dbPTM

DDX18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DDX18_HUMAN
UniProt AC	Q9NVP1
Protein Name	ATP-dependent RNA helicase DDX18
Gene Name	DDX18
Organism	Homo sapiens (Human).
Sequence Length	670
Subcellular Localization	Nucleus, nucleolus . Chromosome .
Protein Description	Probable RNA-dependent helicase..
Protein Sequence	MSHLPMKLLRKKIEKRNLKLRQRNLKFQGASNLTLSETQNGDVSEETMGSRKVKKSKQKPMNVGLSETQNGGMSQEAVGNIKVTKSPQKSTVLTNGEAAMQSSNSESKKKKKKKRKMVNDAEPDTKKAKTENKGKSEEESAETTKETENNVEKPDNDEDESEVPSLPLGLTGAFEDTSFASLCNLVNENTLKAIKEMGFTNMTEIQHKSIRPLLEGRDLLAAAKTGSGKTLAFLIPAVELIVKLRFMPRNGTGVLILSPTRELAMQTFGVLKELMTHHVHTYGLIMGGSNRSAEAQKLGNGINIIVATPGRLLDHMQNTPGFMYKNLQCLVIDEADRILDVGFEEELKQIIKLLPTRRQTMLFSATQTRKVEDLARISLKKEPLYVGVDDDKANATVDGLEQGYVVCPSEKRFLLLFTFLKKNRKKKLMVFFSSCMSVKYHYELLNYIDLPVLAIHGKQKQNKRTTTFFQFCNADSGTLLCTDVAARGLDIPEVDWIVQYDPPDDPKEYIHRVGRTARGLNGRGHALLILRPEELGFLRYLKQSKVPLSEFDFSWSKISDIQSQLEKLIEKNYFLHKSAQEAYKSYIRAYDSHSLKQIFNVNNLNLPQVALSFGFKVPPFVDLNVNSNEGKQKKRGGGGGFGYQKTKKVEKSKIFKHISKKSSDSRQFSH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSHLPMKLL ------CCCCCHHHH	33.46	20068231
7	Acetylation	-MSHLPMKLLRKKIE -CCCCCHHHHHHHHH	42.29	23749302
26	Acetylation	KLRQRNLKFQGASNL HHHHHHCCCCCCCCC	38.91	26051181
31	Phosphorylation	NLKFQGASNLTLSET HCCCCCCCCCEEEEC	38.92	26074081
34	Phosphorylation	FQGASNLTLSETQNG CCCCCCCEEEECCCC	32.27	26074081
36	Phosphorylation	GASNLTLSETQNGDV CCCCCEEEECCCCCC	33.10	26074081
38	Phosphorylation	SNLTLSETQNGDVSE CCCEEEECCCCCCCH	24.77	26074081
44	Phosphorylation	ETQNGDVSEETMGSR ECCCCCCCHHHHCCH	34.16	28985074
47	Phosphorylation	NGDVSEETMGSRKVK CCCCCHHHHCCHHHC	23.84	25159151
50	Phosphorylation	VSEETMGSRKVKKSK CCHHHHCCHHHCCCC	20.36	21712546
57	Acetylation	SRKVKKSKQKPMNVG CHHHCCCCCCCCCCC	71.82	7712417
59	Acetylation	KVKKSKQKPMNVGLS HHCCCCCCCCCCCCC	50.39	26051181
66	Phosphorylation	KPMNVGLSETQNGGM CCCCCCCCCCCCCCC	32.44	26074081
68	Phosphorylation	MNVGLSETQNGGMSQ CCCCCCCCCCCCCCH	24.77	26074081
74	Phosphorylation	ETQNGGMSQEAVGNI CCCCCCCCHHHCCCE	28.30	25159151
82	Acetylation	QEAVGNIKVTKSPQK HHHCCCEEECCCCCC	48.10	19822401
84	Phosphorylation	AVGNIKVTKSPQKST HCCCEEECCCCCCCE	22.32	26074081
86	Phosphorylation	GNIKVTKSPQKSTVL CCEEECCCCCCCEEE	24.17	30266825
90	Phosphorylation	VTKSPQKSTVLTNGE ECCCCCCCEEEECHH	20.64	26074081
91	Phosphorylation	TKSPQKSTVLTNGEA CCCCCCCEEEECHHH	26.94	28464451
94	Phosphorylation	PQKSTVLTNGEAAMQ CCCCEEEECHHHHHH	36.52	26074081
102	Phosphorylation	NGEAAMQSSNSESKK CHHHHHHCCCCHHHH	20.57	29978859
