dbPTM

PGBM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PGBM_HUMAN
UniProt AC	P98160
Protein Name	Basement membrane-specific heparan sulfate proteoglycan core protein
Gene Name	HSPG2
Organism	Homo sapiens (Human).
Sequence Length	4391
Subcellular Localization	Secreted, extracellular space, extracellular matrix, basement membrane.
Protein Description	Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.; Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.; The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity..
Protein Sequence	MGWRAAGALLLALLLHGRLLAVTHGLRAYDGLSLPEDIETVTASQMRWTHSYLSDDEDMLADSISGDDLGSGDLGSGDFQMVYFRALVNFTRSIEYSPQLEDAGSREFREVSEAVVDTLESEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQIQEMLLRVISSGSVASYVTSPQGFQFRRLGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFCFGITSVCQSTRRFRDQIRLRFDQPDDFKGVNVTMPAQPGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYNVRYELARGMLEPVQRPDVVLMGAGYRLLSRGHTPTQPGALNQRQVQFSEEHWVHESGRPVQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHATSHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAASTHTTNEGIFSPTPGELGFSSFHRLLSGPYFWSLPSRFLGDKVTSYGGELRFTVTQRSQPGSTPLHGQPLVVLQGNNIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQPATREHLLMALAGIDTLLIRASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEPVPEGAQLSFGNFAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLSDPDVQITGNNIMLVASQPALQGPERRSYEIMFREEFWRRPDGQPATREHLLMALADLDELLIRATFSSVPLAASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAHGISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRAQAGANTRPCPS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	HGRLLAVTHGLRAYD HHHHHHHHCCCHHCC	12.48	20068231
42	O-linked_Glycosylation	PEDIETVTASQMRWT CCCCCEEEHHHHHCC	28.19	22171320
65	O-linked_Glycosylation	DMLADSISGDDLGSG HHHCHHCCCCCCCCC	39.87	-
71	O-linked_Glycosylation	ISGDDLGSGDLGSGD CCCCCCCCCCCCCCC	36.11	-
76	O-linked_Glycosylation	LGSGDLGSGDFQMVY CCCCCCCCCCCEEEE	42.35	-
89	N-linked_Glycosylation	VYFRALVNFTRSIEY EEEEHHHCHHHCCCC	33.16	UniProtKB CARBOHYD
105	Phosphorylation	PQLEDAGSREFREVS CCCCCCCCHHHHHHH	30.29	26657352
251	O-linked_Glycosylation	TFSLLVETTSLPPRP CEEEEEEECCCCCCC	17.76	OGP
253	Phosphorylation	SLLVETTSLPPRPET EEEEEECCCCCCCCC	46.42	24719451
260	O-linked_Glycosylation	SLPPRPETTIMRQPP CCCCCCCCCCCCCCC	25.06	OGP
269	O-linked_Glycosylation	IMRQPPVTHAPQPLL CCCCCCCCCCCCCCC	20.35	55833085
279	O-linked_Glycosylation	PQPLLPGSVRPLPCG CCCCCCCCCCCCCCC	17.02	55833091
361	O-linked_Glycosylation	TDEANCPTKRPEEVC CCCCCCCCCCHHHHC	41.72	OGP
