dbPTM

TDIF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TDIF2_HUMAN
UniProt AC	Q5QJE6
Protein Name	Deoxynucleotidyltransferase terminal-interacting protein 2
Gene Name	DNTTIP2
Organism	Homo sapiens (Human).
Sequence Length	756
Subcellular Localization	Nucleus .
Protein Description	Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein..
Protein Sequence	MVVTRSARAKASIQAASAESSGQKSFAANGIQAHPESSTGSDARTTAESQTTGKQSLIPRTPKARKRKSRTTGSLPKGTEPSTDGETSEAESNYSVSEHHDTILRVTRRRQILIACSPVSSVRKKPKVTPTKESYTEEIVSEAESHVSGISRIVLPTEKTTGARRSKAKSLTDPSQESHTEAISDAETSSSDISFSGIATRRTRSMQRKLKAQTEKKDSKIVPGNEKQIVGTPVNSEDSDTRQTSHLQARSLSEINKPNFYNNDFDDDFSHRSSENILTVHEQANVESLKETKQNCKDLDEDANGITDEGKEINEKSSQLKNLSELQDTSLQQLVSQRHSTPQNKNAVSVHSNLNSEAVMKSLTQTFATVEVGRWNNNKKSPIKASDLTKFGDCGGSDDEEESTVISVSEDMNSEGNVDFECDTKLYTSAPNTSQGKDNSVLLVLSSDESQQSENSENEEDTLCFVENSGQRESLSGDTGSLSCDNALFVIDTTPGMSADKNFYLEEEDKASEVAIEEEKEEEEDEKSEEDSSDHDENEDEFSDEEDFLNSTKAKLLKLTSSSIDPGLSIKQLGGLYINFNADKLQSNKRTLTQIKEKKKNELLQKAVITPDFEKNHCVPPYSESKYQLQKKRRKERQKTAGDGWFGMKAPEMTNELKNDLKALKMRASMDPKRFYKKNDRDGFPKYFQIGTIVDNPADFYHSRIPKKQRKRTIVEELLADSEFRRYNRRKYSEIMAEKAANAAGKKFRKKKKFRN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Sumoylation	VTRSARAKASIQAAS CCCCHHHHHHHHHHH	36.79	-
10	Sumoylation	VTRSARAKASIQAAS CCCCHHHHHHHHHHH	36.79	-
10	Ubiquitination	VTRSARAKASIQAAS CCCCHHHHHHHHHHH	36.79	29967540
12	Phosphorylation	RSARAKASIQAASAE CCHHHHHHHHHHHHH	17.96	28555341
17	Phosphorylation	KASIQAASAESSGQK HHHHHHHHHHCCCCC	35.27	19691289
20	Phosphorylation	IQAASAESSGQKSFA HHHHHHHCCCCCCCH	39.21	19691289
21	Phosphorylation	QAASAESSGQKSFAA HHHHHHCCCCCCCHH	36.43	25159151
24	Ubiquitination	SAESSGQKSFAANGI HHHCCCCCCCHHCCE	51.58	21963094
24	Acetylation	SAESSGQKSFAANGI HHHCCCCCCCHHCCE	51.58	26051181
25	Phosphorylation	AESSGQKSFAANGIQ HHCCCCCCCHHCCEE	16.54	26699800
37	Phosphorylation	GIQAHPESSTGSDAR CEECCCCCCCCCCCC	37.34	28985074
38	Phosphorylation	IQAHPESSTGSDART EECCCCCCCCCCCCC	34.82	25159151
39	Phosphorylation	QAHPESSTGSDARTT ECCCCCCCCCCCCCH	50.40	25159151
41	Phosphorylation	HPESSTGSDARTTAE CCCCCCCCCCCCHHH	28.34	25159151
52	Phosphorylation	TTAESQTTGKQSLIP CHHHHHCCCCCCCCC	34.44	29759185
54	Sumoylation	AESQTTGKQSLIPRT HHHHCCCCCCCCCCC	34.32	-
54	Ubiquitination	AESQTTGKQSLIPRT HHHHCCCCCCCCCCC	34.32	21906983
54	Sumoylation	AESQTTGKQSLIPRT HHHHCCCCCCCCCCC	34.32	-
56	Phosphorylation	SQTTGKQSLIPRTPK HHCCCCCCCCCCCCC	31.58	23927012
61	Phosphorylation	KQSLIPRTPKARKRK CCCCCCCCCCCCCCC	24.64	23927012
69	Phosphorylation	PKARKRKSRTTGSLP CCCCCCCCCCCCCCC	38.60	22199227
