DHX37_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHX37_HUMAN
• UniProt AC: Q8IY37
• Protein Name: Probable ATP-dependent RNA helicase DHX37
• Gene Name: DHX37
• Organism: Homo sapiens (Human).
• Sequence Length: 1157
• Protein Sequence: MGKLRRRYNIKGRQQAGPGPSKGPPEPPPVQLELEDKDTLKGVDASNALVLPGKKKKKTKAPPLSKKEKKPLTKKEKKVLQKILEQKEKKSQRAEMLQKLSEVQASEAEMRLFYTTSKLGTGNRMYHTKEKADEVVAPGQEKISSLSGAHRKRRRWPSAEEEEEEEEESESELEEESELDEDPAAEPAEAGVGTTVAPLPPAPAPSSQPVPAGMTVPPPPAAAPPLPRALAKPAVFIPVNRSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLRVEDFTQNPRLFAKPPPVIKVESRQFPVTVHFNKRTPLEDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKAFPPSRARPQEKDDDQKDSVEEMRKFKKSRARAKKARAEVLPQINLDHYSVLPAGEGDEDREAEVDEEEGALDSDLDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVINFPFPTPPSVEALLAAEELLIALGALQPPQKAERVKQLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEELDRPAASDEELTRLKSKRARVAQMKRTWAGQGASLKLGDLMVLLGAVGACEYASCTPQFCEANGLRYKAMMEIRRLRGQLTTAVNAVCPEAELFVDPKMQPPTESQVTYLRQIVTAGLGDHLARRVQSEEMLEDKWRNAYKTPLLDDPVFIHPSSVLFKELPEFVVYQEIVETTKMYMKGVSSVEVQWIPALLPSYCQFDKPLEEPAPTYCPERGRVLCHRASVFYRVGWPLPAIEVDFPEGIDRYKHFARFLLEGQVFRKLASYRSCLLSSPGTMLKTWARLQPRTESLLRALVAEKADCHEALLAAWKKNPKYLLAEYCEWLPQAMHPDIEKAWPPTTVH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Acetylation	QAGPGPSKGPPEPPP CCCCCCCCCCCCCCC	77.80	26051181
41	Ubiquitination	LEDKDTLKGVDASNA ECCCCCCCCCCCCCC	60.01	33845483
54	Acetylation	NALVLPGKKKKKTKA CCEECCCCCCCCCCC	60.52	25953088
54	Ubiquitination	NALVLPGKKKKKTKA CCEECCCCCCCCCCC	60.52	33845483
59	Phosphorylation	PGKKKKKTKAPPLSK CCCCCCCCCCCCCCH	41.12	24732914
65	Phosphorylation	KTKAPPLSKKEKKPL CCCCCCCCHHHCCCC	47.67	24732914
91	Phosphorylation	LEQKEKKSQRAEMLQ HHHHHHHHHHHHHHH	35.65	18077418
99	Ubiquitination	QRAEMLQKLSEVQAS HHHHHHHHHHHHHCC	50.44	24816145
106	Phosphorylation	KLSEVQASEAEMRLF HHHHHHCCHHHHHHH	21.90	-
110	Sulfoxidation	VQASEAEMRLFYTTS HHCCHHHHHHHEEEC	6.09	21406390
114	Phosphorylation	EAEMRLFYTTSKLGT HHHHHHHEEECCCCC	17.44	-
116	Phosphorylation	EMRLFYTTSKLGTGN HHHHHEEECCCCCCC	16.69	23186163
117	Phosphorylation	MRLFYTTSKLGTGNR HHHHEEECCCCCCCC	20.34	23917254
118	Ubiquitination	RLFYTTSKLGTGNRM HHHEEECCCCCCCCC	49.17	29967540
118	Acetylation	RLFYTTSKLGTGNRM HHHEEECCCCCCCCC	49.17	25953088
145	Phosphorylation	PGQEKISSLSGAHRK CCHHHHHHCCHHHHH	29.99	25159151
147	Phosphorylation	QEKISSLSGAHRKRR HHHHHHCCHHHHHCC	35.56	25627689
232	Ubiquitination	PLPRALAKPAVFIPV CCCHHHCCCEEEEEC	34.07	29967540
242	Phosphorylation	VFIPVNRSPEMQEER EEEECCCCHHHHHHH	21.73	25159151
295	Phosphorylation	FLYEAGFSSEDSIIG HHHHCCCCCCCCCCC	31.72	-
320	Ubiquitination	AMSQRVAKEMNLSQR HHHHHHHHHCCHHHH	55.42	24816145