472	Phosphorylation	IIRDVKESDQGAYTC EEECCCHHCCCCEEE	29.53	18452278
477	Phosphorylation	KESDQGAYTCEAMNA CHHCCCCEEEHHHHC	20.81	18452278
478	Phosphorylation	ESDQGAYTCEAMNAR HHCCCCEEEHHHHCC	11.88	18452278
554	N-linked_Glycosylation	PDDFKGVNVTMPAQP CCCCCCCEEECCCCC	32.01	19159218
555	N-linked_Glycosylation	DDFKGVNVTMPAQPG CCCCCCEEECCCCCC	4.51	19159218
556	Phosphorylation	DFKGVNVTMPAQPGT CCCCCEEECCCCCCC	16.54	-
563	O-linked_Glycosylation	TMPAQPGTPPLSSTQ ECCCCCCCCCCCCCE	28.54	OGP
563	Phosphorylation	TMPAQPGTPPLSSTQ ECCCCCCCCCCCCCE	28.54	-
616	Phosphorylation	SYGGSLRYNVRYELA CCCCCCHHHHHHHHH	24.25	-
620	Phosphorylation	SLRYNVRYELARGML CCHHHHHHHHHCCCC	15.83	-
642	Phosphorylation	VVLMGAGYRLLSRGH EEEECCCHHHHHCCC	9.50	22210691
646	Phosphorylation	GAGYRLLSRGHTPTQ CCCHHHHHCCCCCCC	40.59	24719451
647	Phosphorylation	AGYRLLSRGHTPTQP CCHHHHHCCCCCCCC	40.66	-
708	Phosphorylation	KMASVGLSDIAMDTT CCCCCCHHHHHCCCC	22.50	22210691
720	Phosphorylation	DTTVTHATSHGRAHS CCCCCCCCCCCCCCC	17.41	22210691
721	Phosphorylation	TTVTHATSHGRAHSV CCCCCCCCCCCCCCC	25.40	22210691
884	Phosphorylation	VRCDERGSMGTSGEA EECCCCCCCCCCCCC	21.91	-
887	Phosphorylation	DERGSMGTSGEACRC CCCCCCCCCCCCCCC	25.56	27251275
888	Phosphorylation	ERGSMGTSGEACRCK CCCCCCCCCCCCCCC	28.98	28857561
914	O-linked_Glycosylation	ADGSFHLSTRNPDGC CCCCEEECCCCCCCC	19.42	OGP
915	O-linked_Glycosylation	DGSFHLSTRNPDGCL CCCEEECCCCCCCCC	40.60	55825543
916	O-linked_Glycosylation	GSFHLSTRNPDGCLK CCEEECCCCCCCCCH	49.67	-
972	O-linked_Glycosylation	NEGIFSPTPGELGFS CCCCCCCCCCCCCCC	42.60	OGP
1001	Ubiquitination	PSRFLGDKVTSYGGE CHHHCCCEEEEECCE	45.68	29967540
1002	Ubiquitination	SRFLGDKVTSYGGEL HHHCCCEEEEECCEE	5.24	29967540
1145	O-linked_Glycosylation	QDCDTGYTRTPSGLY CCCCCCCEECCCCEE	29.43	OGP
1147	O-linked_Glycosylation	CDTGYTRTPSGLYLG CCCCCEECCCCEEEE	17.63	OGP
1345	Phosphorylation	AYTRHLISTHFAPGD HHHHHHHHCCCCCCC	23.38	-
1346	Phosphorylation	YTRHLISTHFAPGDF HHHHHHHCCCCCCCC	17.64	-
1417	Phosphorylation	AYGGKLRYTLSYTAG EECCEEEEEEEEECC	23.59	21902226
1418	Phosphorylation	YGGKLRYTLSYTAGP ECCEEEEEEEEECCC	11.64	21902226
1420	Phosphorylation	GKLRYTLSYTAGPQG CEEEEEEEEECCCCC	16.79	21902226
1422	Phosphorylation	LRYTLSYTAGPQGSP EEEEEEEECCCCCCC	23.05	21902226
1428	Phosphorylation	YTAGPQGSPLSDPDV EECCCCCCCCCCCCC	19.88	21902226
1431	Phosphorylation	GPQGSPLSDPDVQIT CCCCCCCCCCCCEEC	50.94	21902226
1438	Phosphorylation	SDPDVQITGNNIMLV CCCCCEECCCEEEEE	19.43	21902226
1498	Phosphorylation	LLIRATFSSVPLAAS HHHHHHCCCCCCEEE	26.52	22210691
1499	Phosphorylation	LIRATFSSVPLAASI HHHHHCCCCCCEEEE	24.46	22210691
