KI16B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KI16B_HUMAN
• UniProt AC: Q96L93
• Protein Name: Kinesin-like protein KIF16B
• Gene Name: KIF16B
• Organism: Homo sapiens (Human).
• Sequence Length: 1317
• Subcellular Localization: Cytoplasm, cytoskeleton . Early endosome membrane. It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14.
• Protein Description: Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development..
• Protein Sequence: MASVKVAVRVRPMNRREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERTKTFTYDFSFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLIPRICEGLFSRINETTRWDEASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKFDSEMPCETVSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTLAKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLLAQGNQIALLDSPTALSMEEKLQQNEARVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGRDDASTEQDIVLHGLDLESEHCIFENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYNPGLEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEERLREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQEMIQLLRRGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKKEVQEEQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQRHSTLGMEIEEQRQKLASLNSGSREQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYEVDGVQKDHHGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDLHRVISEGCSTSADTMKDNEKLHNGTIQRKLKYERMVSRSLGANPDDLKDPIKISIPRYVLCGQGKDAHFEFEVKITVLDETWTVFRRYSRFREMHKTLKLKYAELAALEFPPKKLFGNKDERVIAERRSHLEKYLRDFFSVMLQSATSPLHINKVGLTLSKHTICEFSPFFKKGVFDYSSHGTG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	FIIQMEKSKTTITNL EEEEECCCCCEEEEE	23.17	-
34	Phosphorylation	QMEKSKTTITNLKIP EECCCCCEEEEEECC	29.55	-
36	Phosphorylation	EKSKTTITNLKIPEG CCCCCEEEEEECCCC	32.19	-
45	Phosphorylation	LKIPEGGTGDSGRER EECCCCCCCCCCCCE	48.98	20068231
48	Phosphorylation	PEGGTGDSGRERTKT CCCCCCCCCCCEEEE	40.89	20068231
53	Phosphorylation	GDSGRERTKTFTYDF CCCCCCEEEEEEEEE	29.68	20068231
55	Phosphorylation	SGRERTKTFTYDFSF CCCCEEEEEEEEEEE	22.16	28270605
57	Phosphorylation	RERTKTFTYDFSFYS CCEEEEEEEEEEEEE	27.67	28270605
58	Phosphorylation	ERTKTFTYDFSFYSA CEEEEEEEEEEEEEC	15.70	28270605
61	Phosphorylation	KTFTYDFSFYSADTK EEEEEEEEEEECCCC	22.00	28270605
72	Phosphorylation	ADTKSPDYVSQEMVF CCCCCCCCCCHHHHH	12.84	-
84	Phosphorylation	MVFKTLGTDVVKSAF HHHHHHCHHHHHHHH	28.82	29396449
89	Phosphorylation	LGTDVVKSAFEGYNA HCHHHHHHHHCCCCE	26.95	30576142
106	Phosphorylation	FAYGQTGSGKSYTMM EEECCCCCCCCEEEC	46.57	30576142
109	Phosphorylation	GQTGSGKSYTMMGNS CCCCCCCCEEECCCC	29.39	-
110	Phosphorylation	QTGSGKSYTMMGNSG CCCCCCCEEECCCCC	11.35	-
111	Phosphorylation	TGSGKSYTMMGNSGD CCCCCCEEECCCCCC	14.05	-
119	Phosphorylation	MMGNSGDSGLIPRIC ECCCCCCCCCHHHHH	38.74	30576142
143	Phosphorylation	TTRWDEASFRTEVSY CCCCCHHHCHHEEEH	17.14	24719451
169	Phosphorylation	LRRKSSKTFNLRVRE HHHCCCCCCCEEEEC	21.50	28674151
211	Phosphorylation	AGNINRTTAATGMND HCCCCCCCCCCCCCC	15.85	-
220	Phosphorylation	ATGMNDVSSRSHAIF CCCCCCCCCCCEEEE	23.93	-
