SIA4A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIA4A_HUMAN
• UniProt AC: Q11201
• Protein Name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
• Gene Name: ST3GAL1
• Organism: Homo sapiens (Human).
• Sequence Length: 340
• Subcellular Localization: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
• Protein Description: Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values..
• Protein Sequence: MVTLRKRTLKVLTFLVLFIFLTSFFLNYSHTMVATTWFPKQMVLELSENLKRLIKHRPCTCTHCIGQRKLSAWFDERFNQTMQPLLTAQNALLEDDTYRWWLRLQREKKPNNLNDTIKELFRVVPGNVDPMLEKRSVGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVVSAITTGTISHTYIPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWHHYWENNPSAGAFRKTGVHDADFESNVTATLASINKIRIFKGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	N-linked_Glycosylation	FLTSFFLNYSHTMVA HHHHHHHCCCCCCHH	30.98	-
27	N-linked_Glycosylation	FLTSFFLNYSHTMVA HHHHHHHCCCCCCHH	30.98	11690653
79	N-linked_Glycosylation	AWFDERFNQTMQPLL HHHHHHHHHHHHHHH	42.51	UniProtKB CARBOHYD
79	N-linked_Glycosylation	AWFDERFNQTMQPLL HHHHHHHHHHHHHHH	42.51	11690653
81	O-linked_Glycosylation	FDERFNQTMQPLLTA HHHHHHHHHHHHHHH	20.91	OGP
87	O-linked_Glycosylation	QTMQPLLTAQNALLE HHHHHHHHHHHHHHC	33.60	OGP
114	N-linked_Glycosylation	EKKPNNLNDTIKELF CCCCCCCHHHHHHHH	46.64	UniProtKB CARBOHYD
114	N-linked_Glycosylation	EKKPNNLNDTIKELF CCCCCCCHHHHHHHH	46.64	11690653
148	Phosphorylation	RCAVVGNSGNLRESS EEEEECCCCCCCCCC	24.11	23879269
201	N-linked_Glycosylation	SFRELGDNVSMILVP HHHHHCCCEEEEEEE	26.43	UniProtKB CARBOHYD
201	N-linked_Glycosylation	SFRELGDNVSMILVP HHHHHCCCEEEEEEE	26.43	11690653
225	O-linked_Glycosylation	VSAITTGTISHTYIP HHHHHCCCCCCEEEC	19.74	OGP
323	N-linked_Glycosylation	HDADFESNVTATLAS CCCCCCCCCEEEEHH	28.14	UniProtKB CARBOHYD
323	N-linked_Glycosylation	HDADFESNVTATLAS CCCCCCCCCEEEEHH	28.14	11690653

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIA4A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIA4A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIA4A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GOLP3_HUMAN	GOLPH3	physical	28514442
ASPH2_HUMAN	ASPHD2	physical	28514442
ZNT7_HUMAN	SLC30A7	physical	28514442
AT2B2_HUMAN	ATP2B2	physical	28514442
ITAV_HUMAN	ITGAV	physical	28514442
RMND1_HUMAN	RMND1	physical	28514442
ANR46_HUMAN	ANKRD46	physical	28514442
CF120_HUMAN	C6orf120	physical	28514442
S39AB_HUMAN	SLC39A11	physical	28514442
UB2J1_HUMAN	UBE2J1	physical	28514442
GPHRA_HUMAN	GPR89B	physical	28514442
GPHRB_HUMAN	GPR89B	physical	28514442
LMBR1_HUMAN	LMBR1	physical	28514442
METL9_HUMAN	METTL9	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.