71	Phosphorylation	ARKRKSRTTGSLPKG CCCCCCCCCCCCCCC	42.47	20860994
72	Phosphorylation	RKRKSRTTGSLPKGT CCCCCCCCCCCCCCC	24.54	22199227
74	Phosphorylation	RKSRTTGSLPKGTEP CCCCCCCCCCCCCCC	39.13	24732914
79	Phosphorylation	TGSLPKGTEPSTDGE CCCCCCCCCCCCCCC	51.34	22167270
82	Phosphorylation	LPKGTEPSTDGETSE CCCCCCCCCCCCCCC	32.66	22167270
83	Phosphorylation	PKGTEPSTDGETSEA CCCCCCCCCCCCCCH	59.75	22167270
87	Phosphorylation	EPSTDGETSEAESNY CCCCCCCCCCHHHCC	37.08	30266825
88	Phosphorylation	PSTDGETSEAESNYS CCCCCCCCCHHHCCC	30.43	30266825
92	Phosphorylation	GETSEAESNYSVSEH CCCCCHHHCCCHHHC	48.38	30266825
94	Phosphorylation	TSEAESNYSVSEHHD CCCHHHCCCHHHCHH	21.52	22167270
95	Phosphorylation	SEAESNYSVSEHHDT CCHHHCCCHHHCHHH	24.34	22167270
97	Phosphorylation	AESNYSVSEHHDTIL HHHCCCHHHCHHHHH	25.85	23663014
102	Phosphorylation	SVSEHHDTILRVTRR CHHHCHHHHHHHHCC	19.97	24732914
117	Phosphorylation	RQILIACSPVSSVRK CEEEEEECCCHHHCC	21.22	29255136
120	Phosphorylation	LIACSPVSSVRKKPK EEEECCCHHHCCCCC	26.88	22167270
121	Phosphorylation	IACSPVSSVRKKPKV EEECCCHHHCCCCCC	26.61	22167270
127	Ubiquitination	SSVRKKPKVTPTKES HHHCCCCCCCCCCCC	68.56	22817900
129	Phosphorylation	VRKKPKVTPTKESYT HCCCCCCCCCCCCCH	31.22	28176443
131	Phosphorylation	KKPKVTPTKESYTEE CCCCCCCCCCCCHHH	37.77	28176443
132	Ubiquitination	KPKVTPTKESYTEEI CCCCCCCCCCCHHHH	45.96	21906983
134	Phosphorylation	KVTPTKESYTEEIVS CCCCCCCCCHHHHHH	38.62	28176443
135	Phosphorylation	VTPTKESYTEEIVSE CCCCCCCCHHHHHHH	21.18	28176443
136	Phosphorylation	TPTKESYTEEIVSEA CCCCCCCHHHHHHHH	36.10	28176443
141	Phosphorylation	SYTEEIVSEAESHVS CCHHHHHHHHHHHHC	36.43	22167270
145	Phosphorylation	EIVSEAESHVSGISR HHHHHHHHHHCCCCE	35.92	22167270
148	Phosphorylation	SEAESHVSGISRIVL HHHHHHHCCCCEEEC	25.61	22167270
151	Phosphorylation	ESHVSGISRIVLPTE HHHHCCCCEEECCCC	21.34	23459991
157	Phosphorylation	ISRIVLPTEKTTGAR CCEEECCCCCCCCCC	46.05	29514088
159	Ubiquitination	RIVLPTEKTTGARRS EEECCCCCCCCCCHH	54.59	21906983
159	Acetylation	RIVLPTEKTTGARRS EEECCCCCCCCCCHH	54.59	26051181
160	Phosphorylation	IVLPTEKTTGARRSK EECCCCCCCCCCHHH	24.99	28555341
161	Phosphorylation	VLPTEKTTGARRSKA ECCCCCCCCCCHHHC	39.65	28555341
170	Phosphorylation	ARRSKAKSLTDPSQE CCHHHCHHCCCCCCH	41.16	23927012
172	Phosphorylation	RSKAKSLTDPSQESH HHHCHHCCCCCCHHH	53.61	23927012
175	Phosphorylation	AKSLTDPSQESHTEA CHHCCCCCCHHHHHH	49.76	23401153
178	Phosphorylation	LTDPSQESHTEAISD CCCCCCHHHHHHHHH	28.24	23927012
180	Phosphorylation	DPSQESHTEAISDAE CCCCHHHHHHHHHCC	36.07	30266825
