ASTE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASTE1_HUMAN
• UniProt AC: Q2TB18
• Protein Name: Protein asteroid homolog 1
• Gene Name: ASTE1
• Organism: Homo sapiens (Human).
• Sequence Length: 679
• Protein Description: Possible role in EGF receptor signaling..
• Protein Sequence: MGIRGLMSFVEDHSNEFFTDLKLRDTKIVIDGYALFHRLCFSSNLDLRYGGDYDSFADVVQKFFESLFACNICPYVVLDGGCDISDKKLTTLKDRAREKIQMAHSLSVGGSGYVCPLLIREVFIQVLIKLRVCFVQCFSEADRDIMTLANHWNCPVLSSDSDFCIFDLKTGFCPLNSFQWRNMNTIKGTQNYIPAKCFSLDAFCHHFSNMNKALLPLFAVLCGNDHVNLPIMETFLSKARLPLGATSSKGRRHHRILGLLNWLSHFANPTEALDNVLKYLPKKDRENVKELLCCSMEEYQQSQVKLQDFFQCGTYVCPDALNLGLPEWVLVALAKGQLSPFISDALVLRRTILPTQVENMQQPNAHRISQPIRQIIYGLLLNASPHLDKTSWNALPPQPLAFSEVERINKNIRTSIIDAVELAKDHSDLSRLTELSLRRRQMLLLETLKVKQTILEPIPTSLKLPIAVSCYWLQHTETKAKLHHLQSLLLTMLVGPLIAIINSPGKEELQEDGAKMLYAEFQRVKAQTRLGTRLDLDTAHIFCQWQSCLQMGMYLNQLLSTPLPEPDLTRLYSGSLVHGLCQQLLASTSVESLLSICPEAKQLYEYLFNATRSYAPAEIFLPKGRSNSKKKRQKKQNTSCSKNRGRTTAHTKCWYEGNNRFGLLMVENLEEHSEASNIE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	TKIVIDGYALFHRLC CEEEEEHHHHHHHHH	9.07	28270605
187	Ubiquitination	WRNMNTIKGTQNYIP CCCCCCCCCCCCCCC	54.59	-
187	Ubiquitination	WRNMNTIKGTQNYIP CCCCCCCCCCCCCCC	54.59	-
264	Phosphorylation	LGLLNWLSHFANPTE HHHHHHHHHCCCHHH	14.26	22673903
270	Phosphorylation	LSHFANPTEALDNVL HHHCCCHHHHHHHHH	33.43	22673903
289	Ubiquitination	KKDRENVKELLCCSM HHCHHCHHHHHHCCH	54.98	-
424	Ubiquitination	IDAVELAKDHSDLSR HHHHHHHCCCCCHHH	69.47	-
424	Ubiquitination	IDAVELAKDHSDLSR HHHHHHHCCCCCHHH	69.47	-
427	Phosphorylation	VELAKDHSDLSRLTE HHHHCCCCCHHHHHH	50.83	27174698
430	Phosphorylation	AKDHSDLSRLTELSL HCCCCCHHHHHHHHH	30.18	27174698
433	Phosphorylation	HSDLSRLTELSLRRR CCCHHHHHHHHHHHH	33.50	27174698
436	Phosphorylation	LSRLTELSLRRRQML HHHHHHHHHHHHHHH	17.38	27174698
614	Phosphorylation	LFNATRSYAPAEIFL HHHHCCCCCCCCHHC	17.20	20049867
626	Phosphorylation	IFLPKGRSNSKKKRQ HHCCCCCCCHHHHHH	54.87	20049867
628	Phosphorylation	LPKGRSNSKKKRQKK CCCCCCCHHHHHHHH	47.28	20049867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASTE1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASTE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASTE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP47_HUMAN	USP47	physical	28514442
ES8L2_HUMAN	EPS8L2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.