EFCB7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFCB7_HUMAN
• UniProt AC: A8K855
• Protein Name: EF-hand calcium-binding domain-containing protein 7
• Gene Name: EFCAB7
• Organism: Homo sapiens (Human).
• Sequence Length: 629
• Subcellular Localization: Cell projection, cilium membrane ; Peripheral membrane protein ; Cytoplasmic side . The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner.
• Protein Description: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia..
• Protein Sequence: MAISPRSDATFSSQKSTPSESPRTKKFPLTEEEIFYMNCRAAYLTVFKSSLENIISKDQLYLALQHAGRNPSQKTINKYWTPQTAKLNFDDFCIILRKEKPTSKAELLKSFKQLDVNDDGCILHTDLYKFLTKRGEKMTREEVNAIINLADVNADGKFDYIKFCKLYMTTNEQCLKTTLEKLEVDSKLMRHQFGNHIEGSPERDPSPVPKPSPKITRKTDPETFLNKGDTRSSLLSATRKFKTSVSFTVTMGANGNRNSKLMEPNLIKDWQHMQSKGCFFLEEDGEIISHQYRMQIAQRSMVYLTIKPLNLSQVEGKPSPWLSVDTALYILKENESQANLQLVCFTELRNREVFGWTGELGPGIYWLIPSTTGCRLRKKIKPVTDEAQLVYRDETGELFLTKEFKSTLSDIFEVIDLDGNGLLSLEEYNFFELRTSGEKCDEDAWAVCRENFDTKRNELTRQGFMDLNLMEANDREGDPCDLWVTLHSMGYNKALELTEACPFVIDIYAEKCKPKIKAVHMEACSGQLEKAICKSVLSNGDAKVMDGYENIIVHTYSCDTWITSVIENKSDEKVIIHISNELSKNCINNRGLNIFAVEVGPKSTMVCQHVMPLNERQEWIYYCIYSLIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAISPRSDATF ----CCCCCCCCCCC	12.53	26074081
7	Phosphorylation	-MAISPRSDATFSSQ -CCCCCCCCCCCCCC	34.67	26074081
10	Phosphorylation	ISPRSDATFSSQKST CCCCCCCCCCCCCCC	29.10	26074081
12	Phosphorylation	PRSDATFSSQKSTPS CCCCCCCCCCCCCCC	27.75	26074081
13	Phosphorylation	RSDATFSSQKSTPSE CCCCCCCCCCCCCCC	37.12	26074081
15	Ubiquitination	DATFSSQKSTPSESP CCCCCCCCCCCCCCC	59.24	29967540
16	Phosphorylation	ATFSSQKSTPSESPR CCCCCCCCCCCCCCC	37.60	21712546
17	Phosphorylation	TFSSQKSTPSESPRT CCCCCCCCCCCCCCC	37.56	21712546
19	Phosphorylation	SSQKSTPSESPRTKK CCCCCCCCCCCCCCC	51.28	28102081
21	Phosphorylation	QKSTPSESPRTKKFP CCCCCCCCCCCCCCC	24.82	28985074
24	Phosphorylation	TPSESPRTKKFPLTE CCCCCCCCCCCCCCH	41.80	28985074
49	Phosphorylation	AYLTVFKSSLENIIS HHHHHHHHHHHHHCC	28.79	28348404
50	Phosphorylation	YLTVFKSSLENIISK HHHHHHHHHHHHCCH	40.05	28348404
57	Ubiquitination	SLENIISKDQLYLAL HHHHHCCHHHHHHHH	38.80	29967540
74	Ubiquitination	AGRNPSQKTINKYWT CCCCCCCCCHHHCCC	56.56	27667366
75	Phosphorylation	GRNPSQKTINKYWTP CCCCCCCCHHHCCCC	23.34	27050516
78	Ubiquitination	PSQKTINKYWTPQTA CCCCCHHHCCCCCCE	38.01	29967540
87	Ubiquitination	WTPQTAKLNFDDFCI CCCCCEECCCCCEEE	7.77	27667366
