dbPTM

ZC3HD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZC3HD_HUMAN
UniProt AC	Q5T200
Protein Name	Zinc finger CCCH domain-containing protein 13 {ECO:0000305}
Gene Name	ZC3H13 {ECO:0000303\|PubMed:29507755, ECO:0000312\|HGNC:HGNC:20368}
Organism	Homo sapiens (Human).
Sequence Length	1668
Subcellular Localization	Nucleus speckle . Nucleus, nucleoplasm .
Protein Description	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. [PubMed: 29507755 Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity]
Protein Sequence	MSKIRRKVTVENTKTISDSTSRRPSVFERLGPSTGSTAETQCRNWLKTGNCLYGNTCRFVHGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKMPDPLDVIDVDWSGLMPKHPKEPREPGAALLKFTPGAVMLRVGISKKLAGSELFAKVKETCQRLLEKPKDADNLFEHELGALNMAALLRKEERASLLSNLGPCCKALCFRRDSAIRKQLVKNEKGTIKQAYTSAPMVDNELLRLSLRLFKRKTTCHAPGHEKTEDNKLSQSSIQQELCVS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSKIRRKVT ------CCCCCCCEE	48.36	26074081
9	Phosphorylation	SKIRRKVTVENTKTI CCCCCCEEECCCEEC	25.74	-
15	Phosphorylation	VTVENTKTISDSTSR EEECCCEECCCCCCC	24.55	23882029
17	Phosphorylation	VENTKTISDSTSRRP ECCCEECCCCCCCCC	30.64	23882029
19	Phosphorylation	NTKTISDSTSRRPSV CCEECCCCCCCCCCH	22.84	23882029
20	Phosphorylation	TKTISDSTSRRPSVF CEECCCCCCCCCCHH	31.10	23882029
21	Phosphorylation	KTISDSTSRRPSVFE EECCCCCCCCCCHHH	30.19	23882029
25	Phosphorylation	DSTSRRPSVFERLGP CCCCCCCCHHHHHCC	37.31	26074081
33	Phosphorylation	VFERLGPSTGSTAET HHHHHCCCCCCCHHH	43.53	23882029
34	Phosphorylation	FERLGPSTGSTAETQ HHHHCCCCCCCHHHH	37.98	23882029
36	Phosphorylation	RLGPSTGSTAETQCR HHCCCCCCCHHHHHH	25.24	23882029
37	Phosphorylation	LGPSTGSTAETQCRN HCCCCCCCHHHHHHH	29.83	23882029
40	Phosphorylation	STGSTAETQCRNWLK CCCCCHHHHHHHHHH	30.42	23882029
47	Methylation	TQCRNWLKTGNCLYG HHHHHHHHHCCCCCC	46.10	115978373
53	Phosphorylation	LKTGNCLYGNTCRFV HHHCCCCCCCCEEEE	15.55	-
64	Phosphorylation	CRFVHGPSPRGKGYS EEEECCCCCCCCCCC	31.64	29255136
66	Methylation	FVHGPSPRGKGYSSN EECCCCCCCCCCCCC	64.89	54560783
68	Methylation	HGPSPRGKGYSSNYR CCCCCCCCCCCCCCC	56.82	115920317
70	Phosphorylation	PSPRGKGYSSNYRRS CCCCCCCCCCCCCCC	16.65	26074081
71	Phosphorylation	SPRGKGYSSNYRRSP CCCCCCCCCCCCCCC	22.30	30576142
72	Phosphorylation	PRGKGYSSNYRRSPE CCCCCCCCCCCCCCC	29.42	26074081
74	Phosphorylation	GKGYSSNYRRSPERP CCCCCCCCCCCCCCC	14.89	30576142
77	Phosphorylation	YSSNYRRSPERPTGD CCCCCCCCCCCCCCH	23.32	29255136
82	Phosphorylation	RRSPERPTGDLRERM CCCCCCCCCHHHHHH	49.93	21955146
98	Phosphorylation	NKRQDVDTEPQKRNT HHCCCCCCCCCCCCC	49.79	26074081
105	Phosphorylation	TEPQKRNTEESSSPV CCCCCCCCCCCCCCC	45.20	23927012
