dbPTM

PHF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PHF3_HUMAN	Jmol._Canvas2D (Jmol) "myJmol"[x]
UniProt AC	Q92576
Protein Name	PHD finger protein 3
Gene Name	PHF3
Organism	Homo sapiens (Human).
Sequence Length	2039
Subcellular Localization
Protein Description
Protein Sequence	MDIVDTFNHLIPTEHLDDALFLGSNLENEVCEDFSASQNVLEDSLKNMLSDKDPMLGSASNQFCLPVLDSNDPNFQMPCSTVVGLDDIMDEGVVKESGNDTIDEEELILPNRNLRDKVEENSVRSPRKSPRLMAQEQVRSLRQSTIAKRSNAAPLSNTKKASGKTVSTAKAGVKQPERSQVKEEVCMSLKPEYHKENRRCSRNSGQIEVVPEVSVSSSHSSVSSCLEMKDEDGLDSKHKCNNPGEIDVPSHELNCSLLSETCVTIGEKKNEALMECKAKPVGSPLFKFSDKEEHEQNDSISGKTGETVVEEMIATRKVEQDSKETVKLSHEDDHILEDAGSSDISSDAACTNPNKTENSLVGLPSCVDEVTECNLELKDTMGIADKTENTLERNKIEPLGYCEDAESNRQLESTEFNKSNLEVVDTSTFGPESNILENAICDVPDQNSKQLNAIESTKIESHETANLQDDRNSQSSSVSYLESKSVKSKHTKPVIHSKQNMTTDAPKKIVAAKYEVIHSKTKVNVKSVKRNTDVPESQQNFHRPVKVRKKQIDKEPKIQSCNSGVKSVKNQAHSVLKKTLQDQTLVQIFKPLTHSLSDKSHAHPGCLKEPHHPAQTGHVSHSSQKQCHKPQQQAPAMKTNSHVKEELEHPGVEHFKEEDKLKLKKPEKNLQPRQRRSSKSFSLDEPPLFIPDNIATIRREGSDHSSSFESKYMWTPSKQCGFCKKPHGNRFMVGCGRCDDWFHGDCVGLSLSQAQQMGEEDKEYVCVKCCAEEDKKTEILDPDTLENQATVEFHSGDKTMECEKLGLSKHTTNDRTKYIDDTVKHKVKILKRESGEGRNSSDCRDNEIKKWQLAPLRKMGQPVLPRRSSEEKSEKIPKESTTVTCTGEKASKPGTHEKQEMKKKKVEKGVLNVHPAASASKPSADQIRQSVRHSLKDILMKRLTDSNLKVPEEKAAKVATKIEKELFSFFRDTDAKYKNKYRSLMFNLKDPKNNILFKKVLKGEVTPDHLIRMSPEELASKELAAWRRRENRHTIEMIEKEQREVERRPITKITHKGEIEIESDAPMKEQEAAMEIQEPAANKSLEKPEGSEKQKEEVDSMSKDTTSQHRQHLFDLNCKICIGRMAPPVDDLSPKKVKVVVGVARKHSDNEAESIADALSSTSNILASEFFEEEKQESPKSTFSPAPRPEMPGTVEVESTFLARLNFIWKGFINMPSVAKFVTKAYPVSGSPEYLTEDLPDSIQVGGRISPQTVWDYVEKIKASGTKEICVVRFTPVTEEDQISYTLLFAYFSSRKRYGVAANNMKQVKDMYLIPLGATDKIPHPLVPFDGPGLELHRPNLLLGLIIRQKLKRQHSACASTSHIAETPESAPPIALPPDKKSKIEVSTEEAPEEENDFFNSFTTVLHKQRNKPQQNLQEDLPTAVEPLMEVTKQEPPKPLRFLPGVLIGWENQPTTLELANKPLPVDDILQSLLGTTGQVYDQAQSVMEQNTVKEIPFLNEQTNSKIEKTDNVEVTDGENKEIKVKVDNISESTDKSAEIETSVVGSSSISAGSLTSLSLRGKPPDVSTEAFLTNLSIQSKQEETVESKEKTLKRQLQEDQENNLQDNQTSNSSPCRSNVGKGNIDGNVSCSENLVANTARSPQFINLKRDPRQAAGRSQPVTTSESKDGDSCRNGEKHMLPGLSHNKEHLTEQINVEEKLCSAEKNSCVQQSDNLKVAQNSPSVENIQTSQAEQAKPLQEDILMQNIETVHPFRRGSAVATSHFEVGNTCPSEFPSKSITFTSRSTSPRTSTNFSPMRPQQPNLQHLKSSPPGFPFPGPPNFPPQSMFGFPPHLPPPLLPPPGFGFAQNPMVPWPPVVHLPGQPQRMMGPLSQASRYIGPQNFYQVKDIRRPERRHSDPWGRQDQQQLDRPFNRGKGDRQRFYSDSHHLKRERHEKEWEQESERHRRRDRSQDKDRDRKSREEGHKDKERARLSHGDRGTDGKASRDSRNVDKKPDKPKSEDYEKDKEREKSKHREGEKDRDRYHKDRDHTDRTKSKR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
97	Phosphorylation	DEGVVKESGNDTIDE CCCCCCCCCCCCCCH	36.86	30266825
