dbPTM

CDK13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDK13_HUMAN
UniProt AC	Q14004
Protein Name	Cyclin-dependent kinase 13
Gene Name	CDK13
Organism	Homo sapiens (Human).
Sequence Length	1512
Subcellular Localization	Nucleus speckle .
Protein Description	Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef..
Protein Sequence	MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLFLAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPVKTGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGILATGEKQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLANSSDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHISTSTGRGRGRGLPY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSSSDTALG -----CCCCCCCCCC	55.09	23663014
4	Phosphorylation	----MPSSSDTALGG ----CCCCCCCCCCC	42.85	23663014
5	Phosphorylation	---MPSSSDTALGGG ---CCCCCCCCCCCC	43.23	23663014
7	Phosphorylation	-MPSSSDTALGGGGG -CCCCCCCCCCCCCC	26.23	23663014
16	Phosphorylation	LGGGGGLSWAEKKLE CCCCCCCHHHHHHHH	27.75	23663014
135	Phosphorylation	QDGGGGASSGGGVTP CCCCCCCCCCCCCCC	32.56	24275569
136	Phosphorylation	DGGGGASSGGGVTPL CCCCCCCCCCCCCCC	40.71	-
141	Phosphorylation	ASSGGGVTPLVEYED CCCCCCCCCCEEEEC	17.74	24275569
151	Phosphorylation	VEYEDVSSQSEQGLL EEEECCCCHHCCCEE	37.26	-
163	Phosphorylation	GLLLGGASAATAATA CEECCHHHHHHHHHH	23.01	26074081
166	Phosphorylation	LGGASAATAATAAGG CCHHHHHHHHHHCCC	19.28	26074081
169	Phosphorylation	ASAATAATAAGGTGG HHHHHHHHHCCCCCC	17.99	26074081
174	Phosphorylation	AATAAGGTGGSGGSP HHHHCCCCCCCCCCC	37.13	26074081
177	Phosphorylation	AAGGTGGSGGSPASS HCCCCCCCCCCCCCC	41.13	26074081
180	Phosphorylation	GTGGSGGSPASSSGT CCCCCCCCCCCCCCC	22.33	26074081
183	Phosphorylation	GSGGSPASSSGTQRR CCCCCCCCCCCCCCC	28.55	26074081
184	Phosphorylation	SGGSPASSSGTQRRG CCCCCCCCCCCCCCC	34.59	26074081
185	Phosphorylation	GGSPASSSGTQRRGE CCCCCCCCCCCCCCC	43.28	26074081
187	Phosphorylation	SPASSSGTQRRGEGS CCCCCCCCCCCCCCC	22.35	26074081
204	Phosphorylation	RPRRDRRSSSGRSKE CCCCCCCCCCCCCHH	29.74	-
205	Phosphorylation	PRRDRRSSSGRSKER CCCCCCCCCCCCHHH	34.69	-
209	Phosphorylation	RRSSSGRSKERHREH CCCCCCCCHHHHHHH	42.25	-
229	Phosphorylation	QRGGSEASKSRSRHS CCCCCHHHHHHCCCC	27.41	17081983
233	Phosphorylation	SEASKSRSRHSHSGE CHHHHHHCCCCCCHH	41.24	23312004
236	Phosphorylation	SKSRSRHSHSGEERA HHHHCCCCCCHHHHH	20.45	30576142
238	Phosphorylation	SRSRHSHSGEERAEV HHCCCCCCHHHHHHH	51.41	30576142
248	Phosphorylation	ERAEVAKSGSSSSSG HHHHHHHCCCCCCCC	33.88	23401153
250	Phosphorylation	AEVAKSGSSSSSGGR HHHHHCCCCCCCCCC	33.85	23401153
251	Phosphorylation	EVAKSGSSSSSGGRR HHHHCCCCCCCCCCC	37.45	23401153