108	Phosphorylation	QKRNTEESSSPVRKE CCCCCCCCCCCCCCC	29.86	30266825
109	Phosphorylation	KRNTEESSSPVRKES CCCCCCCCCCCCCCC	41.77	23401153
110	Phosphorylation	RNTEESSSPVRKESS CCCCCCCCCCCCCCC	36.37	29255136
116	Phosphorylation	SSPVRKESSRGRHRE CCCCCCCCCCCCCCC	28.50	27174698
117	Phosphorylation	SPVRKESSRGRHREK CCCCCCCCCCCCCCH	39.59	27174698
130	Phosphorylation	EKEDIKITKERTPES CHHHCCCCCCCCCCC	23.11	26074081
134	Phosphorylation	IKITKERTPESEEEN CCCCCCCCCCCHHHC	32.28	23927012
137	Phosphorylation	TKERTPESEEENVEW CCCCCCCCHHHCCCC	52.06	25159151
146	Phosphorylation	EENVEWETNRDDSDN HHCCCCCCCCCCCCC	36.31	30576142
151	Phosphorylation	WETNRDDSDNGDINY CCCCCCCCCCCCCCH	36.95	23663014
158	Phosphorylation	SDNGDINYDYVHELS CCCCCCCHHHHHHHH	14.69	22817900
160	Phosphorylation	NGDINYDYVHELSLE CCCCCHHHHHHHHHH	8.05	22817900
165	Phosphorylation	YDYVHELSLEMKRQK HHHHHHHHHHHHHHH	21.21	23312004
179	Sumoylation	KIQRELMKLEQENME HHHHHHHHHHHHCHH	62.59	28112733
194	Sumoylation	KREEIIIKKEVSPEV HHHHHEEECCCCHHH	32.26	-
194	Sumoylation	KREEIIIKKEVSPEV HHHHHEEECCCCHHH	32.26	28112733
198	Phosphorylation	IIIKKEVSPEVVRSK HEEECCCCHHHHHHH	19.21	29255136
204	Phosphorylation	VSPEVVRSKLSPSPS CCHHHHHHHCCCCHH	26.75	30266825
205	Acetylation	SPEVVRSKLSPSPSL CHHHHHHHCCCCHHH	42.28	25953088
207	Phosphorylation	EVVRSKLSPSPSLRK HHHHHHCCCCHHHHC	27.37	19664994
209	Phosphorylation	VRSKLSPSPSLRKSS HHHHCCCCHHHHCCC	24.60	19664994
211	Phosphorylation	SKLSPSPSLRKSSKS HHCCCCHHHHCCCCC	45.18	22167270
216	Phosphorylation	SPSLRKSSKSPKRKS CHHHHCCCCCCCCCC	39.94	-
218	Phosphorylation	SLRKSSKSPKRKSSP HHHCCCCCCCCCCCC	37.29	-
223	Phosphorylation	SKSPKRKSSPKSSSA CCCCCCCCCCCCCCC	56.77	26074081
224	Phosphorylation	KSPKRKSSPKSSSAS CCCCCCCCCCCCCCC	39.11	26074081
227	Phosphorylation	KRKSSPKSSSASKKD CCCCCCCCCCCCHHH	32.67	26074081
228	Phosphorylation	RKSSPKSSSASKKDR CCCCCCCCCCCHHHH	35.73	26074081
229	Phosphorylation	KSSPKSSSASKKDRK CCCCCCCCCCHHHHH	43.59	26074081
231	Phosphorylation	SPKSSSASKKDRKTS CCCCCCCCHHHHHCH	42.03	26074081
237	Phosphorylation	ASKKDRKTSAVSSPL CCHHHHHCHHCCHHH	23.86	30266825
238	Phosphorylation	SKKDRKTSAVSSPLL CHHHHHCHHCCHHHH	29.70	23927012
241	Phosphorylation	DRKTSAVSSPLLDQQ HHHCHHCCHHHHHHH	26.42	29255136
242	Phosphorylation	RKTSAVSSPLLDQQR HHCHHCCHHHHHHHH	16.99	19664994
251	Phosphorylation	LLDQQRNSKTNQSKK HHHHHHHCCCCCCCC	42.94	26074081
253	Phosphorylation	DQQRNSKTNQSKKKG HHHHHCCCCCCCCCC	38.01	26074081
256	Phosphorylation	RNSKTNQSKKKGPRT HHCCCCCCCCCCCCC	48.81	26074081
263	Phosphorylation	SKKKGPRTPSPPPPI CCCCCCCCCCCCCCC	31.11	29255136