184	Phosphorylation	ESHTEAISDAETSSS HHHHHHHHHCCCCCC	37.50	23927012
188	Phosphorylation	EAISDAETSSSDISF HHHHHCCCCCCCCCH	35.31	30266825
189	Phosphorylation	AISDAETSSSDISFS HHHHCCCCCCCCCHH	21.25	30266825
190	Phosphorylation	ISDAETSSSDISFSG HHHCCCCCCCCCHHH	39.18	30266825
191	Phosphorylation	SDAETSSSDISFSGI HHCCCCCCCCCHHHH	38.44	30266825
194	Phosphorylation	ETSSSDISFSGIATR CCCCCCCCHHHHHHH	20.53	23927012
196	Phosphorylation	SSSDISFSGIATRRT CCCCCCHHHHHHHHH	23.62	23927012
200	Phosphorylation	ISFSGIATRRTRSMQ CCHHHHHHHHHHHHH	20.82	23927012
217	Sumoylation	LKAQTEKKDSKIVPG HHHHHCCCCCCCCCC	62.09	28112733
219	Phosphorylation	AQTEKKDSKIVPGNE HHHCCCCCCCCCCCC	32.91	22817900
220	Sumoylation	QTEKKDSKIVPGNEK HHCCCCCCCCCCCCC	58.83	-
220	Sumoylation	QTEKKDSKIVPGNEK HHCCCCCCCCCCCCC	58.83	28112733
227	Acetylation	KIVPGNEKQIVGTPV CCCCCCCCEEECEEC	49.69	25953088
227	Ubiquitination	KIVPGNEKQIVGTPV CCCCCCCCEEECEEC	49.69	21906983
232	Phosphorylation	NEKQIVGTPVNSEDS CCCEEECEECCCCCC	17.11	23927012
236	Phosphorylation	IVGTPVNSEDSDTRQ EECEECCCCCCCCCC	42.91	23401153
239	Phosphorylation	TPVNSEDSDTRQTSH EECCCCCCCCCCCCH	36.51	30266825
241	Phosphorylation	VNSEDSDTRQTSHLQ CCCCCCCCCCCCHHH	28.73	23927012
241	O-linked_Glycosylation	VNSEDSDTRQTSHLQ CCCCCCCCCCCCHHH	28.73	30379171
244	Phosphorylation	EDSDTRQTSHLQARS CCCCCCCCCHHHHHC	18.15	25159151
245	Phosphorylation	DSDTRQTSHLQARSL CCCCCCCCHHHHHCH	17.54	25159151
251	Phosphorylation	TSHLQARSLSEINKP CCHHHHHCHHHCCCC	38.98	30266825
253	Phosphorylation	HLQARSLSEINKPNF HHHHHCHHHCCCCCC	37.36	30266825
257	Acetylation	RSLSEINKPNFYNND HCHHHCCCCCCCCCC	47.18	26051181
257	Sumoylation	RSLSEINKPNFYNND HCHHHCCCCCCCCCC	47.18	-
257	Ubiquitination	RSLSEINKPNFYNND HCHHHCCCCCCCCCC	47.18	21906983
257	Sumoylation	RSLSEINKPNFYNND HCHHHCCCCCCCCCC	47.18	28112733
261	Phosphorylation	EINKPNFYNNDFDDD HCCCCCCCCCCCCCC	21.50	28464451
270	Phosphorylation	NDFDDDFSHRSSENI CCCCCCCCCCCCCCC	25.61	24732914
273	Phosphorylation	DDDFSHRSSENILTV CCCCCCCCCCCCEEH	36.26	25849741
274	Phosphorylation	DDFSHRSSENILTVH CCCCCCCCCCCEEHH	34.32	25849741
279	Phosphorylation	RSSENILTVHEQANV CCCCCCEEHHHHHCH	18.93	23898821
290	Acetylation	QANVESLKETKQNCK HHCHHHHHHHHHHCH	73.03	26051181
297	Acetylation	KETKQNCKDLDEDAN HHHHHHCHHCCCCCC	69.72	26051181
307	Phosphorylation	DEDANGITDEGKEIN CCCCCCCCHHHHHHH	29.42	20068231
311	Ubiquitination	NGITDEGKEINEKSS CCCCHHHHHHHHHHH	54.06	21906983
311	Acetylation	NGITDEGKEINEKSS CCCCHHHHHHHHHHH	54.06	26051181
316	Sumoylation	EGKEINEKSSQLKNL HHHHHHHHHHHCCCH	51.42	-
