ZCHC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZCHC3_HUMAN
• UniProt AC: Q9NUD5
• Protein Name: Zinc finger CCHC domain-containing protein 3
• Gene Name: ZCCHC3
• Organism: Homo sapiens (Human).
• Sequence Length: 404
• Protein Sequence: MATGGGAEEERKRGRPQLLPPARPAARGEEADGGREKMGWAQVVKNLAEKKGEFREPRPPRREEESGGGGGSAGLGGPAGLAAPDLGDFPPAGRGDPKGRRRDPAGEAVDPRKKKGAAEAGRRKKAEAAAAAMATPARPGEAEDAAERPLQDEPAAAAAGPGKGRFLVRICFQGDEGACPTRDFVVGALILRSIGMDPSDIYAVIQIPGSREFDVSFRSAEKLALFLRVYEEKREQEDCWENFVVLGRSKSSLKTLFILFRNETVDVEDIVTWLKRHCDVLAVPVKVTDRFGIWTGEYKCEIELRQGEGGVRHLPGAFFLGAERGYSWYKGQPKTCFKCGSRTHMSGSCTQDRCFRCGEEGHLSPYCRKGIVCNLCGKRGHAFAQCPKAVHNSVAAQLTGVAGH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Ubiquitination	MGWAQVVKNLAEKKG CCHHHHHHHHHHHCC	47.60	22817900
45	Ubiquitination	MGWAQVVKNLAEKKG CCHHHHHHHHHHHCC	47.60	-
50	Ubiquitination	VVKNLAEKKGEFREP HHHHHHHHCCCCCCC	61.54	22817900
94	Methylation	GDFPPAGRGDPKGRR CCCCCCCCCCCCCCC	48.74	80702665
124	Acetylation	AAEAGRRKKAEAAAA HHHHHHHHHHHHHHH	55.78	70875
125	Acetylation	AEAGRRKKAEAAAAA HHHHHHHHHHHHHHH	50.04	70879
201	Phosphorylation	IGMDPSDIYAVIQIP CCCCHHHCEEEEECC	2.53	15592455
202	Phosphorylation	GMDPSDIYAVIQIPG CCCHHHCEEEEECCC	10.37	25147952
222	Ubiquitination	VSFRSAEKLALFLRV EECHHHHHHHHHHHH	38.48	-
275	Ubiquitination	EDIVTWLKRHCDVLA HHHHHHHHHHCCEEE	31.49	-
285	Ubiquitination	CDVLAVPVKVTDRFG CCEEEEEEEEECCCC	6.64	24816145
286	Ubiquitination	DVLAVPVKVTDRFGI CEEEEEEEEECCCCC	33.09	-
329	Ubiquitination	AERGYSWYKGQPKTC CCCCCCCCCCCCCEE	10.17	32015554
329	Neddylation	AERGYSWYKGQPKTC CCCCCCCCCCCCCEE	10.17	32015554
330	Ubiquitination	ERGYSWYKGQPKTCF CCCCCCCCCCCCEEE	44.82	-
350	Phosphorylation	THMSGSCTQDRCFRC CCCCCCCCCCCEECC	34.89	-
353	Methylation	SGSCTQDRCFRCGEE CCCCCCCCEECCCCC	16.20	115920341
363	Phosphorylation	RCGEEGHLSPYCRKG CCCCCCCCCCCCCCC	8.96	24719451
364	Phosphorylation	CGEEGHLSPYCRKGI CCCCCCCCCCCCCCE	14.24	25159151
366	Phosphorylation	EEGHLSPYCRKGIVC CCCCCCCCCCCCEEE	11.08	29396449
369	Ubiquitination	HLSPYCRKGIVCNLC CCCCCCCCCEEECCC	49.80	-
377	Ubiquitination	GIVCNLCGKRGHAFA CEEECCCCCCCCCHH	26.34	32015554
387	Ubiquitination	GHAFAQCPKAVHNSV CCCHHHCCHHHHHHH	18.63	32015554

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZCHC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZCHC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZCHC3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZCHC3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-202, AND MASSSPECTROMETRY.
PubMed: 15592455

Ubiquitylation

"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry.";
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.;
Proteomics 7:868-874(2007).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-45, AND MASSSPECTROMETRY.
PubMed: 17370265