SP17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SP17_HUMAN
• UniProt AC: Q15506
• Protein Name: Sperm surface protein Sp17
• Gene Name: SPA17
• Organism: Homo sapiens (Human).
• Sequence Length: 151
• Subcellular Localization: Membrane ; Peripheral membrane protein .
• Protein Description: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity)..
• Protein Sequence: MSIPFSNTHYRIPQGFGNLLEGLTREILREQPDNIPAFAAAYFESLLEKREKTNFDPAEWGSKVEDRFYNNHAFEEQEPPEKSDPKQEESQISGKEEETSVTILDSSEEDKEKEEVAAVKIQAAFRGHIAREEAKKMKTNSLQNEEKEENK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSIPFSNTH ------CCCCCCCCC	38.68	30622161
6	Phosphorylation	--MSIPFSNTHYRIP --CCCCCCCCCCCCC	35.15	30622161
8	Phosphorylation	MSIPFSNTHYRIPQG CCCCCCCCCCCCCCC	21.06	30622161
45	Phosphorylation	FAAAYFESLLEKREK HHHHHHHHHHHHHHH	28.49	24719451
52	Ubiquitination	SLLEKREKTNFDPAE HHHHHHHHHCCCHHH	53.45	-
62	Phosphorylation	FDPAEWGSKVEDRFY CCHHHHHHHHHHHHH	34.30	30622161
63	Ubiquitination	DPAEWGSKVEDRFYN CHHHHHHHHHHHHHC	45.78	-
63	Acetylation	DPAEWGSKVEDRFYN CHHHHHHHHHHHHHC	45.78	25038526
69	Phosphorylation	SKVEDRFYNNHAFEE HHHHHHHHCCCCCCC	18.89	27642862
90	Phosphorylation	SDPKQEESQISGKEE CCCCHHHHHCCCCCC	31.87	30622161
93	Phosphorylation	KQEESQISGKEEETS CHHHHHCCCCCCCCC	35.85	30622161
99	Phosphorylation	ISGKEEETSVTILDS CCCCCCCCCEEEEEC	31.60	30622161
100	Phosphorylation	SGKEEETSVTILDSS CCCCCCCCEEEEECC	22.12	30622161
102	Phosphorylation	KEEETSVTILDSSEE CCCCCCEEEEECCHH	18.65	30622161
106	Phosphorylation	TSVTILDSSEEDKEK CCEEEEECCHHHHHH	35.88	30622161
107	Phosphorylation	SVTILDSSEEDKEKE CEEEEECCHHHHHHH	44.67	30622161
139	Phosphorylation	EEAKKMKTNSLQNEE HHHHHHHHHHCCHHH	26.92	30622161
141	Phosphorylation	AKKMKTNSLQNEEKE HHHHHHHHCCHHHHH	36.24	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SP17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SP17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SP17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ROP1A_HUMAN	ROPN1	physical	25416956
MYL6B_HUMAN	MYL6B	physical	25416956
KAP3_HUMAN	PRKAR2B	physical	26186194
MYL6B_HUMAN	MYL6B	physical	26186194
SEC63_HUMAN	SEC63	physical	26186194
EFCB7_HUMAN	EFCAB7	physical	26186194
WIPI3_HUMAN	WDR45B	physical	26186194
UBP33_HUMAN	USP33	physical	26186194
EFCB7_HUMAN	EFCAB7	physical	28514442
KAP3_HUMAN	PRKAR2B	physical	28514442
MYL6B_HUMAN	MYL6B	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.