240	Sulfoxidation	QAKFDSEMPCETVSK ECCCCCCCCCCEECE	5.50	21406390
278	Phosphorylation	EGGNINKSLVTLGNV CCCCCCHHHHHHHHH	24.47	26434776
281	Phosphorylation	NINKSLVTLGNVISA CCCHHHHHHHHHHHH	33.95	26434776
287	Phosphorylation	VTLGNVISALADLSQ HHHHHHHHHHHHCCH	16.98	26434776
293	Phosphorylation	ISALADLSQDAANTL HHHHHHCCHHHHHHH	26.93	26434776
299	Phosphorylation	LSQDAANTLAKKKQV CCHHHHHHHHHCCCE	24.30	-
316	Phosphorylation	PYRDSVLTWLLKDSL ECHHHHHHHHHHHCC	16.35	-
351	Phosphorylation	ETLSTLRYANRAKNI HHHHHHHHHHHHHCC	16.02	-
398	Phosphorylation	NQIALLDSPTALSME CEEEEECCHHHCCHH	24.91	22199227
400	Phosphorylation	IALLDSPTALSMEEK EEEECCHHHCCHHHH	44.15	22199227
403	Phosphorylation	LDSPTALSMEEKLQQ ECCHHHCCHHHHHHH	22.99	22199227
420	Ubiquitination	ARVQELTKEWTNKWN HHHHHHHHHHHHHHH	64.97	-
434	Acetylation	NETQNILKEQTLALR HHHHHHHHHHHHHHH	43.93	7978727
442	Acetylation	EQTLALRKEGIGVVL HHHHHHHHCCCEEEE	62.23	7978737
451	Phosphorylation	GIGVVLDSELPHLIG CCEEEECCCCCHHCC	36.55	30622161
465	Phosphorylation	GIDDDLLSTGIILYH CCCHHHHCCCEEEEE	31.70	30622161
466	Phosphorylation	IDDDLLSTGIILYHL CCHHHHCCCEEEEEE	32.16	30622161
471	Phosphorylation	LSTGIILYHLKEGQT HCCCEEEEEECCCCE	8.49	30622161
566	Phosphorylation	KLREKRKSGLLSSFS HHHHHHHHCCHHHHC	38.41	23403867
570	Phosphorylation	KRKSGLLSSFSLSMT HHHHCCHHHHCCCCC	34.09	23403867
571	Phosphorylation	RKSGLLSSFSLSMTD HHHCCHHHHCCCCCC	20.87	23403867
573	Phosphorylation	SGLLSSFSLSMTDLS HCCHHHHCCCCCCHH	22.83	26657352
575	Phosphorylation	LLSSFSLSMTDLSKS CHHHHCCCCCCHHHC	20.59	28102081
577	Phosphorylation	SSFSLSMTDLSKSRE HHHCCCCCCHHHCCC	30.34	22617229
580	Phosphorylation	SLSMTDLSKSRENLS CCCCCCHHHCCCCCH	31.25	23403867
582	Phosphorylation	SMTDLSKSRENLSAV CCCCHHHCCCCCHHH	41.26	30266825
587	Phosphorylation	SKSRENLSAVMLYNP HHCCCCCHHHHHHCC	30.33	30266825
592	Phosphorylation	NLSAVMLYNPGLEFE CCHHHHHHCCCHHHH	10.95	27732954
644	Phosphorylation	VETQRKETEIVQLQI HHHHHHHHHHHHHHH	33.76	28348404
657	Phosphorylation	QIRKQEESLKRRSFH HHHHHHHHHHHHHHH	38.14	27251275
662	Phosphorylation	EESLKRRSFHIENKL HHHHHHHHHHHHHHH	25.80	26657352
670	Trimethylation	FHIENKLKDLLAEKE HHHHHHHHHHHHHHH	48.19	-
670	Methylation	FHIENKLKDLLAEKE HHHHHHHHHHHHHHH	48.19	-
694	Ubiquitination	QQEIELQKKRQEEET HHHHHHHHHHHHHHH	63.65	1720397
695	Ubiquitination	QEIELQKKRQEEETF HHHHHHHHHHHHHHH	46.48	-
713	Ubiquitination	QEELQRLKELNNNEK HHHHHHHHHHCCCHH	63.44	-
723	Ubiquitination	NNNEKAEKFQIFQEL CCCHHHHHHHHHHHH	47.64	-
749	Acetylation	AKLELEKKRLEEQEK HHHHHHHHHHHHHHH	53.49	11925873
772	Ubiquitination	LEEQLREKQEMIQLL HHHHHHHHHHHHHHH	45.16	-
800	Phosphorylation	DLEGIRESLLRVKEA CCHHHHHHHHHHHHH	23.90	23532336
820	Ubiquitination	EDGEELEKAQLRFFE CCHHHHHHHHHHHHH	54.80	-
847	Ubiquitination	EKDLVQQKDILKKEV CHHHHHHHHHHHHHH	29.64	-
852	Ubiquitination	QQKDILKKEVQEEQE HHHHHHHHHHHHHHH	60.72	-
881	Phosphorylation	LLEKHDESVTDVTEV HHHHCCCCCCCCCCC	36.05	25849741
883	Phosphorylation	EKHDESVTDVTEVPQ HHCCCCCCCCCCCCC	33.75	29396449
894	Ubiquitination	EVPQDFEKIKPVEYR CCCCCHHHCCCCCHH	56.90	-