316	Ubiquitination	EGKEINEKSSQLKNL HHHHHHHHHHHCCCH	51.42	21906983
316	Sumoylation	EGKEINEKSSQLKNL HHHHHHHHHHHCCCH	51.42	28112733
316	2-Hydroxyisobutyrylation	EGKEINEKSSQLKNL HHHHHHHHHHHCCCH	51.42	-
316	Acetylation	EGKEINEKSSQLKNL HHHHHHHHHHHCCCH	51.42	26051181
317	Phosphorylation	GKEINEKSSQLKNLS HHHHHHHHHHCCCHH	19.69	-
318	Phosphorylation	KEINEKSSQLKNLSE HHHHHHHHHCCCHHH	51.07	-
321	Sumoylation	NEKSSQLKNLSELQD HHHHHHCCCHHHHCH	48.48	-
321	Ubiquitination	NEKSSQLKNLSELQD HHHHHHCCCHHHHCH	48.48	22817900
321	Sumoylation	NEKSSQLKNLSELQD HHHHHHCCCHHHHCH	48.48	28112733
324	Phosphorylation	SSQLKNLSELQDTSL HHHCCCHHHHCHHHH	45.73	29255136
329	Phosphorylation	NLSELQDTSLQQLVS CHHHHCHHHHHHHHH	20.55	29255136
330	Phosphorylation	LSELQDTSLQQLVSQ HHHHCHHHHHHHHHC	32.25	23401153
336	Phosphorylation	TSLQQLVSQRHSTPQ HHHHHHHHCCCCCCC	30.04	29255136
340	Phosphorylation	QLVSQRHSTPQNKNA HHHHCCCCCCCCCCC	43.93	18669648
341	Phosphorylation	LVSQRHSTPQNKNAV HHHCCCCCCCCCCCE	23.83	25159151
345	Sumoylation	RHSTPQNKNAVSVHS CCCCCCCCCCEECCC	40.82	-
345	Sumoylation	RHSTPQNKNAVSVHS CCCCCCCCCCEECCC	40.82	28112733
345	Ubiquitination	RHSTPQNKNAVSVHS CCCCCCCCCCEECCC	40.82	21963094
349	Phosphorylation	PQNKNAVSVHSNLNS CCCCCCEECCCCCCH	16.23	26074081
352	Phosphorylation	KNAVSVHSNLNSEAV CCCEECCCCCCHHHH	40.64	26074081
356	Phosphorylation	SVHSNLNSEAVMKSL ECCCCCCHHHHHHHH	30.05	26074081
362	Phosphorylation	NSEAVMKSLTQTFAT CHHHHHHHHHHHEEE	20.67	22199227
364	Phosphorylation	EAVMKSLTQTFATVE HHHHHHHHHHEEEEE	32.43	22199227
366	Phosphorylation	VMKSLTQTFATVEVG HHHHHHHHEEEEEEC	15.25	24667141
369	Phosphorylation	SLTQTFATVEVGRWN HHHHHEEEEEECCCC	17.01	24667141
381	Phosphorylation	RWNNNKKSPIKASDL CCCCCCCCCCCHHHC	33.20	30266825
384	Sumoylation	NNKKSPIKASDLTKF CCCCCCCCHHHCCEE	45.26	-
384	Sumoylation	NNKKSPIKASDLTKF CCCCCCCCHHHCCEE	45.26	28112733
386	Phosphorylation	KKSPIKASDLTKFGD CCCCCCHHHCCEECC	28.31	24732914
389	Phosphorylation	PIKASDLTKFGDCGG CCCHHHCCEECCCCC	29.35	26074081
397	Phosphorylation	KFGDCGGSDDEEEST EECCCCCCCCCCCEE	27.46	24275569
414	Phosphorylation	SVSEDMNSEGNVDFE EEECCCCCCCCEEEE	40.00	-
427	Phosphorylation	FECDTKLYTSAPNTS EEECCEEEECCCCCC	10.54	28796482
428	Phosphorylation	ECDTKLYTSAPNTSQ EECCEEEECCCCCCC	28.93	28152594
429	Phosphorylation	CDTKLYTSAPNTSQG ECCEEEECCCCCCCC	28.33	25159151
433	Phosphorylation	LYTSAPNTSQGKDNS EEECCCCCCCCCCCE	22.74	30266825
434	Phosphorylation	YTSAPNTSQGKDNSV EECCCCCCCCCCCEE	43.50	30266825
474	Phosphorylation	ENSGQRESLSGDTGS ECCCCCCCCCCCCCC	29.98	30108239
476	Phosphorylation	SGQRESLSGDTGSLS CCCCCCCCCCCCCCC	43.85	30108239