252	Phosphorylation	VAKSGSSSSSGGRRK HHHCCCCCCCCCCCC	30.16	23401153
253	Phosphorylation	AKSGSSSSSGGRRKS HHCCCCCCCCCCCCC	34.64	23401153
254	Phosphorylation	KSGSSSSSGGRRKSA HCCCCCCCCCCCCCC	47.41	23401153
260	Phosphorylation	SSGGRRKSASATSSS CCCCCCCCCCCCCCC	26.16	24275569
262	Phosphorylation	GGRRKSASATSSSSS CCCCCCCCCCCCCCC	38.89	25849741
264	Phosphorylation	RRKSASATSSSSSSR CCCCCCCCCCCCCCC	27.01	30387612
268	Phosphorylation	ASATSSSSSSRKDRD CCCCCCCCCCCHHHC	33.99	-
276	Phosphorylation	SSRKDRDSKAHRSRT CCCHHHCHHHHHHHC	32.41	-
281	Phosphorylation	RDSKAHRSRTKSSKE HCHHHHHHHCCCCCC	34.14	-
283	Phosphorylation	SKAHRSRTKSSKEPP HHHHHHHCCCCCCCC	36.20	27794612
285	Phosphorylation	AHRSRTKSSKEPPSA HHHHHCCCCCCCCHH	46.13	28985074
286	Phosphorylation	HRSRTKSSKEPPSAY HHHHCCCCCCCCHHH	42.46	28674419
291	Phosphorylation	KSSKEPPSAYKEPPK CCCCCCCHHHCCCCC	55.75	25159151
293	Phosphorylation	SKEPPSAYKEPPKAY CCCCCHHHCCCCCCC	21.88	26074081
315	Phosphorylation	KAYRRRRSLSPLGGR HHHHHHHCCCCCCCC	31.24	29255136
317	Phosphorylation	YRRRRSLSPLGGRDD HHHHHCCCCCCCCCC	21.23	29255136
325	Phosphorylation	PLGGRDDSPVSHRAS CCCCCCCCCCCHHHH	31.33	29255136
328	Phosphorylation	GRDDSPVSHRASQSL CCCCCCCCHHHHHHH	15.61	30266825
332	Phosphorylation	SPVSHRASQSLRSRK CCCCHHHHHHHHHCC	21.91	21406692
334	Phosphorylation	VSHRASQSLRSRKSP CCHHHHHHHHHCCCC	24.21	21406692
337	Phosphorylation	RASQSLRSRKSPSPA HHHHHHHHCCCCCCC	49.72	21955146
340	Phosphorylation	QSLRSRKSPSPAGGG HHHHHCCCCCCCCCC	29.51	22617229
342	Phosphorylation	LRSRKSPSPAGGGSS HHHCCCCCCCCCCCC	34.18	22617229
348	Phosphorylation	PSPAGGGSSPYSRRL CCCCCCCCCCCHHCC	31.26	21955146
349	Phosphorylation	SPAGGGSSPYSRRLP CCCCCCCCCCHHCCC	31.00	21955146
351	Phosphorylation	AGGGSSPYSRRLPRS CCCCCCCCHHCCCCC	19.43	22115753
352	Phosphorylation	GGGSSPYSRRLPRSP CCCCCCCHHCCCCCC	17.82	22115753
358	Phosphorylation	YSRRLPRSPSPYSRR CHHCCCCCCCCCCCC	27.99	23927012
360	Phosphorylation	RRLPRSPSPYSRRRS HCCCCCCCCCCCCCC	37.40	23927012
362	Phosphorylation	LPRSPSPYSRRRSPS CCCCCCCCCCCCCCC	21.10	23927012
363	Phosphorylation	PRSPSPYSRRRSPSY CCCCCCCCCCCCCCC	23.77	23927012
367	Phosphorylation	SPYSRRRSPSYSRHS CCCCCCCCCCCCCCC	19.18	28102081
369	Phosphorylation	YSRRRSPSYSRHSSY CCCCCCCCCCCCCCC	36.67	20363803
370	Phosphorylation	SRRRSPSYSRHSSYE CCCCCCCCCCCCCCC	17.07	17081983
371	Phosphorylation	RRRSPSYSRHSSYER CCCCCCCCCCCCCCC	28.05	20363803
374	Phosphorylation	SPSYSRHSSYERGGD CCCCCCCCCCCCCCC	33.24	24247654
375	Phosphorylation	PSYSRHSSYERGGDV CCCCCCCCCCCCCCC	25.53	30576142
376	Phosphorylation	SYSRHSSYERGGDVS CCCCCCCCCCCCCCC	16.80	-
