| UniProt ID | HELZ2_HUMAN | |
|---|---|---|
| UniProt AC | Q9BYK8 | |
| Protein Name | Helicase with zinc finger domain 2 | |
| Gene Name | HELZ2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 2649 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.. | |
| Protein Sequence | MAVWEAEQLGGLQRGDLLTPPAPDGDGRTAPLGQPPGAQLYCPACLVTCHSQEAFENHCASSEHAQMVAFDQALPWEHRSPPPGLSKFELCPKPDLCEYGDACTKAHSAQELQEWVRRTQAVELRGQAAWQDGLVPYQERLLAEYQRSSSEVLVLAETLDGVRVTCNQPLMYQAQERKTQYSWTFAVHSEEPLLHVALLKQEPGADFSLVAPGLPPGRLYARGERFRVPSSTADFQVGVRVQAASFGTFEQWVVFDFGRRPVLLQKLGLQLGQGRRPGPCRNLALGHPEEMERWHTGNRHVVPGVERTAEQTALMAKYKGPALALEFNRSSVASGPISPTNYRQRMHQFLYEEEAAQQQLVAKLTLRGQVFLKTALQTPALNMLFAPPGALYAEVPVPSSLMPDTDQGFLLGRAVSTALVAPVPAPDNTVFEVRLERRASSEQALWLLLPARCCLALGLQPEARLVLEVQFQIDPMTFRLWHQAVDTLPEEQLVVPDLPTCALPRPWSVPPLRRGNRKQELAVALIAGWGPGDGRRVPPLLIYGPFGTGKTYTLAMASLEVIRRPETKVLICTHTNSAADIYIREYFHSHVSGGHPEATPLRVMYTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTTTSQARELRVPVGFFSHILIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVTPRLFSVARARAAEHTLLHRLFLCYQQETHEVARQSRLVFHENYRCTDAIVSFISRHFYVAKGNPIHARGKVPPHPRHYPLMFCHVAGSPDRDMSMASWLNLAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGAQVSALRQELRRRDLGQVSVGSFEILPGRQFRVVVLSTVHTCQSLLSPGALAPEFFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPEGLSMEQVEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEPGDEALSPASRDITATTAQTEAAAAPAGDAVKEDVVPGACAAGAAAAAGVESTEAEDAEADFWPWDGELNADDAILRELLDESQKVMVTVGEDGLLDTVARPESLQQARLYENLPPAALRKLLHAEPERYRHCSFVPETFERASAIPLDDASSGPIQVRGRLDCGMAFAGDEVLVQLLSGDKAPEGRLRGRVLGVLKRKRHELAFVCRMDTWDPRIMVPINGSVTKIFVAELKDPSQVPIYSLRKGRLQRVGLERLTAEARHSRLFWVQIVLWRQGFYYPLGIVREVLPEASTWEQGLRILGLEYSLRVPPSDQATITKVLQKYHTELGRVAGRREDCRAFLTFTVDPQGACNLDDALSVRDLGPRCEVAVHITDVASFVPRDGVLDVEARRQGAAFYAPGREPVPMLPASLCQDVLSLLPGRDRLAISLFLTMEKASGQLKSLRFAPSVVQSDRQLSYEEAEEVIRQHPGAGRELPARLDSVDACVVAACYFSRLLRRHRLRSDCFYEQPDEDGTLGFRAAHIMVKEYMIQFNRLVAEFLVGSECTRTVTPLRWQPAPRSQQLKALCEKHGDRVPLSLHLGHHLHGGGGSPPDTRLHLLASLWKQVQFAARTQDYEQMVDLVTTDDMHPFLAPAGRDLRKALERSAFGRCARGHQQQGGHYSLQVDWYTWATSPIRRYLDVVLQRQILLALGHGGSAYSARDIDGLCQAFSLQHALAQSYQRRARSLHLAVQLKAQPLDKLGFVVDVEAGSRCFRLLFPSNRETLPDPCPVPYGSLQLAEHPHALAGRPGLRLLWRRRVYSAQGSSPPLPLPGTVPDPHTLAVETALWKQLLELVELQRWPEAAALIQEKGEASQRRELVQVQRSHCGHFLEVARELGSGDTLQVQLGTSLQHGFLVPSPQLWTVAPGFSLCLEHVERPGDCFSGRVYRAPRDRYRDVDEYACVWEPFCALESATGAVAENDSVTLQHLSVSWEASRTPQGQLQGAFRLEAAFLEENCADINFSCCYLCIRLEGLPAPTASPRPGPSSLGPGLNVDPGTYTWVAHGQTQDWDQERRADRQEAPRRVHLFVHHMGMEKVPEEVLRPGTLFTVELLPKQLPDLRKEEAVRGLEEASPLVTSIALGRPVPQPLCRVIPSRFLERQTYNIPGGRHKLNPSQNVAVREALEKPFTVIQGPPGTGKTIVGLHIVFWFHKSNQEQVQPGGPPRGEKRLGGPCILYCGPSNKSVDVLAGLLLRRMELKPLRVYSEQAEASEFPVPRVGSRKLLRKSPREGRPNQSLRSITLHHRIRQAPNPYSSEIKAFDTRLQRGELFSREDLVWYKKVLWEARKFELDRHEVILCTCSCAASASLKILDVRQILVDEAGMATEPETLIPLVQFPQAEKVVLLGDHKQLRPVVKNERLQNLGLDRSLFERYHEDAHMLDTQYRMHEGICAFPSVAFYKSKLKTWQGLRRPPSVLGHAGKESCPVIFGHVQGHERSLLVSTDEGNENSKANLEEVAEVVRITKQLTLGRTVEPQDIAVLTPYNAQASEISKALRREGIAGVAVSSITKSQGSEWRYVLVSTVRTCAKSDLDQRPTKSWLKKFLGFVVDPNQVNVAVTRAQEGLCLIGDHLLLRCCPLWRSLLDFCEAQQTLVPAGQVRVCRRPTMPS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 (in isoform 2) | Phosphorylation | - | 23663014 | ||
| 3 (in isoform 2) | Phosphorylation | - | 23663014 | ||
| 4 (in isoform 2) | Phosphorylation | - | 23663014 | ||
| 6 (in isoform 2) | Phosphorylation | - | 23663014 | ||
| 8 (in isoform 2) | Phosphorylation | - | 23663014 | ||
| 13 (in isoform 2) | Phosphorylation | - | 23663014 | ||
| 14 (in isoform 4) | Phosphorylation | - | 20068231 | ||
| 15 (in isoform 4) | Phosphorylation | - | 20068231 | ||
| 19 (in isoform 4) | Phosphorylation | - | 20068231 | ||
| 19 | Phosphorylation | LQRGDLLTPPAPDGD CCCCCCCCCCCCCCC | 23312004 | ||
| 26 (in isoform 4) | Phosphorylation | - | 20068231 | ||
| 27 (in isoform 4) | Phosphorylation | - | 20068231 | ||
| 31 (in isoform 4) | Phosphorylation | - | 20068231 | ||
| 36 (in isoform 4) | Phosphorylation | - | 23663014 | ||
| 37 (in isoform 4) | Phosphorylation | - | 23663014 | ||
| 38 (in isoform 4) | Phosphorylation | - | 23663014 | ||
| 40 (in isoform 4) | Phosphorylation | - | 23663014 | ||
| 42 (in isoform 4) | Phosphorylation | - | 23663014 | ||
| 47 (in isoform 4) | Phosphorylation | - | 23663014 | ||
| 80 | Phosphorylation | ALPWEHRSPPPGLSK CCCCCCCCCCCCCCC | 28674419 | ||
| 148 | Phosphorylation | LLAEYQRSSSEVLVL HHHHHHCCCCCEEEE | 24719451 | ||
| 149 | Phosphorylation | LAEYQRSSSEVLVLA HHHHHCCCCCEEEEE | 27251275 | ||
| 150 | Phosphorylation | AEYQRSSSEVLVLAE HHHHCCCCCEEEEEE | 27251275 | ||
| 317 | Ubiquitination | EQTALMAKYKGPALA HHHHHHHHHCCCEEE | - | ||
| 330 | Phosphorylation | LALEFNRSSVASGPI EEEEECHHHCCCCCC | 29396449 | ||
| 331 | Phosphorylation | ALEFNRSSVASGPIS EEEECHHHCCCCCCC | 29396449 | ||
| 334 | Phosphorylation | FNRSSVASGPISPTN ECHHHCCCCCCCCCC | 29396449 | ||
| 338 | Phosphorylation | SVASGPISPTNYRQR HCCCCCCCCCCHHHH | 28355574 | ||
| 340 | Phosphorylation | ASGPISPTNYRQRMH CCCCCCCCCHHHHHH | 30278072 | ||
| 342 | Phosphorylation | GPISPTNYRQRMHQF CCCCCCCHHHHHHHH | 29396449 | ||