1510	Phosphorylation	AASISAVSLEVAQPG EEEEEEEEEEECCCC	20.66	22210691
1695	Phosphorylation	VPQGGSHSLRCQVSG ECCCCCCEEEEEEEC	21.14	20068231
1755	N-linked_Glycosylation	CRNLHQSNTSRAELL ECCHHCCCCCCCEEE	35.19	16335952
1756	N-linked_Glycosylation	RNLHQSNTSRAELLV CCHHCCCCCCCEEEE	25.49	16335952
1790	Phosphorylation	VRPGADVTFICTAKS CCCCCCEEEEEECCC	14.08	-
1794	Phosphorylation	ADVTFICTAKSKSPA CCEEEEEECCCCCCC	32.10	-
1799	Phosphorylation	ICTAKSKSPAYTLVW EEECCCCCCCEEEEE	23.12	24719451
1800	Phosphorylation	CTAKSKSPAYTLVWT EECCCCCCCEEEEEE	32.78	-
1802	Phosphorylation	AKSKSPAYTLVWTRL CCCCCCCEEEEEEEE	12.18	-
1816	Phosphorylation	LHNGKLPTRAMDFNG ECCCCCCCCEECCCC	41.31	-
1862	O-linked_Glycosylation	LHVQASGTLSAPVVS EEEEECCEECCCEEE	18.29	OGP
1869	O-linked_Glycosylation	TLSAPVVSIHPPQLT EECCCEEEECCCCEE	18.53	OGP
1876	O-linked_Glycosylation	SIHPPQLTVQPGQLA EECCCCEEECCCCEE	16.31	OGP
1926	O-linked_Glycosylation	RLPAVEPTDQAQYLC EECCCCCCHHHHHHH	27.51	OGP
1986	O-linked_Glycosylation	AAGVPSATITWRKEG HCCCCCEEEEEECCC	24.23	OGP
2005	Phosphorylation	PQARSERTDIATLLI CCCCCCCCCHHHHHH	27.92	24275569
2006	Phosphorylation	QARSERTDIATLLIP CCCCCCCCHHHHHHH	34.44	-
2023	Phosphorylation	TTADAGFYLCVATSP CCCCCCEEEEEEECC	9.77	24275569
2024	Phosphorylation	TADAGFYLCVATSPA CCCCCEEEEEEECCC	1.44	-
2057	Phosphorylation	PPPVKIESSSPSVTE CCCEEEECCCCCCCC	39.32	-
2061	Phosphorylation	KIESSSPSVTEGQTL EEECCCCCCCCCCEE	43.55	-
2063	Phosphorylation	ESSSPSVTEGQTLDL ECCCCCCCCCCEEEE	38.44	-
2112	Phosphorylation	PQVSPADSGEYVCRV CCCCCCCCCCEEEEE	35.31	28857561
2113	Phosphorylation	QVSPADSGEYVCRVE CCCCCCCCCEEEEEE	30.70	-
2121	N-linked_Glycosylation	EYVCRVENGSGPKEA CEEEEEECCCCCCEE	47.26	12754519
2122	N-linked_Glycosylation	YVCRVENGSGPKEAS EEEEEECCCCCCEEE	22.07	12754519
2138	O-linked_Glycosylation	TVSVLHGTHSGPSYT EEEEEECCCCCCCCC	11.34	OGP
2139	O-linked_Glycosylation	VSVLHGTHSGPSYTP EEEEECCCCCCCCCC	35.04	-
2140	O-linked_Glycosylation	SVLHGTHSGPSYTPV EEEECCCCCCCCCCC	52.84	OGP
2141	O-linked_Glycosylation	VLHGTHSGPSYTPVP EEECCCCCCCCCCCC	13.94	-
2143	O-linked_Glycosylation	HGTHSGPSYTPVPGS ECCCCCCCCCCCCCC	45.20	OGP
2143	Phosphorylation	HGTHSGPSYTPVPGS ECCCCCCCCCCCCCC	45.20	30576142
2144	Phosphorylation	GTHSGPSYTPVPGST CCCCCCCCCCCCCCC	20.42	30576142
2145	O-linked_Glycosylation	THSGPSYTPVPGSTR CCCCCCCCCCCCCCC	23.34	OGP
2145	Phosphorylation	THSGPSYTPVPGSTR CCCCCCCCCCCCCCC	23.34	-
2146	O-linked_Glycosylation	HSGPSYTPVPGSTRP CCCCCCCCCCCCCCC	23.28	-
2150	O-linked_Glycosylation	SYTPVPGSTRPIRIE CCCCCCCCCCCEEEC	18.38	OGP
