RHOF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHOF_HUMAN
• UniProt AC: Q9HBH0
• Protein Name: Rho-related GTP-binding protein RhoF
• Gene Name: RHOF
• Organism: Homo sapiens (Human).
• Sequence Length: 211
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytoskeleton.
• Protein Description: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology..
• Protein Sequence: MDAPGALAQTAAPGPGRKELKIVIVGDGGCGKTSLLMVYSQGSFPEHYAPSVFEKYTASVTVGSKEVTLNLYDTAGQEDYDRLRPLSYQNTHLVLICYDVMNPTSYDNVLIKWFPEVTHFCRGIPMVLIGCKTDLRKDKEQLRKLRAAQLEPITYMQGLSACEQIRAALYLECSAKFRENVEDVFREAAKVALSALKKAQRQKKRRLCLLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDAPGALA -------CCCCCCCC	10.01	22814378
10	Phosphorylation	APGALAQTAAPGPGR CCCCCCCCCCCCCCC	21.12	20068231
33	Phosphorylation	GDGGCGKTSLLMVYS ECCCCCCEEEEEEEE	15.19	23403867
34	Phosphorylation	DGGCGKTSLLMVYSQ CCCCCCEEEEEEEEC	24.00	23403867
40	Phosphorylation	TSLLMVYSQGSFPEH EEEEEEEECCCCCCC	19.36	23403867
43	Phosphorylation	LMVYSQGSFPEHYAP EEEEECCCCCCCCCC	29.95	23403867
48	Phosphorylation	QGSFPEHYAPSVFEK CCCCCCCCCCCHHHE	20.67	-
51	Phosphorylation	FPEHYAPSVFEKYTA CCCCCCCCHHHEEEE	31.13	23403867
56	Phosphorylation	APSVFEKYTASVTVG CCCHHHEEEEEEEEC	10.59	23403867
59	Phosphorylation	VFEKYTASVTVGSKE HHHEEEEEEEECCEE	15.55	23403867
61	Phosphorylation	EKYTASVTVGSKEVT HEEEEEEEECCEEEE	19.36	23403867
64	Phosphorylation	TASVTVGSKEVTLNL EEEEEECCEEEEEEE	22.70	23403867
72	Phosphorylation	KEVTLNLYDTAGQED EEEEEEEEECCCCCC	15.35	27259358
74	Phosphorylation	VTLNLYDTAGQEDYD EEEEEEECCCCCCHH	21.09	-
80	Phosphorylation	DTAGQEDYDRLRPLS ECCCCCCHHHHCCCC	11.38	14506284
132	Ubiquitination	PMVLIGCKTDLRKDK CEEEEEECCCCCCCH	39.60	-
176	Ubiquitination	LYLECSAKFRENVED HHHHHHHHHHHCHHH	28.76	33845483
190	Ubiquitination	DVFREAAKVALSALK HHHHHHHHHHHHHHH	34.78	33845483
197	Ubiquitination	KVALSALKKAQRQKK HHHHHHHHHHHHHHH	45.86	33845483
197	2-Hydroxyisobutyrylation	KVALSALKKAQRQKK HHHHHHHHHHHHHHH	45.86	-
208	Methylation	RQKKRRLCLLL---- HHHHHHEECCC----	2.09	-
208	Geranylgeranylation	RQKKRRLCLLL---- HHHHHHEECCC----	2.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHOF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHOF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHOF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANFY1_HUMAN	ANKFY1	physical	24102721
NAA25_HUMAN	NAA25	physical	28514442
GDS1_HUMAN	RAP1GDS1	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.