UTP4_HUMAN - dbPTM
UTP4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UTP4_HUMAN
UniProt AC Q969X6
Protein Name U3 small nucleolar RNA-associated protein 4 homolog
Gene Name UTP4 {ECO:0000312|HGNC:HGNC:1983}
Organism Homo sapiens (Human).
Sequence Length 686
Subcellular Localization Nucleus, nucleolus . Chromosome . Found predominantly at the fibrillar center.
Protein Description Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. [PubMed: 17699751]
Protein Sequence MGEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALISGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGKNGDTLPLSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFFLYRLNYEHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQSGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHDAYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVIRRRTAHAFKISKIYKPLLFMDLLDERTLVAVERPLDDIIAQLPPPIKKKKFGT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Acetylation---MGEFKVHRVRFF
---CCCCEEEEEEEC		27452117
5Ubiquitination---MGEFKVHRVRFF
---CCCCEEEEEEEC		33845483
34PhosphorylationQSNRLAVSRTDGTVE
CCCCEEEECCCCEEE		19053533
36PhosphorylationNRLAVSRTDGTVEIY
CCEEEECCCCEEEEE		30576142
39PhosphorylationAVSRTDGTVEIYNLS
EEECCCCEEEEEEEC		30576142
43PhosphorylationTDGTVEIYNLSANYF
CCCEEEEEEECCCCH		30576142
46PhosphorylationTVEIYNLSANYFQEK
EEEEEEECCCCHHHH		19053533
49PhosphorylationIYNLSANYFQEKFFP
EEEECCCCHHHHCCC		19053533
51UbiquitinationNLSANYFQEKFFPGH
EECCCCHHHHCCCCC		21890473
53UbiquitinationSANYFQEKFFPGHES
CCCCHHHHCCCCCHH		21906983
53 (in isoform 1)Ubiquitination-21890473
53 (in isoform 2)Ubiquitination-21890473
53 (in isoform 3)Ubiquitination-21890473
54UbiquitinationANYFQEKFFPGHESR
CCCHHHHCCCCCHHH		22817900
56UbiquitinationYFQEKFFPGHESRAT
CHHHHCCCCCHHHHH		22817900
86PhosphorylationLNGEIMEYDLQALNI
CCCCCCEEEHHHHCH		29978859
98UbiquitinationLNIKYAMDAFGGPIW
HCHHHHHHHHCCCCE		29967540
110UbiquitinationPIWSMAASPSGSQLL
CCEEEEECCCCCEEE		22817900
112UbiquitinationWSMAASPSGSQLLVG
EEEEECCCCCEEEEE		22817900
134AcetylationLFQITPDKIQFERNF
EEEECCCCEEEEECC		26051181
134UbiquitinationLFQITPDKIQFERNF
EEEECCCCEEEEECC		27667366
134 (in isoform 1)Ubiquitination-21890473
134 (in isoform 2)Ubiquitination-21890473
134 (in isoform 3)Ubiquitination-21890473
175PhosphorylationISVFDVKSGSAVHKM
EEEEEECCCCEEEEE		20068231
177PhosphorylationVFDVKSGSAVHKMIV
EEEECCCCEEEEEEE		20068231
178UbiquitinationFDVKSGSAVHKMIVD
EEECCCCEEEEEEEC		22817900
181UbiquitinationKSGSAVHKMIVDRQY
CCCCEEEEEEECCCC		29967540
182UbiquitinationSGSAVHKMIVDRQYM
CCCEEEEEEECCCCC		21890473
186MethylationVHKMIVDRQYMGVSK
EEEEEECCCCCCCCH		-
188PhosphorylationKMIVDRQYMGVSKRK
EEEECCCCCCCCHHH		20068231
192PhosphorylationDRQYMGVSKRKCIVW
CCCCCCCCHHHEEEE		20068231
193AcetylationRQYMGVSKRKCIVWG
CCCCCCCHHHEEEEE		25953088
193UbiquitinationRQYMGVSKRKCIVWG
