SMHD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMHD1_HUMAN
• UniProt AC: A6NHR9
• Protein Name: Structural maintenance of chromosomes flexible hinge domain-containing protein 1
• Gene Name: SMCHD1
• Organism: Homo sapiens (Human).
• Sequence Length: 2005
• Subcellular Localization: Chromosome .
• Protein Description: Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the methyltransferase DNMT3B (By similarity). Required for DUX4 silencing in somatic cells. [PubMed: 23143600]
• Protein Sequence: MAAADGGGPGGASVGTEEDGGGVGHRTVYLFDRREKESELGDRPLQVGERSDYAGFRACVCQTLGISPEEKFVITTTSRKEITCDNFDETVKDGVTLYLLQSVNQLLLTATKERIDFLPHYDTLVKSGMYEYYASEGQNPLPFALAELIDNSLSATSRNIGVRRIQIKLLFDETQGKPAVAVIDNGRGMTSKQLNNWAVYRLSKFTRQGDFESDHSGYVRPVPVPRSLNSDISYFGVGGKQAVFFVGQSARMISKPADSQDVHELVLSKEDFEKKEKNKEAIYSGYIRNRKPSDSVHITNDDERFLHHLIIEEKEKDSFTAVVITGVQPEHIQYLKNYFHLWTRQLAHIYHYYIHGPKGNEIRTSKEVEPFNNIDIEISMFEKGKVPKIVNLREIQDDMQTLYVNTAADSFEFKAHVEGDGVVEGIIRYHPFLYDRETYPDDPCFPSKLKDEDDEDDCFILEKAARGKRPIFECFWNGRLIPYTSVEDFDWCTPPKKRGLAPIECYNRISGALFTNDKFQVSTNKLTFMDLELKLKDKNTLFTRILNGQEQRMKIDREFALWLKDCHEKYDKQIKFTLFKGVITRPDLPSKKQGPWATYAAIEWDGKIYKAGQLVKTIKTLPLFYGSIVRFFLYGDHDGEVYATGGEVQIAMEPQALYDEVRTVPIAKLDRTVAEKAVKKYVEDEMARLPDRLSVTWPEGDELLPNEVRPAGTPIGALRIEILNKKGEAMQKLPGTSHGGSKKLLVELKVILHSSSGNKEIISHISQHGGKWPYWFKKMENIQKLGNYTLKLQVVLNESNADTYAGRPLPSKAIKFSVKEGKPEKFSFGLLDLPFRVGVPFNIPLEFQDEFGHTSQLVTDIQPVLEASGLSLHYEEITKGPNCVIRGVTAKGPVNSCQGKNYNLKVTLPGLKEDSQILKIRLLPGHPRRLKVKPDSEILVIENGTAFPFQVEVLDESDNITAQPKLIVHCKFSGAPNLPVYVVDCSSSGTSILTGSAIQVQNIKKDQTLKARIEIPSCKDVAPVEKTIKLLPSSHVARLQIFSVEGQKAIQIKHQDEVNWIAGDIMHNLIFQMYDEGEREINITSALAEKIKVNWTPEINKEHLLQGLLPDVQVPTSVKDMRYCQVSFQDDHVSLESAFTVRPLPDEPKHLKCEMKGGKTVQMGQELQGEVVIIITDQYGNQIQAFSPSSLSSLSIAGVGLDSSNLKTTFQENTQSISVRGIKFIPGPPGNKDLCFTWREFSDFIRVQLISGPPAKLLLIDWPELKESIPVINGRDLQNPIIVQLCDQWDNPAPVQHVKISLTKASNLKLMPSNQQHKTDEKGRANLGVFSVFAPRGEHTLQVKAIYNKSIIEGPIIKLMILPDPEKPVRLNVKYDKDASFLAGGLFTDFMISVISEDDSIIKNINPARISMKMWKLSTSGNRPPANAETFSCNKIKDNDKEDGCFYFRDKVIPNKVGTYCIQFGFMMDKTNILNSEQVIVEVLPNQPVKLVPKIKPPTPAVSNVRSVASRTLVRDLHLSITDDYDNHTGIDLVGTIIATIKGSNEEDTDTPLFIGKVRTLEFPFVNGSAEIMSLVLAESSPGRDSTEYFIVFEPRLPLLSRTLEPYILPFMFYNDVKKQQQMAALTKEKDQLSQSIVMYKSLFEASQQLLNEMKCQVEEARLKEAQLRNELKIHNIDIPTTQQVPHIEALLKRKLSEQEELKKKPRRSCTLPNYTKGSGDVLGKIAHLAQIEDDRAAMVISWHLASDMDCVVTLTTDAARRIYDETQGRQQVLPLDSIYKKTLPDWKRSLPHFRNGKLYFKPIGDPVFARDLLTFPDNVEHCETVFGMLLGDTIILDNLDAANHYRKEVVKITHCPTLLTRDGDRIRSNGKFGGLQNKAPPMDKLRGMVFGAPVPKQCLILGEQIDLLQQYRSAVCKLDSVNKDLNSQLEYLRTPDMRKKKQELDEHEKNLKLIEEKLGMTPIRKCNDSLRHSPKVETTDCPVPPKRMRREATRQNRIITKTDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAADGGGP ------CCCCCCCCC	23.74	19413330