101	Phosphorylation	VKESGNDTIDEEELI CCCCCCCCCCHHHHC	34.04	30266825
122	Phosphorylation	RDKVEENSVRSPRKS HHHHHHCCCCCCCCC	23.37	23401153
125	Phosphorylation	VEENSVRSPRKSPRL HHHCCCCCCCCCHHH	27.22	23401153
129	Phosphorylation	SVRSPRKSPRLMAQE CCCCCCCCHHHHHHH	19.28	28985074
144	Phosphorylation	QVRSLRQSTIAKRSN HHHHHHHHHHHHHCC	18.49	22964224
148	Acetylation	LRQSTIAKRSNAAPL HHHHHHHHHCCCCCC	53.13	25953088
156	Phosphorylation	RSNAAPLSNTKKASG HCCCCCCCCCCCCCC	41.20	25159151
158	Phosphorylation	NAAPLSNTKKASGKT CCCCCCCCCCCCCCC	30.46	21815630
159	Acetylation	AAPLSNTKKASGKTV CCCCCCCCCCCCCCH	51.06	25953088
159	Methylation	AAPLSNTKKASGKTV CCCCCCCCCCCCCCH	51.06	-
168	Phosphorylation	ASGKTVSTAKAGVKQ CCCCCHHHHCCCCCC	28.04	-
170	Acetylation	GKTVSTAKAGVKQPE CCCHHHHCCCCCCCC	45.84	25953088
174	Acetylation	STAKAGVKQPERSQV HHHCCCCCCCCHHHH	60.25	25953088
188	Phosphorylation	VKEEVCMSLKPEYHK HCHHHHHHCCHHHHH	28.28	28555341
190	Acetylation	EEVCMSLKPEYHKEN HHHHHHCCHHHHHHC	28.61	23236377
195	Acetylation	SLKPEYHKENRRCSR HCCHHHHHHCCCCCC	56.64	25953088
201	Phosphorylation	HKENRRCSRNSGQIE HHHCCCCCCCCCCEE	32.46	26074081
204	Phosphorylation	NRRCSRNSGQIEVVP CCCCCCCCCCEEEEC	30.85	25159151
250	Phosphorylation	PGEIDVPSHELNCSL CCCCCCCHHHHCHHH	29.46	25627689
256	Phosphorylation	PSHELNCSLLSETCV CHHHHCHHHHHCEEE	31.13	25159151
259	Phosphorylation	ELNCSLLSETCVTIG HHCHHHHHCEEEEEC	35.83	27690223
261	Phosphorylation	NCSLLSETCVTIGEK CHHHHHCEEEEECHH	14.65	27690223
283	Phosphorylation	CKAKPVGSPLFKFSD CCCCCCCCCCCCCCC	20.75	25159151
289	Phosphorylation	GSPLFKFSDKEEHEQ CCCCCCCCCHHHHHC	48.65	25159151
291	Acetylation	PLFKFSDKEEHEQND CCCCCCCHHHHHCCC	64.90	25953088
299	Phosphorylation	EEHEQNDSISGKTGE HHHHCCCCCCCCCCC	26.63	29255136
301	Phosphorylation	HEQNDSISGKTGETV HHCCCCCCCCCCCHH	37.88	29255136
312	Sulfoxidation	GETVVEEMIATRKVE CCHHHHHHHHHCCCC	1.27	21406390
315	Phosphorylation	VVEEMIATRKVEQDS HHHHHHHHCCCCCCC	21.79	24114839
329	Phosphorylation	SKETVKLSHEDDHIL CHHCEECCCCCCCHH	21.07	23663014
341	Phosphorylation	HILEDAGSSDISSDA CHHHCCCCCCCCCCC	26.93	23401153
342	Phosphorylation	ILEDAGSSDISSDAA HHHCCCCCCCCCCCC	37.74	27362937
345	Phosphorylation	DAGSSDISSDAACTN CCCCCCCCCCCCCCC	27.44	23663014
346	Phosphorylation	AGSSDISSDAACTNP CCCCCCCCCCCCCCC	31.44	23663014
351	Phosphorylation	ISSDAACTNPNKTEN CCCCCCCCCCCCCCC	49.32	23663014
359	Phosphorylation	NPNKTENSLVGLPSC CCCCCCCCCCCCHHH	20.42	-
380	Phosphorylation	CNLELKDTMGIADKT CCCEECCCCCCCCCC	18.73	20068231
381	Sulfoxidation	NLELKDTMGIADKTE CCEECCCCCCCCCCC	5.39	21406390