103	Phosphorylation	GEAAMQSSNSESKKK HHHHHHCCCCHHHHH	27.73	22199227
105	Phosphorylation	AAMQSSNSESKKKKK HHHHCCCCHHHHHHH	45.24	22199227
107	Phosphorylation	MQSSNSESKKKKKKK HHCCCCHHHHHHHHH	49.98	22199227
125	Phosphorylation	VNDAEPDTKKAKTEN CCCCCCCHHHHHCCC	45.20	22210691
126	Acetylation	NDAEPDTKKAKTENK CCCCCCHHHHHCCCC	59.10	25953088
130	Phosphorylation	PDTKKAKTENKGKSE CCHHHHHCCCCCCCH	50.04	30576142
135	Sumoylation	AKTENKGKSEEESAE HHCCCCCCCHHHHHH	57.19	-
135	Sumoylation	AKTENKGKSEEESAE HHCCCCCCCHHHHHH	57.19	-
135	Acetylation	AKTENKGKSEEESAE HHCCCCCCCHHHHHH	57.19	26051181
136	Phosphorylation	KTENKGKSEEESAET HCCCCCCCHHHHHHH	59.93	25849741
140	Phosphorylation	KGKSEEESAETTKET CCCCHHHHHHHHHHH	34.38	28985074
195	Ubiquitination	ENTLKAIKEMGFTNM HHHHHHHHHCCCCCC	46.65	21890473
195	Acetylation	ENTLKAIKEMGFTNM HHHHHHHHHCCCCCC	46.65	26051181
195	2-Hydroxyisobutyrylation	ENTLKAIKEMGFTNM HHHHHHHHHCCCCCC	46.65	-
208	Ubiquitination	NMTEIQHKSIRPLLE CCCCCCCCCHHHHHC	31.07	-
224	Acetylation	RDLLAAAKTGSGKTL HHHHHHHHCCCCHHH	49.01	25953088
224	Ubiquitination	RDLLAAAKTGSGKTL HHHHHHHHCCCCHHH	49.01	21890473
225	Phosphorylation	DLLAAAKTGSGKTLA HHHHHHHCCCCHHHH	31.67	18491316
227	Phosphorylation	LAAAKTGSGKTLAFL HHHHHCCCCHHHHHH	42.20	18491316
230	Phosphorylation	AKTGSGKTLAFLIPA HHCCCCHHHHHHHHH	27.18	-
258	Phosphorylation	GTGVLILSPTRELAM CCEEEEECCCHHHHH	19.75	25867546
260	Phosphorylation	GVLILSPTRELAMQT EEEEECCCHHHHHHH	33.14	25867546
265	Sulfoxidation	SPTRELAMQTFGVLK CCCHHHHHHHHHHHH	6.36	21406390
289	Phosphorylation	YGLIMGGSNRSAEAQ HCHHCCCCCHHHHHH	24.28	23532336
297	Acetylation	NRSAEAQKLGNGINI CHHHHHHHHCCCCEE	66.46	25953088
297	Ubiquitination	NRSAEAQKLGNGINI CHHHHHHHHCCCCEE	66.46	21890473
308	Phosphorylation	GINIIVATPGRLLDH CCEEEEECCHHHHHH	18.51	30266825
319	Phosphorylation	LLDHMQNTPGFMYKN HHHHHCCCCCHHHCC	14.11	20860994
324	Phosphorylation	QNTPGFMYKNLQCLV CCCCCHHHCCCEEEE	8.41	-
325	Acetylation	NTPGFMYKNLQCLVI CCCCHHHCCCEEEEE	39.12	26051181
348	Ubiquitination	VGFEEELKQIIKLLP CCCHHHHHHHHHHCC	42.61	-
352	Acetylation	EELKQIIKLLPTRRQ HHHHHHHHHCCCCCH	45.67	25953088
360	Phosphorylation	LLPTRRQTMLFSATQ HCCCCCHHCCEEECC	17.65	20068231
361	Sulfoxidation	LPTRRQTMLFSATQT CCCCCHHCCEEECCC	2.42	28183972
364	Phosphorylation	RRQTMLFSATQTRKV CCHHCCEEECCCCCH	26.84	20068231
366	Phosphorylation	QTMLFSATQTRKVED HHCCEEECCCCCHHH	29.31	20068231
368	Phosphorylation	MLFSATQTRKVEDLA CCEEECCCCCHHHHH	28.27	20068231
