REXO4_HUMAN - dbPTM
REXO4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID REXO4_HUMAN
UniProt AC Q9GZR2
Protein Name RNA exonuclease 4
Gene Name REXO4
Organism Homo sapiens (Human).
Sequence Length 422
Subcellular Localization Nucleus, nucleolus .
Protein Description
Protein Sequence MGKAKVPASKRAPSSPVAKPGPVKTLTRKKNKKKKRFWKSKAREVSKKPASGPGAVVRPPKAPEDFSQNWKALQEWLLKQKSQAPEKPLVISQMGSKKKPKIIQQNKKETSPQVKGEEMPAGKDQEASRGSVPSGSKMDRRAPVPRTKASGTEHNKKGTKERTNGDIVPERGDIEHKKRKAKEAAPAPPTEEDIWFDDVDPADIEAAIGPEAAKIARKQLGQSEGSVSLSLVKEQAFGGLTRALALDCEMVGVGPKGEESMAARVSIVNQYGKCVYDKYVKPTEPVTDYRTAVSGIRPENLKQGEELEVVQKEVAEMLKGRILVGHALHNDLKVLFLDHPKKKIRDTQKYKPFKSQVKSGRPSLRLLSEKILGLQVQQAEHCSIQDAQAAMRLYVMVKKEWESMARDRRPLLTAPDHCSDDA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Methylation-----MGKAKVPASK
-----CCCCCCCHHH		43.68116253741
5Methylation---MGKAKVPASKRA
---CCCCCCCHHHCC		52.84116253745
14PhosphorylationPASKRAPSSPVAKPG
CHHHCCCCCCCCCCC		46.4129255136
15PhosphorylationASKRAPSSPVAKPGP
HHHCCCCCCCCCCCC		23.4929255136
19AcetylationAPSSPVAKPGPVKTL
CCCCCCCCCCCCCCC		51.2226051181
24AcetylationVAKPGPVKTLTRKKN
CCCCCCCCCCCCCCC		40.7325953088
25PhosphorylationAKPGPVKTLTRKKNK
CCCCCCCCCCCCCCH		33.3326074081
27PhosphorylationPGPVKTLTRKKNKKK
CCCCCCCCCCCCHHH		45.7526074081
46PhosphorylationKSKAREVSKKPASGP
HHHHHHHHCCCCCCC		30.1520860994
51PhosphorylationEVSKKPASGPGAVVR
HHHCCCCCCCCCCCC		54.79-
82PhosphorylationEWLLKQKSQAPEKPL
HHHHHCHHCCCCCCE		29.1320860994
87AcetylationQKSQAPEKPLVISQM
CHHCCCCCCEEEEEC		42.4625953088
92PhosphorylationPEKPLVISQMGSKKK
CCCCEEEEECCCCCC		13.4625159151
96PhosphorylationLVISQMGSKKKPKII
EEEEECCCCCCCHHH		35.6425159151
97AcetylationVISQMGSKKKPKIIQ
EEEECCCCCCCHHHH		60.1225953088
1072-HydroxyisobutyrylationPKIIQQNKKETSPQV
CHHHHCCCCCCCCCC		47.88-
110PhosphorylationIQQNKKETSPQVKGE
HHCCCCCCCCCCCCC		55.3728176443
111PhosphorylationQQNKKETSPQVKGEE
HCCCCCCCCCCCCCC		17.9025159151
115SumoylationKETSPQVKGEEMPAG
CCCCCCCCCCCCCCC		56.1928112733
115 (in isoform 2)Phosphorylation-56.1920860994
115SumoylationKETSPQVKGEEMPAG
CCCCCCCCCCCCCCC		56.19-
116 (in isoform 2)Phosphorylation-36.9220860994
123AcetylationGEEMPAGKDQEASRG
CCCCCCCCCCCHHCC		59.3426051181
128PhosphorylationAGKDQEASRGSVPSG
CCCCCCHHCCCCCCC		36.1024732914
129MethylationGKDQEASRGSVPSGS
CCCCCHHCCCCCCCC		48.75115491155
131PhosphorylationDQEASRGSVPSGSKM
CCCHHCCCCCCCCCC		29.7325159151
136PhosphorylationRGSVPSGSKMDRRAP
CCCCCCCCCCCCCCC		29.1920860994
163PhosphorylationKKGTKERTNGDIVPE
CCCCCCCCCCCCCCC		44.6521406692
214UbiquitinationAIGPEAAKIARKQLG
HHCHHHHHHHHHHHC		43.90-
223PhosphorylationARKQLGQSEGSVSLS
HHHHHCCCCCCEEHH		41.9725159151
226PhosphorylationQLGQSEGSVSLSLVK
HHCCCCCCEEHHHHH		12.4125159151
228PhosphorylationGQSEGSVSLSLVKEQ
CCCCCCEEHHHHHHH		17.5924043423
230PhosphorylationSEGSVSLSLVKEQAF
CCCCEEHHHHHHHHC		24.5024719451
256UbiquitinationEMVGVGPKGEESMAA
EEECCCCCCCHHHHH		73.38-
273AcetylationSIVNQYGKCVYDKYV
HHHHHCCCEECCCCC		18.6526051181
278AcetylationYGKCVYDKYVKPTEP
CCCEECCCCCCCCCC		33.9726051181
281UbiquitinationCVYDKYVKPTEPVTD
EECCCCCCCCCCCCC		43.03-
294PhosphorylationTDYRTAVSGIRPENL
CCHHHHHCCCCHHHC		26.4923607784
302AcetylationGIRPENLKQGEELEV
CCCHHHCCCCCCCHH		68.7726051181
302UbiquitinationGIRPENLKQGEELEV
CCCHHHCCCCCCCHH		68.77-
333AcetylationHALHNDLKVLFLDHP
EHHHCCEEEEEECCC		39.4926051181
355PhosphorylationQKYKPFKSQVKSGRP
CCCCCCHHHHHCCCC		40.3530576142
359PhosphorylationPFKSQVKSGRPSLRL
CCHHHHHCCCCHHHH		40.9730576142
363PhosphorylationQVKSGRPSLRLLSEK
HHHCCCCHHHHHHHH		25.4330576142
368PhosphorylationRPSLRLLSEKILGLQ
CCHHHHHHHHHHCCH		41.2424719451
398AcetylationMRLYVMVKKEWESMA
HHHHHHHHHHHHHHH		27.2126051181
413PhosphorylationRDRRPLLTAPDHCSD
CCCCCCCCCCCCCCC		43.7723186163
419PhosphorylationLTAPDHCSDDA----
CCCCCCCCCCC----		34.8023401153
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of REXO4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of REXO4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of REXO4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ESR1_HUMANESR1physical
10908561
ESR2_HUMANESR2physical
10908561
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of REXO4_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, AND MASSSPECTROMETRY.

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