CCCCCCCHHHEEEEE		21906983
193 (in isoform 1)Ubiquitination-21890473
193 (in isoform 2)Ubiquitination-21890473
193 (in isoform 3)Ubiquitination-21890473
195UbiquitinationYMGVSKRKCIVWGVA
CCCCCHHHEEEEEEE		22817900
198UbiquitinationVSKRKCIVWGVAFLS
CCHHHEEEEEEEECC		33845483
211PhosphorylationLSDGTIISVDSAGKV
CCCCCEEEECCCCCE		-
214PhosphorylationGTIISVDSAGKVQFW
CCEEEECCCCCEEEE		-
229UbiquitinationDSATGTLVKSHLIAN
ECCCCCEEEEEEECC		21963094
230UbiquitinationSATGTLVKSHLIANA
CCCCCEEEEEEECCC		-
234UbiquitinationTLVKSHLIANADVQS
CEEEEEEECCCCCEE		22817900
238UbiquitinationSHLIANADVQSIAVA
EEEECCCCCEEEEEE		21890473
246UbiquitinationVQSIAVADQEDSFVV
CEEEEEECCCCCEEE		29967540
247UbiquitinationQSIAVADQEDSFVVG
EEEEEECCCCCEEEE		27667366
281SumoylationEKQWVRTKPFQHHTH
CCEEEECCCCCCCCC		-
281SumoylationEKQWVRTKPFQHHTH
CCEEEECCCCCCCCC		-
281UbiquitinationEKQWVRTKPFQHHTH
CCEEEECCCCCCCCC		33845483
285UbiquitinationVRTKPFQHHTHDVRT
EECCCCCCCCCCCCC		21963094
289UbiquitinationPFQHHTHDVRTVAHS
CCCCCCCCCCCEEEC		21890473
293UbiquitinationHTHDVRTVAHSPTAL
CCCCCCCEEECCCEE		22817900
294UbiquitinationTHDVRTVAHSPTALI
CCCCCCEEECCCEEE		29967540
296PhosphorylationDVRTVAHSPTALISG
CCCCEEECCCEEECC		-
298PhosphorylationRTVAHSPTALISGGT
CCEEECCCEEECCCC		-
303UbiquitinationSPTALISGGTDTHLV
CCCEEECCCCCCEEE		27667366
317UbiquitinationVFRPLMEKVEVKNYD
EEHHHHHEEEECCHH		22817900
321SumoylationLMEKVEVKNYDAALR
HHHEEEECCHHHHHH		28112733
321UbiquitinationLMEKVEVKNYDAALR
HHHEEEECCHHHHHH		22817900
321 (in isoform 1)Ubiquitination-21890473
321 (in isoform 2)Ubiquitination-21890473
321 (in isoform 3)Ubiquitination-21890473
323PhosphorylationEKVEVKNYDAALRKI
HEEEECCHHHHHHHC		29496907
329UbiquitinationNYDAALRKITFPHRC
CHHHHHHHCCCCCCE		29967540
345UbiquitinationISCSKKRQLLLFQFA
EECCCCHHHHHHHHH		21890473
349UbiquitinationKKRQLLLFQFAHHLE
CCHHHHHHHHHHHHH		22817900
368AcetylationGSTVATGKNGDTLPL
CCEEECCCCCCCEEC		26051181
368UbiquitinationGSTVATGKNGDTLPL
CCEEECCCCCCCEEC		21906983
368 (in isoform 1)Ubiquitination-21890473
368 (in isoform 3)Ubiquitination-21890473
377UbiquitinationGDTLPLSKNADHLLH
CCCEECCCCCCEEEE		29967540
386UbiquitinationADHLLHLKTKGPENI
CCEEEECCCCCCCCE		27667366
426PhosphorylationNYEHDNISLKRVSKM
CCCCCCEECCHHHCC		24719451
428AcetylationEHDNISLKRVSKMPA
CCCCEECCHHHCCHH		26051181
428UbiquitinationEHDNISLKRVSKMPA
CCCCEECCHHHCCHH		21906983
428 (in isoform 1)Ubiquitination-21890473
428 (in isoform 3)Ubiquitination-21890473
430UbiquitinationDNISLKRVSKMPAFL
CCEECCHHHCCHHHH		21890473
432UbiquitinationISLKRVSKMPAFLRS
EECCHHHCCHHHHHH		22817900
454 (in isoform 2)Ubiquitination-21890473
478UbiquitinationFKHLHAFQPQSGTVE
CEEEEEECCCCCCEE		21890473
486UbiquitinationPQSGTVEAMCLLAVS
CCCCCEEEEEEEEEC		21890473
502 (in isoform 2)Ubiquitination-21890473
506UbiquitinationLAASGTSAGVHVYNV
EEECCCCCEEEEEEE		22817900
509UbiquitinationSGTSAGVHVYNVKQL
