dbPTM

ATD2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATD2B_HUMAN
UniProt AC	Q9ULI0
Protein Name	ATPase family AAA domain-containing protein 2B
Gene Name	ATAD2B
Organism	Homo sapiens (Human).
Sequence Length	1458
Subcellular Localization	Nucleus . Partially localizes to replication sites.
Protein Description
Protein Sequence	MVNTRKSSLRLLGSKSPGPGPGPGAGAEPGATGGSSHFISSRTRSSKTRAASCPAAKAGGSGGAGVTLDEARKVEVDGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRSTGQREEWNLSTGQARLTSQPGATLPNGHSGLSLRSHPLRGEKKGDGDLSCINGDMEVRKSCRSRKNRFESVNQSLLFDQLVNSTAEAVLQEMDNINIRQNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKSLRRNSYGIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSDTTSSDEERFERRKSKSMARARNRCLPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYHAMQNIVPASQRAVMSSGHALSPIIRPLLERSFNNILAVLQKVFPHAEISQSDKKEDIETLILEDSEDENALSIFETNCHSGSPKKQSSSAAIHKPYLHFTMSPYHQPTSYRPRLLLSGERGSGQTSHLAPALLHTLERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPHIGDWWEAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYIQRPIEEDRRKFFQELILNQASMAPPRRKHAALCAMEVLPLALPSPPRQLSESEKSRMEDQEENTLRELRLFLRDVTKRLATDKRFNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKHNYLTAKDFLKDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKEARIKRGLSVTSEQINPHSTGARKTETRVEEAFRHKQRNPMDVWHNSANKCAFRVRRKSRRRSQWGKGIIKKRKVNNLKKDEEDTKFADYENHTEDRKLLENGEFEVSTDCHEENGEETGDLSMTNDESSCDIMDLDQGQRLNNGAGTKENFASTEEESSNESLLVNSSSSLNPEQTSRKETFLKGNCLNGEASTDSFEGIPVLECQNGKLEVVSFCDSGDKCSSEQKILLEDQSKEKPETSTENHGDDLEKLEALECSNNEKLEPGSDVEVKDAELDKEGASKVKKYRKLILEQAKTTSLELVPEEPSEPVPPLIVDRERLKKLLDLLVDKSNNLAVDQLERLYSLLSQCIYRHRKDYDKSQLVEEMERTVHMFETFL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	SSLRLLGSKSPGPGP HHHHHCCCCCCCCCC	29.90	28464451
16	Phosphorylation	LRLLGSKSPGPGPGP HHHCCCCCCCCCCCC	36.46	29255136
35	Phosphorylation	EPGATGGSSHFISSR CCCCCCCCCCCCCCC	23.22	25627689
52	Phosphorylation	SSKTRAASCPAAKAG CCCCCCCCCCHHHCC	21.46	28985074
61	Phosphorylation	PAAKAGGSGGAGVTL CHHHCCCCCCCCCCH	32.89	25159151
79	Phosphorylation	RKVEVDGSLSDSHVS CEEEECCCCCCCCCC	21.89	23401153
81	Phosphorylation	VEVDGSLSDSHVSPP EEECCCCCCCCCCCC	38.47	30266825
83	Phosphorylation	VDGSLSDSHVSPPAK ECCCCCCCCCCCCHH	23.55	30266825
86	Phosphorylation	SLSDSHVSPPAKRTL CCCCCCCCCCHHCCC	21.53	29255136
90	Acetylation	SHVSPPAKRTLKQPD CCCCCCHHCCCCCCC	52.25	25953088
98	Phosphorylation	RTLKQPDSVCKDKSK CCCCCCCCCCCCCCC	35.78	24719451
109	Phosphorylation	DKSKSRSTGQREEWN CCCCCCCCCCCHHEE	35.90	25627689
118	Phosphorylation	QREEWNLSTGQARLT CCHHEECCCCCEEEC	27.55	21815630
119	Phosphorylation	REEWNLSTGQARLTS CHHEECCCCCEEECC	36.16	27732954
125	Phosphorylation	STGQARLTSQPGATL CCCCEEECCCCCCCC	21.55	23663014
126	Phosphorylation	TGQARLTSQPGATLP CCCEEECCCCCCCCC	38.68	23663014
131	Phosphorylation	LTSQPGATLPNGHSG ECCCCCCCCCCCCCC	48.97	23663014