359	Ubiquitination	VLLKEIQKDFLLLRY CHHHHHHHCHHCCEE	56.99	21890473
417	Phosphorylation	TLRVEDFTQNPRLFA EECHHHHCCCCCCCC	39.49	-
425	Ubiquitination	QNPRLFAKPPPVIKV CCCCCCCCCCCEEEE	51.20	33845483
431	Acetylation	AKPPPVIKVESRQFP CCCCCEEEEECCCCC	39.94	26051181
452	Phosphorylation	KRTPLEDYSGECFRK CCCCCCCCCCHHHHH	14.81	28152594
453	Phosphorylation	RTPLEDYSGECFRKV CCCCCCCCCHHHHHH	40.20	28152594
503	Ubiquitination	SRARPQEKDDDQKDS HHCCCCCCCCCCCCH	62.30	24816145
510	Phosphorylation	KDDDQKDSVEEMRKF CCCCCCCHHHHHHHH	38.16	25159151
613	Phosphorylation	FKPPPEGTRLCVVAT CCCCCCCCEEEEEEE	20.85	-
640	Ubiquitination	KYVVDCGKVKKRYYD EEEEECCCCEEHHHC	58.15	29967540
713	Ubiquitination	EDLILQMKALNVEKV HHHHHHHHCCCHHEE	36.44	21963094
757	Ubiquitination	PQKAERVKQLQENRL CHHHHHHHHHHHCCC	52.06	29967540
765	Phosphorylation	QLQENRLSCPITALG HHHHCCCCCCHHHHC	18.01	21406692
769	Phosphorylation	NRLSCPITALGRTMA CCCCCCHHHHCCHHC	10.85	21406692
786	Ubiquitination	PVAPRYAKMLALSRQ CCCHHHHHHHHHHHH	26.05	-
786	Acetylation	PVAPRYAKMLALSRQ CCCHHHHHHHHHHHH	26.05	7482757
791	Phosphorylation	YAKMLALSRQHGCLP HHHHHHHHHHHCCHH	25.04	24719451
840	Acetylation	RARVAQMKRTWAGQG HHHHHHHHHHHCCCC	34.30	21339330
849	O-linked_Glycosylation	TWAGQGASLKLGDLM HHCCCCCCCCHHHHH	32.63	30379171
882	Phosphorylation	CEANGLRYKAMMEIR HHHCCCHHHHHHHHH	14.24	22817900
903	Glutathionylation	TTAVNAVCPEAELFV HHHHHHHCCCCCEEC	2.04	22555962
918	Phosphorylation	DPKMQPPTESQVTYL CCCCCCCCHHHHHHH	55.76	21406692
920	Phosphorylation	KMQPPTESQVTYLRQ CCCCCCHHHHHHHHH	32.21	21406692
923	Phosphorylation	PPTESQVTYLRQIVT CCCHHHHHHHHHHHH	14.81	21406692
924	Phosphorylation	PTESQVTYLRQIVTA CCHHHHHHHHHHHHC	10.88	21406692
943	Phosphorylation	HLARRVQSEEMLEDK HHHHHHCCHHHHHHH	32.44	20068231
950	Ubiquitination	SEEMLEDKWRNAYKT CHHHHHHHHHHCCCC	38.38	-
956	Ubiquitination	DKWRNAYKTPLLDDP HHHHHCCCCCCCCCC	41.05	-
957	Phosphorylation	KWRNAYKTPLLDDPV HHHHCCCCCCCCCCE	13.39	-
1080	Phosphorylation	VFRKLASYRSCLLSS HHHHHHHHHHHHHCC	10.84	-
1093	Ubiquitination	SSPGTMLKTWARLQP CCCCCHHHHHHHHCC	31.06	-
1113	Acetylation	LRALVAEKADCHEAL HHHHHHHHCCHHHHH	39.52	26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHX37_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHX37_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHX37_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAT10_HUMAN	NAT10	physical	22939629
RPAC1_HUMAN	POLR1C	physical	22939629
DHX15_HUMAN	DHX15	physical	26344197
NAT10_HUMAN	NAT10	physical	26344197
RPAC1_HUMAN	POLR1C	physical	26344197
RBM19_HUMAN	RBM19	physical	26344197
RS3A_HUMAN	RPS3A	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.