386	Acetylation	DTMGIADKTENTLER CCCCCCCCCCCHHHH	49.03	25953088
387	Phosphorylation	TMGIADKTENTLERN CCCCCCCCCCHHHHC	34.71	20068231
390	Phosphorylation	IADKTENTLERNKIE CCCCCCCHHHHCCCC	24.62	28555341
395	Ubiquitination	ENTLERNKIEPLGYC CCHHHHCCCCCCCCC	55.45	-
401	Phosphorylation	NKIEPLGYCEDAESN CCCCCCCCCCCHHHC	10.59	29978859
407	Phosphorylation	GYCEDAESNRQLEST CCCCCHHHCCCCCCC	38.75	29978859
413	Phosphorylation	ESNRQLESTEFNKSN HHCCCCCCCCCCHHC	41.66	29978859
414	Phosphorylation	SNRQLESTEFNKSNL HCCCCCCCCCCHHCC	34.91	29978859
419	Phosphorylation	ESTEFNKSNLEVVDT CCCCCCHHCCEEEEC	47.99	22199227
426	Phosphorylation	SNLEVVDTSTFGPES HCCEEEECCCCCCCC	20.32	28102081
427	Phosphorylation	NLEVVDTSTFGPESN CCEEEECCCCCCCCC	19.78	28102081
428	Phosphorylation	LEVVDTSTFGPESNI CEEEECCCCCCCCCC	34.40	28102081
433	Phosphorylation	TSTFGPESNILENAI CCCCCCCCCCHHHCC	32.10	28102081
461	Phosphorylation	IESTKIESHETANLQ HHCCCCCCCCCCCCC	30.05	30108239
464	Phosphorylation	TKIESHETANLQDDR CCCCCCCCCCCCCCC	18.54	30108239
471	Methylation	TANLQDDRNSQSSSV CCCCCCCCCCCCCCH	53.65	115487379
473	Phosphorylation	NLQDDRNSQSSSVSY CCCCCCCCCCCCHHH	32.12	17525332
475	Phosphorylation	QDDRNSQSSSVSYLE CCCCCCCCCCHHHHH	25.13	30108239
476	Phosphorylation	DDRNSQSSSVSYLES CCCCCCCCCHHHHHH	27.41	30108239
477	Phosphorylation	DRNSQSSSVSYLESK CCCCCCCCHHHHHHC	21.96	30108239
479	Phosphorylation	NSQSSSVSYLESKSV CCCCCCHHHHHHCCC	26.42	27251275
480	Phosphorylation	SQSSSVSYLESKSVK CCCCCHHHHHHCCCC	16.60	27251275
484	Acetylation	SVSYLESKSVKSKHT CHHHHHHCCCCCCCC	50.31	25953088
488	O-linked_Glycosylation	LESKSVKSKHTKPVI HHHCCCCCCCCCCCC	27.75	23301498
498	Acetylation	TKPVIHSKQNMTTDA CCCCCCCCCCCCCCC	31.37	30591289
513	Acetylation	PKKIVAAKYEVIHSK CHHHHEEEHEEEECC	32.00	25953088
514	Phosphorylation	KKIVAAKYEVIHSKT HHHHEEEHEEEECCC	15.65	28796482
519	Phosphorylation	AKYEVIHSKTKVNVK EEHEEEECCCCCCHH	30.78	27470641
520	Acetylation	KYEVIHSKTKVNVKS EHEEEECCCCCCHHH	37.90	25953088
520	Ubiquitination	KYEVIHSKTKVNVKS EHEEEECCCCCCHHH	37.90	-
521	Phosphorylation	YEVIHSKTKVNVKSV HEEEECCCCCCHHHH	43.15	27470641
526	Acetylation	SKTKVNVKSVKRNTD CCCCCCHHHHCCCCC	44.31	25953088
527	O-linked_Glycosylation	KTKVNVKSVKRNTDV CCCCCHHHHCCCCCC	28.70	23301498
532	Phosphorylation	VKSVKRNTDVPESQQ HHHHCCCCCCCHHHH	42.27	28555341
537	Phosphorylation	RNTDVPESQQNFHRP CCCCCCHHHHCCCCC	30.88	24532841
566	Acetylation	QSCNSGVKSVKNQAH CCCCCCHHHHHHHHH	53.72	23749302
569	Acetylation	NSGVKSVKNQAHSVL CCCHHHHHHHHHHHH	50.89	25953088
578	Methylation	QAHSVLKKTLQDQTL HHHHHHHHHHCCCHH	50.75	24129315