13	Phosphorylation	GGGPGGASVGTEEDG CCCCCCCCCCCCCCC	25.10	25849741
16	Phosphorylation	PGGASVGTEEDGGGV CCCCCCCCCCCCCCC	33.76	25850435
26	Methylation	DGGGVGHRTVYLFDR CCCCCCCEEEEEEEC	21.69	115383241
36	Acetylation	YLFDRREKESELGDR EEEECCCCCCCCCCC	65.80	25953088
36	Ubiquitination	YLFDRREKESELGDR EEEECCCCCCCCCCC	65.80	29967540
64	Ubiquitination	RACVCQTLGISPEEK CHHHHHHCCCCHHHC	2.06	21890473
67	Phosphorylation	VCQTLGISPEEKFVI HHHHCCCCHHHCEEE	25.18	28450419
75	Phosphorylation	PEEKFVITTTSRKEI HHHCEEEEECCCCEE	20.79	20068231
76	Phosphorylation	EEKFVITTTSRKEIT HHCEEEEECCCCEEE	16.20	20068231
77	Phosphorylation	EKFVITTTSRKEITC HCEEEEECCCCEEEC	20.20	20068231
78	Phosphorylation	KFVITTTSRKEITCD CEEEEECCCCEEECC	38.98	20068231
80	Acetylation	VITTTSRKEITCDNF EEEECCCCEEECCCC	53.92	27452117
80	Ubiquitination	VITTTSRKEITCDNF EEEECCCCEEECCCC	53.92	29967540
121	Phosphorylation	RIDFLPHYDTLVKSG HHHCCCCHHHHHHHC	14.53	27642862
123	Phosphorylation	DFLPHYDTLVKSGMY HCCCCHHHHHHHCCC	26.70	23186163
177	Acetylation	LFDETQGKPAVAVID EEECCCCCCEEEEEE	21.71	26051181
177	Ubiquitination	LFDETQGKPAVAVID EEECCCCCCEEEEEE	21.71	29967540
191 (in isoform 3)	Ubiquitination	-	14.98	21890473
192	Ubiquitination	NGRGMTSKQLNNWAV CCCCCCHHHHHHHHH	50.03	23000965
192 (in isoform 1)	Ubiquitination	-	50.03	21890473
192 (in isoform 2)	Ubiquitination	-	50.03	21890473
213	Phosphorylation	TRQGDFESDHSGYVR CCCCCCCCCCCCCCC	40.39	26714015
240	Ubiquitination	SYFGVGGKQAVFFVG CEECCCCCEEEEEEE	29.20	-
254	Phosphorylation	GQSARMISKPADSQD ECCCEEECCCCCCCC	24.20	23312004
259	Phosphorylation	MISKPADSQDVHELV EECCCCCCCCHHHHH	30.32	27067055
269	Ubiquitination	VHELVLSKEDFEKKE HHHHHHCHHHHHHHH	58.08	29967540
283	Phosphorylation	EKNKEAIYSGYIRNR HHCHHHHHHHCCCCC	11.77	23917254
291	Ubiquitination	SGYIRNRKPSDSVHI HHCCCCCCCCCCEEE	53.04	-
293	Phosphorylation	YIRNRKPSDSVHITN CCCCCCCCCCEEECC	45.62	29255136
295	Phosphorylation	RNRKPSDSVHITNDD CCCCCCCCEEECCCC	21.67	20873877
299	Phosphorylation	PSDSVHITNDDERFL CCCCEEECCCCHHHH	20.09	23312004
309 (in isoform 3)	Ubiquitination	-	2.69	21890473
314	Ubiquitination	HHLIIEEKEKDSFTA HHHHEEECCCCCCEE	58.22	29967540
388	Ubiquitination	FEKGKVPKIVNLREI ECCCCCCEEECHHHH	63.37	29967540