383	Phosphorylation	YERGGDVSPSPYSSS CCCCCCCCCCCCCCC	25.13	19664994
385	Phosphorylation	RGGDVSPSPYSSSSW CCCCCCCCCCCCCCC	29.03	22167270
387	Phosphorylation	GDVSPSPYSSSSWRR CCCCCCCCCCCCCHH	26.06	22167270
388	Phosphorylation	DVSPSPYSSSSWRRS CCCCCCCCCCCCHHC	27.42	22167270
389	Phosphorylation	VSPSPYSSSSWRRSR CCCCCCCCCCCHHCC	23.65	22167270
390	Phosphorylation	SPSPYSSSSWRRSRS CCCCCCCCCCHHCCC	28.16	22167270
391	Phosphorylation	PSPYSSSSWRRSRSP CCCCCCCCCHHCCCC	26.92	22167270
395	Phosphorylation	SSSSWRRSRSPYSPV CCCCCHHCCCCCCHH	28.65	22167270
397	Phosphorylation	SSWRRSRSPYSPVLR CCCHHCCCCCCHHHH	29.45	22167270
399	Phosphorylation	WRRSRSPYSPVLRRS CHHCCCCCCHHHHCC	27.18	22167270
400	Phosphorylation	RRSRSPYSPVLRRSG HHCCCCCCHHHHCCC	16.36	22167270
406	Phosphorylation	YSPVLRRSGKSRSRS CCHHHHCCCCCCCCC	44.10	24719451
409	Phosphorylation	VLRRSGKSRSRSPYS HHHCCCCCCCCCCCC	38.73	20363803
411	Phosphorylation	RRSGKSRSRSPYSSR HCCCCCCCCCCCCCC	44.17	27362937
413	Phosphorylation	SGKSRSRSPYSSRHS CCCCCCCCCCCCCCH	29.45	27362937
415	Phosphorylation	KSRSRSPYSSRHSRS CCCCCCCCCCCCHHH	22.11	23312004
416	Phosphorylation	SRSRSPYSSRHSRSR CCCCCCCCCCCHHHH	25.04	23663014
417	Phosphorylation	RSRSPYSSRHSRSRS CCCCCCCCCCHHHHH	28.33	20363803
420	Phosphorylation	SPYSSRHSRSRSRHR CCCCCCCHHHHHHHH	30.73	20068231
422	Phosphorylation	YSSRHSRSRSRHRLS CCCCCHHHHHHHHHH	37.31	17081983
429	Phosphorylation	SRSRHRLSRSRSRHS HHHHHHHHHHHHCCC	28.32	28102081
431	Phosphorylation	SRHRLSRSRSRHSSI HHHHHHHHHHCCCCC	31.09	21406692
433	Phosphorylation	HRLSRSRSRHSSISP HHHHHHHHCCCCCCH	35.28	26055452
436	Phosphorylation	SRSRSRHSSISPSTL HHHHHCCCCCCHHHH	28.40	29255136
437	Phosphorylation	RSRSRHSSISPSTLT HHHHCCCCCCHHHHH	22.44	19664994
439	Phosphorylation	RSRHSSISPSTLTLK HHCCCCCCHHHHHHH	18.10	29255136
441	Phosphorylation	RHSSISPSTLTLKSS CCCCCCHHHHHHHHH	29.29	19664994
442	Phosphorylation	HSSISPSTLTLKSSL CCCCCHHHHHHHHHH	27.44	29255136
444	Phosphorylation	SISPSTLTLKSSLAA CCCHHHHHHHHHHHH	32.03	22167270
490	O-linked_Glycosylation	AAKAAKASNTSTPTK HHHHHHHCCCCCCCC	39.68	30059200
490	Phosphorylation	AAKAAKASNTSTPTK HHHHHHHCCCCCCCC	39.68	23927012
492	Phosphorylation	KAAKASNTSTPTKGN HHHHHCCCCCCCCCC	31.33	23927012
493	Phosphorylation	AAKASNTSTPTKGNT HHHHCCCCCCCCCCC	36.32	23927012
494	Phosphorylation	AKASNTSTPTKGNTE HHHCCCCCCCCCCCC	32.70	23927012
496	Phosphorylation	ASNTSTPTKGNTETS HCCCCCCCCCCCCCC	52.23	23927012
500	Phosphorylation	STPTKGNTETSASAS CCCCCCCCCCCCCHH	49.67	23927012
502	Phosphorylation	PTKGNTETSASASQT CCCCCCCCCCCHHCC	27.79	23927012
503	Phosphorylation	TKGNTETSASASQTN CCCCCCCCCCHHCCC	17.62	30108239
505	Phosphorylation	GNTETSASASQTNHV CCCCCCCCHHCCCCC	28.37	28450419
