GAR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GAR1_HUMAN
• UniProt AC: Q9NY12
• Protein Name: H/ACA ribonucleoprotein complex subunit 1
• Gene Name: GAR1
• Organism: Homo sapiens (Human).
• Sequence Length: 217
• Subcellular Localization: Nucleus, nucleolus. Nucleus, Cajal body. Also localized to Cajal bodies (coiled bodies).
• Protein Description: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme..
• Protein Sequence: MSFRGGGRGGFNRGGGGGGFNRGGSSNHFRGGGGGGGGGNFRGGGRGGFGRGGGRGGFNKGQDQGPPERVVLLGEFLHPCEDDIVCKCTTDENKVPYFNAPVYLENKEQIGKVDEIFGQLRDFYFSVKLSENMKASSFKKLQKFYIDPYKLLPLQRFLPRPPGEKGPPRGGGRGGRGGGRGGGGRGGGRGGGFRGGRGGGGGGFRGGRGGGFRGRGH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFRGGGRG ------CCCCCCCCC	24.53	24719451
8	Methylation	MSFRGGGRGGFNRGG CCCCCCCCCCCCCCC	45.39	115485257
13	Methylation	GGRGGFNRGGGGGGF CCCCCCCCCCCCCCC	42.76	115485265
22	Methylation	GGGGGFNRGGSSNHF CCCCCCCCCCCCCCC	48.89	115388961
30	Methylation	GGSSNHFRGGGGGGG CCCCCCCCCCCCCCC	34.98	115485289
51	Methylation	GGRGGFGRGGGRGGF CCCCCCCCCCCCCCC	38.02	24377531
51	Dimethylation	GGRGGFGRGGGRGGF CCCCCCCCCCCCCCC	38.02	-
94	Ubiquitination	KCTTDENKVPYFNAP EECCCCCCCCCCCCC	42.41	29967540
94	Acetylation	KCTTDENKVPYFNAP EECCCCCCCCCCCCC	42.41	25953088
97	Phosphorylation	TDENKVPYFNAPVYL CCCCCCCCCCCCEEE	16.68	20090780
103	Phosphorylation	PYFNAPVYLENKEQI CCCCCCEEECCHHHH	13.77	-
107	Ubiquitination	APVYLENKEQIGKVD CCEEECCHHHHCCHH	41.44	29967540
112	Ubiquitination	ENKEQIGKVDEIFGQ CCHHHHCCHHHHHHH	48.41	29967540
112	2-Hydroxyisobutyrylation	ENKEQIGKVDEIFGQ CCHHHHCCHHHHHHH	48.41	-
112	Acetylation	ENKEQIGKVDEIFGQ CCHHHHCCHHHHHHH	48.41	26051181
124	Phosphorylation	FGQLRDFYFSVKLSE HHHHHHHHHHEECCC	10.15	20068231
126	Phosphorylation	QLRDFYFSVKLSENM HHHHHHHHEECCCCC	13.63	20068231
134	Sumoylation	VKLSENMKASSFKKL EECCCCCCHHHHHHH	57.61	28112733
134	2-Hydroxyisobutyrylation	VKLSENMKASSFKKL EECCCCCCHHHHHHH	57.61	-
134	Ubiquitination	VKLSENMKASSFKKL EECCCCCCHHHHHHH	57.61	33845483
134	Acetylation	VKLSENMKASSFKKL EECCCCCCHHHHHHH	57.61	26822725
134	Sumoylation	VKLSENMKASSFKKL EECCCCCCHHHHHHH	57.61	-
143	Acetylation	SSFKKLQKFYIDPYK HHHHHHHHHCCCHHH	51.04	26051181
143	Ubiquitination	SSFKKLQKFYIDPYK HHHHHHHHHCCCHHH	51.04	33845483
145	Phosphorylation	FKKLQKFYIDPYKLL HHHHHHHCCCHHHHC	16.08	28152594
149	Phosphorylation	QKFYIDPYKLLPLQR HHHCCCHHHHCCHHH	15.54	20090780
150 (in isoform 1)	Ubiquitination	-	49.27	21890473
150 (in isoform 2)	Ubiquitination	-	49.27	21890473
150	Ubiquitination	KFYIDPYKLLPLQRF HHCCCHHHHCCHHHC	49.27	33845483
150	Acetylation	KFYIDPYKLLPLQRF HHCCCHHHHCCHHHC	49.27	26051181
180 (in isoform 2)	Methylation	-	43.81	-
185	Methylation	GGRGGGGRGGGRGGG CCCCCCCCCCCCCCC	43.81	115388953
189	Methylation	GGGRGGGRGGGFRGG CCCCCCCCCCCCCCC	43.81	-
189	Dimethylation	GGGRGGGRGGGFRGG CCCCCCCCCCCCCCC	43.81	-
194	Methylation	GGRGGGFRGGRGGGG CCCCCCCCCCCCCCC	50.35	-
197	Methylation	GGGFRGGRGGGGGGF CCCCCCCCCCCCCCC	43.33	115485273
