| UniProt ID | FBX44_HUMAN | |
|---|---|---|
| UniProt AC | Q9H4M3 | |
| Protein Name | F-box only protein 44 | |
| Gene Name | FBXO44 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 255 | |
| Subcellular Localization | ||
| Protein Description | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.. | |
| Protein Sequence | MAVGNINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLVTLWKRKCLREGFITEDWDQPVADWKIFYFLRSLHRNLLHNPCAEEGFEFWSLDVNGGDEWKVEDLSRDQRKEFPNDQVKKYFVTSYYTCLKSQVVDLKAEGYWEELMDTTRPDIEVKDWFAARPDCGSKYQLCVQLLSSAHAPLGTFQPDPATIQQKSDAKWREVSHTFSNYPPGVRYIWFQHGGVDTHYWAGWYGPRVTNSSITIGPPLP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 35 | Phosphorylation | LNCRLVCSLWRDLID HHHHHHHHHHHHHHH | 24.40 | 24719451 | |
| 130 | Phosphorylation | KKYFVTSYYTCLKSQ HHHHHHHHHHHHHHH | 8.07 | 29759185 | |
| 131 | Phosphorylation | KYFVTSYYTCLKSQV HHHHHHHHHHHHHHH | 7.25 | 29759185 | |
| 132 | Phosphorylation | YFVTSYYTCLKSQVV HHHHHHHHHHHHHHC | 11.79 | 29759185 | |
| 146 (in isoform 2) | Phosphorylation | - | 10.93 | 28674419 | |
| 184 (in isoform 2) | Phosphorylation | - | 10.25 | 27251275 | |
| 188 (in isoform 2) | Dimethylation | - | 11.94 | - | |
| 188 (in isoform 2) | Methylation | - | 11.94 | - | |
| 191 (in isoform 2) | Phosphorylation | - | 10.61 | 28674419 | |
| 198 (in isoform 2) | Methylation | - | 4.42 | - | |
| 215 (in isoform 2) | Phosphorylation | - | 49.49 | 28674419 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FBX44_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FBX44_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FBX44_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SKP1_HUMAN | SKP1 | physical | 17215248 | |
| CUL1_HUMAN | CUL1 | physical | 17215248 | |
| CUL1_HUMAN | CUL1 | physical | 18203720 | |
| SKP1_HUMAN | SKP1 | physical | 18203720 | |
| RBX1_HUMAN | RBX1 | physical | 18203720 | |
| CUL1_HUMAN | CUL1 | physical | 21640084 | |
| RBX1_HUMAN | RBX1 | physical | 21640084 | |
| SKP1_HUMAN | SKP1 | physical | 21640084 | |
| BRCA1_HUMAN | BRCA1 | physical | 23086937 | |
| BARD1_HUMAN | BARD1 | physical | 23086937 | |
| SKP1_HUMAN | SKP1 | physical | 26186194 | |
| CUL1_HUMAN | CUL1 | physical | 26186194 | |
| SP17_HUMAN | SPA17 | physical | 26186194 | |
| RGS2_HUMAN | RGS2 | physical | 25970626 | |
| CUL4B_HUMAN | CUL4B | physical | 25970626 | |
| CUL1_HUMAN | CUL1 | physical | 25970626 | |
| SKP1_HUMAN | SKP1 | physical | 25970626 | |
| DDB1_HUMAN | DDB1 | physical | 25970626 | |
| SKP1_HUMAN | SKP1 | physical | 26460611 | |
| SP17_HUMAN | SPA17 | physical | 28514442 | |
| CUL1_HUMAN | CUL1 | physical | 28514442 | |
| SKP1_HUMAN | SKP1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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