392	Ubiquitination	KVPKIVNLREIQDDM CCCEEECHHHHCCHH	3.44	21890473
431	Ubiquitination	EGIIRYHPFLYDRET EEEEEECCCCCCCCC	16.41	21890473
448	Acetylation	DDPCFPSKLKDEDDE CCCCCCCCCCCCCCC	60.85	26051181
448	Ubiquitination	DDPCFPSKLKDEDDE CCCCCCCCCCCCCCC	60.85	29967540
450	Acetylation	PCFPSKLKDEDDEDD CCCCCCCCCCCCCCC	63.91	26822725
450	Ubiquitination	PCFPSKLKDEDDEDD CCCCCCCCCCCCCCC	63.91	29967540
452	Ubiquitination	FPSKLKDEDDEDDCF CCCCCCCCCCCCCCC	66.82	21890473
463	Acetylation	DDCFILEKAARGKRP CCCCHHHHHHCCCCC	43.85	26822725
463	Ubiquitination	DDCFILEKAARGKRP CCCCHHHHHHCCCCC	43.85	29967540
491	Ubiquitination	TSVEDFDWCTPPKKR CCHHCCCCCCCCCCC	6.46	21890473
492 (in isoform 3)	Ubiquitination	-	4.39	21890473
493	Phosphorylation	VEDFDWCTPPKKRGL HHCCCCCCCCCCCCC	38.07	28348404
496	Ubiquitination	FDWCTPPKKRGLAPI CCCCCCCCCCCCCCH	57.20	-
497	Ubiquitination	DWCTPPKKRGLAPIE CCCCCCCCCCCCCHH	58.43	-
525	Ubiquitination	KFQVSTNKLTFMDLE CEEEECCCEEEEEEE	49.33	29967540
538	Ubiquitination	LELKLKDKNTLFTRI EEEEECCCCHHHHHH	50.69	29967540
564	Ubiquitination	REFALWLKDCHEKYD HHHHHHHHHHHHHHH	46.88	29967540
580	Acetylation	QIKFTLFKGVITRPD CCEEEEEECEECCCC	56.21	26051181
580	Ubiquitination	QIKFTLFKGVITRPD CCEEEEEECEECCCC	56.21	21890473
580 (in isoform 1)	Ubiquitination	-	56.21	21890473
580 (in isoform 2)	Ubiquitination	-	56.21	21890473
590	Phosphorylation	ITRPDLPSKKQGPWA ECCCCCCCCCCCCCE	60.84	24719451
590	Ubiquitination	ITRPDLPSKKQGPWA ECCCCCCCCCCCCCE	60.84	23000965
591	Acetylation	TRPDLPSKKQGPWAT CCCCCCCCCCCCCEE	47.37	25953088
591	Ubiquitination	TRPDLPSKKQGPWAT CCCCCCCCCCCCCEE	47.37	29967540
596	Ubiquitination	PSKKQGPWATYAAIE CCCCCCCCEEEEEEE	14.20	21890473
599	Phosphorylation	KQGPWATYAAIEWDG CCCCCEEEEEEEECC	6.06	17924679
609	Phosphorylation	IEWDGKIYKAGQLVK EEECCEEEEHHHHHH	9.77	17924679
610	Ubiquitination	EWDGKIYKAGQLVKT EECCEEEEHHHHHHH	49.90	29967540
616	Acetylation	YKAGQLVKTIKTLPL EEHHHHHHHHHHHHC	53.80	26051181
616	Ubiquitination	YKAGQLVKTIKTLPL EEHHHHHHHHHHHHC	53.80	29967540
619	Acetylation	GQLVKTIKTLPLFYG HHHHHHHHHHHCCCC	49.60	25953088
619	Ubiquitination	GQLVKTIKTLPLFYG HHHHHHHHHHHCCCC	49.60	21890473
619 (in isoform 1)	Ubiquitination	-	49.60	21890473
619 (in isoform 2)	Ubiquitination	-	49.60	21890473
620	Phosphorylation	QLVKTIKTLPLFYGS HHHHHHHHHHCCCCC	29.74	21406692
624	Ubiquitination	TIKTLPLFYGSIVRF HHHHHHCCCCCEEEE	6.48	21963094
625	Phosphorylation	IKTLPLFYGSIVRFF HHHHHCCCCCEEEEE	20.04	21406692
