GSTA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSTA1_HUMAN
• UniProt AC: P08263
• Protein Name: Glutathione S-transferase A1
• Gene Name: GSTA1
• Organism: Homo sapiens (Human).
• Sequence Length: 222
• Subcellular Localization: Cytoplasm.
• Protein Description: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles..
• Protein Sequence: MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAKLALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MAEKPKLH -------CCCCCCCE	11.10	-
2	Acetylation	------MAEKPKLHY ------CCCCCCCEE	33.26	-
4	Succinylation	----MAEKPKLHYFN ----CCCCCCCEEEC	37.60	-
4	Succinylation	----MAEKPKLHYFN ----CCCCCCCEEEC	37.60	-
9	Phosphorylation	AEKPKLHYFNARGRM CCCCCCEEECCCCCH	14.68	-
18	Phosphorylation	NARGRMESTRWLLAA CCCCCHHHHHHHHHH	17.58	27251275
19	Phosphorylation	ARGRMESTRWLLAAA CCCCHHHHHHHHHHH	16.74	27251275
36	Acetylation	EFEEKFIKSAEDLDK CHHHHHHHCHHHHHH	46.90	27178108
37	Phosphorylation	FEEKFIKSAEDLDKL HHHHHHHCHHHHHHH	31.88	20166139
43	Acetylation	KSAEDLDKLRNDGYL HCHHHHHHHHHCCEE	57.55	27178108
49	Phosphorylation	DKLRNDGYLMFQQVP HHHHHCCEEEEEECC	9.61	28258704
74	Phosphorylation	QTRAILNYIASKYNL HHHHHHHHHHHHCCC	8.40	-
77	Phosphorylation	AILNYIASKYNLYGK HHHHHHHHHCCCCCC	26.56	28857561
79	Phosphorylation	LNYIASKYNLYGKDI HHHHHHHCCCCCCCH	14.12	-
82	Phosphorylation	IASKYNLYGKDIKER HHHHCCCCCCCHHHH	20.63	-
84	Acetylation	SKYNLYGKDIKERAL HHCCCCCCCHHHHHH	42.60	20167786
87	Acetylation	NLYGKDIKERALIDM CCCCCCHHHHHHHHH	51.81	88351
125	Ubiquitination	DAKLALIKEKIKNRY CHHHHHHHHHHHHCC	54.53	-
132	Phosphorylation	KEKIKNRYFPAFEKV HHHHHHCCCHHHHHH	24.25	21253578
138	Acetylation	RYFPAFEKVLKSHGQ CCCHHHHHHHHHCCC	46.55	27178108
142	Phosphorylation	AFEKVLKSHGQDYLV HHHHHHHHCCCCCCC	28.79	20166139
147	Phosphorylation	LKSHGQDYLVGNKLS HHHCCCCCCCCCCCC	8.73	28258704
152	Acetylation	QDYLVGNKLSRADIH CCCCCCCCCCHHHHH	41.74	24885185
154	Phosphorylation	YLVGNKLSRADIHLV CCCCCCCCHHHHHHH	27.34	24275569
172	Phosphorylation	YYVEELDSSLISSFP HHHHHHCHHHHHCHH	39.40	24275569
173	Phosphorylation	YVEELDSSLISSFPL HHHHHCHHHHHCHHH	29.41	24275569
176	Phosphorylation	ELDSSLISSFPLLKA HHCHHHHHCHHHHHH	31.08	24275569
177	Phosphorylation	LDSSLISSFPLLKAL HCHHHHHCHHHHHHH	24.72	24275569
189	Phosphorylation	KALKTRISNLPTVKK HHHHHHHHCCHHHHH	29.08	28857561
193	Phosphorylation	TRISNLPTVKKFLQP HHHHCCHHHHHHCCC	48.39	28857561
195	Acetylation	ISNLPTVKKFLQPGS HHCCHHHHHHCCCCC	40.04	12431263
196	Acetylation	SNLPTVKKFLQPGSP HCCHHHHHHCCCCCC	47.15	12431271
202	Phosphorylation	KKFLQPGSPRKPPMD HHHCCCCCCCCCCCC	28.37	28355574
212	Phosphorylation	KPPMDEKSLEEARKI CCCCCHHHHHHHHHH	38.68	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSTA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSTA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSTA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GSTA1_HUMAN	GSTA1	physical	1530570
A4_HUMAN	APP	physical	21832049
LSM3_HUMAN	LSM3	physical	21988832
PP2AB_HUMAN	PPP2CB	physical	21988832
SIA4A_HUMAN	ST3GAL1	physical	21988832
1433E_HUMAN	YWHAE	physical	21988832
RIP_HUMAN	RPAIN	physical	21988832
GSTA1_HUMAN	GSTA1	physical	8663064
GSTA3_HUMAN	GSTA3	physical	26186194
ZBT21_HUMAN	ZBTB21	physical	26186194
SPDLY_HUMAN	SPDL1	physical	26186194
ACOX1_HUMAN	ACOX1	physical	26186194
GSTA4_HUMAN	GSTA4	physical	26186194
GSTA3_HUMAN	GSTA3	physical	28514442
GSTA4_HUMAN	GSTA4	physical	28514442
SPDLY_HUMAN	SPDL1	physical	28514442
ZBT21_HUMAN	ZBTB21	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00993: Azathioprine
• DB01008: Busulfan
• DB00143: Glutathione