dbPTM

RAI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RAI1_HUMAN
UniProt AC	Q7Z5J4
Protein Name	Retinoic acid-induced protein 1
Gene Name	RAI1
Organism	Homo sapiens (Human).
Sequence Length	1906
Subcellular Localization	Cytoplasm. Nucleus. In neurons, localized to neurites..
Protein Description	Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation..
Protein Sequence	MQSFRERCGFHGKQQNYQQTSQETSRLENYRQPSQAGLSCDRQRLLAKDYYNPQPYPSYEGGAGTPSGTAAAVAADKYHRGSKALPTQQGLQGRPAFPGYGVQDSSPYPGRYAGEESLQAWGAPQPPPPQPQPLPAGVAKYDENLMKKTAVPPSRQYAEQGAQVPFRTHSLHVQQPPPPQQPLAYPKLQRQKLQNDIASPLPFPQGTHFPQHSQSFPTSSTYSSSVQGGGQGAHSYKSCTAPTAQPHDRPLTASSSLAPGQRVQNLHAYQSGRLSYDQQQQQQQQQQQQQQALQSRHHAQETLHYQNLAKYQHYGQQGQGYCQPDAAVRTPEQYYQTFSPSSSHSPARSVGRSPSYSSTPSPLMPNLENFPYSQQPLSTGAFPAGITDHSHFMPLLNPSPTDATSSVDTQAGNCKPLQKDKLPENLLSDLSLQSLTALTSQVENISNTVQQLLLSKAAVPQKKGVKNLVSRTPEQHKSQHCSPEGSGYSAEPAGTPLSEPPSSTPQSTHAEPQEADYLSGSEDPLERSFLYCNQARGSPARVNSNSKAKPESVSTCSVTSPDDMSTKSDDSFQSLHGSLPLDSFSKFVAGERDCPRLLLSALAQEDLASEILGLQEAIGEKADKAWAEAPSLVKDSSKPPFSLENHSACLDSVAKSAWPRPGEPEALPDSLQLDKGGNAKDFSPGLFEDPSVAFATPDPKKTTGPLSFGTKPTLGVPAPDPTTAAFDCFPDTTAASSADSANPFAWPEENLGDACPRWGLHPGELTKGLEQGGKASDGISKGDTHEASACLGFQEEDPPGEKVASLPGDFKQEEVGGVKEEAGGLLQCPEVAKADRWLEDSRHCCSTADFGDLPLLPPTSRKEDLEAEEEYSSLCELLGSPEQRPGMQDPLSPKAPLICTKEEVEEVLDSKAGWGSPCHLSGESVILLGPTVGTESKVQSWFESSLSHMKPGEEGPDGERAPGDSTTSDASLAQKPNKPAVPEAPIAKKEPVPRGKSLRSRRVHRGLPEAEDSPCRAPVLPKDLLLPESCTGPPQGQMEGAGAPGRGASEGLPRMCTRSLTALSEPRTPGPPGLTTTPAPPDKLGGKQRAAFKSGKRVGKPSPKAASSPSNPAALPVASDSSPMGSKTKETDSPSTPGKDQRSMILRSRTKTQEIFHSKRRRPSEGRLPNCRATKKLLDNSHLPATFKVSSSPQKEGRVSQRARVPKPGAGSKLSDRPLHALKRKSAFMAPVPTKKRNLVLRSRSSSSSNASGNGGDGKEERPEGSPTLFKRMSSPKKAKPTKGNGEPATKLPPPETPDACLKLASRAAFQGAMKTKVLPPRKGRGLKLEAIVQKITSPSLKKFACKAPGASPGNPLSPSLSDKDRGLKGAGGSPVGVEEGLVNVGTGQKLPTSGADPLCRNPTNRSLKGKLMNSKKLSSTDCFKTEAFTSPEALQPGGTALAPKKRSRKGRAGAHGLSKGPLEKRPYLGPALLLTPRDRASGTQGASEDNSGGGGKKPKMEELGLASQPPEGRPCQPQTRAQKQPGHTNYSSYSKRKRLTRGRAKNTTSSPCKGRAKRRRQQQVLPLDPAEPEIRLKYISSCKRLRSDSRTPAFSPFVRVEKRDAFTTICTVVNSPGDAPKPHRKPSSSASSSSSSSSFSLDAAGASLATLPGGSILQPRPSLPLSSTMHLGPVVSKALSTSCLVCCLCQNPANFKDLGDLCGPYYPEHCLPKKKPKLKEKVRPEGTCEEASLPLERTLKGPECAAAATAGKPPRPDGPADPAKQGPLRTSARGLSRRLQSCYCCDGREDGGEEAAPADKGRKHECSKEAPAEPGGEAQEHWVHEACAVWTGGVYLVAGKLFGLQEAMKVAVDMMCSSCQEAGATIGCCHKGCLHTYHYPCASDAGCIFIEENFSLKCPKHKRLP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Acetylation	ERCGFHGKQQNYQQT HHHCCCCCCCCHHHC	39.89	26051181
13	Methylation	ERCGFHGKQQNYQQT HHHCCCCCCCCHHHC	39.89	115976111
17	Phosphorylation	FHGKQQNYQQTSQET CCCCCCCHHHCHHHH	9.54	-
