MAML3_HUMAN - dbPTM
MAML3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAML3_HUMAN
UniProt AC Q96JK9
Protein Name Mastermind-like protein 3
Gene Name MAML3 {ECO:0000312|HGNC:HGNC:16272}
Organism Homo sapiens (Human).
Sequence Length 1138
Subcellular Localization Nucleus speckle . Nuclear, in a punctate manner.
Protein Description Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1..
Protein Sequence MGDFAAPAAAANGSSICINSSLNSSLGGAGIGVNNTPNSTPAAPSSNHPAAGGCGGSGGPGGGSAAVPKHSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLEQRAKKSGAGTGKQQHPSKPQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAEQQLQQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPMVMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYERNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
131AcetylationKSGAGTGKQQHPSKP
HCCCCCCCCCCCCCC		46.7726051181
137AcetylationGKQQHPSKPQQDAEA
CCCCCCCCCHHHHHH		51.8226822725
170PhosphorylationRKLEGARSPLNGDQQ
HHHCCCCCCCCCCCC		32.9523401153
186PhosphorylationGACDGNFSPTSKRIR
CCCCCCCCCCHHHHH		31.1329214152
190AcetylationGNFSPTSKRIRKDIS
CCCCCCHHHHHHHHH		55.0825953088
265PhosphorylationGCSDLEDSFTILQSK
CCCCHHHHEEEEECC		18.21-
272AcetylationSFTILQSKDLKQEPL
HEEEEECCCCCCCCC		54.8626051181
275SumoylationILQSKDLKQEPLDDP
EEECCCCCCCCCCCC		63.85-
287PhosphorylationDDPTCIDTSETSLSN
CCCCCCCCCCCCCCC		14.4621712546
288PhosphorylationDPTCIDTSETSLSNQ
CCCCCCCCCCCCCCC		34.8221712546
291PhosphorylationCIDTSETSLSNQNKL
CCCCCCCCCCCCCCC		26.2521712546
348PhosphorylationFSQPATETPLSQESA
CCCCCCCCCCCHHCC		25.7727732954
351PhosphorylationPATETPLSQESASVK
CCCCCCCCHHCCCCC		32.8627732954
354PhosphorylationETPLSQESASVKSDP
CCCCCHHCCCCCCCC		20.4327732954
356PhosphorylationPLSQESASVKSDPSH
CCCHHCCCCCCCCCC		39.0827732954
359PhosphorylationQESASVKSDPSHSPF
HHCCCCCCCCCCCCC		53.2327732954
362PhosphorylationASVKSDPSHSPFAHV
CCCCCCCCCCCCCCC		41.4027732954
364PhosphorylationVKSDPSHSPFAHVSM
CCCCCCCCCCCCCCC		26.5023401153
370PhosphorylationHSPFAHVSMGSPQAR
CCCCCCCCCCCCCCC		13.9423401153
373PhosphorylationFAHVSMGSPQARPSS
CCCCCCCCCCCCCCC		12.7523401153
599AcetylationKQHNILTYGNTKPLT
CCCCEECCCCCCCCC		41.8719608861
603AcetylationILTYGNTKPLTHFNA
EECCCCCCCCCCCCC		22.9619608861
617PhosphorylationADLSQRMTPPVANPN
CCHHHCCCCCCCCCC		31.3829802988
685PhosphorylationVMNQPMAYAALPSHG
CCCCCCHHHHCCCCC		21.3929083192
690PhosphorylationMAYAALPSHGQEQHP
CHHHHCCCCCCCCCC		56.2929083192
698MethylationHGQEQHPVGLPRTTG
CCCCCCCCCCCCCCC		50.38-
702MethylationQHPVGLPRTTGPMQS
CCCCCCCCCCCCCCC		18.62115482515
1062PhosphorylationVPGMPAFSQPPAQQQ
CCCCCCCCCCCHHHC		26.88-
1117PhosphorylationDGADLVDSIIKGGPG
CCHHHHHHHHHCCCC		36.8024719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MAML3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAML3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAML3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MAML1_HUMANMAML1physical
12370315
SUH_HUMANRBPJphysical
12370315
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAML3_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-599, AND MASS SPECTROMETRY.

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