265	Phosphorylation	KKGPRTPSPPPPIPE CCCCCCCCCCCCCCC	49.80	29255136
280	Phosphorylation	DIALGKKYKEKYKVK HHHCCHHHHHHHCCC	28.06	26074081
284	Phosphorylation	GKKYKEKYKVKDRIE CHHHHHHHCCCHHHH	23.31	26074081
316	Phosphorylation	EKRDKPRSTSPAGQH HHCCCCCCCCCCCCC	41.59	22167270
317	Phosphorylation	KRDKPRSTSPAGQHH HCCCCCCCCCCCCCC	39.75	22167270
318	Phosphorylation	RDKPRSTSPAGQHHS CCCCCCCCCCCCCCC	17.63	22167270
325	Phosphorylation	SPAGQHHSPISSRHH CCCCCCCCCCCCCCC	23.08	22167270
328	Phosphorylation	GQHHSPISSRHHSSS CCCCCCCCCCCCCCC	25.38	23927012
329	Phosphorylation	QHHSPISSRHHSSSS CCCCCCCCCCCCCCC	36.03	30266825
333	Phosphorylation	PISSRHHSSSSQSGS CCCCCCCCCCCCCCC	26.28	26055452
334	Phosphorylation	ISSRHHSSSSQSGSS CCCCCCCCCCCCCCC	29.65	30631047
335	Phosphorylation	SSRHHSSSSQSGSSI CCCCCCCCCCCCCCC	35.10	30631047
336	Phosphorylation	SRHHSSSSQSGSSIQ CCCCCCCCCCCCCCC	30.25	30631047
338	Phosphorylation	HHSSSSQSGSSIQRH CCCCCCCCCCCCCCC	42.46	27794612
340	Phosphorylation	SSSSQSGSSIQRHSP CCCCCCCCCCCCCCC	29.52	30631047
341	Phosphorylation	SSSQSGSSIQRHSPS CCCCCCCCCCCCCCC	26.68	30631047
346	Phosphorylation	GSSIQRHSPSPRRKR CCCCCCCCCCCCCCC	29.30	27794612
348	Phosphorylation	SIQRHSPSPRRKRTP CCCCCCCCCCCCCCC	33.77	27794612
354	Phosphorylation	PSPRRKRTPSPSYQR CCCCCCCCCCCCHHH	31.02	23401153
356	Phosphorylation	PRRKRTPSPSYQRTL CCCCCCCCCCHHHCC	26.35	23401153
358	Phosphorylation	RKRTPSPSYQRTLTP CCCCCCCCHHHCCCC	37.93	22167270
359	Phosphorylation	KRTPSPSYQRTLTPP CCCCCCCHHHCCCCC	12.85	30631047
362	Phosphorylation	PSPSYQRTLTPPLRR CCCCHHHCCCCCCCC	21.32	30266825
364	Phosphorylation	PSYQRTLTPPLRRSA CCHHHCCCCCCCCCC	23.42	23401153
370	Phosphorylation	LTPPLRRSASPYPSH CCCCCCCCCCCCCCC	27.02	22167270
372	Phosphorylation	PPLRRSASPYPSHSL CCCCCCCCCCCCCCC	26.64	22167270
374	Phosphorylation	LRRSASPYPSHSLSS CCCCCCCCCCCCCCC	18.18	22167270
376	Phosphorylation	RSASPYPSHSLSSPQ CCCCCCCCCCCCCCC	21.62	22167270
378	Phosphorylation	ASPYPSHSLSSPQRK CCCCCCCCCCCCCCC	33.99	22167270
380	Phosphorylation	PYPSHSLSSPQRKQS CCCCCCCCCCCCCCC	42.88	22167270
381	Phosphorylation	YPSHSLSSPQRKQSP CCCCCCCCCCCCCCC	30.28	22167270
387	Phosphorylation	SSPQRKQSPPRHRSP CCCCCCCCCCCCCCC	39.65	30278072
393	Phosphorylation	QSPPRHRSPMREKGR CCCCCCCCCCHHHCC	19.54	27174698
406	Phosphorylation	GRHDHERTSQSHDRR CCCCCCCCCHHHHHH	28.29	30242111
407	Phosphorylation	RHDHERTSQSHDRRH CCCCCCCCHHHHHHH	35.59	30242111
409	Phosphorylation	DHERTSQSHDRRHER CCCCCCHHHHHHHHH	27.42	29743597
430	Phosphorylation	KRDREKDSREEREYE HHHHHHHHHHHHHHH	53.30	24719451