370	Ubiquitination	FSATQTRKVEDLARI EEECCCCCHHHHHCC	54.05	-
380	Sumoylation	DLARISLKKEPLYVG HHHCCCCCCCCCEEC	48.58	-
381	Ubiquitination	LARISLKKEPLYVGV HHCCCCCCCCCEECC	70.61	-
381	2-Hydroxyisobutyrylation	LARISLKKEPLYVGV HHCCCCCCCCCEECC	70.61	-
385	Phosphorylation	SLKKEPLYVGVDDDK CCCCCCCEECCCCCC	13.08	27642862
392	Acetylation	YVGVDDDKANATVDG EECCCCCCCCCEECC	51.00	26051181
411	Acetylation	YVVCPSEKRFLLLFT EEECCCHHHHHHHHH	53.43	26051181
411	2-Hydroxyisobutyrylation	YVVCPSEKRFLLLFT EEECCCHHHHHHHHH	53.43	-
434	Phosphorylation	KLMVFFSSCMSVKYH EEEEEHHCCCCHHHH	14.53	-
437	Phosphorylation	VFFSSCMSVKYHYEL EEHHCCCCHHHHHHH	21.56	24719451
440	Phosphorylation	SSCMSVKYHYELLNY HCCCCHHHHHHHHHH	13.89	22817900
442	Phosphorylation	CMSVKYHYELLNYID CCCHHHHHHHHHHCC	12.75	22817900
447	Phosphorylation	YHYELLNYIDLPVLA HHHHHHHHCCCCEEE	8.86	22817900
458	Acetylation	PVLAIHGKQKQNKRT CEEEEECCCCCCCCC	39.91	23954790
458	Malonylation	PVLAIHGKQKQNKRT CEEEEECCCCCCCCC	39.91	26320211
507	Acetylation	YDPPDDPKEYIHRVG CCCCCCHHHHHHHHH	70.87	26051181
545	Ubiquitination	LRYLKQSKVPLSEFD HHHHHHCCCCHHHCC	45.43	-
545	Acetylation	LRYLKQSKVPLSEFD HHHHHHCCCCHHHCC	45.43	23954790
549	Phosphorylation	KQSKVPLSEFDFSWS HHCCCCHHHCCCCHH	30.10	-
554	Phosphorylation	PLSEFDFSWSKISDI CHHHCCCCHHHHHHH	32.08	28348404
557	Ubiquitination	EFDFSWSKISDIQSQ HCCCCHHHHHHHHHH	39.72	21890473
563	Phosphorylation	SKISDIQSQLEKLIE HHHHHHHHHHHHHHH	36.75	27050516
567	Acetylation	DIQSQLEKLIEKNYF HHHHHHHHHHHHHCC	64.46	25953088
567	Ubiquitination	DIQSQLEKLIEKNYF HHHHHHHHHHHHHCC	64.46	-
571	2-Hydroxyisobutyrylation	QLEKLIEKNYFLHKS HHHHHHHHHCCCCHH	50.37	-
571	Ubiquitination	QLEKLIEKNYFLHKS HHHHHHHHHCCCCHH	50.37	21906983
571	Acetylation	QLEKLIEKNYFLHKS HHHHHHHHHCCCCHH	50.37	19608861
577	Ubiquitination	EKNYFLHKSAQEAYK HHHCCCCHHHHHHHH	50.03	-
577	Acetylation	EKNYFLHKSAQEAYK HHHCCCCHHHHHHHH	50.03	25825284
584	Acetylation	KSAQEAYKSYIRAYD HHHHHHHHHHHHHHH	43.78	26051181
584	Ubiquitination	KSAQEAYKSYIRAYD HHHHHHHHHHHHHHH	43.78	-
588	Methylation	EAYKSYIRAYDSHSL HHHHHHHHHHHHCCC	20.89	-
627	Phosphorylation	FVDLNVNSNEGKQKK EEECCCCCCCCCCCC	31.79	30266825
635	Methylation	NEGKQKKRGGGGGFG CCCCCCCCCCCCCCC	56.90	-
643	Phosphorylation	GGGGGFGYQKTKKVE CCCCCCCHHHCCCCH	12.46	20860994
645	Acetylation	GGGFGYQKTKKVEKS CCCCCHHHCCCCHHH	54.55	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DDX18_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DDX18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DDX18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