30	Phosphorylation	ETSRLENYRQPSQAG HHHHHHHHCCHHHCC	10.97	-
34	Phosphorylation	LENYRQPSQAGLSCD HHHHCCHHHCCCCCH	25.07	28555341
39	Phosphorylation	QPSQAGLSCDRQRLL CHHHCCCCCHHHHHC	17.04	21815630
48	Ubiquitination	DRQRLLAKDYYNPQP HHHHHCHHCCCCCCC	46.35	29967540
50	Phosphorylation	QRLLAKDYYNPQPYP HHHCHHCCCCCCCCC	12.39	27642862
51	Phosphorylation	RLLAKDYYNPQPYPS HHCHHCCCCCCCCCC	30.42	24275569
56	Phosphorylation	DYYNPQPYPSYEGGA CCCCCCCCCCCCCCC	10.28	22199227
58	Phosphorylation	YNPQPYPSYEGGAGT CCCCCCCCCCCCCCC	29.94	22199227
59	Phosphorylation	NPQPYPSYEGGAGTP CCCCCCCCCCCCCCC	17.68	22199227
65	Phosphorylation	SYEGGAGTPSGTAAA CCCCCCCCCCCHHHH	17.47	30576142
67	Phosphorylation	EGGAGTPSGTAAAVA CCCCCCCCCHHHHHH	48.92	22199227
69	Phosphorylation	GAGTPSGTAAAVAAD CCCCCCCHHHHHHHH	19.91	22199227
77	Acetylation	AAAVAADKYHRGSKA HHHHHHHHCCCCCCC	37.92	25953088
78	Phosphorylation	AAVAADKYHRGSKAL HHHHHHHCCCCCCCC	9.41	-
100	Phosphorylation	GRPAFPGYGVQDSSP CCCCCCCCCCCCCCC	17.86	27732954
105	Phosphorylation	PGYGVQDSSPYPGRY CCCCCCCCCCCCCCC	19.00	25159151
106	Phosphorylation	GYGVQDSSPYPGRYA CCCCCCCCCCCCCCC	36.42	25159151
108	Phosphorylation	GVQDSSPYPGRYAGE CCCCCCCCCCCCCCH	21.92	27732954
149	Phosphorylation	DENLMKKTAVPPSRQ CHHHHHHCCCCCHHH	27.63	20068231
154	Phosphorylation	KKTAVPPSRQYAEQG HHCCCCCHHHHHHCC	26.41	20068231
168	Phosphorylation	GAQVPFRTHSLHVQQ CCCCCCEECCEECCC	19.05	28857561
170	Phosphorylation	QVPFRTHSLHVQQPP CCCCEECCEECCCCC	21.40	23401153
187	Ubiquitination	QQPLAYPKLQRQKLQ CCCCCCHHHHHHHHH	44.57	29967540
249	Methylation	PTAQPHDRPLTASSS CCCCCCCCCCCCCCC	25.70	97770759
256	Phosphorylation	RPLTASSSLAPGQRV CCCCCCCCCCCCCCC	26.51	28555341
269	Phosphorylation	RVQNLHAYQSGRLSY CCCCHHHHHHCCCCH	7.77	27642862
271	Phosphorylation	QNLHAYQSGRLSYDQ CCHHHHHHCCCCHHH	17.13	-
302	Phosphorylation	SRHHAQETLHYQNLA HHHHHHHHHHHHHHH	13.52	29978859
305	Phosphorylation	HAQETLHYQNLAKYQ HHHHHHHHHHHHHHH	11.38	25884760
321	Phosphorylation	YGQQGQGYCQPDAAV HCCCCCCCCCCCHHC	4.68	27642862
330	Phosphorylation	QPDAAVRTPEQYYQT CCCHHCCCHHHHHHH	25.28	23927012
334	Phosphorylation	AVRTPEQYYQTFSPS HCCCHHHHHHHCCCC	8.90	23927012
335	Phosphorylation	VRTPEQYYQTFSPSS CCCHHHHHHHCCCCC	10.77	23927012
337	Phosphorylation	TPEQYYQTFSPSSSH CHHHHHHHCCCCCCC	15.23	30108239
339	Phosphorylation	EQYYQTFSPSSSHSP HHHHHHCCCCCCCCC	27.53	25159151
341	Phosphorylation	YYQTFSPSSSHSPAR HHHHCCCCCCCCCCC	43.18	23927012
342	Phosphorylation	YQTFSPSSSHSPARS HHHCCCCCCCCCCCC	35.14	23927012
343	O-linked_Glycosylation	QTFSPSSSHSPARSV HHCCCCCCCCCCCCC	32.11	30379171