| 440 | Phosphorylation | VRLERRASSEQALWL EEEEECCCHHHHHHH | 28348404 | ||
| 441 | Phosphorylation | RLERRASSEQALWLL EEEECCCHHHHHHHH | 28348404 | ||
| 551 | Phosphorylation | GPFGTGKTYTLAMAS CCCCCCHHHHHEEEE | 23403867 | ||
| 553 | Phosphorylation | FGTGKTYTLAMASLE CCCCHHHHHEEEEEH | 23403867 | ||
| 558 | Phosphorylation | TYTLAMASLEVIRRP HHHHEEEEEHHHHCC | 23403867 | ||
| 573 | Phosphorylation | ETKVLICTHTNSAAD CCEEEEEECCCCHHH | - | ||
| 582 | Phosphorylation | TNSAADIYIREYFHS CCCHHHHHHHHHHHH | 23663014 | ||
| 700 | Phosphorylation | AGDHMQVTPRLFSVA ECCCCCCCHHHHHHH | 20068231 | ||
| 724 | Phosphorylation | LHRLFLCYQQETHEV HHHHHHHHHHHHHHH | 20068231 | ||
| 728 | Phosphorylation | FLCYQQETHEVARQS HHHHHHHHHHHHHHH | 20068231 | ||
| 754 | Phosphorylation | DAIVSFISRHFYVAK HHHHHHHHHHCEEEC | 24719451 | ||
| 788 | Phosphorylation | MFCHVAGSPDRDMSM EEEEECCCCCCCCCH | - | ||
| 815 | Phosphorylation | VEKVQEAYNTWPSCW HHHHHHHHHHCCCCC | - | ||
| 817 | Phosphorylation | KVQEAYNTWPSCWGG HHHHHHHHCCCCCCC | 26503892 | ||
| 820 | Phosphorylation | EAYNTWPSCWGGREQ HHHHHCCCCCCCCCC | 26503892 | ||
| 900 | Phosphorylation | TDARVLNTVLTRAQS CCHHHHHHHHHHHHH | - | ||
| 1006 | Phosphorylation | EPGDEALSPASRDIT CCCCCCCCHHHCCCC | 28355574 | ||
| 1009 | Phosphorylation | DEALSPASRDITATT CCCCCHHHCCCCCCC | 23403867 | ||
| 1082 | Phosphorylation | LRELLDESQKVMVTV HHHHHHCCCCEEEEE | 21815630 | ||
| 1103 | Phosphorylation | DTVARPESLQQARLY CCCCCCHHHHHHHHH | 22210691 | ||
| 1138 | Phosphorylation | HCSFVPETFERASAI CCCCCCHHHHHHCCC | 26074081 | ||
| 1143 | Phosphorylation | PETFERASAIPLDDA CHHHHHHCCCCCCCC | 26074081 | ||
| 1151 | Phosphorylation | AIPLDDASSGPIQVR CCCCCCCCCCCCEEE | 25850435 | ||
| 1152 | Phosphorylation | IPLDDASSGPIQVRG CCCCCCCCCCCEEEE | 25850435 | ||
| 1196 | Methylation | GRVLGVLKRKRHELA HHHHHHHHCCCCEEE | 115975679 | ||
| 1210 | Phosphorylation | AFVCRMDTWDPRIMV EEEEECCCCCCCEEE | - | ||
| 1241 | Phosphorylation | PSQVPIYSLRKGRLQ HHHCCEEECCCCCCH | 24719451 | ||
| 1304 | Phosphorylation | LRILGLEYSLRVPPS HHEECEEEEEECCCC | 20068231 | ||
| 1305 | Phosphorylation | RILGLEYSLRVPPSD HEECEEEEEECCCCH | 24719451 | ||
| 1315 | Phosphorylation | VPPSDQATITKVLQK CCCCHHHHHHHHHHH | - | ||
| 1325 | Phosphorylation | KVLQKYHTELGRVAG HHHHHHHHHHHHHCC | 24719451 | ||
| 1417 | Phosphorylation | SLCQDVLSLLPGRDR HHHHHHHHHCCCCCH | 27067055 | ||
| 1428 | Phosphorylation | GRDRLAISLFLTMEK CCCHHHHHHHHHHHH | 27067055 | ||
| 1432 | Phosphorylation | LAISLFLTMEKASGQ HHHHHHHHHHHHCCC | 27067055 | ||
