dbPTM

ADNP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ADNP_HUMAN
UniProt AC	Q9H2P0
Protein Name	Activity-dependent neuroprotector homeobox protein
Gene Name	ADNP
Organism	Homo sapiens (Human).
Sequence Length	1102
Subcellular Localization	Nucleus .
Protein Description	Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation..
Protein Sequence	MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNASAPSSSLSTFKDKNKNDGLKPKQADSVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVPLGSNAREESSIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQDKKSMGLPPRIGSLASGNVRSLPSQQMVNRLSIPKPNLNSTGVNMMSSVHLQQNNYGVKSVGQGYSVGQSMRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGSEQRSQAPARYSLQSANASSLSSGQLKSPSLSQSQASRVLGQSSSKPAAAATGPPPGNTSSTQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAYHAQNNPPVPPKPQPKVQEKADIPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPSLAPVKRTYEQMEFPLLKKRKLDDDSDSPSFFEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKDSRVNASKTADKKLNLGKEDDSSSDSFENLEEESNESGSPFDPVFEVEPKISNDNPEEHVLKVIPEDASESEEKLDQKEDGSKYETIHLTEEPTKLMHNASDSEVDQDDVVEWKDGASPSESGPGSQQVSDFEDNTCEMKPGTWSDESSQSEDARSSKPAAKKKATMQGDREQLKWKNSSYGKVEGFWSKDQSQWKNASENDERLSNPQIEWQNSTIDSEDGEQFDNMTDGVAEPMHGSLAGVKLSSQQA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	LPVNNLGSLRKARKT CCCCCHHHHHHHHHH	28.32	101545283
32	Ubiquitination	DIGLEYCKEHIEDFK HHCHHHHHHHHHHHH	51.96	-
39	Sumoylation	KEHIEDFKQFEPNDF HHHHHHHHHCCCCCE	67.41	28112733
39	Ubiquitination	KEHIEDFKQFEPNDF HHHHHHHHHCCCCCE	67.41	-
65	Ubiquitination	LWDPSLTKNQDYRTK CCCCCCCCCCCCCCC	58.88	-
69	Phosphorylation	SLTKNQDYRTKPFCC CCCCCCCCCCCCCCC	15.49	23663014
71	Phosphorylation	TKNQDYRTKPFCCSA CCCCCCCCCCCCCCC	36.52	23663014
72	Acetylation	KNQDYRTKPFCCSAC CCCCCCCCCCCCCCC	27.39	26051181
72	Sumoylation	KNQDYRTKPFCCSAC CCCCCCCCCCCCCCC	27.39	28112733
84	Acetylation	SACPFSSKFFSAYKS CCCCCCHHHHHHHHH	49.59	26051181
87	Phosphorylation	PFSSKFFSAYKSHFR CCCHHHHHHHHHHHC	33.55	21712546
98	Phosphorylation	SHFRNVHSEDFENRI HHHCCCCCHHHCCCE	34.28	29255136
118	Acetylation	YCTFNADKKTLETHI CCCCCCCHHHHHHHE	45.29	26051181
126	Ubiquitination	KTLETHIKIFHAPNA HHHHHHEEEEECCCC	31.54	21890473
134	Phosphorylation	IFHAPNASAPSSSLS EEECCCCCCCCCCCH	47.56	30387612
138	Phosphorylation	PNASAPSSSLSTFKD CCCCCCCCCCHHCCC	33.95	28555341
139	Phosphorylation	NASAPSSSLSTFKDK CCCCCCCCCHHCCCC	30.58	28555341