343	Phosphorylation	QTFSPSSSHSPARSV HHCCCCCCCCCCCCC	32.11	23927012
345	Phosphorylation	FSPSSSHSPARSVGR CCCCCCCCCCCCCCC	23.39	23401153
399	Phosphorylation	FMPLLNPSPTDATSS CCCCCCCCCCCCCCC	39.08	26074081
401	Phosphorylation	PLLNPSPTDATSSVD CCCCCCCCCCCCCCC	42.47	26074081
404	Phosphorylation	NPSPTDATSSVDTQA CCCCCCCCCCCCCCC	25.09	26074081
405	Phosphorylation	PSPTDATSSVDTQAG CCCCCCCCCCCCCCC	30.04	26074081
406	Phosphorylation	SPTDATSSVDTQAGN CCCCCCCCCCCCCCC	21.47	26074081
462	Ubiquitination	SKAAVPQKKGVKNLV HHCCCCHHHCCCCHH	45.48	23000965
463	Ubiquitination	KAAVPQKKGVKNLVS HCCCCHHHCCCCHHH	64.78	23000965
466	Ubiquitination	VPQKKGVKNLVSRTP CCHHHCCCCHHHCCH	53.91	23000965
470	Phosphorylation	KGVKNLVSRTPEQHK HCCCCHHHCCHHHHH	33.33	23403867
472	Phosphorylation	VKNLVSRTPEQHKSQ CCCHHHCCHHHHHHC	24.54	25159151
498	Phosphorylation	EPAGTPLSEPPSSTP CCCCCCCCCCCCCCC	49.62	26074081
502	Phosphorylation	TPLSEPPSSTPQSTH CCCCCCCCCCCCCCC	58.52	26074081
503	Phosphorylation	PLSEPPSSTPQSTHA CCCCCCCCCCCCCCC	50.29	26074081
504	Phosphorylation	LSEPPSSTPQSTHAE CCCCCCCCCCCCCCC	29.68	26074081
507	Phosphorylation	PPSSTPQSTHAEPQE CCCCCCCCCCCCHHH	24.30	26074081
508	Phosphorylation	PSSTPQSTHAEPQEA CCCCCCCCCCCHHHC	21.62	26074081
517	Phosphorylation	AEPQEADYLSGSEDP CCHHHCCCCCCCCCH	15.15	28387310
519	Phosphorylation	PQEADYLSGSEDPLE HHHCCCCCCCCCHHH	33.76	30576142
521	Phosphorylation	EADYLSGSEDPLERS HCCCCCCCCCHHHHH	35.14	26074081
528	Phosphorylation	SEDPLERSFLYCNQA CCCHHHHHHHHHHCC	15.38	23401153
531	Phosphorylation	PLERSFLYCNQARGS HHHHHHHHHHCCCCC	6.32	25841592
538	Phosphorylation	YCNQARGSPARVNSN HHHCCCCCCCCCCCC	15.16	23403867
544	Phosphorylation	GSPARVNSNSKAKPE CCCCCCCCCCCCCCC	39.36	26074081
552	Phosphorylation	NSKAKPESVSTCSVT CCCCCCCCCCCCEEC	29.87	30108239
554	Phosphorylation	KAKPESVSTCSVTSP CCCCCCCCCCEECCC	32.73	30108239
555	Phosphorylation	AKPESVSTCSVTSPD CCCCCCCCCEECCCC	13.47	30108239
557	Phosphorylation	PESVSTCSVTSPDDM CCCCCCCEECCCCCC	28.63	30108239
559	Phosphorylation	SVSTCSVTSPDDMST CCCCCEECCCCCCCC	20.46	25849741
560	Phosphorylation	VSTCSVTSPDDMSTK CCCCEECCCCCCCCC	24.95	25849741
565	Phosphorylation	VTSPDDMSTKSDDSF ECCCCCCCCCCCCCH	39.41	25849741
566	Phosphorylation	TSPDDMSTKSDDSFQ CCCCCCCCCCCCCHH	28.12	30108239
568	Phosphorylation	PDDMSTKSDDSFQSL CCCCCCCCCCCHHHH	46.90	29255136
571	Phosphorylation	MSTKSDDSFQSLHGS CCCCCCCCHHHHHCC	30.12	29255136
574	Phosphorylation	KSDDSFQSLHGSLPL CCCCCHHHHHCCCCH	21.96	29255136
578	Phosphorylation	SFQSLHGSLPLDSFS CHHHHHCCCCHHHHH	18.96	23663014