627	Phosphorylation	TLPLFYGSIVRFFLY HHHCCCCCEEEEEEE	13.41	21406692
627	Ubiquitination	TLPLFYGSIVRFFLY HHHCCCCCEEEEEEE	13.41	22817900
650	Ubiquitination	ATGGEVQIAMEPQAL EECCEEEEEECCHHH	4.81	23000965
656	Ubiquitination	QIAMEPQALYDEVRT EEEECCHHHHCCCCC	20.85	21890473
668	Acetylation	VRTVPIAKLDRTVAE CCCCCHHHHCHHHHH	52.20	23749302
668	Ubiquitination	VRTVPIAKLDRTVAE CCCCCHHHHCHHHHH	52.20	-
672	Phosphorylation	PIAKLDRTVAEKAVK CHHHHCHHHHHHHHH	24.59	20068231
676	Acetylation	LDRTVAEKAVKKYVE HCHHHHHHHHHHHHH	49.06	25953088
684	Ubiquitination	AVKKYVEDEMARLPD HHHHHHHHHHHCCCC	40.71	21963094
687	Ubiquitination	KYVEDEMARLPDRLS HHHHHHHHCCCCCCE	14.07	22817900
725	Ubiquitination	LRIEILNKKGEAMQK HEEEEECCCCHHHHH	59.72	29967540
732	Ubiquitination	KKGEAMQKLPGTSHG CCCHHHHHCCCCCCC	43.49	29967540
737 (in isoform 3)	Ubiquitination	-	26.50	21890473
754	Phosphorylation	ELKVILHSSSGNKEI EEEEEEECCCCCHHH	23.82	30266825
755	Phosphorylation	LKVILHSSSGNKEII EEEEEECCCCCHHHH	31.36	30266825
756	Phosphorylation	KVILHSSSGNKEIIS EEEEECCCCCHHHHH	49.77	30266825
759	Ubiquitination	LHSSSGNKEIISHIS EECCCCCHHHHHHHH	54.54	29967540
771	Acetylation	HISQHGGKWPYWFKK HHHHCCCCCCCHHHH	49.98	23954790
777	Acetylation	GKWPYWFKKMENIQK CCCCCHHHHCHHHHH	36.74	26051181
778	Ubiquitination	KWPYWFKKMENIQKL CCCCHHHHCHHHHHH	41.81	23000965
784	Acetylation	KKMENIQKLGNYTLK HHCHHHHHHCCEEEE	55.34	26051181
784	Ubiquitination	KKMENIQKLGNYTLK HHCHHHHHHCCEEEE	55.34	23000965
784 (in isoform 1)	Ubiquitination	-	55.34	21890473
784 (in isoform 2)	Ubiquitination	-	55.34	21890473
811	Phosphorylation	YAGRPLPSKAIKFSV CCCCCCCCCCEEEEE	42.26	24719451
812	Acetylation	AGRPLPSKAIKFSVK CCCCCCCCCEEEEEE	52.79	26051181
812	Ubiquitination	AGRPLPSKAIKFSVK CCCCCCCCCEEEEEE	52.79	21963094
812 (in isoform 1)	Ubiquitination	-	52.79	21890473
812 (in isoform 2)	Ubiquitination	-	52.79	21890473
815	Acetylation	PLPSKAIKFSVKEGK CCCCCCEEEEEECCC	36.12	25953088
815	Ubiquitination	PLPSKAIKFSVKEGK CCCCCCEEEEEECCC	36.12	22817900
819	Ubiquitination	KAIKFSVKEGKPEKF CCEEEEEECCCCCCE	60.60	29967540
822	Ubiquitination	KFSVKEGKPEKFSFG EEEEECCCCCCEEEE	51.61	-
860	Ubiquitination	HTSQLVTDIQPVLEA CHHHEEEHHHHHHHH	30.00	21890473
865	Ubiquitination	VTDIQPVLEASGLSL EEHHHHHHHHCCCEE	6.07	23000965
891	Acetylation	VIRGVTAKGPVNSCQ EEEECEECCCCCCCC	55.15	25953088
891	Ubiquitination	VIRGVTAKGPVNSCQ EEEECEECCCCCCCC	55.15	29967540
900	Acetylation	PVNSCQGKNYNLKVT CCCCCCCCCCEEEEE	30.31	26051181