507	Phosphorylation	TETSASASQTNHVKD CCCCCCHHCCCCCCC	34.73	23927012
509	Phosphorylation	TSASASQTNHVKDVK CCCCHHCCCCCCCCE	25.46	25627689
519	Sumoylation	VKDVKKIKIEHAPSP CCCCEEEEEEECCCC	51.42	-
519	Sumoylation	VKDVKKIKIEHAPSP CCCCEEEEEEECCCC	51.42	28112733
525	Phosphorylation	IKIEHAPSPSSGGTL EEEEECCCCCCCCCC	37.89	29255136
527	Phosphorylation	IEHAPSPSSGGTLKN EEECCCCCCCCCCCC	46.05	29255136
528	Phosphorylation	EHAPSPSSGGTLKND EECCCCCCCCCCCCC	44.63	25159151
531	Phosphorylation	PSPSSGGTLKNDKAK CCCCCCCCCCCCCCC	37.78	26055452
539	Phosphorylation	LKNDKAKTKPPLQVT CCCCCCCCCCCCEEE	54.35	26074081
547	Sumoylation	KPPLQVTKVENNLIV CCCCEEEEEECCEEE	49.01	28112733
556	Acetylation	ENNLIVDKATKKAVI ECCEEECCCCCEEEE	47.24	19608861
566	Acetylation	KKAVIVGKESKSAAT CEEEEEECCCCCCCC	48.17	25953088
583	Acetylation	ESVSLKEKTKPLTPS HCCCHHHCCCCCCCC	61.33	19666929
584	Phosphorylation	SVSLKEKTKPLTPSI CCCHHHCCCCCCCCC	38.70	23403867
585	Acetylation	VSLKEKTKPLTPSIG CCHHHCCCCCCCCCC	49.45	19666941
588	Phosphorylation	KEKTKPLTPSIGAKE HHCCCCCCCCCCCCH	24.42	25159151
590	Phosphorylation	KTKPLTPSIGAKEKE CCCCCCCCCCCCHHH	28.55	25159151
624	Phosphorylation	PEDKEADSLRGNISV CCCHHHCCCCCCCCH	27.32	20068231
630	Phosphorylation	DSLRGNISVKAVKKE CCCCCCCCHHHHHHH	22.89	-
632	Ubiquitination	LRGNISVKAVKKEVE CCCCCCHHHHHHHHH	40.44	-
662	Phosphorylation	LPGGDDLSKSPEEKK CCCCCCCCCCHHHHH	37.77	30278072
664	Phosphorylation	GGDDLSKSPEEKKTA CCCCCCCCHHHHHHH	33.88	22617229
670	Phosphorylation	KSPEEKKTATQLHSK CCHHHHHHHHHHHHC	46.11	26074081
672	Phosphorylation	PEEKKTATQLHSKRR HHHHHHHHHHHHCCC	36.57	26074081
677	Acetylation	TATQLHSKRRPKICG HHHHHHHCCCCCCCC	41.50	25953088
687	Phosphorylation	PKICGPRYGETKEKD CCCCCCCCCCCCHHC	23.58	-
699	Ubiquitination	EKDIDWGKRCVDKFD HHCCCHHHHHCCCCC	38.07	-
716	Phosphorylation	GIIGEGTYGQVYKAR EEEECCCCCEEEEEE	19.20	22817900
725	Acetylation	QVYKARDKDTGEMVA EEEEEECCCCCCEEE	52.19	19413330
742	Ubiquitination	KVRLDNEKEGFPITA EEECCCCCCCCCCHH	70.19	-
748	Phosphorylation	EKEGFPITAIREIKI CCCCCCCHHHHHHHH	19.10	20068231
774	Acetylation	MKEIVTDKEDALDFK HHHHCCCHHHHHHHC	48.40	25953088
774	Ubiquitination	MKEIVTDKEDALDFK HHHHCCCHHHHHHHC	48.40	-
781	Ubiquitination	KEDALDFKKDKGAFY HHHHHHHCCCCCCEE	60.78	-
827	Phosphorylation	QLMEGLDYCHKKNFL HHHHHHHHHHHCCCC	11.07	20860994
862	Phosphorylation	DFGLARLYSSEESRP HHHHCCCCCCCCCCC	12.47	23403867
863	Phosphorylation	FGLARLYSSEESRPY HHHCCCCCCCCCCCC	35.55	23927012
864	Phosphorylation	GLARLYSSEESRPYT HHCCCCCCCCCCCCC	31.65	23927012
867	Phosphorylation	RLYSSEESRPYTNKV CCCCCCCCCCCCCCE	34.21	25159151