2150	Phosphorylation	SYTPVPGSTRPIRIE CCCCCCCCCCCEEEC	18.38	30576142
2151	O-linked_Glycosylation	YTPVPGSTRPIRIEP CCCCCCCCCCEEECC	46.51	68705341
2151	Phosphorylation	YTPVPGSTRPIRIEP CCCCCCCCCCEEECC	46.51	-
2152	O-linked_Glycosylation	TPVPGSTRPIRIEPS CCCCCCCCCEEECCC	26.75	-
2191	Phosphorylation	TWHKRGGSLPARHQT EEECCCCCCCCCCCC	33.72	24719451
2209	Phosphorylation	LLRLHQVTPADSGEY EEEEEEECCCCCCCE	13.24	24275569
2213	Phosphorylation	HQVTPADSGEYVCHV EEECCCCCCCEEEEE	35.31	24275569
2284	Phosphorylation	TWYKRGGSLPARHQV EEEECCCCCCCCCCC	33.72	24719451
2398	Phosphorylation	LLRLYQASPADSGEY CEEEEECCCCCCCCC	12.70	24719451
2399	Phosphorylation	LRLYQASPADSGEYV EEEEECCCCCCCCCC	43.00	-
2402	Phosphorylation	YQASPADSGEYVCRV EECCCCCCCCCCHHH	35.31	28857561
2403	Phosphorylation	QASPADSGEYVCRVL ECCCCCCCCCCHHHC	30.70	-
2405	Phosphorylation	SPADSGEYVCRVLGS CCCCCCCCCHHHCCC	14.36	23312004
2429	O-linked_Glycosylation	VTIEPAGSVPALGVT EEEECCCCCCCCCCC	27.34	OGP
2476	Phosphorylation	TWHKRGGSLPARHQV EEECCCCCCCCCCEE	33.72	24719451
2486	Phosphorylation	ARHQVHGSRLRLLQV CCCEECCCCEEEEEE	17.17	-
2525	Phosphorylation	VTIQQRLSGSHSQGV EEEEHHHCCCCCCCE	40.20	23312004
2527	Phosphorylation	IQQRLSGSHSQGVAY EEHHHCCCCCCCEEE	19.31	23312004
2529	O-linked_Glycosylation	QRLSGSHSQGVAYPV HHHCCCCCCCEEEEE	30.26	OGP
2529	Phosphorylation	QRLSGSHSQGVAYPV HHHCCCCCCCEEEEE	30.26	23312004
2530	O-linked_Glycosylation	RLSGSHSQGVAYPVR HHCCCCCCCEEEEEE	44.98	-
2534	Phosphorylation	SHSQGVAYPVRIESS CCCCCEEEEEEEECC	10.39	23312004
2559	O-linked_Glycosylation	DLNCLVASQAPHTIT EECEEEECCCCCEEE	21.28	OGP
2637	O-linked_Glycosylation	PPIRIESSSPTVVEG CCEEEECCCCEEECC	27.78	OGP
2638	O-linked_Glycosylation	PIRIESSSPTVVEGQ CEEEECCCCEEECCC	33.59	OGP
2646	O-linked_Glycosylation	PTVVEGQTLDLNCVV CEEECCCEEEEECEE	32.85	OGP
2691	Phosphorylation	HQMSVADSGEYVCRA EEEEHHCCCCEEEEC	24.64	27251275
2692	Phosphorylation	QMSVADSGEYVCRAN EEEHHCCCCEEEECC	30.70	-
2716	O-linked_Glycosylation	IVISVSPSAGSPSAP EEEEECCCCCCCCCC	37.44	OGP
2719	O-linked_Glycosylation	SVSPSAGSPSAPGSS EECCCCCCCCCCCCC	18.52	OGP
2721	O-linked_Glycosylation	SPSAGSPSAPGSSMP CCCCCCCCCCCCCCC	49.12	OGP
2815	O-linked_Glycosylation	VTIEASGSSAVHVPA EEEEECCCCCEEECC	16.78	OGP
2816	O-linked_Glycosylation	TIEASGSSAVHVPAP EEEECCCCCEEECCC	37.52	OGP
2834	Phosphorylation	PPIRIEPSSSRVAEG CCEEECCCCCCCCCC	28.31	20068231
2835	Phosphorylation	PIRIEPSSSRVAEGQ CEEECCCCCCCCCCC	32.64	20068231
2836	Phosphorylation	IRIEPSSSRVAEGQT EEECCCCCCCCCCCE	34.80	20068231
2843	Phosphorylation	SRVAEGQTLDLKCVV CCCCCCCEEEEEEEC	32.85	20068231