900	Ubiquitination	PVNSCQGKNYNLKVT CCCCCCCCCCEEEEE	30.31	29967540
902	Ubiquitination	NSCQGKNYNLKVTLP CCCCCCCCEEEEECC	25.92	23503661
904	Ubiquitination	CQGKNYNLKVTLPGL CCCCCCEEEEECCCC	3.13	23503661
905	Acetylation	QGKNYNLKVTLPGLK CCCCCEEEEECCCCC	29.54	30592515
912	Ubiquitination	KVTLPGLKEDSQILK EEECCCCCCCCCEEE	66.45	-
919	Acetylation	KEDSQILKIRLLPGH CCCCCEEEEEECCCC	27.66	25953088
920	Ubiquitination	EDSQILKIRLLPGHP CCCCEEEEEECCCCC	3.17	21890473
925	Ubiquitination	LKIRLLPGHPRRLKV EEEEECCCCCCCCCC	43.32	23000965
962	Ubiquitination	DESDNITAQPKLIVH CCCCCCCCCCEEEEE	21.63	23503661
964	Ubiquitination	SDNITAQPKLIVHCK CCCCCCCCEEEEEEE	30.84	23503661
1019	Acetylation	RIEIPSCKDVAPVEK EEECCCCCCCCCHHH	60.62	26051181
1019	Ubiquitination	RIEIPSCKDVAPVEK EEECCCCCCCCCHHH	60.62	32015554
1026	Acetylation	KDVAPVEKTIKLLPS CCCCCHHHHEEECCC	56.64	26051181
1026	Ubiquitination	KDVAPVEKTIKLLPS CCCCCHHHHEEECCC	56.64	29967540
1033	Phosphorylation	KTIKLLPSSHVARLQ HHEEECCCCCEEEEE	32.80	23312004
1034	Phosphorylation	TIKLLPSSHVARLQI HEEECCCCCEEEEEE	21.75	23312004
1048	Ubiquitination	IFSVEGQKAIQIKHQ EEEECCCEEEEEEEH	59.31	23000965
1048 (in isoform 1)	Ubiquitination	-	59.31	21890473
1048 (in isoform 2)	Ubiquitination	-	59.31	21890473
1053	Ubiquitination	GQKAIQIKHQDEVNW CCEEEEEEEHHHCCH	20.88	23000965
1068	Ubiquitination	IAGDIMHNLIFQMYD HHHHHHHHHHHHCCC	19.90	21890473
1078	Ubiquitination	FQMYDEGEREINITS HHCCCCCCCEEECCH	45.13	23503661
1090	Ubiquitination	ITSALAEKIKVNWTP CCHHHHHHHCCCCCC	42.07	23503661
1090 (in isoform 2)	Ubiquitination	-	42.07	-
1092	Ubiquitination	SALAEKIKVNWTPEI HHHHHHHCCCCCCCC	40.35	23503661
1101	Ubiquitination	NWTPEINKEHLLQGL CCCCCCCHHHHHHCC	52.77	29967540
1119	Ubiquitination	VQVPTSVKDMRYCQV CCCCCCCCCCCEEEE	45.64	32015554
1128	Ubiquitination	MRYCQVSFQDDHVSL CCEEEEEECCCCEEE	10.96	21890473
1138	Ubiquitination	DHVSLESAFTVRPLP CCEEEEECEEEEECC	8.51	23503661
1186	Ubiquitination	YGNQIQAFSPSSLSS CCCEEEEECHHHCCC	6.72	21890473
1189	Ubiquitination	QIQAFSPSSLSSLSI EEEEECHHHCCCCEE	42.59	23000965
1208	Phosphorylation	LDSSNLKTTFQENTQ CCCCCCCCCCHHCCC	35.69	-
1209	Phosphorylation	DSSNLKTTFQENTQS CCCCCCCCCHHCCCC	23.02	-
1232	Acetylation	IPGPPGNKDLCFTWR ECCCCCCCCCEEEHH	58.97	26051181
1246	Ubiquitination	REFSDFIRVQLISGP HHCCCCEEEEECCCC	15.32	21890473
1249	Ubiquitination	SDFIRVQLISGPPAK CCCEEEEECCCCCCE	2.85	23000965
1256	Ubiquitination	LISGPPAKLLLIDWP ECCCCCCEEEEEECH	45.50	21890473
