EXOSX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXOSX_HUMAN
• UniProt AC: Q01780
• Protein Name: Exosome component 10
• Gene Name: EXOSC10
• Organism: Homo sapiens (Human).
• Sequence Length: 885
• Subcellular Localization: Cytoplasm. Nucleus, nucleolus. Nucleus. Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.
• Protein Description: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA..
• Protein Sequence: MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEYDFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDANDVILERVGILLDEASGVNKNQQPVLPAGLQVPKTVVSSWNRKAAEYGKKAKSETFRLLHAKNIIRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSKERRERPQDRPEDLDVPPALADFIHQQRTQQVEQDMFAHPYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVELNEKLLNCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMYILNESLTDPAIVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGRHSLDHLLKLYCNVDSNKQYQLADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEMWERGNGQPVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNWPQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	TREPRVLSATSATKS CCCCCEEECCCCCCC	27.00	25159151
15	Phosphorylation	EPRVLSATSATKSDG CCCEEECCCCCCCCC	18.60	21406692
16	Phosphorylation	PRVLSATSATKSDGE CCEEECCCCCCCCCC	33.39	25159151
18	Phosphorylation	VLSATSATKSDGEMV EEECCCCCCCCCCEE	30.74	24719451
19	Ubiquitination	LSATSATKSDGEMVL EECCCCCCCCCCEEC	46.39	-
19	Sumoylation	LSATSATKSDGEMVL EECCCCCCCCCCEEC	46.39	28112733
24	Sulfoxidation	ATKSDGEMVLPGFPD CCCCCCCEECCCCCC	4.60	21406390
37	Acetylation	PDADSFVKFALGSVV CCHHHHHHHHHCCEE	23.94	20167786
48	Ubiquitination	GSVVAVTKASGGLPQ CCEEEEEECCCCCCC	33.68	-
79	Methylation	FCETQGDRLLQCMSR HHHHHHHHHHHHHHH	44.09	-
90	Phosphorylation	CMSRVMQYHGCRSNI HHHHHHHHHCCCCCC	5.10	-
109	Acetylation	KVTELEDKFDLLVDA HCCHHHHHHHEEECC	31.25	30588635
136	Ubiquitination	DEASGVNKNQQPVLP HCCCCCCCCCCCCCC	54.44	22817900
136 (in isoform 1)	Ubiquitination	-	54.44	21906983
136 (in isoform 2)	Ubiquitination	-	54.44	21906983
150	Ubiquitination	PAGLQVPKTVVSSWN CCCCCCCCHHHHHHH	55.91	29967540
155	Phosphorylation	VPKTVVSSWNRKAAE CCCHHHHHHHHHHHH	19.43	25627689
168	Sumoylation	AEYGKKAKSETFRLL HHHHHHHHHHHHHHH	58.67	-
168	Sumoylation	AEYGKKAKSETFRLL HHHHHHHHHHHHHHH	58.67	-
178	Ubiquitination	TFRLLHAKNIIRPQL HHHHHHHHHCCCCCH	37.62	29967540
178	Acetylation	TFRLLHAKNIIRPQL HHHHHHHHHCCCCCH	37.62	25953088
186	Ubiquitination	NIIRPQLKFREKIDN HCCCCCHHHHHHCCC	36.81	29967540
190	Ubiquitination	PQLKFREKIDNSNTP CCHHHHHHCCCCCCC	51.62	33845483
194	Phosphorylation	FREKIDNSNTPFLPK HHHHCCCCCCCCCCE	38.03	29396449
196	Phosphorylation	EKIDNSNTPFLPKIF HHCCCCCCCCCCEEC	18.42	25159151
201	Sumoylation	SNTPFLPKIFIKPNA CCCCCCCEECCCCCC	53.01	-
205	Sumoylation	FLPKIFIKPNAQKPL CCCEECCCCCCCCCC	22.82	-