870	Phosphorylation	SSEESRPYTNKVITL CCCCCCCCCCCEEEE	23.10	23927012
871	Phosphorylation	SEESRPYTNKVITLW CCCCCCCCCCEEEEE	31.11	25159151
927	Phosphorylation	LAQLELISRICGSPC HHHHHHHHHHHCCCC	28.37	24719451
943	Ubiquitination	AVWPDVIKLPYFNTM CCCCCCCCCCCCCCC	43.17	-
951	Acetylation	LPYFNTMKPKKQYRR CCCCCCCCCHHHHHH	52.20	23954790
951	Malonylation	LPYFNTMKPKKQYRR CCCCCCCCCHHHHHH	52.20	32601280
1022	Phosphorylation	QDCHELWSKKRRRQK HHHHHHHHHHHHHHH	40.71	25159151
1034	Phosphorylation	RQKQMGMTDDVSTIK HHHHHCCCCCHHHCC	24.26	29457462
1045	Acetylation	STIKAPRKDLSLGLD HHCCCCCCCCCCCCC	63.06	26051181
1045	Ubiquitination	STIKAPRKDLSLGLD HHCCCCCCCCCCCCC	63.06	-
1048	Phosphorylation	KAPRKDLSLGLDDSR CCCCCCCCCCCCCCC	30.44	23401153
1054	Phosphorylation	LSLGLDDSRTNTPQG CCCCCCCCCCCCCCC	40.44	29255136
1054 (in isoform 2)	Phosphorylation	-	40.44	18220336
1056	Phosphorylation	LGLDDSRTNTPQGVL CCCCCCCCCCCCCCC	47.60	23401153
1058	Phosphorylation	LDDSRTNTPQGVLPS CCCCCCCCCCCCCCH	19.17	22167270
1065	Phosphorylation	TPQGVLPSSQLKSQG CCCCCCCHHHHHCCC	26.93	23927012
1065 (in isoform 2)	Phosphorylation	-	26.93	30131370
1066	Phosphorylation	PQGVLPSSQLKSQGS CCCCCCHHHHHCCCC	37.28	17525332
1074 (in isoform 2)	Phosphorylation	-	41.99	22210691
1083 (in isoform 2)	Phosphorylation	-	44.49	18669648
1086 (in isoform 2)	Phosphorylation	-	34.22	25849741
1087 (in isoform 2)	Phosphorylation	-	4.79	25849741
1092 (in isoform 2)	Phosphorylation	-	3.94	21552520
1093 (in isoform 2)	Phosphorylation	-	6.07	22210691
1138	Phosphorylation	LPAGILATGEKQTDP CCCCCCCCCCCCCCC	42.29	23401153
1143	Phosphorylation	LATGEKQTDPSTPQQ CCCCCCCCCCCCCCC	62.03	30278072
1146	Phosphorylation	GEKQTDPSTPQQESS CCCCCCCCCCCCCCC	56.37	29255136
1147	Phosphorylation	EKQTDPSTPQQESSK CCCCCCCCCCCCCCC	30.42	29255136
1152	Phosphorylation	PSTPQQESSKPLGGI CCCCCCCCCCCCCCC	39.05	29255136
1153	Phosphorylation	STPQQESSKPLGGIQ CCCCCCCCCCCCCCC	37.22	23927012
1154	Acetylation	TPQQESSKPLGGIQP CCCCCCCCCCCCCCC	54.24	26051181
1162	Phosphorylation	PLGGIQPSSQTIQPK CCCCCCCCCCCCCCC	20.78	25159151
1163	Phosphorylation	LGGIQPSSQTIQPKV CCCCCCCCCCCCCCC	37.72	25159151
1165	Phosphorylation	GIQPSSQTIQPKVET CCCCCCCCCCCCCCC	24.43	25159151
1199	Ubiquitination	KAQQSKQKDVLLEER HHHHHHCCCCEEEEC	54.24	-
1210	Phosphorylation	LEERENGSGHEASLQ EEECCCCCCCCCEEE	48.86	25850435
1215	Phosphorylation	NGSGHEASLQLRPPP CCCCCCCEEEECCCC	17.42	25850435
1225	Phosphorylation	LRPPPEPSTPVSGQD ECCCCCCCCCCCCCC	43.62	23401153
1226	Phosphorylation	RPPPEPSTPVSGQDD CCCCCCCCCCCCCCC	38.12	21082442
1229	Phosphorylation	PEPSTPVSGQDDLIQ CCCCCCCCCCCCCHH	31.75	25850435
