRY.	16565220 [Abstract]