579	Phosphorylation	AHSVLKKTLQDQTLV HHHHHHHHHCCCHHH	28.23	-
584	Phosphorylation	KKTLQDQTLVQIFKP HHHHCCCHHHHHHHH	36.87	21406692
590	Acetylation	QTLVQIFKPLTHSLS CHHHHHHHHCHHCCC	40.52	23954790
593	Phosphorylation	VQIFKPLTHSLSDKS HHHHHHCHHCCCCCC	20.25	21406692
595	Phosphorylation	IFKPLTHSLSDKSHA HHHHCHHCCCCCCCC	25.08	21406692
597	Phosphorylation	KPLTHSLSDKSHAHP HHCHHCCCCCCCCCC	46.11	21406692
608	Acetylation	HAHPGCLKEPHHPAQ CCCCCCCCCCCCCCC	73.59	26051181
644	Sumoylation	MKTNSHVKEELEHPG CCCCHHHHHHHCCCC	39.79	28112733
677	Phosphorylation	LQPRQRRSSKSFSLD CCCCCHHCCCCCCCC	44.28	23927012
678	Phosphorylation	QPRQRRSSKSFSLDE CCCCHHCCCCCCCCC	30.43	23927012
680	Phosphorylation	RQRRSSKSFSLDEPP CCHHCCCCCCCCCCC	23.24	25159151
682	Phosphorylation	RRSSKSFSLDEPPLF HHCCCCCCCCCCCCC	41.84	23927012
696	Phosphorylation	FIPDNIATIRREGSD CCCCCHHHEEECCCC	15.95	23927012
702	Phosphorylation	ATIRREGSDHSSSFE HHEEECCCCCCCCCC	27.65	23401153
705	Phosphorylation	RREGSDHSSSFESKY EECCCCCCCCCCCCC	32.44	29255136
706	Phosphorylation	REGSDHSSSFESKYM ECCCCCCCCCCCCCC	35.31	29396449
707	Phosphorylation	EGSDHSSSFESKYMW CCCCCCCCCCCCCCC	35.73	29396449
710	Phosphorylation	DHSSSFESKYMWTPS CCCCCCCCCCCCCCC	27.38	27251275
712	Phosphorylation	SSSFESKYMWTPSKQ CCCCCCCCCCCCCCC	13.73	27642862
715	Phosphorylation	FESKYMWTPSKQCGF CCCCCCCCCCCCCCC	10.93	22199227
717	Phosphorylation	SKYMWTPSKQCGFCK CCCCCCCCCCCCCCC	28.16	27251275
752	Phosphorylation	DCVGLSLSQAQQMGE CCCEECHHHHHHCCC	21.79	-
818	Phosphorylation	TTNDRTKYIDDTVKH CCCCCCCCCCHHHHH	14.68	24719451
822	Phosphorylation	RTKYIDDTVKHKVKI CCCCCCHHHHHHEEE	27.92	24719451
834	Phosphorylation	VKILKRESGEGRNSS EEEEECCCCCCCCCH	46.29	24719451
840	Phosphorylation	ESGEGRNSSDCRDNE CCCCCCCCHHCCCCH	26.62	30242111
841	Phosphorylation	SGEGRNSSDCRDNEI CCCCCCCHHCCCCHH	44.25	29449344
858	Methylation	WQLAPLRKMGQPVLP HHHHHHHHCCCCCCC	55.88	116253329
868	O-linked_Glycosylation	QPVLPRRSSEEKSEK CCCCCCCCCHHHHHC	43.30	23301498
868	Phosphorylation	QPVLPRRSSEEKSEK CCCCCCCCCHHHHHC	43.30	29496963
869	Phosphorylation	PVLPRRSSEEKSEKI CCCCCCCCHHHHHCC	48.22	25159151
872	Acetylation	PRRSSEEKSEKIPKE CCCCCHHHHHCCCCC	60.92	7664547
873	Phosphorylation	RRSSEEKSEKIPKES CCCCHHHHHCCCCCC	47.61	23312004
875	Acetylation	SSEEKSEKIPKESTT CCHHHHHCCCCCCCE	71.98	7664559
876 (in isoform 2)	Ubiquitination	-	5.31	21890473
878	Acetylation	EKSEKIPKESTTVTC HHHHCCCCCCCEEEE	68.70	7664571
880	Phosphorylation	SEKIPKESTTVTCTG HHCCCCCCCEEEECC	35.19	26074081
881	Phosphorylation	EKIPKESTTVTCTGE HCCCCCCCEEEECCC	26.78	26074081