100	Ubiquitination	CIILRKEKPTSKAEL EEEEECCCCCCHHHH	57.54	29967540
104	Ubiquitination	RKEKPTSKAELLKSF ECCCCCCHHHHHHHH	48.64	-
109	Ubiquitination	TSKAELLKSFKQLDV CCHHHHHHHHHHCCC	67.48	-
110	Phosphorylation	SKAELLKSFKQLDVN CHHHHHHHHHHCCCC	37.33	24719451
112	Ubiquitination	AELLKSFKQLDVNDD HHHHHHHHHCCCCCC	57.98	29967540
128	Phosphorylation	CILHTDLYKFLTKRG EEEEHHHHHHHHHHC	11.51	25147952
129	Ubiquitination	ILHTDLYKFLTKRGE EEEHHHHHHHHHHCC	40.99	29967540
157	Ubiquitination	ADVNADGKFDYIKFC HHCCCCCCCCEEEEE	35.29	29967540
165	Ubiquitination	FDYIKFCKLYMTTNE CCEEEEEEEEECCCH	45.87	-
181	Ubiquitination	CLKTTLEKLEVDSKL HHHHHHHHHHHCHHH	53.73	29967540
187	Ubiquitination	EKLEVDSKLMRHQFG HHHHHCHHHHHHHCC	41.67	29967540
200	Phosphorylation	FGNHIEGSPERDPSP CCCCCCCCCCCCCCC	15.70	26055452
206	Phosphorylation	GSPERDPSPVPKPSP CCCCCCCCCCCCCCC	42.70	26055452
210	Ubiquitination	RDPSPVPKPSPKITR CCCCCCCCCCCCCCC	59.36	-
212	Phosphorylation	PSPVPKPSPKITRKT CCCCCCCCCCCCCCC	44.97	26055452
227	Acetylation	DPETFLNKGDTRSSL CHHHHHCCCCCHHHH	61.38	7712211
227	Ubiquitination	DPETFLNKGDTRSSL CHHHHHCCCCCHHHH	61.38	29967540
232	Phosphorylation	LNKGDTRSSLLSATR HCCCCCHHHHHHHHC	27.68	28555341
233	Phosphorylation	NKGDTRSSLLSATRK CCCCCHHHHHHHHCC	30.00	28555341
243	Phosphorylation	SATRKFKTSVSFTVT HHHCCCCCEEEEEEE	37.18	22210691
244	Phosphorylation	ATRKFKTSVSFTVTM HHCCCCCEEEEEEEE	19.16	22210691
246	Phosphorylation	RKFKTSVSFTVTMGA CCCCCEEEEEEEECC	18.24	22210691
250	Phosphorylation	TSVSFTVTMGANGNR CEEEEEEEECCCCCC	13.56	22210691
260	Ubiquitination	ANGNRNSKLMEPNLI CCCCCCCCCCCCCHH	56.24	25015289
273	Ubiquitination	LIKDWQHMQSKGCFF HHHCHHHHHHCCCEE	2.63	25015289
381	Ubiquitination	CRLRKKIKPVTDEAQ CCCCCCCCCCCCCCE	42.17	29967540
395	Phosphorylation	QLVYRDETGELFLTK EEEEECCCCCEEEEH	40.00	28348404
402	Ubiquitination	TGELFLTKEFKSTLS CCCEEEEHHHHHHHH	64.40	29967540
439	Ubiquitination	ELRTSGEKCDEDAWA EEECCCCCCCHHHHH	50.97	-
525	Phosphorylation	AVHMEACSGQLEKAI EEHHHHCCHHHHHHH	36.30	23403867
535	Phosphorylation	LEKAICKSVLSNGDA HHHHHHHHHHHCCCC	24.71	29978859
538	Phosphorylation	AICKSVLSNGDAKVM HHHHHHHHCCCCEEE	36.29	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFCB7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFCB7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFCB7_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EFCB7_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.