ZSWM8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZSWM8_HUMAN
• UniProt AC: A7E2V4
• Protein Name: Zinc finger SWIM domain-containing protein 8
• Gene Name: ZSWIM8
• Organism: Homo sapiens (Human).
• Sequence Length: 1837
• Protein Sequence: MELMFAEWEDGERFSFEDSDRFEEDSLCSFISEAESLCQNWRGWRKQSAGPNSPTGGGGGGGSGGTRMRDGLVIPLVELSAKQVAFHIPFEVVEKVYPPVPEQLQLRIAFWSFPENEEDIRLYSCLANGSADEFQRGDQLFRMRAVKDPLQIGFHLSATVVPPQMVPPKGAYNVAVMFDRCRVTSCSCTCGAGAKWCTHVVALCLFRIHNASAVCLRAPVSESLSRLQRDQLQKFAQYLISELPQQILPTAQRLLDELLSSQSTAINTVCGAPDPTAGPSASDQSTWYLDESTLTDNIKKTLHKFCGPSPVVFSDVNSMYLSSTEPPAAAEWACLLRPLRGREPEGVWNLLSIVREMFKRRDSNAAPLLEILTDQCLTYEQITGWWYSVRTSASHSSASGHTGRSNGQSEVAAHACASMCDEMVTLWRLAVLDPALSPQRRRELCTQLRQWQLKVIENVKRGQHKKTLERLFPGFRPAVEACYFNWEEAYPLPGVTYSGTDRKLALCWARALPSRPGASRSGGLEESRDRPRPLPTEPAVRPKEPGTKRKGLGEGVPSSQRGPRRLSAEGGDKALHKMGPGGGKAKALGGAGSGSKGSAGGGSKRRLSSEDSSLEPDLAEMSLDDSSLALGAEASTFGGFPESPPPCPLHGGSRGPSTFLPEPPDTYEEDGGVYFSEGPEPPTASVGPPGLLPGDVCTQDDLPSTDESGNGLPKTKEAAPAVGEEDDDYQAYYLNAQDGAGGEEEKAEGGAGEEHDLFAGLKPLEQESRMEVLFACAEALHAHGYSSEASRLTVELAQDLLANPPDLKVEPPPAKGKKNKVSTSRQTWVATNTLSKAAFLLTVLSERPEHHNLAFRVGMFALELQRPPASTKALEVKLAYQESEVAALLKKIPLGPSEMSTMRCRAEELREGTLCDYRPVLPLMLASFIFDVLCAPGSRPPSRNWNSETPGDEELGFEAAVAALGMKTTVSEAEHPLLCEGTRREKGDLALALMITYKDDQAKLKKILDKLLDRESQTHKPQTLSSFYSSSRPTTASQRSPSKHGGPSAPGALQPLTSGSAGPAQPGSVAGAGPGPTEGFTEKNVPESSPHSPCEGLPSEAALTPRPEGKVPSRLALGSRGGYNGRGWGSPGRPKKKHTGMASIDSSAPETTSDSSPTLSRRPLRGGWAPTSWGRGQDSDSISSSSSDSLGSSSSSGSRRASASGGARAKTVEVGRYKGRRPESHAPHVPNQPSEAAAHFYFELAKTVLIKAGGNSSTSIFTHPSSSGGHQGPHRNLHLCAFEIGLYALGLHNFVSPNWLSRTYSSHVSWITGQAMEIGSAALTILVECWDGHLTPPEVASLADRASRARDSNMVRAAAELALSCLPHAHALNPNEIQRALVQCKEQDNLMLEKACMAVEEAAKGGGVYPEVLFEVAHQWFWLYEQTAGGSSTAREGATSCSASGIRAGGEAGRGMPEGRGGPGTEPVTVAAAAVTAAATVVPVISVGSSLYPGPGLGHGHSPGLHPYTALQPHLPCSPQYLTHPAHPAHPMPHMPRPAVFPVPSSAYPQGVHPAFLGAQYPYSVTPPSLAATAVSFPVPSMAPITVHPYHTEPGLPLPTSVACELWGQGTVSSVHPASTFPAIQGASLPALTTQPSPLVSGGFPPPEEETHSQPVNPHSLHHLHAAYRVGMLALEMLGRRAHNDHPNNFSRSPPYTDDVKWLLGLAAKLGVNYVHQFCVGAAKGVLSPFVLQEIVMETLQRLSPAHAHNHLRAPAFHQLVQRCQQAYMQYIHHRLIHLTPADYDDFVNAIRSARSAFCLTPMGMMQFNDILQNLKRSKQTKELWQRVSLEMATFSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	WEDGERFSFEDSDRF ECCCCCCCCCCCCCC		26471730
19	Phosphorylation	ERFSFEDSDRFEEDS CCCCCCCCCCCCCCC		26471730
36	Phosphorylation	SFISEAESLCQNWRG HHHHHHHHHHHHHCC		24275569
46	Ubiquitination	QNWRGWRKQSAGPNS HHHCCHHHCCCCCCC		29967540
48	Phosphorylation	WRGWRKQSAGPNSPT HCCHHHCCCCCCCCC		26055452
53	Phosphorylation	KQSAGPNSPTGGGGG HCCCCCCCCCCCCCC		29255136