479	Phosphorylation	RESLSGDTGSLSCDN CCCCCCCCCCCCCCC	31.99	30108239
481	Phosphorylation	SLSGDTGSLSCDNAL CCCCCCCCCCCCCEE	21.14	30108239
483	Phosphorylation	SGDTGSLSCDNALFV CCCCCCCCCCCEEEE	22.56	30108239
493	Phosphorylation	NALFVIDTTPGMSAD CEEEEEECCCCCCCC	24.62	26074081
494	Phosphorylation	ALFVIDTTPGMSADK EEEEEECCCCCCCCC	17.69	26074081
498	Phosphorylation	IDTTPGMSADKNFYL EECCCCCCCCCCEEC	38.95	26074081
512	Phosphorylation	LEEEDKASEVAIEEE CCCHHCHHHHHHHHH	38.04	28355574
528	Phosphorylation	EEEEDEKSEEDSSDH HHHHHHCCCCCCCCC	44.14	20363803
532	Phosphorylation	DEKSEEDSSDHDENE HHCCCCCCCCCCCCC	40.73	20363803
533	Phosphorylation	EKSEEDSSDHDENED HCCCCCCCCCCCCCC	51.81	25849741
543	Phosphorylation	DENEDEFSDEEDFLN CCCCCCCCCHHHHHH	41.90	20363803
551	Phosphorylation	DEEDFLNSTKAKLLK CHHHHHHHHHHHHHH	33.17	20068231
552	Phosphorylation	EEDFLNSTKAKLLKL HHHHHHHHHHHHHHH	33.67	20068231
553	Ubiquitination	EDFLNSTKAKLLKLT HHHHHHHHHHHHHHH	43.26	23000965
555	Ubiquitination	FLNSTKAKLLKLTSS HHHHHHHHHHHHHHC	56.77	23000965
558	Sumoylation	STKAKLLKLTSSSID HHHHHHHHHHHCCCC	61.22	-
558	Sumoylation	STKAKLLKLTSSSID HHHHHHHHHHHCCCC	61.22	28112733
558	Ubiquitination	STKAKLLKLTSSSID HHHHHHHHHHHCCCC	61.22	23000965
560	Phosphorylation	KAKLLKLTSSSIDPG HHHHHHHHHCCCCCC	25.60	22210691
561	Phosphorylation	AKLLKLTSSSIDPGL HHHHHHHHCCCCCCC	32.31	23403867
562	Phosphorylation	KLLKLTSSSIDPGLS HHHHHHHCCCCCCCC	26.52	23186163
563	Phosphorylation	LLKLTSSSIDPGLSI HHHHHHCCCCCCCCH	30.67	23403867
569	Phosphorylation	SSIDPGLSIKQLGGL CCCCCCCCHHHCCCE	33.38	23403867
577	Phosphorylation	IKQLGGLYINFNADK HHHCCCEEEECCHHH	9.33	20068231
584	Acetylation	YINFNADKLQSNKRT EEECCHHHHHHCCCH	46.12	26051181
584	Sumoylation	YINFNADKLQSNKRT EEECCHHHHHHCCCH	46.12	28112733
587	Phosphorylation	FNADKLQSNKRTLTQ CCHHHHHHCCCHHHH	55.55	29496963
596	Ubiquitination	KRTLTQIKEKKKNEL CCHHHHHHHHHHHHH	54.38	29967540
600	Sumoylation	TQIKEKKKNELLQKA HHHHHHHHHHHHHHH	67.72	-
600	Sumoylation	TQIKEKKKNELLQKA HHHHHHHHHHHHHHH	67.72	-
606	Sumoylation	KKNELLQKAVITPDF HHHHHHHHHCCCCCH	44.59	-
606	Sumoylation	KKNELLQKAVITPDF HHHHHHHHHCCCCCH	44.59	28112733
606	Ubiquitination	KKNELLQKAVITPDF HHHHHHHHHCCCCCH	44.59	29967540
610	Phosphorylation	LLQKAVITPDFEKNH HHHHHCCCCCHHCCC	15.37	25218447
615	Acetylation	VITPDFEKNHCVPPY CCCCCHHCCCCCCCC	52.57	26051181
622	Phosphorylation	KNHCVPPYSESKYQL CCCCCCCCCHHHHHH	20.99	29396449
623	Phosphorylation	NHCVPPYSESKYQLQ CCCCCCCCHHHHHHH	40.96	25159151
625	Phosphorylation	CVPPYSESKYQLQKK CCCCCCHHHHHHHHH	30.62	29396449