2844	Phosphorylation	RVAEGQTLDLKCVVP CCCCCCEEEEEEECC	5.81	20068231
2964	Phosphorylation	TWYKRGGSLPARHQT EEEECCCCCCCCCCC	33.72	24719451
2986	Phosphorylation	HLVSPADSGEYVCRA EEECCCCCCCEEEEE	40.35	26657352
2987	Phosphorylation	LVSPADSGEYVCRAA EECCCCCCCEEEEEC	30.70	-
2989	Phosphorylation	SPADSGEYVCRAASG CCCCCCCEEEEECCC	14.36	28857561
2995	O-linked_Glycosylation	EYVCRAASGPGPEQE CEEEEECCCCCCCCE	44.53	-
3032	O-linked_Glycosylation	SIDPPSSTVQQGQDA EECCCCCCCCCCCCC	27.03	OGP
3040	Phosphorylation	VQQGQDASFKCLIHD CCCCCCCEEEEEEEC	33.26	24719451
3072	N-linked_Glycosylation	DNVHISPNGSIITIV CCEEECCCCCEEEEE	50.48	19159218
3073	N-linked_Glycosylation	NVHISPNGSIITIVG CEEECCCCCEEEEEE	24.49	19159218
3105	N-linked_Glycosylation	GVAQSVVNLSVHGPP CEEEEEEEEECCCCC	25.17	UniProtKB CARBOHYD
3142	Phosphorylation	VSAGEPRSSARWTRI ECCCCCCCCCCEEEC	38.78	30631047
3151	Phosphorylation	ARWTRISSTPAKLEQ CCEEECCCCCHHHHH	35.72	-
3152	O-linked_Glycosylation	RWTRISSTPAKLEQR CEEECCCCCHHHHHH	22.07	OGP
3152	Phosphorylation	RWTRISSTPAKLEQR CEEECCCCCHHHHHH	22.07	-
3153	O-linked_Glycosylation	WTRISSTPAKLEQRT EEECCCCCHHHHHHH	29.37	-
3204	Phosphorylation	QVEVIVDTGAMAPGA EEEEEEECCCCCCCC	18.88	22210691
3262	Phosphorylation	QHRLEGDTLIIPRVA CCCCCCCEEEECCEE	30.61	-
3279	N-linked_Glycosylation	DSGQYICNATSPAGH CCCCEEEECCCCCCC	36.37	UniProtKB CARBOHYD
3392	O-linked_Glycosylation	PPGSLPATSIPAGST CCCCCCCCCCCCCCC	25.83	OGP
3393	O-linked_Glycosylation	PGSLPATSIPAGSTP CCCCCCCCCCCCCCC	28.78	OGP
3398	O-linked_Glycosylation	ATSIPAGSTPTVQVT CCCCCCCCCCEEEEC	33.06	OGP
3399	O-linked_Glycosylation	TSIPAGSTPTVQVTP CCCCCCCCCEEEECC	23.28	OGP
3401	O-linked_Glycosylation	IPAGSTPTVQVTPQL CCCCCCCEEEECCCE	24.53	OGP
3405	O-linked_Glycosylation	STPTVQVTPQLETKS CCCEEEECCCEEECC	6.55	OGP
3412	O-linked_Glycosylation	TPQLETKSIGASVEF CCCEEECCCCCEEEE	33.40	OGP
3413	O-linked_Glycosylation	PQLETKSIGASVEFH CCEEECCCCCEEEEE	5.95	-
3488	Phosphorylation	LVIQALPSVLINIRT HHHHHHHHHHHCCCC	30.33	22210691
3630	O-linked_Glycosylation	NNMLMLPSVRPQDAG CCEEECCCCCHHHCC	27.14	OGP
3630	Phosphorylation	NNMLMLPSVRPQDAG CCEEECCCCCHHHCC	27.14	20860994
3631	Phosphorylation	NMLMLPSVRPQDAGT CEEECCCCCHHHCCE	11.06	-
3712	Phosphorylation	GQKRVPGSPTNLANR CEECCCCCCCCHHHC	23.60	28857561
3713	Phosphorylation	QKRVPGSPTNLANRQ EECCCCCCCCHHHCC	31.08	-
3714	Phosphorylation	KRVPGSPTNLANRQP ECCCCCCCCHHHCCC	44.56	23312004
3767	Phosphorylation	VTLLRSLTQGSLIVG HHHHHHHHCCCEEEE	31.93	-
3780	N-linked_Glycosylation	VGDLAPVNGTSQGKF EEEEECCCCCCCCEE	47.14	19159218