882	Phosphorylation	KIPKESTTVTCTGEK CCCCCCCEEEECCCC	24.09	26074081
884	Phosphorylation	PKESTTVTCTGEKAS CCCCCEEEECCCCCC	11.40	26074081
886	Phosphorylation	ESTTVTCTGEKASKP CCCEEEECCCCCCCC	38.72	26074081
891	Phosphorylation	TCTGEKASKPGTHEK EECCCCCCCCCCHHH	50.91	26074081
895	Phosphorylation	EKASKPGTHEKQEMK CCCCCCCCHHHHHHH	35.07	26074081
921	Acetylation	HPAASASKPSADQIR CCCCCCCCCCHHHHH	42.58	23954790
961	Ubiquitination	KAAKVATKIEKELFS HHHHHHHHHHHHHHH	38.85	-
964	Sumoylation	KVATKIEKELFSFFR HHHHHHHHHHHHHHC	64.29	-
964	Sumoylation	KVATKIEKELFSFFR HHHHHHHHHHHHHHC	64.29	28112733
964	Ubiquitination	KVATKIEKELFSFFR HHHHHHHHHHHHHHC	64.29	21890473
964 (in isoform 1)	Ubiquitination	-	64.29	21890473
968	Phosphorylation	KIEKELFSFFRDTDA HHHHHHHHHHCCCCH	35.78	24719451
981	Phosphorylation	DAKYKNKYRSLMFNL CHHHHHHCHHHHHCC	18.15	29083192
983	Phosphorylation	KYKNKYRSLMFNLKD HHHHHCHHHHHCCCC	22.54	29083192
989	Ubiquitination	RSLMFNLKDPKNNIL HHHHHCCCCCCCCEE	73.43	-
1006	Phosphorylation	KVLKGEVTPDHLIRM HHHCCCCCHHHHHCC	20.78	25159151
1014	Phosphorylation	PDHLIRMSPEELASK HHHHHCCCHHHHHHH	21.22	21815630
1021	Ubiquitination	SPEELASKELAAWRR CHHHHHHHHHHHHHH	51.65	-
1034	Phosphorylation	RRRENRHTIEMIEKE HHHHHHHHHHHHHHH	18.52	23312004
1051	Phosphorylation	EVERRPITKITHKGE HHHCCCCCCCEECCE	21.05	26074081
1054	Phosphorylation	RRPITKITHKGEIEI CCCCCCCEECCEEEE	21.06	26074081
1063	Phosphorylation	KGEIEIESDAPMKEQ CCEEEECCCCCHHHH	44.74	25159151
1084	Phosphorylation	QEPAANKSLEKPEGS CCCHHCCCCCCCCCC	41.38	28985074
1091	Phosphorylation	SLEKPEGSEKQKEEV CCCCCCCCHHHHHHH	39.70	26714015
1132 (in isoform 2)	Ubiquitination	-	9.04	21890473
1133	Phosphorylation	APPVDDLSPKKVKVV CCCCCCCCHHHEEEE	41.49	19664994
1148	Phosphorylation	VGVARKHSDNEAESI EEEECCCCCCHHHHH	45.20	25159151
1154	Phosphorylation	HSDNEAESIADALSS CCCCHHHHHHHHHHH	30.08	22617229
1160	Phosphorylation	ESIADALSSTSNILA HHHHHHHHHHHHHHH	33.04	28450419
1161	Phosphorylation	SIADALSSTSNILAS HHHHHHHHHHHHHHH	36.38	28450419
1162	Phosphorylation	IADALSSTSNILASE HHHHHHHHHHHHHHH	23.55	28450419
1163	Phosphorylation	ADALSSTSNILASEF HHHHHHHHHHHHHHH	24.66	28450419
1168	Phosphorylation	STSNILASEFFEEEK HHHHHHHHHHHHHHH	31.33	22617229
1178	Phosphorylation	FEEEKQESPKSTFSP HHHHHCCCCCCCCCC	34.82	22617229
1181	Phosphorylation	EKQESPKSTFSPAPR HHCCCCCCCCCCCCC	37.76	30266825
1182	Phosphorylation	KQESPKSTFSPAPRP HCCCCCCCCCCCCCC	33.97	30266825
1184	Phosphorylation	ESPKSTFSPAPRPEM CCCCCCCCCCCCCCC	21.90	30266825