141	Phosphorylation	SAPSSSLSTFKDKNK CCCCCCCHHCCCCCC	33.47	25159151
142	Phosphorylation	APSSSLSTFKDKNKN CCCCCCHHCCCCCCC	39.74	25159151
144	Sumoylation	SSSLSTFKDKNKNDG CCCCHHCCCCCCCCC	68.81	-
144	Sumoylation	SSSLSTFKDKNKNDG CCCCHHCCCCCCCCC	68.81	28112733
144	Ubiquitination	SSSLSTFKDKNKNDG CCCCHHCCCCCCCCC	68.81	-
155	Sumoylation	KNDGLKPKQADSVEQ CCCCCCHHHCCCHHH	57.44	28112733
199	Acetylation	VAAPYIAKAGEKSLN CCHHHHHHHCCCCCC	47.57	23236377
203	Sumoylation	YIAKAGEKSLNGAVP HHHHHCCCCCCCCCC	60.36	28112733
204	Acetylation	IAKAGEKSLNGAVPL HHHHCCCCCCCCCCC	23.82	19413330
204	Phosphorylation	IAKAGEKSLNGAVPL HHHHCCCCCCCCCCC	23.82	28555341
213	Phosphorylation	NGAVPLGSNAREESS CCCCCCCCCCCCCCC	34.69	72550325
219	Phosphorylation	GSNAREESSIHCKRC CCCCCCCCCCCCCCC	29.82	22210691
231	Sumoylation	KRCLFMPKSYEALVQ CCCCCCCCCHHHHHH	54.61	28112733
249	Phosphorylation	EDHERIGYQVTAMIG HHHHHHCEEEEEEEC	9.46	24144214
252	Phosphorylation	ERIGYQVTAMIGHTN HHHCEEEEEEECCCE	8.59	24144214
258	Phosphorylation	VTAMIGHTNVVVPRS EEEEECCCEEEECCC	25.21	20860994
265	O-linked_Glycosylation	TNVVVPRSKPLMLIA CEEEECCCCCEEEEC	32.33	30059200
265	Phosphorylation	TNVVVPRSKPLMLIA CEEEECCCCCEEEEC	32.33	24719451
266	Acetylation	NVVVPRSKPLMLIAP EEEECCCCCEEEECC	43.37	26051181
266	Sumoylation	NVVVPRSKPLMLIAP EEEECCCCCEEEECC	43.37	28112733
274	Sumoylation	PLMLIAPKPQDKKSM CEEEECCCCCCCCCC	46.41	-
274	Sumoylation	PLMLIAPKPQDKKSM CEEEECCCCCCCCCC	46.41	28112733
278	Sumoylation	IAPKPQDKKSMGLPP ECCCCCCCCCCCCCC	41.31	28112733
279	Sumoylation	APKPQDKKSMGLPPR CCCCCCCCCCCCCCC	54.70	-
279	Sumoylation	APKPQDKKSMGLPPR CCCCCCCCCCCCCCC	54.70	25218447
280	Phosphorylation	PKPQDKKSMGLPPRI CCCCCCCCCCCCCCC	24.67	23612710
289	Phosphorylation	GLPPRIGSLASGNVR CCCCCCHHHHCCCCC	20.56	18212344
292	Phosphorylation	PRIGSLASGNVRSLP CCCHHHHCCCCCCCC	35.87	25367160
297	Phosphorylation	LASGNVRSLPSQQMV HHCCCCCCCCCHHHH	40.11	28555341
303	Sulfoxidation	RSLPSQQMVNRLSIP CCCCCHHHHHHCCCC	1.93	21406390
306	Methylation	PSQQMVNRLSIPKPN CCHHHHHHCCCCCCC	20.57	-
308	Phosphorylation	QQMVNRLSIPKPNLN HHHHHHCCCCCCCCC	33.34	24719451
311	Sumoylation	VNRLSIPKPNLNSTG HHHCCCCCCCCCCCC	44.88	28112733
335	Sumoylation	QQNNYGVKSVGQGYS CCCCCCCCCCCCCCC	34.75	28112733
336	Phosphorylation	QNNYGVKSVGQGYSV CCCCCCCCCCCCCCC	29.13	101545287
346	Phosphorylation	QGYSVGQSMRLGLGG CCCCCCCCCCCCCCC	10.43	113334145