205	Sumoylation	FLPKIFIKPNAQKPL CCCEECCCCCCCCCC	22.82	-
205	Ubiquitination	FLPKIFIKPNAQKPL CCCEECCCCCCCCCC	22.82	27667366
210	Ubiquitination	FIKPNAQKPLPQALS CCCCCCCCCCCHHHC	46.22	-
217	Phosphorylation	KPLPQALSKERRERP CCCCHHHCHHHHHCC	35.17	25159151
218	Ubiquitination	PLPQALSKERRERPQ CCCHHHCHHHHHCCC	56.97	33845483
218	Acetylation	PLPQALSKERRERPQ CCCHHHCHHHHHCCC	56.97	26051181
278	Ubiquitination	VLQKPQPQLYRPIEE HCCCCCCCCCCCCCC	45.97	21987572
294	Ubiquitination	PCHFISSLDELVELN CCCHHCCHHHHHHHH	4.78	21987572
347	Ubiquitination	IDTLELRSDMYILNE EEEEHHCCCEEEECC	39.08	24816145
352	Ubiquitination	LRSDMYILNESLTDP HCCCEEEECCCCCCH	2.99	24816145
363	Ubiquitination	LTDPAIVKVFHGADS CCCHHHHHHHCCCCC	32.82	24816145
365	Ubiquitination	DPAIVKVFHGADSDI CHHHHHHHCCCCCCH	3.49	24816145
368	Ubiquitination	IVKVFHGADSDIEWL HHHHHCCCCCCHHHH	12.45	24816145
370	Phosphorylation	KVFHGADSDIEWLQK HHHCCCCCCHHHHHH	39.70	-
370	Ubiquitination	KVFHGADSDIEWLQK HHHCCCCCCHHHHHH	39.70	24816145
381	Ubiquitination	WLQKDFGLYVVNMFD HHHHHHCEEEEECCC	2.71	24816145
386	Ubiquitination	FGLYVVNMFDTHQAA HCEEEEECCCHHHHH	1.86	24816145
408	Acetylation	HSLDHLLKLYCNVDS CCHHHHHHHHCCCCC	43.71	26051181
417	Ubiquitination	YCNVDSNKQYQLADW HCCCCCCCCEEECCE	55.10	21963094
417	Acetylation	YCNVDSNKQYQLADW HCCCCCCCCEEECCE	55.10	26051181
419	Phosphorylation	NVDSNKQYQLADWRI CCCCCCCEEECCEEE	13.70	27642862
441	Phosphorylation	LSYARDDTHYLLYIY HHHCCCCCEEEEEEE	19.40	21406692
443	Phosphorylation	YARDDTHYLLYIYDK HCCCCCEEEEEEEHH	10.65	21406692
446	Phosphorylation	DDTHYLLYIYDKMRL CCCEEEEEEEHHHHH	8.54	21406692
448	Phosphorylation	THYLLYIYDKMRLEM CEEEEEEEHHHHHHH	8.92	21406692
450	Acetylation	YLLYIYDKMRLEMWE EEEEEEHHHHHHHHH	14.67	26051181
480	Acetylation	SRDICLKKFIKPIFT CHHHHHHHHHHCCCC	39.10	26051181
483	Sumoylation	ICLKKFIKPIFTDES HHHHHHHHCCCCCHH	34.88	-
483	Sumoylation	ICLKKFIKPIFTDES HHHHHHHHCCCCCHH	34.88	-
490	Phosphorylation	KPIFTDESYLELYRK HCCCCCHHHHHHHHH	37.52	18452278
490 (in isoform 2)	Phosphorylation	-	37.52	-
491	Phosphorylation	PIFTDESYLELYRKQ CCCCCHHHHHHHHHH	11.36	18452278
491 (in isoform 2)	Phosphorylation	-	11.36	-
530	Phosphorylation	REDESYGYVLPNHMM CCCCCCCCCCCCCHH	7.20	-
583	Sumoylation	AREMPLLKSEVAAGV HHHCCCHHHHHHHCC	52.86	-
583	Sumoylation	AREMPLLKSEVAAGV HHHCCCHHHHHHHCC	52.86	25114211
583	Ubiquitination	AREMPLLKSEVAAGV HHHCCCHHHHHHHCC	52.86	29967540
591	Ubiquitination	SEVAAGVKKSGPLPS HHHHHCCCCCCCCCC	40.06	33845483
592	Ubiquitination	EVAAGVKKSGPLPSA HHHHCCCCCCCCCCH	59.23	29967540
593	Phosphorylation	VAAGVKKSGPLPSAE HHHCCCCCCCCCCHH	39.67	25159151
598	Phosphorylation	KKSGPLPSAERLENV CCCCCCCCHHHHHCC	50.90	30177828
633	Ubiquitination	SGSVPVQKQASLFPD CCCCCCCCCHHCCCC	48.33	29967540
636	Phosphorylation	VPVQKQASLFPDEKE CCCCCCHHCCCCCCC	28.22	21815630
642	Sumoylation	ASLFPDEKEDNLLGT HHCCCCCCCCCCCHH	77.18	-