583	Phosphorylation	HGSLPLDSFSKFVAG HCCCCHHHHHHHHCC	38.82	25850435
585	Phosphorylation	SLPLDSFSKFVAGER CCCHHHHHHHHCCCC	29.18	25850435
586	Ubiquitination	LPLDSFSKFVAGERD CCHHHHHHHHCCCCC	41.68	29967540
600	Phosphorylation	DCPRLLLSALAQEDL CHHHHHHHHHHHHHH	22.62	27732954
621	Sumoylation	LQEAIGEKADKAWAE HHHHHHHHHHHHHHH	57.58	-
621	Sumoylation	LQEAIGEKADKAWAE HHHHHHHHHHHHHHH	57.58	-
631	Phosphorylation	KAWAEAPSLVKDSSK HHHHHCCHHHCCCCC	53.49	28555341
634	Ubiquitination	AEAPSLVKDSSKPPF HHCCHHHCCCCCCCC	58.13	29967540
636	Phosphorylation	APSLVKDSSKPPFSL CCHHHCCCCCCCCCC	34.25	25627689
637	Phosphorylation	PSLVKDSSKPPFSLE CHHHCCCCCCCCCCC	60.35	30108239
638	Acetylation	SLVKDSSKPPFSLEN HHHCCCCCCCCCCCC	61.74	25953088
638	Ubiquitination	SLVKDSSKPPFSLEN HHHCCCCCCCCCCCC	61.74	29967540
642	Phosphorylation	DSSKPPFSLENHSAC CCCCCCCCCCCHHHH	40.31	28555341
647	Phosphorylation	PFSLENHSACLDSVA CCCCCCHHHHHHHHH	32.05	28555341
652	Phosphorylation	NHSACLDSVAKSAWP CHHHHHHHHHHHCCC	15.83	28555341
675	Acetylation	PDSLQLDKGGNAKDF CCCCEECCCCCCCCC	76.84	25953088
675	Ubiquitination	PDSLQLDKGGNAKDF CCCCEECCCCCCCCC	76.84	29967540
680	Ubiquitination	LDKGGNAKDFSPGLF ECCCCCCCCCCCCCC	64.40	29967540
683	Phosphorylation	GGNAKDFSPGLFEDP CCCCCCCCCCCCCCC	28.35	23401153
691	Phosphorylation	PGLFEDPSVAFATPD CCCCCCCCEEEECCC	38.10	29255136
696	Phosphorylation	DPSVAFATPDPKKTT CCCEEEECCCCCCCC	23.05	29255136
700	Ubiquitination	AFATPDPKKTTGPLS EEECCCCCCCCCCCC	70.86	29967540
767	Acetylation	LHPGELTKGLEQGGK CCHHHHHHHHHHCCC	74.29	26051181
767	Ubiquitination	LHPGELTKGLEQGGK CCHHHHHHHHHHCCC	74.29	29967540
774	Acetylation	KGLEQGGKASDGISK HHHHHCCCCCCCCCC	52.09	23749302
774	Ubiquitination	KGLEQGGKASDGISK HHHHHCCCCCCCCCC	52.09	19608861
776	Phosphorylation	LEQGGKASDGISKGD HHHCCCCCCCCCCCC	39.60	25159151
781	Acetylation	KASDGISKGDTHEAS CCCCCCCCCCCCCCH	59.91	26051181
805	Phosphorylation	PPGEKVASLPGDFKQ CCCCCCCCCCCCCCH	37.78	29255136
811	Sumoylation	ASLPGDFKQEEVGGV CCCCCCCCHHHHCCC	62.63	-
811	Sumoylation	ASLPGDFKQEEVGGV CCCCCCCCHHHHCCC	62.63	28112733
811	Ubiquitination	ASLPGDFKQEEVGGV CCCCCCCCHHHHCCC	62.63	29967540
819	Sumoylation	QEEVGGVKEEAGGLL HHHHCCCCCCCCCCC	53.78	25114211
833	Ubiquitination	LQCPEVAKADRWLED CCCHHHHHHHHHHHH	56.87	32015554
841	Phosphorylation	ADRWLEDSRHCCSTA HHHHHHHCCCCCCCC	17.97	24719451
846	Phosphorylation	EDSRHCCSTADFGDL HHCCCCCCCCCCCCC	31.83	25849741
847	Phosphorylation	DSRHCCSTADFGDLP HCCCCCCCCCCCCCC	19.14	29255136
871	Phosphorylation	DLEAEEEYSSLCELL HHHHHHHHHHHHHHH	13.57	27422710
872	Phosphorylation	LEAEEEYSSLCELLG HHHHHHHHHHHHHHC	21.80	23898821