1256 (in isoform 1)	Ubiquitination	-	45.50	21890473
1256 (in isoform 2)	Ubiquitination	-	45.50	21890473
1266	Ubiquitination	LIDWPELKESIPVIN EEECHHHHHHCCEEC	47.99	33845483
1266 (in isoform 2)	Ubiquitination	-	47.99	-
1301	Phosphorylation	PVQHVKISLTKASNL CCCEEEEEEEEHHCC	25.03	24719451
1304	Malonylation	HVKISLTKASNLKLM EEEEEEEEHHCCEEC	55.93	26320211
1304	Ubiquitination	HVKISLTKASNLKLM EEEEEEEEHHCCEEC	55.93	29967540
1349	Acetylation	QVKAIYNKSIIEGPI EEEEEEECCCEECCE	26.51	19608861
1349	Ubiquitination	QVKAIYNKSIIEGPI EEEEEEECCCEECCE	26.51	32015554
1358	Acetylation	IIEGPIIKLMILPDP CEECCEEEEEECCCC	32.49	18585689
1367	Acetylation	MILPDPEKPVRLNVK EECCCCCCCEEEEEE	54.95	18585699
1367	Neddylation	MILPDPEKPVRLNVK EECCCCCCCEEEEEE	54.95	32015554
1369	Ubiquitination	LPDPEKPVRLNVKYD CCCCCCCEEEEEECC	18.84	23503661
1374	Sumoylation	KPVRLNVKYDKDASF CCEEEEEECCCCCHH	46.81	-
1374	Neddylation	KPVRLNVKYDKDASF CCEEEEEECCCCCHH	46.81	32015554
1374	Sumoylation	KPVRLNVKYDKDASF CCEEEEEECCCCCHH	46.81	28112733
1374	Ubiquitination	KPVRLNVKYDKDASF CCEEEEEECCCCCHH	46.81	23000965
1374 (in isoform 1)	Ubiquitination	-	46.81	21890473
1374 (in isoform 2)	Ubiquitination	-	46.81	21890473
1377	Ubiquitination	RLNVKYDKDASFLAG EEEEECCCCCHHHCC	52.70	23000965
1400	Phosphorylation	SVISEDDSIIKNINP EEECCCCCHHHCCCH	38.24	24719451
1420	Phosphorylation	KMWKLSTSGNRPPAN EEEEECCCCCCCCCC	30.60	28985074
1429	Ubiquitination	NRPPANAETFSCNKI CCCCCCCCEEEECCC	50.63	23503661
1430	Ubiquitination	RPPANAETFSCNKIK CCCCCCCEEEECCCC	20.59	23503661
1431	Ubiquitination	PPANAETFSCNKIKD CCCCCCEEEECCCCC	6.20	23503661
1435	Ubiquitination	AETFSCNKIKDNDKE CCEEEECCCCCCCCC	56.30	32015554
1437	Acetylation	TFSCNKIKDNDKEDG EEEECCCCCCCCCCC	52.68	25953088
1437	Ubiquitination	TFSCNKIKDNDKEDG EEEECCCCCCCCCCC	52.68	29967540
1441	Ubiquitination	NKIKDNDKEDGCFYF CCCCCCCCCCCCEEE	65.05	29967540
1451	Ubiquitination	GCFYFRDKVIPNKVG CCEEECCCCCCCCCE	37.50	29967540
1490	Ubiquitination	VLPNQPVKLVPKIKP ECCCCCCEECCCCCC	50.91	23503661
1491	Ubiquitination	LPNQPVKLVPKIKPP CCCCCCEECCCCCCC	8.97	23503661
1496	Sumoylation	VKLVPKIKPPTPAVS CEECCCCCCCCCCCC	51.58	28112733
1499	Phosphorylation	VPKIKPPTPAVSNVR CCCCCCCCCCCCCHH	32.19	20068231
1503	Phosphorylation	KPPTPAVSNVRSVAS CCCCCCCCCHHHHHH	31.54	20068231
1507	Phosphorylation	PAVSNVRSVASRTLV CCCCCHHHHHHHHHH	20.11	24719451
1544	Phosphorylation	IIATIKGSNEEDTDT EEEEEECCCCCCCCC	35.75	20860994