436	Phosphorylation	DSREEREYEQDQSSS HHHHHHHHHHHHCCC	25.72	27642862
441	Phosphorylation	REYEQDQSSSRDHRD HHHHHHHCCCCCCCC	38.27	24719451
442	Phosphorylation	EYEQDQSSSRDHRDD HHHHHHCCCCCCCCC	24.61	29449344
443	Phosphorylation	YEQDQSSSRDHRDDR HHHHHCCCCCCCCCC	47.15	29449344
473	Phosphorylation	DRRELRDSRDMRDSR HHHHHHHHHHHHHHH	24.60	30001349
479	Phosphorylation	DSRDMRDSREMRDYS HHHHHHHHHHHHHHC	21.56	30576142
492	Phosphorylation	YSRDTKESRDPRDSR HCCCCCCCCCCCCCC	43.47	22817900
515	Phosphorylation	RDREGRDTHRKEDTY CCCCCCCCCCCCCCC	23.40	29449344
521	Phosphorylation	DTHRKEDTYPEESRS CCCCCCCCCCHHHHH	41.91	29449344
522	Phosphorylation	THRKEDTYPEESRSY CCCCCCCCCHHHHHH	22.44	29449344
538	Phosphorylation	RNHLREESSRTEIRN CHHHCCHHHHHHHHH	21.99	23403867
539	Phosphorylation	NHLREESSRTEIRNE HHHCCHHHHHHHHHC	46.64	23403867
541	Phosphorylation	LREESSRTEIRNESR HCCHHHHHHHHHCHH	37.40	23403867
563	Phosphorylation	RNDRMGRSRGRVPEL HHCCCCCCCCCCCCC	33.10	23403867
573	Acetylation	RVPELPEKGSRGSRG CCCCCCCCCCCCCCC	61.31	25953088
575	Phosphorylation	PELPEKGSRGSRGSQ CCCCCCCCCCCCCCC	44.53	28555341
578	Phosphorylation	PEKGSRGSRGSQIDS CCCCCCCCCCCCCCC	32.15	30576142
581	Phosphorylation	GSRGSRGSQIDSHSS CCCCCCCCCCCCCCC	23.89	17525332
585	Phosphorylation	SRGSQIDSHSSNSNY CCCCCCCCCCCCCCC	27.22	28450419
587	Phosphorylation	GSQIDSHSSNSNYHD CCCCCCCCCCCCCCC	34.86	28450419
588	Phosphorylation	SQIDSHSSNSNYHDS CCCCCCCCCCCCCCC	38.56	28450419
590	Phosphorylation	IDSHSSNSNYHDSWE CCCCCCCCCCCCCCC	40.49	28796482
592	Phosphorylation	SHSSNSNYHDSWETR CCCCCCCCCCCCCCC	13.56	28796482
595	Phosphorylation	SNSNYHDSWETRSSY CCCCCCCCCCCCCCC	17.31	28796482
600	Phosphorylation	HDSWETRSSYPERDR CCCCCCCCCCCCHHC	41.46	28152594
601	Phosphorylation	DSWETRSSYPERDRY CCCCCCCCCCCHHCC	41.22	28152594
602	Phosphorylation	SWETRSSYPERDRYP CCCCCCCCCCHHCCC	15.45	28152594
608	Phosphorylation	SYPERDRYPERDNRD CCCCHHCCCCCCCHH	17.46	28152594
620	Phosphorylation	NRDQARDSSFERRHG CHHHHHHHHHHHHHC	31.23	20873877
621	Phosphorylation	RDQARDSSFERRHGE HHHHHHHHHHHHHCH	35.10	28355574
642	Phosphorylation	RERDQRPSSPIRHQG HHHHCCCCCCCCCCC	51.43	29255136
643	Phosphorylation	ERDQRPSSPIRHQGR HHHCCCCCCCCCCCC	27.33	29255136
826	Phosphorylation	ERKSKKRYRNEGSPS HHHHHHHHCCCCCCC	27.03	28152594
831	Phosphorylation	KRYRNEGSPSPRQSP HHHCCCCCCCCCCCC	18.94	29255136
833	Phosphorylation	YRNEGSPSPRQSPKR HCCCCCCCCCCCCCH	34.12	29255136
837	Phosphorylation	GSPSPRQSPKRRREH CCCCCCCCCCHHHCC	33.40	20164059
845	Phosphorylation	PKRRREHSPDSDAYN CCHHHCCCCCCCCCC	26.16	29255136
848	Phosphorylation	RREHSPDSDAYNSGD HHCCCCCCCCCCCCC	27.76	29255136