55	Phosphorylation	SAGPNSPTGGGGGGG CCCCCCCCCCCCCCC		29255136
63	Phosphorylation	GGGGGGGSGGTRMRD CCCCCCCCCCCCCCC		28176443
66	Phosphorylation	GGGGSGGTRMRDGLV CCCCCCCCCCCCCEE		23403867
157	Phosphorylation	LQIGFHLSATVVPPQ CEEEEEEEEEECCCC		-
159	Phosphorylation	IGFHLSATVVPPQMV EEEEEEEEECCCCCC		-
184	Phosphorylation	MFDRCRVTSCSCTCG EECCCEEEECCCCCC		-
185	Phosphorylation	FDRCRVTSCSCTCGA ECCCEEEECCCCCCC		-
187	Phosphorylation	RCRVTSCSCTCGAGA CCEEEECCCCCCCHH		-
189	Phosphorylation	RVTSCSCTCGAGAKW EEEECCCCCCCHHHH		-
352	Phosphorylation	EGVWNLLSIVREMFK CHHHHHHHHHHHHHH		24719451
399	Phosphorylation	SASHSSASGHTGRSN CCCCCCCCCCCCCCC		-
437	Phosphorylation	AVLDPALSPQRRREL HHHCCCCCHHHHHHH		25850435
460	Ubiquitination	LKVIENVKRGQHKKT HHHHHHHHCCCCHHH		29967540
460 (in isoform 2)	Ubiquitination	-		-
503	Acetylation	TYSGTDRKLALCWAR EECCCCHHHHHHHHH		19813049
503	Ubiquitination	TYSGTDRKLALCWAR EECCCCHHHHHHHHH		-
503 (in isoform 2)	Ubiquitination	-		-
519	Phosphorylation	LPSRPGASRSGGLEE CCCCCCCCCCCCCCC		25002506
521	Phosphorylation	SRPGASRSGGLEESR CCCCCCCCCCCCCCC		25002506
527	Phosphorylation	RSGGLEESRDRPRPL CCCCCCCCCCCCCCC		25002506
536	Phosphorylation	DRPRPLPTEPAVRPK CCCCCCCCCCCCCCC		28555341
558	Phosphorylation	GLGEGVPSSQRGPRR CCCCCCCHHHCCCCC		25159151
559	Phosphorylation	LGEGVPSSQRGPRRL CCCCCCHHHCCCCCC		25627689
567	Phosphorylation	QRGPRRLSAEGGDKA HCCCCCCCCCCCCHH		25159151
593	Phosphorylation	KALGGAGSGSKGSAG CCCCCCCCCCCCCCC		22199227
595	Phosphorylation	LGGAGSGSKGSAGGG CCCCCCCCCCCCCCC		22199227
598	Phosphorylation	AGSGSKGSAGGGSKR CCCCCCCCCCCCCCC		22199227
603	Phosphorylation	KGSAGGGSKRRLSSE CCCCCCCCCCCCCCC		22199227
608	Phosphorylation	GGSKRRLSSEDSSLE CCCCCCCCCCCCCCC		28655764
609	Phosphorylation	GSKRRLSSEDSSLEP CCCCCCCCCCCCCCC		24275569
612	Phosphorylation	RRLSSEDSSLEPDLA CCCCCCCCCCCCCHH		27251275
613	Phosphorylation	RLSSEDSSLEPDLAE CCCCCCCCCCCCHHH		27251275
716	Ubiquitination	GNGLPKTKEAAPAVG CCCCCCCCCCCCCCC		29967540
762	Ubiquitination	HDLFAGLKPLEQESR CCCCCCCCCCCHHHH		29967540
890	Ubiquitination	SEVAALLKKIPLGPS HHHHHHHHCCCCCHH		29967540
891 (in isoform 2)	Ubiquitination	-		-
891	Ubiquitination	EVAALLKKIPLGPSE HHHHHHHCCCCCHHH		-
901	Phosphorylation	LGPSEMSTMRCRAEE CCHHHHHHCCCCHHH		-
1010	Ubiquitination	KLKKILDKLLDRESQ HHHHHHHHHHCCCCC		29967540
1015	Ubiquitination	LDKLLDRESQTHKPQ HHHHHCCCCCCCCCC		29967540
1020	Ubiquitination	DRESQTHKPQTLSSF CCCCCCCCCCCHHHH		29967540
1025	Ubiquitination	THKPQTLSSFYSSSR CCCCCCHHHHHCCCC		29967540