873	Phosphorylation	EAEEEYSSLCELLGS HHHHHHHHHHHHHCC	35.82	28102081
880	Phosphorylation	SLCELLGSPEQRPGM HHHHHHCCCCCCCCC	25.82	23898821
892	Phosphorylation	PGMQDPLSPKAPLIC CCCCCCCCCCCCEEE	29.73	23401153
900	Phosphorylation	PKAPLICTKEEVEEV CCCCEEECHHHHHHH	34.20	26074081
901	Acetylation	KAPLICTKEEVEEVL CCCEEECHHHHHHHH	47.68	26051181
901	Sumoylation	KAPLICTKEEVEEVL CCCEEECHHHHHHHH	47.68	25114211
901	Ubiquitination	KAPLICTKEEVEEVL CCCEEECHHHHHHHH	47.68	32015554
910	Phosphorylation	EVEEVLDSKAGWGSP HHHHHHHCCCCCCCC	21.90	29255136
911	Ubiquitination	VEEVLDSKAGWGSPC HHHHHHCCCCCCCCC	51.06	29967540
916	Phosphorylation	DSKAGWGSPCHLSGE HCCCCCCCCCCCCCC	20.18	23927012
921	Phosphorylation	WGSPCHLSGESVILL CCCCCCCCCCEEEEE	19.49	23927012
924	Phosphorylation	PCHLSGESVILLGPT CCCCCCCEEEEECCC	20.27	23927012
931	Phosphorylation	SVILLGPTVGTESKV EEEEECCCCCCHHHH	29.75	23403867
934	Phosphorylation	LLGPTVGTESKVQSW EECCCCCCHHHHHHH	32.52	23403867
936	Phosphorylation	GPTVGTESKVQSWFE CCCCCCHHHHHHHHH	37.65	23403867
940	Phosphorylation	GTESKVQSWFESSLS CCHHHHHHHHHHHHC	36.40	27732954
944	Phosphorylation	KVQSWFESSLSHMKP HHHHHHHHHHCCCCC	27.40	27732954
945	Phosphorylation	VQSWFESSLSHMKPG HHHHHHHHHCCCCCC	27.05	27732954
947	Phosphorylation	SWFESSLSHMKPGEE HHHHHHHCCCCCCCC	24.39	27732954
950	Acetylation	ESSLSHMKPGEEGPD HHHHCCCCCCCCCCC	44.43	26051181
975	Acetylation	SDASLAQKPNKPAVP CCHHHCCCCCCCCCC	44.97	26051181
978	Acetylation	SLAQKPNKPAVPEAP HHCCCCCCCCCCCCC	42.77	26051181
997	Phosphorylation	EPVPRGKSLRSRRVH CCCCCCCCHHHHCCC	31.66	-
1000	Phosphorylation	PRGKSLRSRRVHRGL CCCCCHHHHCCCCCC	29.72	24719451
1013	Phosphorylation	GLPEAEDSPCRAPVL CCCCCCCCCCCCCCC	19.87	21712546
1059	Phosphorylation	LPRMCTRSLTALSEP CCHHHCHHHHHHCCC	16.36	23403867
1061	Phosphorylation	RMCTRSLTALSEPRT HHHCHHHHHHCCCCC	27.14	25394399
1064	Phosphorylation	TRSLTALSEPRTPGP CHHHHHHCCCCCCCC	42.99	25159151
1068	Phosphorylation	TALSEPRTPGPPGLT HHHCCCCCCCCCCCC	43.23	23401153
1075	Phosphorylation	TPGPPGLTTTPAPPD CCCCCCCCCCCCCCC	34.24	23403867
1076	Phosphorylation	PGPPGLTTTPAPPDK CCCCCCCCCCCCCCC	35.51	25627689
1077	Phosphorylation	GPPGLTTTPAPPDKL CCCCCCCCCCCCCCC	16.53	25159151
1083	Acetylation	TTPAPPDKLGGKQRA CCCCCCCCCCCCCHH	55.60	25953088
1087	Acetylation	PPDKLGGKQRAAFKS CCCCCCCCCHHHHHC	34.51	25953088
1093	Acetylation	GKQRAAFKSGKRVGK CCCHHHHHCCCCCCC	54.28	26051181
1096	Acetylation	RAAFKSGKRVGKPSP HHHHHCCCCCCCCCC	51.51	26051181
1102	Phosphorylation	GKRVGKPSPKAASSP CCCCCCCCCCCCCCC	42.38	29691806
1107	Phosphorylation	KPSPKAASSPSNPAA CCCCCCCCCCCCCCC	47.87	22167270