851	Phosphorylation	HSPDSDAYNSGDDKN CCCCCCCCCCCCCHH	18.17	25159151
853	Phosphorylation	PDSDAYNSGDDKNEK CCCCCCCCCCCHHHH	30.81	29255136
865	Phosphorylation	NEKHRLLSQVVRPQE HHHHHHHHHHHCCCH	26.06	30266825
873	O-linked_Glycosylation	QVVRPQESRSLSPSH HHHCCCHHCCCCHHH	23.17	30379171
873	Phosphorylation	QVVRPQESRSLSPSH HHHCCCHHCCCCHHH	23.17	30266825
875	Phosphorylation	VRPQESRSLSPSHLT HCCCHHCCCCHHHCC	42.34	29255136
877	O-linked_Glycosylation	PQESRSLSPSHLTED CCHHCCCCHHHCCCC	26.13	30379171
877	Phosphorylation	PQESRSLSPSHLTED CCHHCCCCHHHCCCC	26.13	23927012
879	Phosphorylation	ESRSLSPSHLTEDRQ HHCCCCHHHCCCCCC	27.96	25463755
882	Phosphorylation	SLSPSHLTEDRQGRW CCCHHHCCCCCCCCC	30.34	23927012
901	Phosphorylation	RKPERKESSRRYEEQ CCCCHHHHHHHHHHH	31.98	20068231
902	Phosphorylation	KPERKESSRRYEEQE CCCHHHHHHHHHHHH	23.13	20068231
905	Phosphorylation	RKESSRRYEEQELKE HHHHHHHHHHHHHHH	23.78	20049867
924	Phosphorylation	VDKQREQTEILESSR HHHHHHHHHHHHHHH	21.90	28060719
930	Phosphorylation	QTEILESSRMRAQDI HHHHHHHHHHHHHHH	22.26	28555341
943	Phosphorylation	DIIGHHQSEDRETSD HHHCCCCCCCCCCCH	36.79	23401153
948	Phosphorylation	HQSEDRETSDRAHDE CCCCCCCCCHHCCHH	36.50	23927012
949	Phosphorylation	QSEDRETSDRAHDEN CCCCCCCCHHCCHHH	21.98	23927012
984	Phosphorylation	IERGNIETTSEDGQV CCCCCCEEECCCCCE	31.65	30266825
985	Phosphorylation	ERGNIETTSEDGQVF CCCCCEEECCCCCEE	19.82	29255136
986	Phosphorylation	RGNIETTSEDGQVFS CCCCEEECCCCCEEC	40.90	29255136
993	Phosphorylation	SEDGQVFSPKKGQKK CCCCCEECCCCCCCC	36.63	19664994
1010	Phosphorylation	IEKKRKKSKGDSDIS HHHHHHHCCCCCCCC	44.93	22167270
1014	Phosphorylation	RKKSKGDSDISDEEA HHHCCCCCCCCHHHH	45.58	22167270
1017	Phosphorylation	SKGDSDISDEEAAQQ CCCCCCCCHHHHHHH	43.91	29255136
1025	Phosphorylation	DEEAAQQSKKKRGPR HHHHHHHHHHHCCCC	34.07	23927012
1033	Phosphorylation	KKKRGPRTPPITTKE HHHCCCCCCCCCCHH	36.23	23401153
1037	Phosphorylation	GPRTPPITTKEELVE CCCCCCCCCHHHHHH	37.27	23927012
1038	Phosphorylation	PRTPPITTKEELVEM CCCCCCCCHHHHHHH	36.86	23927012
1056	Phosphorylation	KNGILEDSQKKEDTA CCCCCCCHHCCCCCC	34.23	17525332
1062	Phosphorylation	DSQKKEDTAFSDWSD CHHCCCCCCCCCCCC	30.60	25850435
1065	Phosphorylation	KKEDTAFSDWSDEDV CCCCCCCCCCCCCCC	35.39	30631047
1068	Phosphorylation	DTAFSDWSDEDVPDR CCCCCCCCCCCCCCC	35.79	30631047
1170	Phosphorylation	TRVEKVETPHVTIED HCCCCCCCCCEEHHH	22.98	25159151
1174	Phosphorylation	KVETPHVTIEDAQHR CCCCCCEEHHHHCCC	18.67	29396449
1189	Phosphorylation	KPMDQKRSSSLGSNR CCCCCCCHHCCCCCC	31.17	30266825
1190	Phosphorylation	PMDQKRSSSLGSNRS CCCCCCHHCCCCCCC	33.35	30266825