348	Asymmetric dimethylarginine	YSVGQSMRLGLGGNA CCCCCCCCCCCCCCC	30.74	-
348	Methylation	YSVGQSMRLGLGGNA CCCCCCCCCCCCCCC	30.74	-
358	O-linked_Glycosylation	LGGNAPVSIPQQSQS CCCCCCCCCCCCCCC	27.73	30059200
358	Phosphorylation	LGGNAPVSIPQQSQS CCCCCCCCCCCCCCC	27.73	28555341
363	Phosphorylation	PVSIPQQSQSVKQLL CCCCCCCCCCHHHHC	21.12	28555341
365	Phosphorylation	SIPQQSQSVKQLLPS CCCCCCCCHHHHCCC	36.21	24719451
367	Acetylation	PQQSQSVKQLLPSGN CCCCCCHHHHCCCCC	40.24	26051181
367	Sumoylation	PQQSQSVKQLLPSGN CCCCCCHHHHCCCCC	40.24	28112733
372	Phosphorylation	SVKQLLPSGNGRSYG CHHHHCCCCCCCCCC	44.88	36012783
377	O-linked_Glycosylation	LPSGNGRSYGLGSEQ CCCCCCCCCCCCCHH	25.58	30059200
382	Phosphorylation	GRSYGLGSEQRSQAP CCCCCCCCHHHCCCC	35.28	28555341
385	Methylation	YGLGSEQRSQAPARY CCCCCHHHCCCCCCC	27.04	-
391	Methylation	QRSQAPARYSLQSAN HHCCCCCCCCCCCCC	22.10	-
392	Phosphorylation	RSQAPARYSLQSANA HCCCCCCCCCCCCCC	18.81	28152594
393	Phosphorylation	SQAPARYSLQSANAS CCCCCCCCCCCCCCC	17.87	28152594
396	Phosphorylation	PARYSLQSANASSLS CCCCCCCCCCCCCCC	28.87	24732914
400	Phosphorylation	SLQSANASSLSSGQL CCCCCCCCCCCCCCC	31.45	24732914
401	Phosphorylation	LQSANASSLSSGQLK CCCCCCCCCCCCCCC	29.84	24732914
403	Phosphorylation	SANASSLSSGQLKSP CCCCCCCCCCCCCCC	34.08	24732914
404	Phosphorylation	ANASSLSSGQLKSPS CCCCCCCCCCCCCCC	35.53	24732914
408	Sumoylation	SLSSGQLKSPSLSQS CCCCCCCCCCCCCHH	53.05	-
408	Methylation	SLSSGQLKSPSLSQS CCCCCCCCCCCCCHH	53.05	-
408	Sumoylation	SLSSGQLKSPSLSQS CCCCCCCCCCCCCHH	53.05	28112733
409	Phosphorylation	LSSGQLKSPSLSQSQ CCCCCCCCCCCCHHH	28.45	29255136
411	Phosphorylation	SGQLKSPSLSQSQAS CCCCCCCCCCHHHHH	47.98	29255136
413	Phosphorylation	QLKSPSLSQSQASRV CCCCCCCCHHHHHHH	31.93	17525332
415	Phosphorylation	KSPSLSQSQASRVLG CCCCCCHHHHHHHHC	25.08	25159151
418	Phosphorylation	SLSQSQASRVLGQSS CCCHHHHHHHHCCCC	18.45	24732914
424	Phosphorylation	ASRVLGQSSSKPAAA HHHHHCCCCCCCCHH	34.48	28450419
425	Phosphorylation	SRVLGQSSSKPAAAA HHHHCCCCCCCCHHH	34.20	28450419
426	Phosphorylation	RVLGQSSSKPAAAAT HHHCCCCCCCCHHHC	48.16	28450419
427	Sumoylation	VLGQSSSKPAAAATG HHCCCCCCCCHHHCC	40.39	-
427	Acetylation	VLGQSSSKPAAAATG HHCCCCCCCCHHHCC	40.39	25953088
427	Sumoylation	VLGQSSSKPAAAATG HHCCCCCCCCHHHCC	40.39	28112733
427	Ubiquitination	VLGQSSSKPAAAATG HHCCCCCCCCHHHCC	40.39	-
433	Phosphorylation	SKPAAAATGPPPGNT CCCCHHHCCCCCCCC	45.56	28450419