1025	Phosphorylation	THKPQTLSSFYSSSR CCCCCCHHHHHCCCC		27080861
1026	Phosphorylation	HKPQTLSSFYSSSRP CCCCCHHHHHCCCCC		27080861
1028	Phosphorylation	PQTLSSFYSSSRPTT CCCHHHHHCCCCCCC		27080861
1029	Phosphorylation	QTLSSFYSSSRPTTA CCHHHHHCCCCCCCC		29083192
1030	Phosphorylation	TLSSFYSSSRPTTAS CHHHHHCCCCCCCCC		29083192
1031	Phosphorylation	LSSFYSSSRPTTASQ HHHHHCCCCCCCCCC		29083192
1034	Phosphorylation	FYSSSRPTTASQRSP HHCCCCCCCCCCCCC		29083192
1035	Phosphorylation	YSSSRPTTASQRSPS HCCCCCCCCCCCCCC		29083192
1037	Phosphorylation	SSRPTTASQRSPSKH CCCCCCCCCCCCCCC		29083192
1040	Phosphorylation	PTTASQRSPSKHGGP CCCCCCCCCCCCCCC		23312004
1042	Phosphorylation	TASQRSPSKHGGPSA CCCCCCCCCCCCCCC		23312004
1048	Phosphorylation	PSKHGGPSAPGALQP CCCCCCCCCCCCCCC		23312004
1057	Phosphorylation	PGALQPLTSGSAGPA CCCCCCCCCCCCCCC		23312004
1058	Phosphorylation	GALQPLTSGSAGPAQ CCCCCCCCCCCCCCC		23312004
1060	Phosphorylation	LQPLTSGSAGPAQPG CCCCCCCCCCCCCCC		23312004
1068	Phosphorylation	AGPAQPGSVAGAGPG CCCCCCCCCCCCCCC		23312004
1077	Phosphorylation	AGAGPGPTEGFTEKN CCCCCCCCCCCCCCC		23312004
1081	Phosphorylation	PGPTEGFTEKNVPES CCCCCCCCCCCCCCC		23312004
1088	Phosphorylation	TEKNVPESSPHSPCE CCCCCCCCCCCCCCC		21712546
1089	Phosphorylation	EKNVPESSPHSPCEG CCCCCCCCCCCCCCC		25159151
1092	Phosphorylation	VPESSPHSPCEGLPS CCCCCCCCCCCCCCC		25159151
1093	Phosphorylation	PESSPHSPCEGLPSE CCCCCCCCCCCCCCC		24719451
1094	Phosphorylation	ESSPHSPCEGLPSEA CCCCCCCCCCCCCCC		24719451
1097	Phosphorylation	PHSPCEGLPSEAALT CCCCCCCCCCCCCCC		24719451
1099	Phosphorylation	SPCEGLPSEAALTPR CCCCCCCCCCCCCCC		23663014
1104	Phosphorylation	LPSEAALTPRPEGKV CCCCCCCCCCCCCCC		26055452
1109	Phosphorylation	ALTPRPEGKVPSRLA CCCCCCCCCCCCCEE		24719451
1120	Methylation	SRLALGSRGGYNGRG CCEECCCCCCCCCCC		30988037
1130	Phosphorylation	YNGRGWGSPGRPKKK CCCCCCCCCCCCCCC		23401153
1135	Phosphorylation	WGSPGRPKKKHTGMA CCCCCCCCCCCCCCC		24719451
1139	Phosphorylation	GRPKKKHTGMASIDS CCCCCCCCCCCCCCC		20873877
1143	Phosphorylation	KKHTGMASIDSSAPE CCCCCCCCCCCCCCC		30576142
1146	Phosphorylation	TGMASIDSSAPETTS CCCCCCCCCCCCCCC		30576142
1147	Phosphorylation	GMASIDSSAPETTSD CCCCCCCCCCCCCCC		30576142
1151	Phosphorylation	IDSSAPETTSDSSPT CCCCCCCCCCCCCCC		23927012
1152	Phosphorylation	DSSAPETTSDSSPTL CCCCCCCCCCCCCCC		30278072
1153	Phosphorylation	SSAPETTSDSSPTLS CCCCCCCCCCCCCCC		30278072
1155	Phosphorylation	APETTSDSSPTLSRR CCCCCCCCCCCCCCC		23401153
1156	Phosphorylation	PETTSDSSPTLSRRP CCCCCCCCCCCCCCC		22167270
1157	Phosphorylation	ETTSDSSPTLSRRPL CCCCCCCCCCCCCCC		24719451
