ZKSC8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZKSC8_HUMAN
• UniProt AC: Q15776
• Protein Name: Zinc finger protein with KRAB and SCAN domains 8
• Gene Name: ZKSCAN8
• Organism: Homo sapiens (Human).
• Sequence Length: 578
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MAEESRKPSAPSPPDQTPEEDLVIVKVEEDHGWDQESSLHESNPLGQEVFRLRFRQLRYQETLGPREALIQLRALCHQWLRPDLNTKEQILELLVLEQFLTILPEELQTLVKEHQLENGEEVVTLLEDLERQIDILGRPVSARVHGHRVLWEEVVHSASAPEPPNTQLQSEATQHKSPVPQESQERAMSTSQSPTRSQKGSSGDQEMTATLLTAGFQTLEKIEDMAVSLIREEWLLDPSQKDLCRDNRPENFRNMFSLGGETRSENRELASKQVISTGIQPHGETAAKCNGDVIRGLEHEEARDLLGRLERQRGNPTQERRHKCDECGKSFAQSSGLVRHWRIHTGEKPYQCNVCGKAFSYRSALLSHQDIHNKVKRYHCKECGKAFSQNTGLILHQRIHTGEKPYQCNQCGKAFSQSAGLILHQRIHSGERPYECNECGKAFSHSSHLIGHQRIHTGEKPYECDECGKTFRRSSHLIGHQRSHTGEKPYKCNECGRAFSQKSGLIEHQRIHTGERPYKCKECGKAFNGNTGLIQHLRIHTGEKPYQCNECGKAFIQRSSLIRHQRIHSGEKSESISV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAEESRKPSAPS ---CCCCCCCCCCCC		26074081
9	Phosphorylation	AEESRKPSAPSPPDQ CCCCCCCCCCCCCCC		30266825
12	Phosphorylation	SRKPSAPSPPDQTPE CCCCCCCCCCCCCCC		29255136
17	Phosphorylation	APSPPDQTPEEDLVI CCCCCCCCCCCCEEE		30266825
26	Sumoylation	EEDLVIVKVEEDHGW CCCEEEEEEEECCCC		28112733
37	Phosphorylation	DHGWDQESSLHESNP CCCCCCCCCCCCCCC		28387310
38	Phosphorylation	HGWDQESSLHESNPL CCCCCCCCCCCCCCC		25849741
42	Phosphorylation	QESSLHESNPLGQEV CCCCCCCCCCCHHHH		30108239
59	Phosphorylation	LRFRQLRYQETLGPR HHHHHHHHHHHHCHH		-
62	Phosphorylation	RQLRYQETLGPREAL HHHHHHHHHCHHHHH		-
157	Phosphorylation	LWEEVVHSASAPEPP EHHHHHHHCCCCCCC		27251275
159	Phosphorylation	EEVVHSASAPEPPNT HHHHHHCCCCCCCCC		27251275
166	Phosphorylation	SAPEPPNTQLQSEAT CCCCCCCCCCCCHHH		30576142
170	Phosphorylation	PPNTQLQSEATQHKS CCCCCCCCHHHCCCC		30108239
173	Phosphorylation	TQLQSEATQHKSPVP CCCCCHHHCCCCCCC		30108239
176	Sumoylation	QSEATQHKSPVPQES CCHHHCCCCCCCHHH		28112733
177	Phosphorylation	SEATQHKSPVPQESQ CHHHCCCCCCCHHHH		29255136
183	Phosphorylation	KSPVPQESQERAMST CCCCCHHHHHHHHHC		17525332
189	Phosphorylation	ESQERAMSTSQSPTR HHHHHHHHCCCCCCC		28450419
190	Phosphorylation	SQERAMSTSQSPTRS HHHHHHHCCCCCCCC		28176443
191	Phosphorylation	QERAMSTSQSPTRSQ HHHHHHCCCCCCCCC		17525332
193	Phosphorylation	RAMSTSQSPTRSQKG HHHHCCCCCCCCCCC		29255136
195	Phosphorylation	MSTSQSPTRSQKGSS HHCCCCCCCCCCCCC		17525332
197	Phosphorylation	TSQSPTRSQKGSSGD CCCCCCCCCCCCCCC		20363803
199	Ubiquitination	QSPTRSQKGSSGDQE CCCCCCCCCCCCCHH		-
199	Sumoylation	QSPTRSQKGSSGDQE CCCCCCCCCCCCCHH		28112733
201	Phosphorylation	PTRSQKGSSGDQEMT CCCCCCCCCCCHHHH		-