1194	Phosphorylation	PRPEMPGTVEVESTF CCCCCCCEEEEEHHH	13.97	30266825
1220	Ubiquitination	INMPSVAKFVTKAYP CCCHHHHHHHCEECC	37.91	21890473
1220 (in isoform 1)	Ubiquitination	-	37.91	21890473
1264	Phosphorylation	YVEKIKASGTKEICV HHHHHHCCCCCEEEE	41.83	25367160
1266	Phosphorylation	EKIKASGTKEICVVR HHHHCCCCCEEEEEE	24.02	25367160
1284	Phosphorylation	VTEEDQISYTLLFAY CCHHHHHHHHHHHHH	13.36	21955146
1285	Phosphorylation	TEEDQISYTLLFAYF CHHHHHHHHHHHHHH	11.75	21955146
1286	Phosphorylation	EEDQISYTLLFAYFS HHHHHHHHHHHHHHH	15.36	21955146
1291	Phosphorylation	SYTLLFAYFSSRKRY HHHHHHHHHHCCCHH	9.17	21955146
1293	Phosphorylation	TLLFAYFSSRKRYGV HHHHHHHHCCCHHCC	19.29	21955146
1294	Phosphorylation	LLFAYFSSRKRYGVA HHHHHHHCCCHHCCC	31.74	21955146
1298	Phosphorylation	YFSSRKRYGVAANNM HHHCCCHHCCCCCCC	20.98	-
1312	Phosphorylation	MKQVKDMYLIPLGAT CHHCCCEEEEECCCC	16.18	-
1319	Phosphorylation	YLIPLGATDKIPHPL EEEECCCCCCCCCCC	35.71	-
1356	Phosphorylation	QKLKRQHSACASTSH HHHHHCCCCCCCCCC	19.39	25159151
1360	Phosphorylation	RQHSACASTSHIAET HCCCCCCCCCCCCCC	30.26	30576142
1361	Phosphorylation	QHSACASTSHIAETP CCCCCCCCCCCCCCC	13.05	30576142
1362	Phosphorylation	HSACASTSHIAETPE CCCCCCCCCCCCCCC	15.48	25159151
1367	Phosphorylation	STSHIAETPESAPPI CCCCCCCCCCCCCCC	24.27	30576142
1370	Phosphorylation	HIAETPESAPPIALP CCCCCCCCCCCCCCC	47.48	23186163
1401	Phosphorylation	EENDFFNSFTTVLHK HHCCCCHHHHHHHHH	20.86	21712546
1403	Phosphorylation	NDFFNSFTTVLHKQR CCCCHHHHHHHHHHC	18.80	27690223
1404	Phosphorylation	DFFNSFTTVLHKQRN CCCHHHHHHHHHHCC	21.04	27690223
1516	Phosphorylation	KTDNVEVTDGENKEI ECCCEEECCCCCCEE	25.44	-
1521	Acetylation	EVTDGENKEIKVKVD EECCCCCCEEEEEEE	57.42	26051181
1557	Phosphorylation	ISAGSLTSLSLRGKP CCCCCCCEEECCCCC	22.66	17081983
1559	Phosphorylation	AGSLTSLSLRGKPPD CCCCCEEECCCCCCC	18.78	24719451
1563	Acetylation	TSLSLRGKPPDVSTE CEEECCCCCCCCCHH	47.12	26051181
1568	Phosphorylation	RGKPPDVSTEAFLTN CCCCCCCCHHHHHHH	28.10	20068231
1569	Phosphorylation	GKPPDVSTEAFLTNL CCCCCCCHHHHHHHC	31.05	20068231
1574	Phosphorylation	VSTEAFLTNLSIQSK CCHHHHHHHCCCCCC	27.88	20068231
1577	Phosphorylation	EAFLTNLSIQSKQEE HHHHHHCCCCCCCHH	22.20	20068231
1580	Phosphorylation	LTNLSIQSKQEETVE HHHCCCCCCCHHHHH	34.34	20068231
1588	Phosphorylation	KQEETVESKEKTLKR CCHHHHHHHHHHHHH	41.60	20393185
1589	Acetylation	QEETVESKEKTLKRQ CHHHHHHHHHHHHHH	50.12	26051181
1610	Phosphorylation	NNLQDNQTSNSSPCR HCCCCCCCCCCCCCH	35.81	30266825
1611	Phosphorylation	NLQDNQTSNSSPCRS CCCCCCCCCCCCCHH	25.58	30266825
1613	Phosphorylation	QDNQTSNSSPCRSNV CCCCCCCCCCCHHCC	35.11	23401153