1246	Phosphorylation	DMRILELTPEPDRPR CCEEEECCCCCCCCC	19.07	29255136
1271	Phosphorylation	PPEPPPVTEEDLDYR CCCCCCCCHHHCCCC	39.16	20068231
1277	Phosphorylation	VTEEDLDYRTENQHV CCHHHCCCCCCCCCC	27.08	20068231
1286	O-linked_Glycosylation	TENQHVPTTSSSLTD CCCCCCCCCCCCCCC	37.92	30059200
1287	O-linked_Glycosylation	ENQHVPTTSSSLTDP CCCCCCCCCCCCCCC	22.12	30059200
1288	O-linked_Glycosylation	NQHVPTTSSSLTDPH CCCCCCCCCCCCCCC	22.02	30059200
1289	O-linked_Glycosylation	QHVPTTSSSLTDPHA CCCCCCCCCCCCCCH	27.55	30059200
1290	O-linked_Glycosylation	HVPTTSSSLTDPHAG CCCCCCCCCCCCCHH	34.75	30059200
1292	O-linked_Glycosylation	PTTSSSLTDPHAGVK CCCCCCCCCCCHHHH	49.81	30059200
1316	Ubiquitination	HQPQDDPKREGGIDY CCCCCCCCCCCCCCC	70.81	-
1335	Phosphorylation	TYVSTSDYKDNFGSS EEEECCCCCCCCCCC	21.73	30576142
1342	Phosphorylation	YKDNFGSSSFSSAPY CCCCCCCCCCCCCCC	35.46	25159151
1343	Phosphorylation	KDNFGSSSFSSAPYV CCCCCCCCCCCCCCC	30.74	25627689
1345	Phosphorylation	NFGSSSFSSAPYVSN CCCCCCCCCCCCCCC	27.77	30576142
1346	Phosphorylation	FGSSSFSSAPYVSND CCCCCCCCCCCCCCC	31.11	25159151
1471	Phosphorylation	GNLQENPSGPSLMHG CCCCCCCCCCCCCCC	74.95	18691976
1474	Phosphorylation	QENPSGPSLMHGQTW CCCCCCCCCCCCCEE	41.68	28348404
1480	Phosphorylation	PSLMHGQTWTSPAQG CCCCCCCEECCCCCC	34.99	28348404
1482	Phosphorylation	LMHGQTWTSPAQGPG CCCCCEECCCCCCCC	28.37	26074081
1483	Phosphorylation	MHGQTWTSPAQGPGY CCCCEECCCCCCCCC	15.14	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
437	S	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CDK13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDK13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDK12_HUMAN	CDK12	physical	22939629
MK14_HUMAN	MAPK14	physical	22939629
PRPF3_HUMAN	PRPF3	physical	22939629
MTA3_HUMAN	MTA3	physical	22939629
NSUN5_HUMAN	NSUN5	physical	22939629
TCPG_HUMAN	CCT3	physical	25852190
EF2_HUMAN	EEF2	physical	25852190
TBB5_HUMAN	TUBB	physical	26186194
TBB4B_HUMAN	TUBB4B	physical	26186194
TBB3_HUMAN	TUBB3	physical	26186194
TBB8_HUMAN	TUBB8	physical	26186194
HS90A_HUMAN	HSP90AA1	physical	26186194
HS90B_HUMAN	HSP90AB1	physical	26186194
FKBP5_HUMAN	FKBP5	physical	26186194
KEAP1_HUMAN	KEAP1	physical	26186194
CDC37_HUMAN	CDC37	physical	26186194
PLSI_HUMAN	PLS1	physical	26186194
SPSB3_HUMAN	SPSB3	physical	26186194
DUSTY_HUMAN	DSTYK	physical	26186194
CDK12_HUMAN	CDK12	physical	26186194
RB_HUMAN	RB1	physical	26186194
FBX11_HUMAN	FBXO11	physical	26186194
TBA4A_HUMAN	TUBA4A	physical	26186194
TBA1A_HUMAN	TUBA1A	physical	26186194
TBA1C_HUMAN	TUBA1C	physical	26186194
CCNK_HUMAN	CCNK	physical	26186194
EDRF1_HUMAN	EDRF1	physical	26186194