| 1503 | Phosphorylation | LRRHRLRSDCFYEQP HHHHCCCCCCCCCCC | 19690332 | ||
| 1507 | Phosphorylation | RLRSDCFYEQPDEDG CCCCCCCCCCCCCCC | 17053785 | ||
| 1564 | Methylation | APRSQQLKALCEKHG CCHHHHHHHHHHHHC | 24129315 | ||
| 1583 | Ubiquitination | LSLHLGHHLHGGGGS EEEEECCCCCCCCCC | 29967540 | ||
| 1615 | Phosphorylation | FAARTQDYEQMVDLV HHHHCCCHHHHHCCC | - | ||
| 1696 | Phosphorylation | LALGHGGSAYSARDI HHHCCCCCCCCHHCH | 22210691 | ||
| 1698 | Phosphorylation | LGHGGSAYSARDIDG HCCCCCCCCHHCHHH | 22210691 | ||
| 1711 | Phosphorylation | DGLCQAFSLQHALAQ HHHHHHHHHHHHHHH | 30206219 | ||
| 1751 | Phosphorylation | VVDVEAGSRCFRLLF EEEEECCCEEEEECC | 18452278 | ||
| 1821 | Ubiquitination | TVPDPHTLAVETALW CCCCHHHHHHHHHHH | 29967540 | ||
| 1922 (in isoform 4) | Ubiquitination | - | 21906983 | ||
| 1922 | Ubiquitination | HVERPGDCFSGRVYR CCCCCCCCCCCCEEE | 22817900 | ||
| 1922 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 1936 | Ubiquitination | RAPRDRYRDVDEYAC ECCCHHCCCCHHHHH | 29967540 | ||
| 1955 | Phosphorylation | FCALESATGAVAEND CEEHHCCCCCEECCC | 18452278 | ||
| 2019 | Phosphorylation | LEGLPAPTASPRPGP HCCCCCCCCCCCCCC | 30266825 | ||
| 2021 | Phosphorylation | GLPAPTASPRPGPSS CCCCCCCCCCCCCCC | 30266825 | ||
| 2027 | Phosphorylation | ASPRPGPSSLGPGLN CCCCCCCCCCCCCCE | 28348404 | ||
| 2028 | Phosphorylation | SPRPGPSSLGPGLNV CCCCCCCCCCCCCEE | 28348404 | ||
| 2152 | Ubiquitination | NIPGGRHKLNPSQNV ECCCCCCCCCHHHCH | 29967540 | ||
| 2294 | Phosphorylation | IRQAPNPYSSEIKAF HHCCCCCCCHHHHHH | 22210691 | ||
| 2295 | Phosphorylation | RQAPNPYSSEIKAFD HCCCCCCCHHHHHHC | 22210691 | ||
| 2296 | Phosphorylation | QAPNPYSSEIKAFDT CCCCCCCHHHHHHCH | 24719451 | ||
| 2390 | Ubiquitination | VVLLGDHKQLRPVVK EEEECCCCCCCHHHC | 29967540 | ||
| 2491 | Ubiquitination | DEGNENSKANLEEVA CCCCCCCCCCHHHHH | 22817900 | ||
| 2491 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 2505 | Ubiquitination | AEVVRITKQLTLGRT HHHHHHHCCEECCCC | 29967540 | ||
| 2547 | Phosphorylation | IAGVAVSSITKSQGS CCEEEEEEEECCCCC | 22468782 | ||
| 2558 | Phosphorylation | SQGSEWRYVLVSTVR CCCCCEEEEEEEEHH | 26657352 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HELZ2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HELZ2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HELZ2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of HELZ2_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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