440	Phosphorylation	TGPPPGNTSSTQKWK CCCCCCCCCHHHCCE	29.94	25627689
441	Phosphorylation	GPPPGNTSSTQKWKI CCCCCCCCHHHCCEE	35.07	25627689
442	Phosphorylation	PPPGNTSSTQKWKIC CCCCCCCHHHCCEEE	32.58	25627689
443	Phosphorylation	PPGNTSSTQKWKICT CCCCCCHHHCCEEEH	33.66	25627689
445	Acetylation	GNTSSTQKWKICTIC CCCCHHHCCEEEHHH	51.01	26051181
445	Ubiquitination	GNTSSTQKWKICTIC CCCCHHHCCEEEHHH	51.01	-
490	Acetylation	KIHNFTSKCLYCNRY HHCCCCCCCCCCCCC	25.79	26051181
600	Sumoylation	PQPKVQEKADIPVKS CCCCCCCCCCCCCCC	33.98	-
600	Sumoylation	PQPKVQEKADIPVKS CCCCCCCCCCCCCCC	33.98	28112733
606	Sumoylation	EKADIPVKSSPQAAV CCCCCCCCCCCCCCC	39.60	-
606	Acetylation	EKADIPVKSSPQAAV CCCCCCCCCCCCCCC	39.60	25953088
606	Sumoylation	EKADIPVKSSPQAAV CCCCCCCCCCCCCCC	39.60	28112733
607	Phosphorylation	KADIPVKSSPQAAVP CCCCCCCCCCCCCCC	47.70	25159151
608	Phosphorylation	ADIPVKSSPQAAVPY CCCCCCCCCCCCCCC	18.47	25159151
615	Phosphorylation	SPQAAVPYKKDVGKT CCCCCCCCCCCCCCC	24.87	24732914
616	Sumoylation	PQAAVPYKKDVGKTL CCCCCCCCCCCCCCH	36.11	28112733
616	Ubiquitination	PQAAVPYKKDVGKTL CCCCCCCCCCCCCCH	36.11	-
621	Sumoylation	PYKKDVGKTLCPLCF CCCCCCCCCHHHHHH	37.87	28112733
621	Ubiquitination	PYKKDVGKTLCPLCF CCCCCCCCCHHHHHH	37.87	-
629	Phosphorylation	TLCPLCFSILKGPIS CHHHHHHHHHHCCHH	26.47	24719451
632	Sumoylation	PLCFSILKGPISDAL HHHHHHHHCCHHHHH	62.05	28112733
636	Phosphorylation	SILKGPISDALAHHL HHHHCCHHHHHHHHH	21.69	28555341
652	Phosphorylation	ERHQVIQTVHPVEKK HHHCHHHHCCCCCCH	15.06	28555341
658	Sumoylation	QTVHPVEKKLTYKCI HHCCCCCCHHHHHHH	54.00	-
658	2-Hydroxyisobutyrylation	QTVHPVEKKLTYKCI HHCCCCCCHHHHHHH	54.00	-
658	Sumoylation	QTVHPVEKKLTYKCI HHCCCCCCHHHHHHH	54.00	28112733
676	Phosphorylation	GVYTSNMTASTITLH CCCCCCCCCCEEEEE	23.00	19690332
678	Phosphorylation	YTSNMTASTITLHLV CCCCCCCCEEEEEEE	15.92	22817900
681	Phosphorylation	NMTASTITLHLVHCR CCCCCEEEEEEEEEC	14.28	19690332
692	Ubiquitination	VHCRGVGKTQNGQDK EEECCCCCCCCCCCC	44.52	-
699	Sumoylation	KTQNGQDKTNAPSRL CCCCCCCCCCCCHHH	35.47	28112733
700	Phosphorylation	TQNGQDKTNAPSRLN CCCCCCCCCCCHHHC	44.92	26074081
704	Phosphorylation	QDKTNAPSRLNQSPS CCCCCCCHHHCCCCC	47.17	25159151
709	Phosphorylation	APSRLNQSPSLAPVK CCHHHCCCCCCCCCC	18.51	29255136
711	Phosphorylation	SRLNQSPSLAPVKRT HHHCCCCCCCCCCCH	42.27	30266825
716	Sumoylation	SPSLAPVKRTYEQME CCCCCCCCCHHHHCC	37.65	-
716	2-Hydroxyisobutyrylation	SPSLAPVKRTYEQME CCCCCCCCCHHHHCC	37.65	-