649	Phosphorylation	KEDNLLGTTCLIATA CCCCCCHHHHHHHHH	17.82	26074081
650	Phosphorylation	EDNLLGTTCLIATAV CCCCCHHHHHHHHHH	11.97	26074081
655	Phosphorylation	GTTCLIATAVITLFN HHHHHHHHHHHHHHC	17.92	26074081
659	Phosphorylation	LIATAVITLFNEPSA HHHHHHHHHHCCCCC	20.78	26074081
671	Ubiquitination	PSAEDSKKGPLTVAQ CCCCHHCCCCCCHHH	70.48	29967540
679	Ubiquitination	GPLTVAQKKAQNIME CCCCHHHHHHHHHHH	40.10	29967540
680	Ubiquitination	PLTVAQKKAQNIMES CCCHHHHHHHHHHHH	43.03	-
698	Phosphorylation	PFRMFLPSLGHRAPV HHHHHHHHHCCCCCH	49.48	21406692
710	Sumoylation	APVSQAAKFDPSTKI CCHHHHCCCCCCCCE	54.00	-
710	Ubiquitination	APVSQAAKFDPSTKI CCHHHHCCCCCCCCE	54.00	27667366
710	Sumoylation	APVSQAAKFDPSTKI CCHHHHCCCCCCCCE	54.00	28112733
710	Acetylation	APVSQAAKFDPSTKI CCHHHHCCCCCCCCE	54.00	25953088
716	Ubiquitination	AKFDPSTKIYEISNR CCCCCCCCEEEECCC	47.86	29967540
718	Phosphorylation	FDPSTKIYEISNRWK CCCCCCEEEECCCEE	14.57	28442448
725	Ubiquitination	YEISNRWKLAQVQVQ EEECCCEEEEEEEEC	30.61	-
747	Phosphorylation	KKKAAEQTAAREQAK HHHHHHHHHHHHHHH	17.50	-
754	Trimethylation	TAAREQAKEACKAAA HHHHHHHHHHHHHHH	45.60	-
754	Ubiquitination	TAAREQAKEACKAAA HHHHHHHHHHHHHHH	45.60	24816145
754	Methylation	TAAREQAKEACKAAA HHHHHHHHHHHHHHH	45.60	-
766	Phosphorylation	AAAEQAISVRQQVVL HHHHHHHHHHHHHHH	17.79	29978859
772	Ubiquitination	ISVRQQVVLENAAKK HHHHHHHHHHHHHHH	4.89	24816145
778	Acetylation	VVLENAAKKRERATS HHHHHHHHHHHHHCC	50.37	25953088
779	Ubiquitination	VLENAAKKRERATSD HHHHHHHHHHHHCCC	55.56	24816145
784	Phosphorylation	AKKRERATSDPRTTE HHHHHHHCCCCCCHH	39.62	23312004
784	Ubiquitination	AKKRERATSDPRTTE HHHHHHHCCCCCCHH	39.62	24816145
785	Phosphorylation	KKRERATSDPRTTEQ HHHHHHCCCCCCHHH	44.63	25849741
788	Ubiquitination	ERATSDPRTTEQKQE HHHCCCCCCHHHHHH	60.31	33845483
789	Phosphorylation	RATSDPRTTEQKQEK HHCCCCCCHHHHHHH	39.82	23312004
790	Phosphorylation	ATSDPRTTEQKQEKK HCCCCCCHHHHHHHH	37.38	23312004
797	Ubiquitination	TEQKQEKKRLKISKK HHHHHHHHHHCCCCC	63.31	24816145
801	Ubiquitination	QEKKRLKISKKPKDP HHHHHHCCCCCCCCC	9.63	32015554
802	Ubiquitination	EKKRLKISKKPKDPE HHHHHCCCCCCCCCC	32.80	24816145
813	Ubiquitination	KDPEPPEKEFTPYDY CCCCCCCCCCCCCCC	64.99	33845483
816	Phosphorylation	EPPEKEFTPYDYSQS CCCCCCCCCCCCCHH	23.25	28796482
818	Phosphorylation	PEKEFTPYDYSQSDF CCCCCCCCCCCHHHH	25.18	23663014
820	Phosphorylation	KEFTPYDYSQSDFKA CCCCCCCCCHHHHHH	11.63	23663014
821	Phosphorylation	EFTPYDYSQSDFKAF CCCCCCCCHHHHHHH	21.95	25159151
823	Phosphorylation	TPYDYSQSDFKAFAG CCCCCCHHHHHHHCC	38.79	23663014
826	Sumoylation	DYSQSDFKAFAGNSK CCCHHHHHHHCCCCC	47.81	-
826	Sumoylation	DYSQSDFKAFAGNSK CCCHHHHHHHCCCCC	47.81	28112733
826	Ubiquitination	DYSQSDFKAFAGNSK CCCHHHHHHHCCCCC	47.81	32015554
833	Sumoylation	KAFAGNSKSKVSSQF HHHCCCCCCCCHHCC	59.29	28112733