CCCCCEEEEEEEEEE		21963094
533 (in isoform 2)Ubiquitination-21890473
534UbiquitinationFPVTAMAIAPNTNNL
CCEEEEEECCCCCCE		21963094
541UbiquitinationIAPNTNNLVIAHSDQ
ECCCCCCEEEEECCC		22817900
542UbiquitinationAPNTNNLVIAHSDQQ
CCCCCCEEEEECCCE		22817900
543UbiquitinationPNTNNLVIAHSDQQV
CCCCCEEEEECCCEE		22817900
544UbiquitinationNTNNLVIAHSDQQVF
CCCCEEEEECCCEEE		22817900
559UbiquitinationEYSIPDKQYTDWSRT
EEECCCHHCCCCHHH		29967540
560PhosphorylationYSIPDKQYTDWSRTV
EECCCHHCCCCHHHH		23403867
561PhosphorylationSIPDKQYTDWSRTVQ
ECCCHHCCCCHHHHH		23403867
562UbiquitinationIPDKQYTDWSRTVQK
CCCHHCCCCHHHHHH		22817900
564PhosphorylationDKQYTDWSRTVQKQG
CHHCCCCHHHHHHCC		23403867
565UbiquitinationKQYTDWSRTVQKQGF
HHCCCCHHHHHHCCC		21963094
565 (in isoform 2)Ubiquitination-21890473
569UbiquitinationDWSRTVQKQGFHHLW
CCHHHHHHCCCEEEE		23000965
569 (in isoform 1)Ubiquitination-21890473
569 (in isoform 3)Ubiquitination-21890473
581PhosphorylationHLWLQRDTPITHISF
EEEECCCCCCEEEEC		20873877
597UbiquitinationPKRPMHILLHDAYMF
CCCCCEEEECCEEEE		33845483
598UbiquitinationKRPMHILLHDAYMFC
CCCCEEEECCEEEEE		22817900
599UbiquitinationRPMHILLHDAYMFCI
CCCEEEECCEEEEEE		22817900
600UbiquitinationPMHILLHDAYMFCII
CCEEEECCEEEEEEE		22817900
602PhosphorylationHILLHDAYMFCIIDK
EEEECCEEEEEEEEC		-
617UbiquitinationSLPLPNDKTLLYNPF
CCCCCCCCCCEECCC		21963094
617 (in isoform 1)Ubiquitination-21890473
618PhosphorylationLPLPNDKTLLYNPFP
CCCCCCCCCEECCCC		21945579
621PhosphorylationPNDKTLLYNPFPPTN
CCCCCCEECCCCCCC		21945579
637PhosphorylationSDVIRRRTAHAFKIS
HHHHHHHHHHHHHHH		20068231
642UbiquitinationRRTAHAFKISKIYKP
HHHHHHHHHHHHCCC		29967540
645AcetylationAHAFKISKIYKPLLF
HHHHHHHHHCCCCHH		26051181
645UbiquitinationAHAFKISKIYKPLLF
HHHHHHHHHCCCCHH		22817900
648UbiquitinationFKISKIYKPLLFMDL
HHHHHHCCCCHHHHH		21906983
648 (in isoform 1)Ubiquitination-21890473
680UbiquitinationAQLPPPIKKKKFGT-
HHCCCCCCCCCCCC-		22817900
680 (in isoform 1)Ubiquitination-21890473
681UbiquitinationQLPPPIKKKKFGT--
HCCCCCCCCCCCC--		22817900
682UbiquitinationLPPPIKKKKFGT---
CCCCCCCCCCCC---		22817900
683UbiquitinationPPPIKKKKFGT----
CCCCCCCCCCC----		22817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UTP4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UTP4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UTP4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
UTP15_HUMANUTP15physical
22939629
NOP53_HUMANGLTSCR2physical
22939629
WDR43_HUMANWDR43physical
26344197
WDR43_HUMANWDR43physical
28514442
NOL11_HUMANNOL11physical
28514442
UTP15_HUMANUTP15physical
28514442
WDR75_HUMANWDR75physical
28514442
ANR28_HUMANANKRD28physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UTP4_HUMAN

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Related Literatures of Post-Translational Modification

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