1108	Phosphorylation	PSPKAASSPSNPAAL CCCCCCCCCCCCCCC	27.85	22167270
1110	Phosphorylation	PKAASSPSNPAALPV CCCCCCCCCCCCCCC	58.35	22167270
1119	Phosphorylation	PAALPVASDSSPMGS CCCCCCCCCCCCCCC	37.95	29255136
1121	Phosphorylation	ALPVASDSSPMGSKT CCCCCCCCCCCCCCC	33.57	29255136
1122	Phosphorylation	LPVASDSSPMGSKTK CCCCCCCCCCCCCCC	24.72	29255136
1126	Phosphorylation	SDSSPMGSKTKETDS CCCCCCCCCCCCCCC	30.79	29255136
1128	Phosphorylation	SSPMGSKTKETDSPS CCCCCCCCCCCCCCC	35.49	23403867
1131	Phosphorylation	MGSKTKETDSPSTPG CCCCCCCCCCCCCCC	43.25	23403867
1133	Phosphorylation	SKTKETDSPSTPGKD CCCCCCCCCCCCCHH	28.33	29255136
1135	Phosphorylation	TKETDSPSTPGKDQR CCCCCCCCCCCHHHH	51.70	23401153
1136	Phosphorylation	KETDSPSTPGKDQRS CCCCCCCCCCHHHHH	39.17	29255136
1139	Acetylation	DSPSTPGKDQRSMIL CCCCCCCHHHHHHHH	52.47	23749302
1150	Phosphorylation	SMILRSRTKTQEIFH HHHHHCCCHHHHHHH	39.42	24719451
1152	Phosphorylation	ILRSRTKTQEIFHSK HHHCCCHHHHHHHCC	30.71	25159151
1158	Phosphorylation	KTQEIFHSKRRRPSE HHHHHHHCCCCCCCC	19.67	25159151
1164	Phosphorylation	HSKRRRPSEGRLPNC HCCCCCCCCCCCCCC	51.36	26330541
1174	Phosphorylation	RLPNCRATKKLLDNS CCCCCHHHHHHHHCC	14.90	22210691
1181	Phosphorylation	TKKLLDNSHLPATFK HHHHHHCCCCCCEEE	26.52	23403867
1186	Phosphorylation	DNSHLPATFKVSSSP HCCCCCCEEEECCCC	23.27	23403867
1188	Sumoylation	SHLPATFKVSSSPQK CCCCCEEEECCCCCC	36.53	-
1188	Methylation	SHLPATFKVSSSPQK CCCCCEEEECCCCCC	36.53	110873173
1188	Sumoylation	SHLPATFKVSSSPQK CCCCCEEEECCCCCC	36.53	-
1190	Phosphorylation	LPATFKVSSSPQKEG CCCEEEECCCCCCCC	26.20	24732914
1191	Phosphorylation	PATFKVSSSPQKEGR CCEEEECCCCCCCCC	49.37	24732914
1192	Phosphorylation	ATFKVSSSPQKEGRV CEEEECCCCCCCCCC	24.68	28176443
1223	Methylation	DRPLHALKRKSAFMA CCCCHHHHHCCCCCC	59.57	115976103
1226	Phosphorylation	LHALKRKSAFMAPVP CHHHHHCCCCCCCCC	30.67	22199227
1235	Acetylation	FMAPVPTKKRNLVLR CCCCCCCCCCCEEEE	43.60	25953088
1243	Phosphorylation	KRNLVLRSRSSSSSN CCCEEEEECCCCCCC	32.14	24719451
1245	Phosphorylation	NLVLRSRSSSSSNAS CEEEEECCCCCCCCC	35.50	30108239
1246	Phosphorylation	LVLRSRSSSSSNASG EEEEECCCCCCCCCC	32.88	30108239
1247	Phosphorylation	VLRSRSSSSSNASGN EEEECCCCCCCCCCC	38.75	23401153
1248	Phosphorylation	LRSRSSSSSNASGNG EEECCCCCCCCCCCC	29.56	25884760
1249	Phosphorylation	RSRSSSSSNASGNGG EECCCCCCCCCCCCC	38.06	30108239
1252	Phosphorylation	SSSSSNASGNGGDGK CCCCCCCCCCCCCCC	36.72	30108239
1259	Acetylation	SGNGGDGKEERPEGS CCCCCCCCCCCCCCC	62.23	26051181
1266	Phosphorylation	KEERPEGSPTLFKRM CCCCCCCCCCHHHHC	17.04	23401153