137	Phosphorylation	ATLPNGHSGLSLRSH CCCCCCCCCCCCCCC	42.71	23663014
140	Phosphorylation	PNGHSGLSLRSHPLR CCCCCCCCCCCCCCC	25.84	23663014
143	Phosphorylation	HSGLSLRSHPLRGEK CCCCCCCCCCCCCCC	34.45	23663014
157	Phosphorylation	KKGDGDLSCINGDME CCCCCCCCCCCCCHH	20.07	21712546
173	Acetylation	RKSCRSRKNRFESVN HHHHHHCCCHHHHHH	54.44	18604609
221	Phosphorylation	VERLRMWTDTEFENM HHHHHEECCCCCCCC	24.57	27422710
223	Phosphorylation	RLRMWTDTEFENMDM HHHEECCCCCCCCHH	34.89	27732954
245	Phosphorylation	RKSLRRNSYGIQNHH HHHHHHCCCCCCCCC	23.95	27251275
246	Phosphorylation	KSLRRNSYGIQNHHE HHHHHCCCCCCCCCC	23.07	27251275
255	Phosphorylation	IQNHHEVSTEGEEEE CCCCCCCCCCCCCHH	20.11	30576142
256	Phosphorylation	QNHHEVSTEGEEEES CCCCCCCCCCCCHHC	53.86	30576142
263	Phosphorylation	TEGEEEESQEEDGDI CCCCCHHCCCCCCCC	46.28	30576142
291	Phosphorylation	YNLRQRKTVDRYQAP CCHHHCCCCCHHCCC	29.81	27174698
295	Phosphorylation	QRKTVDRYQAPPIVP HCCCCCHHCCCCCCC	12.45	27642862
306	Ubiquitination	PIVPAHQKKRENTLF CCCCHHHCCCCCCCC	43.88	-
311	Phosphorylation	HQKKRENTLFDIHRS HHCCCCCCCCCCCCC	24.85	28348404
318	Phosphorylation	TLFDIHRSPARRSHI CCCCCCCCHHHHHHH	14.56	23401153
334	Phosphorylation	RKKHAIHSSDTTSSD HHCCCCCCCCCCCCH	24.64	23663014
335	Phosphorylation	KKHAIHSSDTTSSDE HCCCCCCCCCCCCHH	25.47	23663014
337	Phosphorylation	HAIHSSDTTSSDEER CCCCCCCCCCCHHHH	30.44	23663014
338	Phosphorylation	AIHSSDTTSSDEERF CCCCCCCCCCHHHHH	31.09	23663014
339	Phosphorylation	IHSSDTTSSDEERFE CCCCCCCCCHHHHHH	37.57	23663014
340	Phosphorylation	HSSDTTSSDEERFER CCCCCCCCHHHHHHH	47.12	23663014
372	Phosphorylation	FRAEDLASGILRERV CCHHHHHHHHHHHHH	33.39	21815630
384	Phosphorylation	ERVKVGASLADVDPM HHHCCCCCCCCCCCC	20.40	24719451
395	Ubiquitination	VDPMNIDKSVRFDSI CCCCCCCCCCCCCCC	47.24	-
396	Phosphorylation	DPMNIDKSVRFDSIG CCCCCCCCCCCCCCC	18.12	24260401
430	Ubiquitination	PEIFEKFKIQPPRGC HHHHHHCCCCCCCCE	52.04	-
447	Ubiquitination	YGPPGTGKTLVARAL ECCCCCCHHHHHHHH	38.22	-
471	Ubiquitination	KVAFFMRKGADCLSK HHHHHHHHCHHHHHH	46.81	-
478	Ubiquitination	KGADCLSKWVGESER HCHHHHHHHCCCCHH	32.71	-
523	Phosphorylation	SRQDQIHSSIVSTLL CCHHHHHHHHHHHHH	24.32	23401153
524	Phosphorylation	RQDQIHSSIVSTLLA CHHHHHHHHHHHHHH	16.91	23401153
527	Phosphorylation	QIHSSIVSTLLALMD HHHHHHHHHHHHHHH	16.21	23401153
553	Phosphorylation	GATNRLDSIDPALRR ECCCCCCCCCHHHCC	33.22	23186163
592	Ubiquitination	HTRDWNPKLSDAFLG ECCCCCHHHCHHHHH	58.36	-
604	Ubiquitination	FLGELAEKCVGYCGA HHHHHHHHHHHHCCC	28.72	-
635	Phosphorylation	RYPQIYASSHKLQLD HCHHHHHCCCCEECC	18.92	28555341
636	Phosphorylation	YPQIYASSHKLQLDV CHHHHHCCCCEECCH	19.23	29083192
714	Phosphorylation	DKKEDIETLILEDSE CCHHHHEEEEECCCC	21.31	20873877
720	Phosphorylation	ETLILEDSEDENALS EEEEECCCCCCCHHH	37.26	26657352
727	Phosphorylation	SEDENALSIFETNCH CCCCCHHHHEEECCC	23.87	20873877
731	Phosphorylation	NALSIFETNCHSGSP CHHHHEEECCCCCCC	32.18	20873877