PRP6_HUMAN	PRPF6	physical	22939629
REQU_HUMAN	DPF2	physical	22939629
PR40A_HUMAN	PRPF40A	physical	22939629
SRSF3_HUMAN	SRSF3	physical	22939629
ABCF2_HUMAN	ABCF2	physical	26344197
BCCIP_HUMAN	BCCIP	physical	26344197
BRX1_HUMAN	BRIX1	physical	26344197
BYST_HUMAN	BYSL	physical	26344197
DCA13_HUMAN	DCAF13	physical	26344197
DDX24_HUMAN	DDX24	physical	26344197
DDX47_HUMAN	DDX47	physical	26344197
DDX5_HUMAN	DDX5	physical	26344197
DDX55_HUMAN	DDX55	physical	26344197
DDX56_HUMAN	DDX56	physical	26344197
DHX15_HUMAN	DHX15	physical	26344197
DKC1_HUMAN	DKC1	physical	26344197
EBP2_HUMAN	EBNA1BP2	physical	26344197
ESF1_HUMAN	ESF1	physical	26344197
FBRL_HUMAN	FBL	physical	26344197
GAR1_HUMAN	GAR1	physical	26344197
GLYR1_HUMAN	GLYR1	physical	26344197
GNL1_HUMAN	GNL1	physical	26344197
GRWD1_HUMAN	GRWD1	physical	26344197
NOG1_HUMAN	GTPBP4	physical	26344197
HNRPR_HUMAN	HNRNPR	physical	26344197
MPP10_HUMAN	MPHOSPH10	physical	26344197
NAT10_HUMAN	NAT10	physical	26344197
NH2L1_HUMAN	NHP2L1	physical	26344197
MK67I_HUMAN	NIFK	physical	26344197
NIP7_HUMAN	NIP7	physical	26344197
NOC2L_HUMAN	NOC2L	physical	26344197
NOL10_HUMAN	NOL10	physical	26344197
NOL6_HUMAN	NOL6	physical	26344197
NOP2_HUMAN	NOP2	physical	26344197
NOP56_HUMAN	NOP56	physical	26344197
NOP58_HUMAN	NOP58	physical	26344197
NSA2_HUMAN	NSA2	physical	26344197
RPA2_HUMAN	POLR1B	physical	26344197
RPAC1_HUMAN	POLR1C	physical	26344197
RPA49_HUMAN	POLR1E	physical	26344197
PWP1_HUMAN	PWP1	physical	26344197
PWP2_HUMAN	PWP2	physical	26344197
RBM28_HUMAN	RBM28	physical	26344197
RPF2_HUMAN	RPF2	physical	26344197
RL11_HUMAN	RPL11	physical	26344197
RL18A_HUMAN	RPL18A	physical	26344197
RL23_HUMAN	RPL23	physical	26344197
RL27_HUMAN	RPL27	physical	26344197
RL36_HUMAN	RPL36	physical	26344197
RL5_HUMAN	RPL5	physical	26344197
RL8_HUMAN	RPL8	physical	26344197
RL9_HUMAN	RPL9	physical	26344197
RS15A_HUMAN	RPS15A	physical	26344197
RS4X_HUMAN	RPS4X	physical	26344197
RS6_HUMAN	RPS6	physical	26344197
RS7_HUMAN	RPS7	physical	26344197
RRP15_HUMAN	RRP15	physical	26344197
RRS1_HUMAN	RRS1	physical	26344197
TBL3_HUMAN	TBL3	physical	26344197
TSR1_HUMAN	TSR1	physical	26344197
UT14A_HUMAN	UTP14A	physical	26344197
UTP20_HUMAN	UTP20	physical	26344197
WDR3_HUMAN	WDR3	physical	26344197
WDR36_HUMAN	WDR36	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DDX18_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-7 AND LYS-571, AND MASSSPECTROMETRY.	19608861 [Abstract]