716	Acetylation	SPSLAPVKRTYEQME CCCCCCCCCHHHHCC	37.65	25953088
716	Methylation	SPSLAPVKRTYEQME CCCCCCCCCHHHHCC	37.65	-
716	Sumoylation	SPSLAPVKRTYEQME CCCCCCCCCHHHHCC	37.65	28112733
716	Ubiquitination	SPSLAPVKRTYEQME CCCCCCCCCHHHHCC	37.65	-
718	Phosphorylation	SLAPVKRTYEQMEFP CCCCCCCHHHHCCCC	26.20	28796482
719	Phosphorylation	LAPVKRTYEQMEFPL CCCCCCHHHHCCCCH	14.27	28796482
728	Sumoylation	QMEFPLLKKRKLDDD HCCCCHHHCCCCCCC	59.21	28112733
731	Sumoylation	FPLLKKRKLDDDSDS CCHHHCCCCCCCCCC	66.21	-
731	Sumoylation	FPLLKKRKLDDDSDS CCHHHCCCCCCCCCC	66.21	28112733
731	Ubiquitination	FPLLKKRKLDDDSDS CCHHHCCCCCCCCCC	66.21	-
736	Phosphorylation	KRKLDDDSDSPSFFE CCCCCCCCCCCCHHC	47.16	25159151
738	Phosphorylation	KLDDDSDSPSFFEEK CCCCCCCCCCHHCCC	26.79	25159151
740	Phosphorylation	DDDSDSPSFFEEKPE CCCCCCCCHHCCCCC	46.66	21712546
745	Sumoylation	SPSFFEEKPEEPVVL CCCHHCCCCCCCEEE	51.00	28112733
757	Ubiquitination	VVLALDPKGHEDDSY EEEEECCCCCCCCCH	72.99	-
763	O-linked_Glycosylation	PKGHEDDSYEARKSF CCCCCCCCHHHHHHH	36.88	30059200
764	Phosphorylation	KGHEDDSYEARKSFL CCCCCCCHHHHHHHH	22.17	29214152
768	Ubiquitination	DDSYEARKSFLTKYF CCCHHHHHHHHHHHH	53.24	-
769	Phosphorylation	DSYEARKSFLTKYFN CCHHHHHHHHHHHHC	21.67	28450419
772	Phosphorylation	EARKSFLTKYFNKQP HHHHHHHHHHHCCCC	22.99	28450419
773	Ubiquitination	ARKSFLTKYFNKQPY HHHHHHHHHHCCCCC	50.41	21890473
774	Phosphorylation	RKSFLTKYFNKQPYP HHHHHHHHHCCCCCC	13.72	20068231
777	Ubiquitination	FLTKYFNKQPYPTRR HHHHHHCCCCCCCHH	42.63	21890473
802	Phosphorylation	LWKSDIASHFSNKRK HHHHHHHHHHCCCHH	25.96	27251275
805	Phosphorylation	SDIASHFSNKRKKCV HHHHHHHCCCHHHHH	35.70	25159151
807	Acetylation	IASHFSNKRKKCVRD HHHHHCCCHHHHHHH	65.48	25953088
807	Sumoylation	IASHFSNKRKKCVRD HHHHHCCCHHHHHHH	65.48	28112733
807	Ubiquitination	IASHFSNKRKKCVRD HHHHHCCCHHHHHHH	65.48	-
819	Sumoylation	VRDCEKYKPGVLLGF HHHHHHHCCCEEEEC	46.49	-
819	Sumoylation	VRDCEKYKPGVLLGF HHHHHHHCCCEEEEC	46.49	-
829	Sumoylation	VLLGFNMKELNKVKH EEEECCHHHHHCCCE	61.22	28112733
829	Ubiquitination	VLLGFNMKELNKVKH EEEECCHHHHHCCCE	61.22	21890473
835	Sumoylation	MKELNKVKHEMDFDA HHHHHCCCEECCCCH	35.14	-
835	Sumoylation	MKELNKVKHEMDFDA HHHHHCCCEECCCCH	35.14	28112733
861	Phosphorylation	SRVNASKTADKKLNL CCCCCCHHHHHHCCC	37.28	46159853
874	Phosphorylation	NLGKEDDSSSDSFEN CCCCCCCCCCHHHHC	44.02	22617229