626	Sumoylation	VPPYSESKYQLQKKR CCCCCHHHHHHHHHH	32.72	-
626	Sumoylation	VPPYSESKYQLQKKR CCCCCHHHHHHHHHH	32.72	28112733
626	Ubiquitination	VPPYSESKYQLQKKR CCCCCHHHHHHHHHH	32.72	29967540
626	Acetylation	VPPYSESKYQLQKKR CCCCCHHHHHHHHHH	32.72	26051181
649	Sumoylation	GDGWFGMKAPEMTNE CCCCCCCCCHHHHHH	62.26	-
649	Sumoylation	GDGWFGMKAPEMTNE CCCCCCCCCHHHHHH	62.26	28112733
649	Ubiquitination	GDGWFGMKAPEMTNE CCCCCCCCCHHHHHH	62.26	32015554
649	Acetylation	GDGWFGMKAPEMTNE CCCCCCCCCHHHHHH	62.26	26051181
658	Sumoylation	PEMTNELKNDLKALK HHHHHHHHHHHHHHH	42.09	-
658	Sumoylation	PEMTNELKNDLKALK HHHHHHHHHHHHHHH	42.09	28112733
658	Ubiquitination	PEMTNELKNDLKALK HHHHHHHHHHHHHHH	42.09	-
686	Sumoylation	NDRDGFPKYFQIGTI CCCCCCCCEEEEEEE	57.33	-
686	Sumoylation	NDRDGFPKYFQIGTI CCCCCCCCEEEEEEE	57.33	28112733
701	Phosphorylation	VDNPADFYHSRIPKK ECCHHHHHHCCCCHH	10.22	-
703	Phosphorylation	NPADFYHSRIPKKQR CHHHHHHCCCCHHHH	22.11	-
713	Phosphorylation	PKKQRKRTIVEELLA CHHHHCHHHHHHHHC	32.20	28555341
731	Sumoylation	FRRYNRRKYSEIMAE HHHHHHHHHHHHHHH	50.30	-
731	Sumoylation	FRRYNRRKYSEIMAE HHHHHHHHHHHHHHH	50.30	28112733
733	Phosphorylation	RYNRRKYSEIMAEKA HHHHHHHHHHHHHHH	24.55	24247654
739	Ubiquitination	YSEIMAEKAANAAGK HHHHHHHHHHHHHHH	43.17	32015554

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TDIF2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TDIF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TDIF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ESR1_HUMAN	ESR1	physical	15047147
RXRA_HUMAN	RXRA	physical	15047147
PPARG_HUMAN	PPARG	physical	15047147
ESR2_HUMAN	ESR2	physical	15047147
TDT_HUMAN	DNTT	physical	12786946
H2A3_HUMAN	HIST3H2A	physical	12786946
H2B1A_HUMAN	HIST1H2BA	physical	12786946
KAT5_HUMAN	KAT5	physical	21668587

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TDIF2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141; SER-145; SER-184AND THR-232, AND MASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-117; SER-121;THR-129; SER-141; SER-145; SER-148; SER-184; THR-188; SER-189;SER-191; SER-194; THR-232; SER-324 AND SER-381, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141; SER-145 ANDSER-330, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-121, ANDMASS SPECTROMETRY.	16565220 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117; SER-184; SER-189;SER-190; SER-191; SER-528; SER-532; SER-533 AND SER-543, AND MASSSPECTROMETRY.	17081983 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-232, AND MASSSPECTROMETRY.	16964243 [Abstract]