1557	Ubiquitination	DTPLFIGKVRTLEFP CCCEEEEEEEEEECC	24.59	21906983
1557 (in isoform 1)	Ubiquitination	-	24.59	21890473
1557 (in isoform 2)	Ubiquitination	-	24.59	21890473
1614	Ubiquitination	YILPFMFYNDVKKQQ CCHHHHCCHHHHHHH	9.92	21890473
1618	Ubiquitination	FMFYNDVKKQQQMAA HHCCHHHHHHHHHHH	47.96	23503661
1618 (in isoform 2)	Ubiquitination	-	47.96	-
1619	Ubiquitination	MFYNDVKKQQQMAAL HCCHHHHHHHHHHHH	53.86	23503661
1627	Phosphorylation	QQQMAALTKEKDQLS HHHHHHHHHHHHHHH	32.22	29743597
1628	Ubiquitination	QQMAALTKEKDQLSQ HHHHHHHHHHHHHHH	64.71	32015554
1636	Phosphorylation	EKDQLSQSIVMYKSL HHHHHHHHHHHHHHH	17.49	28555341
1642	Phosphorylation	QSIVMYKSLFEASQQ HHHHHHHHHHHHHHH	22.32	28555341
1647	Phosphorylation	YKSLFEASQQLLNEM HHHHHHHHHHHHHHH	15.97	28555341
1655	Ubiquitination	QQLLNEMKCQVEEAR HHHHHHHHHHHHHHH	18.48	32015554
1664	Ubiquitination	QVEEARLKEAQLRNE HHHHHHHHHHHHHHC	45.51	29967540
1674	Ubiquitination	QLRNELKIHNIDIPT HHHHCCEECCCCCCC	4.74	21890473
1693	Acetylation	PHIEALLKRKLSEQE CCHHHHHHHHCCHHH	48.62	25953088
1697	Phosphorylation	ALLKRKLSEQEELKK HHHHHHCCHHHHHHC	40.02	29255136
1703	Acetylation	LSEQEELKKKPRRSC CCHHHHHHCCCCCCC	63.13	23749302
1703	Ubiquitination	LSEQEELKKKPRRSC CCHHHHHHCCCCCCC	63.13	32015554
1709	Phosphorylation	LKKKPRRSCTLPNYT HHCCCCCCCCCCCCC	16.84	25159151
1711	Phosphorylation	KKPRRSCTLPNYTKG CCCCCCCCCCCCCCC	46.63	30108239
1715	Phosphorylation	RSCTLPNYTKGSGDV CCCCCCCCCCCCCCH	14.11	28985074
1716	Phosphorylation	SCTLPNYTKGSGDVL CCCCCCCCCCCCCHH	35.25	29396449
1717	Acetylation	CTLPNYTKGSGDVLG CCCCCCCCCCCCHHH	40.49	26051181
1725	Ubiquitination	GSGDVLGKIAHLAQI CCCCHHHHHHHHHHC	32.34	-
1762	Ubiquitination	LTTDAARRIYDETQG EEHHHHHHHHHHCCC	27.39	21890473
1767	Phosphorylation	ARRIYDETQGRQQVL HHHHHHHCCCCCCEE	33.16	30576142
1770	Ubiquitination	IYDETQGRQQVLPLD HHHHCCCCCCEECHH	17.59	21890473
1778	Phosphorylation	QQVLPLDSIYKKTLP CCEECHHHHHCCCCC	35.19	30576142
1780	Phosphorylation	VLPLDSIYKKTLPDW EECHHHHHCCCCCHH	15.47	21406692
1781	Acetylation	LPLDSIYKKTLPDWK ECHHHHHCCCCCHHH	37.30	25953088
1782	Ubiquitination	PLDSIYKKTLPDWKR CHHHHHCCCCCHHHH	38.02	29967540
1788	Ubiquitination	KKTLPDWKRSLPHFR CCCCCHHHHHCCCCC	39.22	29967540
1790	Phosphorylation	TLPDWKRSLPHFRNG CCCHHHHHCCCCCCC	42.39	29214152
1798	Acetylation	LPHFRNGKLYFKPIG CCCCCCCEEEEEECC	43.49	25953088
1802	Acetylation	RNGKLYFKPIGDPVF CCCEEEEEECCCCEE	23.36	25953088
