dbPTM

RIP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RIP_HUMAN
UniProt AC	Q86UA6
Protein Name	RPA-interacting protein
Gene Name	RPAIN
Organism	Homo sapiens (Human).
Sequence Length	219
Subcellular Localization	Isoform 1: Cytoplasm. Nucleus. Isoform 2: Nucleus, PML body.
Protein Description	Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism..
Protein Sequence	MAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQAGSSGPGNSQNSFLVQEVMEEEWNALQSVENCPEDLAQLEELIDMAVLEEIQQELINQEQSIISEYEKSLQFDEKCLSIMLAEWEANPLICPVCTKYNLRITSGVVVCQCGLSIPSHSSELTEQKLRACLEGSINEHSAHCPHTPEFSVTGGTEEKSSLLMSCLACDTWAVIL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAESLRSPRRS ----CCHHHCCCCHH	21.39	30108239
6	Methylation	--MAESLRSPRRSLY --CCHHHCCCCHHHH	54.62	115368269
7	Phosphorylation	-MAESLRSPRRSLYK -CCHHHCCCCHHHHH	28.22	29255136
11	Phosphorylation	SLRSPRRSLYKLVGS HHCCCCHHHHHHHCC	37.01	26074081
13	Phosphorylation	RSPRRSLYKLVGSPP CCCCHHHHHHHCCCH	11.97	-
14 (in isoform 5)	Ubiquitination	-	41.83	21890473
14 (in isoform 1)	Ubiquitination	-	41.83	21890473
14 (in isoform 2)	Ubiquitination	-	41.83	21890473
14	Ubiquitination	SPRRSLYKLVGSPPW CCCHHHHHHHCCCHH	41.83	21890473
14 (in isoform 3)	Ubiquitination	-	41.83	21890473
14 (in isoform 4)	Ubiquitination	-	41.83	21890473
14 (in isoform 6)	Ubiquitination	-	41.83	21890473
14 (in isoform 7)	Ubiquitination	-	41.83	21890473
14	Ubiquitination	SPRRSLYKLVGSPPW CCCHHHHHHHCCCHH	41.83	21890473
18	Phosphorylation	SLYKLVGSPPWKEAF HHHHHHCCCHHHHHH	21.95	25159151
22	Ubiquitination	LVGSPPWKEAFRQRC HHCCCHHHHHHHHHH	44.96	21890473
22 (in isoform 5)	Ubiquitination	-	44.96	21890473
22 (in isoform 4)	Ubiquitination	-	44.96	21890473
22 (in isoform 3)	Ubiquitination	-	44.96	21890473
22 (in isoform 6)	Ubiquitination	-	44.96	21890473
22 (in isoform 7)	Ubiquitination	-	44.96	21890473
22 (in isoform 2)	Ubiquitination	-	44.96	21890473
22 (in isoform 1)	Ubiquitination	-	44.96	21890473
22	Ubiquitination	LVGSPPWKEAFRQRC HHCCCHHHHHHHHHH	44.96	2189047
36	Phosphorylation	CLERMRNSRDRLLNR HHHHHHHHHHHHHHH	25.78	29978859
112 (in isoform 8)	Phosphorylation	-	23.13	27642862
114	Ubiquitination	SIISEYEKSLQFDEK HHHHHHHHHHCCCHH	56.41	-
121	Sumoylation	KSLQFDEKCLSIMLA HHHCCCHHHHHHHHH	42.17	16135809
148	Phosphorylation	TKYNLRITSGVVVCQ CCCCCEECCCEEEEE	17.00	21406692
149	Phosphorylation	KYNLRITSGVVVCQC CCCCEECCCEEEEEC	27.50	21406692
159	Phosphorylation	VVCQCGLSIPSHSSE EEEECCCCCCCCCHH	20.10	21406692
162	Phosphorylation	QCGLSIPSHSSELTE ECCCCCCCCCHHHHH	34.04	21406692
164	Phosphorylation	GLSIPSHSSELTEQK CCCCCCCCHHHHHHH	29.82	21406692
165	Phosphorylation	LSIPSHSSELTEQKL CCCCCCCHHHHHHHH	31.07	21406692
168	Phosphorylation	PSHSSELTEQKLRAC CCCCHHHHHHHHHHH	32.11	21406692
171	Ubiquitination	SSELTEQKLRACLEG CHHHHHHHHHHHHHC	33.44	-
190	Phosphorylation	HSAHCPHTPEFSVTG CCCCCCCCCCEEECC	15.06	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RIP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
103	K	Sumoylation		16135809
Variant 'Lys-103' adds a sumoylation site and increases total sumoylation levels.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RIP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFA1_HUMAN	RPA1	physical	26186194
RFA2_HUMAN	RPA2	physical	26186194
UBR7_HUMAN	UBR7	physical	26186194
RFA1_HUMAN	RPA1	physical	28514442
UBR7_HUMAN	UBR7	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RIP_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND MASSSPECTROMETRY.	19413330 [Abstract]

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