3781	N-linked_Glycosylation	GDLAPVNGTSQGKFQ EEEECCCCCCCCEEC	27.29	19159218
3782	Phosphorylation	DLAPVNGTSQGKFQG EEECCCCCCCCEECC	16.81	-
3783	Phosphorylation	LAPVNGTSQGKFQGL EECCCCCCCCEECCC	38.03	-
3836	N-linked_Glycosylation	EIVFHDLNLTAHGIS EEEEEECCCEECCCC	41.21	19159218
3837	N-linked_Glycosylation	IVFHDLNLTAHGISH EEEEECCCEECCCCC	6.10	19159218
3933	O-linked_Glycosylation	TVTTPSLSGAGSYLA EEECCCCCCCCCEEE	30.82	-
4068	N-linked_Glycosylation	VPLSPATNMSAHFRG CCCCCCCCCCHHCCC	25.23	19159218
4069	N-linked_Glycosylation	PLSPATNMSAHFRGC CCCCCCCCCHHCCCC	3.04	19159218
4171	O-linked_Glycosylation	CLCLPGFSGPRCQQG EEECCCCCCCCCCCC	54.53	28657654
4171	Phosphorylation	CLCLPGFSGPRCQQG EEECCCCCCCCCCCC	54.53	24719451
4179	O-linked_Glycosylation	GPRCQQGSGHGIAES CCCCCCCCCCCCCCC	24.23	-
4277	Phosphorylation	VFRYQLGSGEARLVS EEEEECCCCCEEEEE	41.89	29759185
4306	Phosphorylation	LREGRRGSIQVDGEE CCCCCCEEEEECCEE	14.18	23312004
4307	Phosphorylation	REGRRGSIQVDGEEL CCCCCEEEEECCEEE	5.29	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PGBM_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PGBM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PGBM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TTHY_HUMAN	TTR	physical	9307034
NID2_HUMAN	NID2	physical	11493006
FINC_HUMAN	FN1	physical	11493006
FBLN2_HUMAN	FBLN2	physical	11493006
FBLN2_HUMAN	FBLN2	physical	7500359
PDGFA_HUMAN	PDGFA	physical	9692901
PDGFB_HUMAN	PDGFB	physical	9692901

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
255800	Schwartz-Jampel syndrome (SJS1)
224410	Dyssegmental dysplasia Silverman-Handmaker type (DDSH)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PGBM_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-554; ASN-1755; ASN-3072;ASN-3780; ASN-3836 AND ASN-4068, AND MASS SPECTROMETRY.	19159218 [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1755, AND MASSSPECTROMETRY.	16335952 [Abstract]
"Identification and quantification of N-linked glycoproteins usinghydrazide chemistry, stable isotope labeling and mass spectrometry."; Zhang H., Li X.-J., Martin D.B., Aebersold R.; Nat. Biotechnol. 21:660-666(2003). Cited for: GLYCOSYLATION AT ASN-2121.	12754519 [Abstract]
O-linked Glycosylation
Reference	PubMed
"Human urinary glycoproteomics; attachment site specific analysis ofN-and O-linked glycosylations by CID and ECD."; Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.; Mol. Cell. Proteomics 0:0-0(2011). Cited for: GLYCOSYLATION AT THR-42, STRUCTURE OF CARBOHYDRATES, AND MASSSPECTROMETRY.	22171320 [Abstract]