1268	Phosphorylation	ERPEGSPTLFKRMSS CCCCCCCCHHHHCCC	46.66	25850435
1274	Phosphorylation	PTLFKRMSSPKKAKP CCHHHHCCCCCCCCC	47.74	-
1275	Phosphorylation	TLFKRMSSPKKAKPT CHHHHCCCCCCCCCC	31.25	-
1297	Phosphorylation	TKLPPPETPDACLKL CCCCCCCCHHHHHHH	32.04	29255136
1303	Methylation	ETPDACLKLASRAAF CCHHHHHHHHHHHHH	41.72	115976119
1303	Ubiquitination	ETPDACLKLASRAAF CCHHHHHHHHHHHHH	41.72	32015554
1328	Sumoylation	PRKGRGLKLEAIVQK CCCCCCCCHHHHHHH	47.29	-
1328	Sumoylation	PRKGRGLKLEAIVQK CCCCCCCCHHHHHHH	47.29	-
1337	Phosphorylation	EAIVQKITSPSLKKF HHHHHHHCCHHHHHH	41.44	24702127
1338	Phosphorylation	AIVQKITSPSLKKFA HHHHHHCCHHHHHHC	18.90	20068231
1340	Phosphorylation	VQKITSPSLKKFACK HHHHCCHHHHHHCCC	53.22	20068231
1347	Methylation	SLKKFACKAPGASPG HHHHHCCCCCCCCCC	54.94	115976127
1352	Phosphorylation	ACKAPGASPGNPLSP CCCCCCCCCCCCCCC	38.98	29255136
1358	Phosphorylation	ASPGNPLSPSLSDKD CCCCCCCCCCCCHHH	17.44	23401153
1360	Phosphorylation	PGNPLSPSLSDKDRG CCCCCCCCCCHHHCC	36.81	29255136
1362	Phosphorylation	NPLSPSLSDKDRGLK CCCCCCCCHHHCCCC	47.13	29255136
1364	Acetylation	LSPSLSDKDRGLKGA CCCCCCHHHCCCCCC	46.05	26051181
1374	Phosphorylation	GLKGAGGSPVGVEEG CCCCCCCCCCCHHCC	18.59	29255136
1387	Phosphorylation	EGLVNVGTGQKLPTS CCEEECCCCCCCCCC	31.96	30266825
1393	Phosphorylation	GTGQKLPTSGADPLC CCCCCCCCCCCCCCC	50.67	21130716
1394	Phosphorylation	TGQKLPTSGADPLCR CCCCCCCCCCCCCCC	30.00	21815630
1411	Acetylation	TNRSLKGKLMNSKKL CCCCHHHHHCCCCCC	42.87	25953088
1419	Phosphorylation	LMNSKKLSSTDCFKT HCCCCCCCCCCCCCC	39.82	25159151
1420	Phosphorylation	MNSKKLSSTDCFKTE CCCCCCCCCCCCCCC	38.41	-
1425	Sumoylation	LSSTDCFKTEAFTSP CCCCCCCCCCCCCCH	52.35	28112733
1426	Phosphorylation	SSTDCFKTEAFTSPE CCCCCCCCCCCCCHH	16.58	24732914
1430	Phosphorylation	CFKTEAFTSPEALQP CCCCCCCCCHHHCCC	50.88	25159151
1431	Phosphorylation	FKTEAFTSPEALQPG CCCCCCCCHHHCCCC	17.81	25159151
1440	Phosphorylation	EALQPGGTALAPKKR HHCCCCCCCCCCCCC	25.14	24732914
1448	Phosphorylation	ALAPKKRSRKGRAGA CCCCCCCCCCCCCCC	47.42	-
1452	Methylation	KKRSRKGRAGAHGLS CCCCCCCCCCCCCCC	32.65	115490193
1468	Phosphorylation	GPLEKRPYLGPALLL CCCCCCCCCCCEEEE	28.46	27642862
1476	Phosphorylation	LGPALLLTPRDRASG CCCEEEECHHHCCCC	19.08	22617229
1482	Phosphorylation	LTPRDRASGTQGASE ECHHHCCCCCCCCCC	43.18	20860994
1488	Phosphorylation	ASGTQGASEDNSGGG CCCCCCCCCCCCCCC	52.92	24732914
1492	Phosphorylation	QGASEDNSGGGGKKP CCCCCCCCCCCCCCC	51.65	24732914
1508	Phosphorylation	MEELGLASQPPEGRP HHHCCCCCCCCCCCC	48.54	28555341
1532	Phosphorylation	QPGHTNYSSYSKRKR CCCCCCCHHHHHHCH	25.52	25627689