1191	Phosphorylation	MDQKRSSSLGSNRSN CCCCCHHCCCCCCCC	37.69	30266825
1194	Phosphorylation	KRSSSLGSNRSNRSH CCHHCCCCCCCCCCC	34.07	30266825
1197	Phosphorylation	SSLGSNRSNRSHTSG HCCCCCCCCCCCCCC	40.62	27362937
1200	Phosphorylation	GSNRSNRSHTSGRLR CCCCCCCCCCCCCCC	35.05	29449344
1202	Phosphorylation	NRSNRSHTSGRLRSP CCCCCCCCCCCCCCC	33.84	28985074
1203	Phosphorylation	RSNRSHTSGRLRSPS CCCCCCCCCCCCCCC	19.25	28985074
1208	Phosphorylation	HTSGRLRSPSNDSAH CCCCCCCCCCCCCCC	36.95	22167270
1210	Phosphorylation	SGRLRSPSNDSAHRS CCCCCCCCCCCCCCC	55.29	22167270
1213	Phosphorylation	LRSPSNDSAHRSGDD CCCCCCCCCCCCCCC	30.17	23401153
1217	Phosphorylation	SNDSAHRSGDDQSGR CCCCCCCCCCCCCCC	36.39	30576142
1222	Phosphorylation	HRSGDDQSGRKRVLH CCCCCCCCCCCCEEC	47.78	20873877
1230	Phosphorylation	GRKRVLHSGSRDREK CCCCEECCCCCCHHH	34.01	30266825
1232	Phosphorylation	KRVLHSGSRDREKTK CCEECCCCCCHHHCC	33.74	30266825
1238	Phosphorylation	GSRDREKTKSLEITG CCCCHHHCCCEEECC	22.55	30266825
1240	Phosphorylation	RDREKTKSLEITGER CCHHHCCCEEECCCH	36.14	23401153
1244	Phosphorylation	KTKSLEITGERKSRI HCCCEEECCCHHHHH	24.50	30266825
1260	Phosphorylation	QLKRGEPSRSTSSDR HHHCCCCCCCCCCCC	34.26	30576142
1262	Phosphorylation	KRGEPSRSTSSDRQD HCCCCCCCCCCCCHH	36.66	29052541
1263	Phosphorylation	RGEPSRSTSSDRQDS CCCCCCCCCCCCHHH	31.01	29052541
1264	Phosphorylation	GEPSRSTSSDRQDSR CCCCCCCCCCCHHHC	31.33	29052541
1265	Phosphorylation	EPSRSTSSDRQDSRS CCCCCCCCCCHHHCC	36.58	30576142
1270	Phosphorylation	TSSDRQDSRSHSSRR CCCCCHHHCCCCCCC	27.61	29052541
1274	Phosphorylation	RQDSRSHSSRRSSPE CHHHCCCCCCCCCHH	27.13	26055452
1278	Phosphorylation	RSHSSRRSSPESDRQ CCCCCCCCCHHHHHH	49.48	20068231
1279	Phosphorylation	SHSSRRSSPESDRQV CCCCCCCCHHHHHHH	30.76	26329039
1282	Phosphorylation	SRRSSPESDRQVHSR CCCCCHHHHHHHHHC	41.29	20068231
1288	Phosphorylation	ESDRQVHSRSGSFDS HHHHHHHHCCCCCCH	29.32	20164059
1290	Phosphorylation	DRQVHSRSGSFDSRD HHHHHHCCCCCCHHH	41.63	30266825
1292	Phosphorylation	QVHSRSGSFDSRDRL HHHHCCCCCCHHHHH	27.42	30266825
1295	Phosphorylation	SRSGSFDSRDRLQER HCCCCCCHHHHHHHH	33.79	20164059
1318	Phosphorylation	RERERRDTRQREWDR HHHHHHHHHHHHHHH	27.22	22817900
1364	Phosphorylation	RERERLISDSVERDR HHHHHHHHHHHHHHH	28.55	23401153
1366	Phosphorylation	RERLISDSVERDRDR HHHHHHHHHHHHHHC	21.06	23401153
1378	Phosphorylation	RDRDRDRTFESSQIE HHCHHHHCCCHHHHH	35.72	28555341
1381	Phosphorylation	DRDRTFESSQIESVK HHHHCCCHHHHHHHH	24.29	29214152
1382	Phosphorylation	RDRTFESSQIESVKR HHHCCCHHHHHHHHH	28.16	17525332
1386	Phosphorylation	FESSQIESVKRCEAK CCHHHHHHHHHHHHH	34.27	25159151
