ASPH2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASPH2_HUMAN
• UniProt AC: Q6ICH7
• Protein Name: Aspartate beta-hydroxylase domain-containing protein 2
• Gene Name: ASPHD2
• Organism: Homo sapiens (Human).
• Sequence Length: 369
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Description: May function as 2-oxoglutarate-dependent dioxygenase..
• Protein Sequence: MVWAPLGPPRTDCLTLLHTPSKDSPKMSLEWLVAWSWSLDGLRDCIATGIQSVRDCDTTAVITVACLLVLFVWYCYHVGREQPRPYVSVNSLMQAADANGLQNGYVYCQSPECVRCTHNEGLNQKLYHNLQEYAKRYSWSGMGRIHKGIREQGRYLNSRPSIQKPEVFFLPDLPTTPYFSRDAQKHDVEVLERNFQTILCEFETLYKAFSNCSLPQGWKMNSTPSGEWFTFYLVNQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACISVLSPGTVITEHYGPTNIRIRCHLGLKTPNGCELVVGGEPQCWAEGRCLLFDDSFLHAAFHEGSAEDGPRVVFMVDLWHPNVAAAERQALDFIFAPGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	APLGPPRTDCLTLLH CCCCCCCCCEEEEEC	36.52	30576142
15	Phosphorylation	PPRTDCLTLLHTPSK CCCCCEEEEECCCCC	33.34	30576142
19	Phosphorylation	DCLTLLHTPSKDSPK CEEEEECCCCCCCCC	29.27	30576142
86	Phosphorylation	GREQPRPYVSVNSLM CCCCCCCCEEHHHHH	13.46	-
105	Phosphorylation	ANGLQNGYVYCQSPE HCCCCCCEEEECCCC	8.87	-
107	Phosphorylation	GLQNGYVYCQSPECV CCCCCEEEECCCCEE	4.01	-
135	Methylation	HNLQEYAKRYSWSGM HHHHHHHHHCCCCCC	51.47	-
175	Phosphorylation	FFLPDLPTTPYFSRD EECCCCCCCCCCCCC	47.93	26074081
176	Phosphorylation	FLPDLPTTPYFSRDA ECCCCCCCCCCCCCH	17.66	26074081
178	Phosphorylation	PDLPTTPYFSRDAQK CCCCCCCCCCCCHHH	16.46	26074081
185	Ubiquitination	YFSRDAQKHDVEVLE CCCCCHHHCCHHHHH	43.42	-
211	N-linked_Glycosylation	TLYKAFSNCSLPQGW HHHHHHCCCCCCCCC	16.97	UniProtKB CARBOHYD
256	Phosphorylation	RTYRLLGSLRTCIGN CHHHHHHHHHHHHCC	18.04	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASPH2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASPH2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASPH2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ASPH2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.