dbPTM

PALD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PALD_HUMAN
UniProt AC	Q9ULE6
Protein Name	Paladin
Gene Name	PALD1
Organism	Homo sapiens (Human).
Sequence Length	856
Subcellular Localization	Cytoplasm, cytosol .
Protein Description
Protein Sequence	MGTTASTAQQTVSAGTPFEGLQGSGTMDSRHSVSIHSFQSTSLHNSKAKSIIPNKVAPVVITYNCKEEFQIHDELLKAHYTLGRLSDNTPEHYLVQGRYFLVRDVTEKMDVLGTVGSCGAPNFRQVQGGLTVFGMGQPSLSGFRRVLQKLQKDGHRECVIFCVREEPVLFLRADEDFVSYTPRDKQNLHENLQGLGPGVRVESLELAIRKEIHDFAQLSENTYHVYHNTEDLWGEPHAVAIHGEDDLHVTEEVYKRPLFLQPTYRYHRLPLPEQGSPLEAQLDAFVSVLRETPSLLQLRDAHGPPPALVFSCQMGVGRTNLGMVLGTLILLHRSGTTSQPEAAPTQAKPLPMEQFQVIQSFLRMVPQGRRMVEEVDRAITACAELHDLKEVVLENQKKLEGIRPESPAQGSGSRHSVWQRALWSLERYFYLILFNYYLHEQYPLAFALSFSRWLCAHPELYRLPVTLSSAGPVAPRDLIARGSLREDDLVSPDALSTVREMDVANFRRVPRMPIYGTAQPSAKALGSILAYLTDAKRRLRKVVWVSLREEAVLECDGHTYSLRWPGPPVAPDQLETLEAQLKAHLSEPPPGKEGPLTYRFQTCLTMQEVFSQHRRACPGLTYHRIPMPDFCAPREEDFDQLLEALRAALSKDPGTGFVFSCLSGQGRTTTAMVVAVLAFWHIQGFPEVGEEELVSVPDAKFTKGEFQVVMKVVQLLPDGHRVKKEVDAALDTVSETMTPMHYHLREIIICTYRQAKAAKEAQEMRRLQLRSLQYLERYVCLILFNAYLHLEKADSWQRPFSTWMQEVASKAGIYEILNELGFPELESGEDQPFSRLRYRWQEQSCSLEPSAPEDLL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGTTASTAQ ------CCCCCCCCC	31.60	-
2	Myristoylation	------MGTTASTAQ ------CCCCCCCCC	31.60	20213681
32	Phosphorylation	GTMDSRHSVSIHSFQ CCCCCCCEEEEEEEE	19.22	27251275
34	Phosphorylation	MDSRHSVSIHSFQST CCCCCEEEEEEEECC	20.00	27422710
37	Phosphorylation	RHSVSIHSFQSTSLH CCEEEEEEEECCCCC	24.26	24501219
40	Phosphorylation	VSIHSFQSTSLHNSK EEEEEEECCCCCCCC	20.25	30177828
41	Phosphorylation	SIHSFQSTSLHNSKA EEEEEECCCCCCCCC	25.23	30177828
42	Phosphorylation	IHSFQSTSLHNSKAK EEEEECCCCCCCCCC	32.64	30177828
46	Phosphorylation	QSTSLHNSKAKSIIP ECCCCCCCCCCCCCC	24.20	30177828
50	Phosphorylation	LHNSKAKSIIPNKVA CCCCCCCCCCCCCEE	30.52	-
55	Acetylation	AKSIIPNKVAPVVIT CCCCCCCCEECEEEE	34.13	7710607
86	Phosphorylation	HYTLGRLSDNTPEHY HHHHHCCCCCCCCCE	27.70	23312004
89	Phosphorylation	LGRLSDNTPEHYLVQ HHCCCCCCCCCEEEE	34.74	30624053
93	Phosphorylation	SDNTPEHYLVQGRYF CCCCCCCEEEECCEE	13.60	23312004
181	Phosphorylation	DEDFVSYTPRDKQNL CCCCCCCCCCHHCCH	12.35	26546556
185	Ubiquitination	VSYTPRDKQNLHENL CCCCCCHHCCHHHHC	42.22	21906983
263	Phosphorylation	RPLFLQPTYRYHRLP CCCCCCCCCCCCCCC	13.99	24260401
264	Phosphorylation	PLFLQPTYRYHRLPL CCCCCCCCCCCCCCC	18.83	24260401
266	Phosphorylation	FLQPTYRYHRLPLPE CCCCCCCCCCCCCCC	4.85	24260401
397	Ubiquitination	EVVLENQKKLEGIRP HHHHHCHHHHCCCCC	71.55	-
406	Phosphorylation	LEGIRPESPAQGSGS HCCCCCCCCCCCCCC	28.37	21082442
411	Phosphorylation	PESPAQGSGSRHSVW CCCCCCCCCCCHHHH	22.86	23403867
413	Phosphorylation	SPAQGSGSRHSVWQR CCCCCCCCCHHHHHH	28.63	23403867
424	Phosphorylation	VWQRALWSLERYFYL HHHHHHHHHHHHHHH	22.62	24719451
449	Phosphorylation	YPLAFALSFSRWLCA CCHHHHHHHHHHHHH	20.11	24945436
531	Phosphorylation	ALGSILAYLTDAKRR HHHHHHHHHHHHHHH	13.49	-
533	Phosphorylation	GSILAYLTDAKRRLR HHHHHHHHHHHHHHH	22.64	-
536	Acetylation	LAYLTDAKRRLRKVV HHHHHHHHHHHHHEE	40.64	30589707
561	Phosphorylation	ECDGHTYSLRWPGPP EECCEEEEEECCCCC	16.77	24719451
582	Ubiquitination	ETLEAQLKAHLSEPP HHHHHHHHHHHCCCC	22.98	21906983
756	Acetylation	ICTYRQAKAAKEAQE HHHHHHHHHHHHHHH	40.30	19818197

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PALD_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PALD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PALD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PALD_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PALD_HUMAN

Related Literatures of Post-Translational Modification

Myristoylation
Reference	PubMed
"Strategy for comprehensive identification of human N-myristoylatedproteins using an insect cell-free protein synthesis system."; Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E.,Tsunasawa S., Utsumi T.; Proteomics 10:1780-1793(2010). Cited for: MYRISTOYLATION AT GLY-2.	20213681 [Abstract]