924	Ubiquitination	LPTLLEEKQRAFEIL HHHHHHHHHHHHHHH	35.39	-
937	Phosphorylation	ILDRGPLSLDNTLYQ HHHCCCCCCCCHHHH	36.49	26471730
941	Phosphorylation	GPLSLDNTLYQVEKE CCCCCCCHHHHHHHH	26.89	28509920
943	Phosphorylation	LSLDNTLYQVEKEME CCCCCHHHHHHHHHH	14.42	28509920
1017	Phosphorylation	ARLERRHSALQRHST HHHHHHHHHHHHHHH	28.94	24732914
1023	Phosphorylation	HSALQRHSTLGMEIE HHHHHHHHHHCCHHH	27.76	28348404
1024	Phosphorylation	SALQRHSTLGMEIEE HHHHHHHHHCCHHHH	22.62	28348404
1035	Ubiquitination	EIEEQRQKLASLNSG HHHHHHHHHHHCCCC	48.48	-
1038	Phosphorylation	EQRQKLASLNSGSRE HHHHHHHHCCCCCHH	38.22	20068231
1041	Phosphorylation	QKLASLNSGSREQSG HHHHHCCCCCHHHHH	43.36	20068231
1043	Phosphorylation	LASLNSGSREQSGLQ HHHCCCCCHHHHHHH	32.25	20068231
1047	Phosphorylation	NSGSREQSGLQASLE CCCCHHHHHHHHHHH	36.40	25850435
1052	Phosphorylation	EQSGLQASLEAEQEA HHHHHHHHHHHHHHH	17.49	10997877
1062	Ubiquitination	AEQEALEKDQERLEY HHHHHHHHHHHHHHH	66.61	-
1069	Phosphorylation	KDQERLEYEIQQLKQ HHHHHHHHHHHHHHH	23.95	21945579
1075	Ubiquitination	EYEIQQLKQKIYEVD HHHHHHHHHHHHEEC	45.25	-
1079	Phosphorylation	QQLKQKIYEVDGVQK HHHHHHHHEECCCCC	19.55	25884760
1086	Ubiquitination	YEVDGVQKDHHGTLE HEECCCCCCCCCCEE	57.53	-
1095	Ubiquitination	HHGTLEGKVASSSLP CCCCEEEEEECCCCC	25.83	-
1098	Phosphorylation	TLEGKVASSSLPVSA CEEEEEECCCCCCCC	24.36	28348404
1099	Phosphorylation	LEGKVASSSLPVSAE EEEEEECCCCCCCCC	26.59	29255136
1100	Phosphorylation	EGKVASSSLPVSAEK EEEEECCCCCCCCCH	33.91	29255136
1104	Phosphorylation	ASSSLPVSAEKSHLV ECCCCCCCCCHHCCC	28.86	29255136
1107	Ubiquitination	SLPVSAEKSHLVPLM CCCCCCCHHCCCHHH	42.78	-
1107 (in isoform 2)	Ubiquitination	-	42.78	-
1108	Phosphorylation	LPVSAEKSHLVPLMD CCCCCCHHCCCHHHH	17.35	21712546
1148	Sulfoxidation	CSTSADTMKDNEKLH CCCCCCCCCCCCHHC	5.44	21406390
1149 (in isoform 2)	Ubiquitination	-	60.54	-
1172	Phosphorylation	YERMVSRSLGANPDD HHHHHHHHCCCCHHH	24.53	26657352
1181	Ubiquitination	GANPDDLKDPIKISI CCCHHHCCCCCEEEC	69.33	-
1187	Phosphorylation	LKDPIKISIPRYVLC CCCCCEEECCCEEEE	22.87	24719451
1191	Phosphorylation	IKISIPRYVLCGQGK CEEECCCEEEECCCC	7.75	29496907
1278	Phosphorylation	FFSVMLQSATSPLHI HHHHHHHCCCCCCEE	29.56	-
1280	Phosphorylation	SVMLQSATSPLHINK HHHHHCCCCCCEECC	35.80	-
1281	Phosphorylation	VMLQSATSPLHINKV HHHHCCCCCCEECCC	25.77	-
1291	Phosphorylation	HINKVGLTLSKHTIC EECCCCEEECCCCCE	24.05	-
1311	Phosphorylation	FKKGVFDYSSHGTG- HCCCCCCCCCCCCC-	10.70	27642862
1316	Phosphorylation	FDYSSHGTG------ CCCCCCCCC------	34.00	27642862
1341 (in isoform 2)	Phosphorylation	-		28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KI16B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KI16B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KI16B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MON1B_HUMAN	MON1B	physical	28514442
CCZ1B_HUMAN	CCZ1	physical	28514442
CCZ1_HUMAN	CCZ1	physical	28514442
JIP4_HUMAN	SPAG9	physical	28514442
CARM1_HUMAN	CARM1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.