1614	Phosphorylation	DNQTSNSSPCRSNVG CCCCCCCCCCHHCCC	32.06	19664994
1618	Phosphorylation	SNSSPCRSNVGKGNI CCCCCCHHCCCCCCC	42.45	30576142
1630	Phosphorylation	GNIDGNVSCSENLVA CCCCCCCCCCCCCCC	18.87	30576142
1632	Phosphorylation	IDGNVSCSENLVANT CCCCCCCCCCCCCCC	23.24	30576142
1639	Phosphorylation	SENLVANTARSPQFI CCCCCCCCCCCCCCC	17.45	25159151
1642	Phosphorylation	LVANTARSPQFINLK CCCCCCCCCCCCCCC	22.16	19664994
1649	Acetylation	SPQFINLKRDPRQAA CCCCCCCCCCHHHHC	50.71	25953088
1649	Ubiquitination	SPQFINLKRDPRQAA CCCCCCCCCCHHHHC	50.71	-
1659	Phosphorylation	PRQAAGRSQPVTTSE HHHHCCCCCCCCCCC	37.61	23090842
1663	Phosphorylation	AGRSQPVTTSESKDG CCCCCCCCCCCCCCC	31.15	23090842
1664	Phosphorylation	GRSQPVTTSESKDGD CCCCCCCCCCCCCCC	30.63	23090842
1665	Phosphorylation	RSQPVTTSESKDGDS CCCCCCCCCCCCCCC	30.43	23090842
1667	Phosphorylation	QPVTTSESKDGDSCR CCCCCCCCCCCCCCC	35.50	23090842
1668	Acetylation	PVTTSESKDGDSCRN CCCCCCCCCCCCCCC	62.77	26051181
1678	Acetylation	DSCRNGEKHMLPGLS CCCCCCCCCCCCCCC	35.39	25953088
1703	Phosphorylation	NVEEKLCSAEKNSCV CHHHHHHHHHHCCHH	50.31	21712546
1706	Acetylation	EKLCSAEKNSCVQQS HHHHHHHHCCHHCCH	54.61	25953088
1708	Phosphorylation	LCSAEKNSCVQQSDN HHHHHHCCHHCCHHC	27.08	21712546
1722	Phosphorylation	NLKVAQNSPSVENIQ CCEECCCCCCHHHHC	13.38	25159151
1724	Phosphorylation	KVAQNSPSVENIQTS EECCCCCCHHHHCCC	41.71	25159151
1730	Phosphorylation	PSVENIQTSQAEQAK CCHHHHCCCHHHHCC	21.00	30108239
1731	Phosphorylation	SVENIQTSQAEQAKP CHHHHCCCHHHHCCC	15.83	28464451
1750	Phosphorylation	ILMQNIETVHPFRRG HHHHCCCCCCCCCCC	21.96	26074081
1756	Methylation	ETVHPFRRGSAVATS CCCCCCCCCCEEEEC	43.74	115487403
1758	Phosphorylation	VHPFRRGSAVATSHF CCCCCCCCEEEECCC	20.12	23401153
1762	Phosphorylation	RRGSAVATSHFEVGN CCCCEEEECCCCCCC	19.01	30576142
1763	Phosphorylation	RGSAVATSHFEVGNT CCCEEEECCCCCCCC	19.21	28464451
1773	O-linked_Glycosylation	EVGNTCPSEFPSKSI CCCCCCCCCCCCCEE	54.75	23301498
1778	Acetylation	CPSEFPSKSITFTSR CCCCCCCCEEEEEEC	46.22	26051181
1779	Phosphorylation	PSEFPSKSITFTSRS CCCCCCCEEEEEECC	31.06	21406692
1781	Phosphorylation	EFPSKSITFTSRSTS CCCCCEEEEEECCCC	28.14	21406692
1783	Phosphorylation	PSKSITFTSRSTSPR CCCEEEEEECCCCCC	17.99	21406692
1784	Phosphorylation	SKSITFTSRSTSPRT CCEEEEEECCCCCCC	21.75	21406692
1785	Methylation	KSITFTSRSTSPRTS CEEEEEECCCCCCCC	40.68	81452645
1786	O-linked_Glycosylation	SITFTSRSTSPRTST EEEEEECCCCCCCCC	32.76	23301498
1786	Phosphorylation	SITFTSRSTSPRTST EEEEEECCCCCCCCC	32.76	21406692