205	Methylation	GGGGGGFRGGRGGGF CCCCCCCCCCCCCCC	50.35	-
208	Methylation	GGGFRGGRGGGFRGR CCCCCCCCCCCCCCC	43.33	115485281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GAR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GAR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GAR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMN_HUMAN	SMN1	physical	11509230
GEMI2_HUMAN	GEMIN2	physical	11509230
DDX20_HUMAN	DDX20	physical	11509230
GEMI4_HUMAN	GEMIN4	physical	11509230
RS4X_HUMAN	RPS4X	physical	22939629
NHP2_HUMAN	NHP2	physical	22939629
NOP10_HUMAN	NOP10	physical	26186194
ANM5_HUMAN	PRMT5	physical	26186194
GEMI5_HUMAN	GEMIN5	physical	26186194
DKC1_HUMAN	DKC1	physical	26186194
RIOK1_HUMAN	RIOK1	physical	26186194
SHQ1_HUMAN	SHQ1	physical	26186194
ICLN_HUMAN	CLNS1A	physical	26186194
WAP53_HUMAN	WRAP53	physical	26186194
COPRS_HUMAN	COPRS	physical	26186194
DKC1_HUMAN	DKC1	physical	26344197
NHP2_HUMAN	NHP2	physical	26344197
PUS7_HUMAN	PUS7	physical	26344197
SRP14_HUMAN	SRP14	physical	26344197
TNPO1_HUMAN	TNPO1	physical	26344197
TSR1_HUMAN	TSR1	physical	26344197
ALBU_HUMAN	ALB	physical	26496610
LYST_HUMAN	LYST	physical	26496610
ICLN_HUMAN	CLNS1A	physical	26496610
DKC1_HUMAN	DKC1	physical	26496610
PGBM_HUMAN	HSPG2	physical	26496610
TAU_HUMAN	MAPT	physical	26496610
NPAT_HUMAN	NPAT	physical	26496610
RL27_HUMAN	RPL27	physical	26496610
STX3_HUMAN	STX3	physical	26496610
TAF1_HUMAN	TAF1	physical	26496610
CTR9_HUMAN	CTR9	physical	26496610
KEAP1_HUMAN	KEAP1	physical	26496610
FARP1_HUMAN	FARP1	physical	26496610
ANM5_HUMAN	PRMT5	physical	26496610
TTLL5_HUMAN	TTLL5	physical	26496610
GEMI5_HUMAN	GEMIN5	physical	26496610
ASTE1_HUMAN	ASTE1	physical	26496610
ESF1_HUMAN	ESF1	physical	26496610
RHOF_HUMAN	RHOF	physical	26496610
OTUD4_HUMAN	OTUD4	physical	26496610
WAP53_HUMAN	WRAP53	physical	26496610
LRRC1_HUMAN	LRRC1	physical	26496610
NOP10_HUMAN	NOP10	physical	26496610
KI16B_HUMAN	KIF16B	physical	26496610
NHP2_HUMAN	NHP2	physical	26496610
NEUL_HUMAN	NLN	physical	26496610
TFB2M_HUMAN	TFB2M	physical	26496610
NSD1_HUMAN	NSD1	physical	26496610
MEP50_HUMAN	WDR77	physical	26496610
ZMYM1_HUMAN	ZMYM1	physical	26496610
WDCP_HUMAN	C2orf44	physical	26496610
RIOK1_HUMAN	RIOK1	physical	26496610
CEP89_HUMAN	CEP89	physical	26496610
BAP18_HUMAN	C17orf49	physical	26496610
FAP20_HUMAN	C1orf86	physical	26496610
DDX51_HUMAN	DDX51	physical	26496610
GEMI5_HUMAN	GEMIN5	physical	28514442
SHQ1_HUMAN	SHQ1	physical	28514442
DKC1_HUMAN	DKC1	physical	28514442
RIOK1_HUMAN	RIOK1	physical	28514442
NOP10_HUMAN	NOP10	physical	28514442
GSTA1_HUMAN	GSTA1	physical	28514442
ANM5_HUMAN	PRMT5	physical	28514442
COPRS_HUMAN	COPRS	physical	28514442
H14_HUMAN	HIST1H1E	physical	28514442
WAP53_HUMAN	WRAP53	physical	28514442
RU17_HUMAN	SNRNP70	physical	28514442
HNRPQ_HUMAN	SYNCRIP	physical	28514442
ICLN_HUMAN	CLNS1A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.