NEK3_HUMAN	NEK3	physical	26186194
WDR34_HUMAN	WDR34	physical	26186194
GBB2_HUMAN	GNB2	physical	26186194
FBX44_HUMAN	FBXO44	physical	26186194
PALD_HUMAN	PALD1	physical	26186194
TTC9C_HUMAN	TTC9C	physical	26186194
PPM1B_HUMAN	PPM1B	physical	26344197
CDK12_HUMAN	CDK12	physical	28514442
NEK3_HUMAN	NEK3	physical	28514442
SPSB3_HUMAN	SPSB3	physical	28514442
FKBP5_HUMAN	FKBP5	physical	28514442
HS90A_HUMAN	HSP90AA1	physical	28514442
HS90B_HUMAN	HSP90AB1	physical	28514442
FBX44_HUMAN	FBXO44	physical	28514442
RB_HUMAN	RB1	physical	28514442
CCNK_HUMAN	CCNK	physical	28514442
FBX11_HUMAN	FBXO11	physical	28514442
KEAP1_HUMAN	KEAP1	physical	28514442
DUSTY_HUMAN	DSTYK	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
TBB4A_HUMAN	TUBB4A	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442
EDRF1_HUMAN	EDRF1	physical	28514442
TBB4B_HUMAN	TUBB4B	physical	28514442
TBA1A_HUMAN	TUBA1A	physical	28514442
PALD_HUMAN	PALD1	physical	28514442
PLSI_HUMAN	PLS1	physical	28514442
TBB5_HUMAN	TUBB	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CDK13_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-556, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383 AND SER-437, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3; SER-238; SER-315;SER-317; SER-325; SER-342; SER-348; SER-358; SER-360; SER-383;SER-385; SER-395; SER-397; SER-413; SER-436; SER-437; SER-439;SER-490; THR-492; SER-525; SER-527; SER-662; SER-664; SER-863;TYR-870; THR-871; SER-1048; SER-1054; THR-1058; THR-1143; SER-1146;THR-1147 AND THR-1246, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383 AND THR-494, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315; SER-317; SER-325;SER-340; SER-342; SER-349; SER-383; SER-395; SER-397; SER-400;SER-437; SER-439; THR-871 AND THR-1246, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315; SER-317; SER-325;SER-358; SER-360; SER-383; SER-395; SER-397; SER-400; SER-437;SER-439; SER-525; SER-664; THR-871; THR-1056 AND THR-1246, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1054, AND MASSSPECTROMETRY.	18220336 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1066, AND MASSSPECTROMETRY.	17525332 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437 AND SER-441, ANDMASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315; SER-317; SER-325;SER-437; SER-439 AND THR-1246, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317; SER-340; SER-342;SER-367 AND SER-383, AND MASS SPECTROMETRY.	15302935 [Abstract]
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437 AND THR-442, ANDMASS SPECTROMETRY.	15144186 [Abstract]