1787	Phosphorylation	ITFTSRSTSPRTSTN EEEEECCCCCCCCCC	41.46	26074081
1788	Phosphorylation	TFTSRSTSPRTSTNF EEEECCCCCCCCCCC	17.40	26074081
1790	Methylation	TSRSTSPRTSTNFSP EECCCCCCCCCCCCC	40.87	81452639
1793	Phosphorylation	STSPRTSTNFSPMRP CCCCCCCCCCCCCCC	39.40	28555341
1796	Phosphorylation	PRTSTNFSPMRPQQP CCCCCCCCCCCCCCC	21.61	25159151
1799	Dimethylation	STNFSPMRPQQPNLQ CCCCCCCCCCCCCCC	29.29	-
1799	Methylation	STNFSPMRPQQPNLQ CCCCCCCCCCCCCCC	29.29	52719573
1809	Methylation	QPNLQHLKSSPPGFP CCCCCHHCCCCCCCC	46.92	115487419
1867	Asymmetric dimethylarginine	HLPGQPQRMMGPLSQ CCCCCCCCCCCCHHH	24.60	-
1867	Methylation	HLPGQPQRMMGPLSQ CCCCCCCCCCCCHHH	24.60	24129315
1877	Asymmetric dimethylarginine	GPLSQASRYIGPQNF CCHHHHHHHHCCCCC	30.06	-
1877	Methylation	GPLSQASRYIGPQNF CCHHHHHHHHCCCCC	30.06	24129315
1898	Phosphorylation	RRPERRHSDPWGRQD CCCCCCCCCCCCCCC	43.48	23401153
1911	Methylation	QDQQQLDRPFNRGKG CCHHHHCCCCCCCCC	46.42	54557985
1915	Methylation	QLDRPFNRGKGDRQR HHCCCCCCCCCHHHH	48.88	54557977
1917	Methylation	DRPFNRGKGDRQRFY CCCCCCCCCHHHHHC	55.17	115487387
1922	Methylation	RGKGDRQRFYSDSHH CCCCHHHHHCCCCHH	33.11	115487395
1924	Phosphorylation	KGDRQRFYSDSHHLK CCHHHHHCCCCHHHH	17.47	27273156
1925	Phosphorylation	GDRQRFYSDSHHLKR CHHHHHCCCCHHHHH	29.89	23401153
1927	Phosphorylation	RQRFYSDSHHLKRER HHHHCCCCHHHHHHH	13.58	23927012
1931	Sumoylation	YSDSHHLKRERHEKE CCCCHHHHHHHHHHH	48.10	28112733
1952	Phosphorylation	RHRRRDRSQDKDRDR HHHHHHHHHHHHHHH	47.20	-
1975	Phosphorylation	DKERARLSHGDRGTD HHHHHHHCCCCCCCC	21.63	21857030

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PHF3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PHF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PHF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PHF3_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PHF3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1178, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-1133; SER-1614;SER-1618; SER-1722 AND SER-1724, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-1133 ANDSER-1642, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-677; SER-678; SER-1184AND SER-1925, AND MASS SPECTROMETRY.	18220336 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-473, AND MASSSPECTROMETRY.	17525332 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1614 AND SER-1642, ANDMASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-680 ANDSER-1927, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1133, AND MASSSPECTROMETRY.	15302935 [Abstract]