1404	Phosphorylation	EHERDLESTSRDSLA CCHHHHHHCCHHHHH	38.69	23401153
1405	Phosphorylation	HERDLESTSRDSLAL CHHHHHHCCHHHHHH	20.57	30266825
1406	Phosphorylation	ERDLESTSRDSLALD HHHHHHCCHHHHHHC	43.29	30266825
1409	Phosphorylation	LESTSRDSLALDKER HHHCCHHHHHHCHHH	17.90	30266825
1423	Phosphorylation	RMDKDLGSVQGFEET HHHHCCCCCCCHHHC	20.68	22617229
1430	Phosphorylation	SVQGFEETNKSERTE CCCCHHHCCHHHCCC	40.52	29255136
1433	Phosphorylation	GFEETNKSERTESLE CHHHCCHHHCCCCCC	34.09	29255136
1433 (in isoform 2)	Phosphorylation	-	34.09	29507054
1436	Phosphorylation	ETNKSERTESLEGDD HCCHHHCCCCCCCCC	26.35	30576142
1436 (in isoform 2)	Phosphorylation	-	26.35	20068231
1438	Phosphorylation	NKSERTESLEGDDES CHHHCCCCCCCCCHH	30.98	29255136
1438 (in isoform 2)	Phosphorylation	-	30.98	25849741
1445	Phosphorylation	SLEGDDESKLDDAHS CCCCCCHHHCCCHHH	45.58	21815630
1446 (in isoform 2)	Phosphorylation	-	54.62	28985074
1452	Phosphorylation	SKLDDAHSLGSGAGE HHCCCHHHCCCCCCC	35.83	26503892
1453	Phosphorylation	KLDDAHSLGSGAGEG HCCCHHHCCCCCCCC	4.55	18452278
1453 (in isoform 2)	Phosphorylation	-	4.55	25137130
1455	Phosphorylation	DDAHSLGSGAGEGYE CCHHHCCCCCCCCCC	30.66	26503892
1456	Phosphorylation	DAHSLGSGAGEGYEP CHHHCCCCCCCCCCC	35.48	19651622
1456 (in isoform 2)	Phosphorylation	-	35.48	25137130
1461	Phosphorylation	GSGAGEGYEPISDDE CCCCCCCCCCCCHHH	17.77	20873877
1462	Phosphorylation	SGAGEGYEPISDDEL CCCCCCCCCCCHHHH	47.19	-
1462 (in isoform 2)	Phosphorylation	-	47.19	25137130
1465	Phosphorylation	GEGYEPISDDELDEI CCCCCCCCHHHHHHH	50.12	26503892
1466	Phosphorylation	EGYEPISDDELDEIL CCCCCCCHHHHHHHH	54.87	19651622
1466 (in isoform 2)	Phosphorylation	-	54.87	28387310
1522	Phosphorylation	GAALLKFTPGAVMLR CCEEEECCCCCEEEE	21.16	20068231
1523	Phosphorylation	AALLKFTPGAVMLRV CEEEECCCCCEEEEE	31.70	-
1533	Phosphorylation	VMLRVGISKKLAGSE EEEEECCCHHHCCCH	20.15	20068231
1593	Ubiquitination	SNLGPCCKALCFRRD HHHHHHHHHHHHCCC	51.62	-
1601	Phosphorylation	ALCFRRDSAIRKQLV HHHHCCCHHHHHHHH	24.63	23882029
1616	Ubiquitination	KNEKGTIKQAYTSAP HCCCCCCCEEHHCCC	28.81	-
1633	Phosphorylation	DNELLRLSLRLFKRK CHHHHHHHHHHHHCC	12.66	23532336
1657	Phosphorylation	KTEDNKLSQSSIQQE CCCCCCCCHHHHHHH	29.62	17525332
1659	Phosphorylation	EDNKLSQSSIQQELC CCCCCCHHHHHHHHH	26.49	25159151
1660	Phosphorylation	DNKLSQSSIQQELCV CCCCCHHHHHHHHHC	19.44	28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZC3HD_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZC3HD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZC3HD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED12_HUMAN	MED12	physical	20133760