875	Phosphorylation	LGKEDDSSSDSFENL CCCCCCCCCHHHHCH	45.20	18669648
876	Phosphorylation	GKEDDSSSDSFENLE CCCCCCCCHHHHCHH	41.02	28102081
878	Phosphorylation	EDDSSSDSFENLEEE CCCCCCHHHHCHHHH	36.09	22617229
886	Phosphorylation	FENLEEESNESGSPF HHCHHHHHCCCCCCC	49.53	30624053
889	Phosphorylation	LEEESNESGSPFDPV HHHHHCCCCCCCCCC	49.15	30624053
891	Phosphorylation	EESNESGSPFDPVFE HHHCCCCCCCCCCEE	31.50	30087585
904	Phosphorylation	FEVEPKISNDNPEEH EEECCCCCCCCHHHH	44.23	30266825
914	Sumoylation	NPEEHVLKVIPEDAS CHHHHEEEECCCCCC	36.71	28112733
914	Ubiquitination	NPEEHVLKVIPEDAS CHHHHEEEECCCCCC	36.71	-
921	Phosphorylation	KVIPEDASESEEKLD EECCCCCCCCHHHHH	54.71	29255136
923	Phosphorylation	IPEDASESEEKLDQK CCCCCCCCHHHHHCC	48.86	30266825
930	Sumoylation	SEEKLDQKEDGSKYE CHHHHHCCCCCCCCE	58.39	-
930	Sumoylation	SEEKLDQKEDGSKYE CHHHHHCCCCCCCCE	58.39	28112733
934	Phosphorylation	LDQKEDGSKYETIHL HHCCCCCCCCEEEEC	44.37	29978859
935	Acetylation	DQKEDGSKYETIHLT HCCCCCCCCEEEECC	53.27	26051181
935	Sumoylation	DQKEDGSKYETIHLT HCCCCCCCCEEEECC	53.27	28112733
935	Ubiquitination	DQKEDGSKYETIHLT HCCCCCCCCEEEECC	53.27	-
936	Phosphorylation	QKEDGSKYETIHLTE CCCCCCCCEEEECCC	21.72	28796482
938	Phosphorylation	EDGSKYETIHLTEEP CCCCCCEEEECCCCC	15.59	29978859
942	Phosphorylation	KYETIHLTEEPTKLM CCEEEECCCCCCCCC	24.92	29978859
946	Phosphorylation	IHLTEEPTKLMHNAS EECCCCCCCCCCCCC	39.84	26714015
953	Phosphorylation	TKLMHNASDSEVDQD CCCCCCCCCCCCCHH	47.16	22167270
955	Phosphorylation	LMHNASDSEVDQDDV CCCCCCCCCCCHHHC	36.70	22167270
970	Phosphorylation	VEWKDGASPSESGPG EEECCCCCCCCCCCC	34.19	23663014
972	Phosphorylation	WKDGASPSESGPGSQ ECCCCCCCCCCCCCC	41.73	23663014
974	Phosphorylation	DGASPSESGPGSQQV CCCCCCCCCCCCCCC	55.41	23663014
978	Phosphorylation	PSESGPGSQQVSDFE CCCCCCCCCCCCCCC	22.15	23663014
982	Phosphorylation	GPGSQQVSDFEDNTC CCCCCCCCCCCCCCE	32.04	25849741
995	Phosphorylation	TCEMKPGTWSDESSQ CEEECCCCCCCCCCC	30.26	27732954
997	Phosphorylation	EMKPGTWSDESSQSE EECCCCCCCCCCCCC	31.19	25849741
1000	Phosphorylation	PGTWSDESSQSEDAR CCCCCCCCCCCCCHH	38.37	20363803
1001	Phosphorylation	GTWSDESSQSEDARS CCCCCCCCCCCCHHH	35.36	20363803
1003	Phosphorylation	WSDESSQSEDARSSK CCCCCCCCCCHHHCC	39.12	25849741
1016	Sumoylation	SKPAAKKKATMQGDR CCCHHHHHHCHHCCH	48.67	28112733
1018	Phosphorylation	PAAKKKATMQGDREQ CHHHHHHCHHCCHHH	20.93	28674151
1031	Phosphorylation	EQLKWKNSSYGKVEG HHHHHCCCCCCCEEC	22.62	21712546