228	Phosphorylation	KIEDMAVSLIREEWL HHHHHHHHHHHHHHH		29457462
241	Ubiquitination	WLLDPSQKDLCRDNR HHCCHHHHHHCCCCC		-
257	Phosphorylation	ENFRNMFSLGGETRS HHHHHHHHCCCCCHH		28555341
272	Ubiquitination	ENRELASKQVISTGI HHHHHHHHHHHHCCC		-
272	Sumoylation	ENRELASKQVISTGI HHHHHHHHHHHHCCC		28112733
288	Sumoylation	PHGETAAKCNGDVIR CCCHHHHHCCCCHHC		28112733
288	Ubiquitination	PHGETAAKCNGDVIR CCCHHHHHCCCCHHC		-
317	Phosphorylation	ERQRGNPTQERRHKC HHHCCCCCHHHHHCC		20068231
330	Phosphorylation	KCDECGKSFAQSSGL CCHHHHHHHHHHCCC		28555341
345	Phosphorylation	VRHWRIHTGEKPYQC EEEEEEECCCCCEEC		28111955
374	Sumoylation	SHQDIHNKVKRYHCK HCHHHHHHHHHHHHH		28112733
401	Phosphorylation	ILHQRIHTGEKPYQC EEEEEEECCCCCCCC		26055452
413	Sumoylation	YQCNQCGKAFSQSAG CCCCCCHHHHHHCCC		-
413	Sumoylation	YQCNQCGKAFSQSAG CCCCCCHHHHHHCCC		-
429	Phosphorylation	ILHQRIHSGERPYEC HHHHHHCCCCCCEEC		25159151
441	Sumoylation	YECNECGKAFSHSSH EECCCCHHCCCCCHH		28112733
446	Phosphorylation	CGKAFSHSSHLIGHQ CHHCCCCCHHHCCCC		-
447	Phosphorylation	GKAFSHSSHLIGHQR HHCCCCCHHHCCCCC		-
457	Phosphorylation	IGHQRIHTGEKPYEC CCCCCCCCCCCCCCC		25159151
470	Phosphorylation	ECDECGKTFRRSSHL CCCCCCCCCCCCCCC		24719451
475	Phosphorylation	GKTFRRSSHLIGHQR CCCCCCCCCCCCCCC		28555341
483	Phosphorylation	HLIGHQRSHTGEKPY CCCCCCCCCCCCCCC		24719451
485	Phosphorylation	IGHQRSHTGEKPYKC CCCCCCCCCCCCCCC		24719451
502	Ubiquitination	CGRAFSQKSGLIEHQ CHHHHHCCCCCEECC		-
502	Sumoylation	CGRAFSQKSGLIEHQ CHHHHHCCCCCEECC		-
502	Sumoylation	CGRAFSQKSGLIEHQ CHHHHHCCCCCEECC		28112733
513	Phosphorylation	IEHQRIHTGERPYKC EECCEECCCCCCEEC		27251275
519	Acetylation	HTGERPYKCKECGKA CCCCCCEECCCCCCC		20167786
521	Acetylation	GERPYKCKECGKAFN CCCCEECCCCCCCCC		20167786
531	Phosphorylation	GKAFNGNTGLIQHLR CCCCCCCCCCEEEEE		28555341
541	Phosphorylation	IQHLRIHTGEKPYQC EEEEEEECCCCCEEC		21712546
560	Phosphorylation	KAFIQRSSLIRHQRI HHHHHHHHHHHHCCC		24719451
569	Phosphorylation	IRHQRIHSGEKSESI HHHCCCCCCCCCCCC		26055452
572	Sumoylation	QRIHSGEKSESISV- CCCCCCCCCCCCCC-		-
572	Sumoylation	QRIHSGEKSESISV- CCCCCCCCCCCCCC-		28112733
577	Phosphorylation	GEKSESISV------ CCCCCCCCC------		26425664

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZKSC8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZKSC8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZKSC8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN165_HUMAN	ZNF165	physical	10567577
ZNF24_HUMAN	ZNF24	physical	10567577
ZKSC8_HUMAN	ZKSCAN8	physical	10567577

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.