MED13_HUMAN	MED13	physical	20133760
CCNC_HUMAN	CCNC	physical	20133760
MED25_HUMAN	MED25	physical	20133760
MED16_HUMAN	MED16	physical	20133760
MED17_HUMAN	MED17	physical	20133760
MED1_HUMAN	MED1	physical	20133760
MED28_HUMAN	MED28	physical	20133760
MED24_HUMAN	MED24	physical	20133760
MED23_HUMAN	MED23	physical	20133760
MED4_HUMAN	MED4	physical	20133760
MED29_HUMAN	MED29	physical	20133760
MED8_HUMAN	MED8	physical	20133760
MED15_HUMAN	MED15	physical	20133760
MED6_HUMAN	MED6	physical	20133760
MED14_HUMAN	MED14	physical	20133760
CDK19_HUMAN	CDK19	physical	20133760
MED30_HUMAN	MED30	physical	20133760
MED26_HUMAN	MED26	physical	20133760
RPB1_HUMAN	POLR2A	physical	20133760
RPB2_HUMAN	POLR2B	physical	20133760
MED9_HUMAN	MED9	physical	20133760
MED19_HUMAN	MED19	physical	20133760
MED27_HUMAN	MED27	physical	20133760
MED20_HUMAN	MED20	physical	20133760
MED21_HUMAN	MED21	physical	20133760
CDK9_HUMAN	CDK9	physical	20133760

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZC3HD_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242; SER-986; SER-993;SER-1014; SER-1017 AND SER-1364, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207; SER-209; SER-238;SER-242; THR-263; SER-265; THR-317; SER-318; SER-325; SER-370;SER-372; SER-381; SER-875; SER-877; THR-984; SER-986; SER-993;SER-1014 AND SER-1017, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198; SER-207; SER-209;SER-242; THR-263; SER-265; SER-318; SER-325; THR-354; SER-356;THR-364; SER-370; SER-372; SER-381; SER-831; SER-833; SER-837;SER-845; SER-848; SER-853; SER-875; SER-877; SER-986; SER-993;SER-1010; SER-1014 AND SER-1017, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-993, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-877 AND SER-1208, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-581; SER-1056; SER-1382AND SER-1657, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238 AND SER-241, ANDMASS SPECTROMETRY.	17287340 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-263; SER-265; THR-354;SER-356 AND SER-993, AND MASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64; SER-77; SER-198;SER-207; SER-209; THR-263; SER-265; SER-316; THR-317; SER-325;SER-492; SER-875; SER-877; SER-993; SER-1279; SER-1288 AND THR-1318,AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242; THR-263 ANDSER-265, AND MASS SPECTROMETRY.	15302935 [Abstract]
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207 AND SER-209, ANDMASS SPECTROMETRY.	15144186 [Abstract]