1032	Phosphorylation	QLKWKNSSYGKVEGF HHHHCCCCCCCEECC	47.50	23917254
1033	Phosphorylation	LKWKNSSYGKVEGFW HHHCCCCCCCEECCC	22.31	23186163
1035	Sumoylation	WKNSSYGKVEGFWSK HCCCCCCCEECCCCC	28.96	-
1035	Acetylation	WKNSSYGKVEGFWSK HCCCCCCCEECCCCC	28.96	19608861
1035	Sumoylation	WKNSSYGKVEGFWSK HCCCCCCCEECCCCC	28.96	28112733
1042	Acetylation	KVEGFWSKDQSQWKN CEECCCCCCHHHHCC	50.84	19608861
1042	Sumoylation	KVEGFWSKDQSQWKN CEECCCCCCHHHHCC	50.84	28112733
1042	Ubiquitination	KVEGFWSKDQSQWKN CEECCCCCCHHHHCC	50.84	19608861
1048	Ubiquitination	SKDQSQWKNASENDE CCCHHHHCCCCCCCH	34.69	-
1051	Phosphorylation	QSQWKNASENDERLS HHHHCCCCCCCHHHC	46.45	30576142
1058	Phosphorylation	SENDERLSNPQIEWQ CCCCHHHCCCCCEEC	53.32	20068231
1067	Phosphorylation	PQIEWQNSTIDSEDG CCCEECCCCCCCCCC	16.19	22115753
1068	Phosphorylation	QIEWQNSTIDSEDGE CCEECCCCCCCCCCC	36.03	22115753
1071	Phosphorylation	WQNSTIDSEDGEQFD ECCCCCCCCCCCCCC	33.46	22115753
1081	Phosphorylation	GEQFDNMTDGVAEPM CCCCCCCCCCCCCCC	35.54	20068231
1091	Phosphorylation	VAEPMHGSLAGVKLS CCCCCCCCCCCCCCC	10.60	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ADNP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ADNP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ADNP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARI1A_HUMAN	ARID1A	physical	17878164
SMRC2_HUMAN	SMARCC2	physical	17878164
SMCA4_HUMAN	SMARCA4	physical	17878164
SEPT2_HUMAN	SEPT2	physical	22939629
SERA_HUMAN	PHGDH	physical	22939629
EBP2_HUMAN	EBNA1BP2	physical	22939629
NFIA_HUMAN	NFIA	physical	22939629
RRS1_HUMAN	RRS1	physical	22939629
SAP18_HUMAN	SAP18	physical	22939629
EMD_HUMAN	EMD	physical	22939629
CDC27_HUMAN	CDC27	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615873	Helsmoortel-van der Aa syndrome (HVDAS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ADNP_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1035 AND LYS-1042, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-736 AND SER-955, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-921; SER-970 ANDSER-982, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-409; SER-709;SER-736; SER-876; SER-878; SER-953 AND SER-955, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-709, AND MASSSPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-953 AND SER-955,AND MASS SPECTROMETRY.	17081983 [Abstract]