1533	Phosphorylation	PGHTNYSSYSKRKRL CCCCCCHHHHHHCHH	24.06	25627689
1549	Phosphorylation	RGRAKNTTSSPCKGR CCCCCCCCCCCCCHH	36.28	28634120
1550	Phosphorylation	GRAKNTTSSPCKGRA CCCCCCCCCCCCHHH	30.19	25849741
1551	Phosphorylation	RAKNTTSSPCKGRAK CCCCCCCCCCCHHHH	32.02	25849741
1581	Phosphorylation	EIRLKYISSCKRLRS HHHHHHHHHCCHHCC	26.96	29691806
1582	Phosphorylation	IRLKYISSCKRLRSD HHHHHHHHCCHHCCC	17.69	29691806
1584	Acetylation	LKYISSCKRLRSDSR HHHHHHCCHHCCCCC	57.31	25953088
1588	Phosphorylation	SSCKRLRSDSRTPAF HHCCHHCCCCCCCCC	44.52	25106551
1590	Phosphorylation	CKRLRSDSRTPAFSP CCHHCCCCCCCCCCC	39.02	30108239
1592	Phosphorylation	RLRSDSRTPAFSPFV HHCCCCCCCCCCCCE	23.95	25106551
1596	Phosphorylation	DSRTPAFSPFVRVEK CCCCCCCCCCEEEEC	21.38	30108239
1608	Phosphorylation	VEKRDAFTTICTVVN EECCCCCEEEEEEEC	19.57	24732914
1609	Phosphorylation	EKRDAFTTICTVVNS ECCCCCEEEEEEECC	13.96	24732914
1612	Phosphorylation	DAFTTICTVVNSPGD CCCEEEEEEECCCCC	24.52	24732914
1616	Phosphorylation	TICTVVNSPGDAPKP EEEEEECCCCCCCCC	20.74	23927012
1733	Phosphorylation	EGTCEEASLPLERTL CCCCCCCCCCCCHHC	33.52	23312004
1753	Acetylation	AAAATAGKPPRPDGP HHHHHCCCCCCCCCC	49.76	26051181
1772	O-linked_Glycosylation	KQGPLRTSARGLSRR HCCCCHHCHHHHHHH	14.99	30379171
1772	Phosphorylation	KQGPLRTSARGLSRR HCCCCHHCHHHHHHH	14.99	24719451
1777	Phosphorylation	RTSARGLSRRLQSCY HHCHHHHHHHCCCCE	20.41	-
1782	Phosphorylation	GLSRRLQSCYCCDGR HHHHHCCCCEECCCC	16.20	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RAI1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RAI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RAI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHP3_HUMAN	TESC	physical	16189514
MAML3_HUMAN	MAML3	physical	20211142
ZN496_HUMAN	ZNF496	physical	20211142

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
182290	Smith-Magenis syndrome (SMS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RAI1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-774, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-683; SER-1064; THR-1068AND SER-1374, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107; SER-1110;SER-1119; SER-1126; SER-1338; SER-1352; SER-1358 AND SER-1374, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-683; THR-696; SER-880;SER-892; SER-1108; SER-1122; SER-1352; SER-1358; SER-1374 ANDSER-1431, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-345, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-568; SER-571 ANDSER-574, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1476, AND MASSSPECTROMETRY.	17924679 [Abstract]