835	Methylation	FAGNSKSKVSSQFDP HCCCCCCCCHHCCCC	50.28	23644510
835	Sumoylation	FAGNSKSKVSSQFDP HCCCCCCCCHHCCCC	50.28	-
835	Sumoylation	FAGNSKSKVSSQFDP HCCCCCCCCHHCCCC	50.28	-
837	Phosphorylation	GNSKSKVSSQFDPNK CCCCCCCHHCCCCCC	23.35	24732914
838	Phosphorylation	NSKSKVSSQFDPNKQ CCCCCCHHCCCCCCC	37.54	24732914
844	Acetylation	SSQFDPNKQTPSGKK HHCCCCCCCCCCCCC	62.02	26051181
846	Phosphorylation	QFDPNKQTPSGKKCI CCCCCCCCCCCCCEE	22.49	25159151
848	Phosphorylation	DPNKQTPSGKKCIAA CCCCCCCCCCCEEEH	67.63	24732914
850	Acetylation	NKQTPSGKKCIAAKK CCCCCCCCCEEEHHH	49.13	26051181
851	Acetylation	KQTPSGKKCIAAKKI CCCCCCCCEEEHHHH	34.11	11924287
859	Sumoylation	CIAAKKIKQSVGNKS EEEHHHHHHHHCCCC	45.46	28112733
861	Phosphorylation	AAKKIKQSVGNKSMS EHHHHHHHHCCCCCC	27.30	24719451
865	Acetylation	IKQSVGNKSMSFPTG HHHHHCCCCCCCCCC	41.42	30588629
866	Phosphorylation	KQSVGNKSMSFPTGK HHHHCCCCCCCCCCC	24.53	25159151
868	Phosphorylation	SVGNKSMSFPTGKSD HHCCCCCCCCCCCCC	34.85	25159151
871	Phosphorylation	NKSMSFPTGKSDRGF CCCCCCCCCCCCCCC	56.05	23312004
873	Sumoylation	SMSFPTGKSDRGFRY CCCCCCCCCCCCCCC	52.22	-
873	Sumoylation	SMSFPTGKSDRGFRY CCCCCCCCCCCCCCC	52.22	28112733
873	Acetylation	SMSFPTGKSDRGFRY CCCCCCCCCCCCCCC	52.22	25953088
874	Phosphorylation	MSFPTGKSDRGFRYN CCCCCCCCCCCCCCC	33.61	28555341
880	Phosphorylation	KSDRGFRYNWPQR-- CCCCCCCCCCCCC--	21.22	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXOSX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXOSX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXOSX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AICDA_HUMAN	AICDA	physical	21255825
EXOS4_HUMAN	EXOSC4	physical	15231747
SKIV2_HUMAN	SKIV2L	physical	15231747
CIB1_HUMAN	CIB1	physical	15231747
TOX4_HUMAN	TOX4	physical	15231747
SCRIB_HUMAN	SCRIB	physical	15231747
PGES2_HUMAN	PTGES2	physical	15231747
RUVB2_HUMAN	RUVBL2	physical	15231747
NOMO1_HUMAN	NOMO1	physical	15231747
NOMO2_HUMAN	NOMO2	physical	15231747
SSRP1_HUMAN	SSRP1	physical	15231747
UBP21_HUMAN	USP21	physical	15231747
B9D1_HUMAN	B9D1	physical	15231747
FXRD1_HUMAN	FOXRED1	physical	15231747
CHSS2_HUMAN	CHPF	physical	15231747
MIC60_HUMAN	IMMT	physical	15231747
RPE_HUMAN	RPE	physical	15231747
URP2_HUMAN	FERMT3	physical	15231747
LCAT_HUMAN	LCAT	physical	15231747
AL1B1_HUMAN	ALDH1B1	physical	15231747
EXOS6_HUMAN	EXOSC6	physical	15231747
EXOS8_HUMAN	EXOSC8	physical	15231747
DXO_HUMAN	DXO	physical	15231747
RRP44_HUMAN	DIS3	physical	15231747
EIF3M_HUMAN	EIF3M	physical	15231747
TADBP_HUMAN	TARDBP	physical	15231747
UBP16_HUMAN	USP16	physical	15231747
EXOS3_HUMAN	EXOSC3	physical	26344197
HNRPR_HUMAN	HNRNPR	physical	26344197
SK2L2_HUMAN	SKIV2L2	physical	26344197
LA_HUMAN	SSB	physical	26344197
SPT6H_HUMAN	SUPT6H	physical	26344197
UT14A_HUMAN	UTP14A	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.