1158	Phosphorylation	TTSDSSPTLSRRPLR CCCCCCCCCCCCCCC		22167270
1160	Phosphorylation	SDSSPTLSRRPLRGG CCCCCCCCCCCCCCC		22167270
1161	Phosphorylation	DSSPTLSRRPLRGGW CCCCCCCCCCCCCCC		24719451
1162	Methylation	SSPTLSRRPLRGGWA CCCCCCCCCCCCCCC		115920697
1165	Methylation	TLSRRPLRGGWAPTS CCCCCCCCCCCCCCC		58860413
1171	Phosphorylation	LRGGWAPTSWGRGQD CCCCCCCCCCCCCCC		23312004
1172	Phosphorylation	RGGWAPTSWGRGQDS CCCCCCCCCCCCCCC		25159151
1175	Methylation	WAPTSWGRGQDSDSI CCCCCCCCCCCCCCC		115383271
1202	Phosphorylation	SSGSRRASASGGARA CCCCCCCCCCCCCCC		22210691
1204	Phosphorylation	GSRRASASGGARAKT CCCCCCCCCCCCCEE		24719451
1209	Phosphorylation	SASGGARAKTVEVGR CCCCCCCCEEEECCC		24719451
1210	Ubiquitination	ASGGARAKTVEVGRY CCCCCCCEEEECCCC		29967540
1211	Phosphorylation	SGGARAKTVEVGRYK CCCCCCEEEECCCCC		24719451
1215	Ubiquitination	RAKTVEVGRYKGRRP CCEEEECCCCCCCCC		29967540
1216	Phosphorylation	AKTVEVGRYKGRRPE CEEEECCCCCCCCCC		24719451
1217	Phosphorylation	KTVEVGRYKGRRPES EEEECCCCCCCCCCC		24719451
1222	Phosphorylation	GRYKGRRPESHAPHV CCCCCCCCCCCCCCC		24719451
1256	Phosphorylation	LIKAGGNSSTSIFTH EEECCCCCCCEEEEC		26699800
1257	Phosphorylation	IKAGGNSSTSIFTHP EECCCCCCCEEEECC		26699800
1258	Phosphorylation	KAGGNSSTSIFTHPS ECCCCCCCEEEECCC		26699800
1259	Phosphorylation	AGGNSSTSIFTHPSS CCCCCCCEEEECCCC		26699800
1262	Phosphorylation	NSSTSIFTHPSSSGG CCCCEEEECCCCCCC		26699800
1265	Phosphorylation	TSIFTHPSSSGGHQG CEEEECCCCCCCCCC		28152594
1266	Phosphorylation	SIFTHPSSSGGHQGP EEEECCCCCCCCCCC		28152594
1267	Phosphorylation	IFTHPSSSGGHQGPH EEECCCCCCCCCCCC		28152594
1385	Ubiquitination	QRALVQCKEQDNLML HHHHHHCHHHCCHHH		-
1385 (in isoform 2)	Ubiquitination	-		-
1394	Ubiquitination	QDNLMLEKACMAVEE HCCHHHHHHHHHHHH		-
1394 (in isoform 2)	Ubiquitination	-		-
1454	Methylation	RAGGEAGRGMPEGRG CCCCCCCCCCCCCCC		82796417
1460	Methylation	GRGMPEGRGGPGTEP CCCCCCCCCCCCCCC		97825373
1693	Phosphorylation	HPNNFSRSPPYTDDV CCCCCCCCCCCCHHH		21815630
1821	Phosphorylation	NLKRSKQTKELWQRV HHHHHHHHHHHHHHH		30257219
1834	Phosphorylation	RVSLEMATFSP---- HHHHHHHHCCC----		28674151
1836	Phosphorylation	SLEMATFSP------ HHHHHHCCC------		25159151
1841	Phosphorylation	TFSP----------- HCCC-----------		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZSWM8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZSWM8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZSWM8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZSWM8_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.