1802	Succinylation	RNGKLYFKPIGDPVF CCCEEEEEECCCCEE	23.36	-
1802	Succinylation	RNGKLYFKPIGDPVF CCCEEEEEECCCCEE	23.36	21890473
1802	Ubiquitination	RNGKLYFKPIGDPVF CCCEEEEEECCCCEE	23.36	21890473
1802 (in isoform 1)	Ubiquitination	-	23.36	21890473
1802 (in isoform 2)	Ubiquitination	-	23.36	21890473
1822	Ubiquitination	TFPDNVEHCETVFGM CCCCCHHHHHHHHHH	15.49	21890473
1830	Ubiquitination	CETVFGMLLGDTIIL HHHHHHHHHCCEEEE	5.04	21890473
1872	Acetylation	DRIRSNGKFGGLQNK CCCCCCCCCCCCCCC	45.12	23749302
1885	Acetylation	NKAPPMDKLRGMVFG CCCCCHHHHCCHHCC	33.56	26051181
1918	2-Hydroxyisobutyrylation	QYRSAVCKLDSVNKD HHHHHHHHHHHCCCH	49.05	-
1918	Ubiquitination	QYRSAVCKLDSVNKD HHHHHHHHHHHCCCH	49.05	29967540
1921	Phosphorylation	SAVCKLDSVNKDLNS HHHHHHHHCCCHHHH	37.72	-
1924	Ubiquitination	CKLDSVNKDLNSQLE HHHHHCCCHHHHHHH	62.53	29967540
1928	Phosphorylation	SVNKDLNSQLEYLRT HCCCHHHHHHHHHCC	43.36	28348404
1932	Phosphorylation	DLNSQLEYLRTPDMR HHHHHHHHHCCHHHH	15.29	28555341
1935	Phosphorylation	SQLEYLRTPDMRKKK HHHHHHCCHHHHHHH	22.50	28348404
1950	Ubiquitination	QELDEHEKNLKLIEE HHHHHHHHHHHHHHH	70.28	21890473
1950 (in isoform 1)	Ubiquitination	-	70.28	21890473
1958	Ubiquitination	NLKLIEEKLGMTPIR HHHHHHHHHCCCCCH	37.23	32015554
1958 (in isoform 1)	Ubiquitination	-	37.23	21890473
1962	Phosphorylation	IEEKLGMTPIRKCND HHHHHCCCCCHHCCH	17.48	21815630
1970	Phosphorylation	PIRKCNDSLRHSPKV CCHHCCHHHCCCCCC	17.20	24732914
1974	Phosphorylation	CNDSLRHSPKVETTD CCHHHCCCCCCCCCC	21.71	23143600
1979	Phosphorylation	RHSPKVETTDCPVPP CCCCCCCCCCCCCCC	30.81	23403867
1980	Phosphorylation	HSPKVETTDCPVPPK CCCCCCCCCCCCCCH	23.30	24732914
2001	Phosphorylation	TRQNRIITKTDV--- HHHCCCEECCCC---	26.06	30266825
2002	Sumoylation	RQNRIITKTDV---- HHCCCEECCCC----	32.11	-
2002	Sumoylation	RQNRIITKTDV---- HHCCCEECCCC----	32.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMHD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMHD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMHD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ECM29_HUMAN	KIAA0368	physical	26344197
MB12A_HUMAN	MVB12A	physical	26344197
TRI25_HUMAN	TRIM25	physical	26344197
SYWC_HUMAN	WARS	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 158901: Facioscapulohumeral muscular dystrophy 2 (FSHD2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1349, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-599 AND TYR-609, ANDMASS SPECTROMETRY.
PubMed: 17924679