735	Phosphorylation	IFETNCHSGSPKKQS HEEECCCCCCCCCCC	43.07	20873877
737	Phosphorylation	ETNCHSGSPKKQSSS EECCCCCCCCCCCCC	36.24	20873877
755	Phosphorylation	HKPYLHFTMSPYHQP CCCEEEEECCCCCCC	13.14	24719451
757	Phosphorylation	PYLHFTMSPYHQPTS CEEEEECCCCCCCCC	21.17	28348404
772	Phosphorylation	YRPRLLLSGERGSGQ CCCEEEEECCCCCCC	38.28	20068231
795	Phosphorylation	LHTLERFSVHRLDLP HHHHHHCCEECCCCC	24.20	22468782
805	Phosphorylation	RLDLPALYSVSAKTP CCCCCCCEEECCCCC	14.77	20068231
806	Phosphorylation	LDLPALYSVSAKTPE CCCCCCEEECCCCCH	15.50	22468782
808	Phosphorylation	LPALYSVSAKTPEES CCCCEEECCCCCHHH	20.36	22468782
810	Ubiquitination	ALYSVSAKTPEESCA CCEEECCCCCHHHHH	58.04	-
939	Phosphorylation	VLPLALPSPPRQLSE HHHHCCCCCCCCCCH	48.68	30266825
945	Phosphorylation	PSPPRQLSESEKSRM CCCCCCCCHHHHHHC	30.64	25159151
947	Phosphorylation	PPRQLSESEKSRMED CCCCCCHHHHHHCHH	47.12	28450419
950	Phosphorylation	QLSESEKSRMEDQEE CCCHHHHHHCHHHHH	32.57	25159151
976	Phosphorylation	DVTKRLATDKRFNIF HHHHHHHCCCCCCCC	46.79	-
984	Phosphorylation	DKRFNIFSKPVDIEE CCCCCCCCCCCCHHH	32.05	24719451
995	Phosphorylation	DIEEVSDYLEVIKEP CHHHHHHHHHHHCCC	9.39	30576142
1006	Phosphorylation	IKEPMDLSTVITKID HCCCCCHHHHHHHHH	19.16	21815630
1007	Phosphorylation	KEPMDLSTVITKIDK CCCCCHHHHHHHHHH	24.19	21815630
1088	Phosphorylation	ARIKRGLSVTSEQIN HHHHHCCCCCHHHCC	26.60	28555341
1090	Phosphorylation	IKRGLSVTSEQINPH HHHCCCCCHHHCCCC	24.14	21712546
1091	Phosphorylation	KRGLSVTSEQINPHS HHCCCCCHHHCCCCC	25.91	22468782
1098	Phosphorylation	SEQINPHSTGARKTE HHHCCCCCCCCCCHH	29.78	28674419
1099	Phosphorylation	EQINPHSTGARKTET HHCCCCCCCCCCHHH	31.65	21712546
1104	Phosphorylation	HSTGARKTETRVEEA CCCCCCCHHHHHHHH	36.72	22468782
1106	Phosphorylation	TGARKTETRVEEAFR CCCCCHHHHHHHHHH	45.29	22468782
1126	Phosphorylation	PMDVWHNSANKCAFR CHHHHCCCCCHHHHH	21.97	25849741
1138	Phosphorylation	AFRVRRKSRRRSQWG HHHHHHHHHCHHHCC	29.25	-
1142	Phosphorylation	RRKSRRRSQWGKGII HHHHHCHHHCCCHHH	28.59	24719451
1169	Phosphorylation	EDTKFADYENHTEDR HHCCCCCCCCCHHCH	18.40	28796482
1173	Phosphorylation	FADYENHTEDRKLLE CCCCCCCHHCHHHHH	51.68	-
1233	Phosphorylation	GTKENFASTEEESSN CCCCCCCCCCCCCCC	32.01	30177828
1234	Phosphorylation	TKENFASTEEESSNE CCCCCCCCCCCCCCC	43.94	30177828
1238	Phosphorylation	FASTEEESSNESLLV CCCCCCCCCCCCEEE	41.57	30177828
1239	Phosphorylation	ASTEEESSNESLLVN CCCCCCCCCCCEEEC	48.15	30177828
1242	Phosphorylation	EEESSNESLLVNSSS CCCCCCCCEEECCCC	31.11	27251275
1247	Phosphorylation	NESLLVNSSSSLNPE CCCEEECCCCCCCHH	24.90	30177828
1248	Phosphorylation	ESLLVNSSSSLNPEQ CCEEECCCCCCCHHH	20.81	30177828
1249	Phosphorylation	SLLVNSSSSLNPEQT CEEECCCCCCCHHHC	38.37	20873877
1273	Phosphorylation	NCLNGEASTDSFEGI CCCCCCCCCCCCCCC	28.57	29449344
1274	Phosphorylation	CLNGEASTDSFEGIP CCCCCCCCCCCCCCE	42.59	29449344
1276	Phosphorylation	NGEASTDSFEGIPVL CCCCCCCCCCCCEEE	25.86	29449344
1294	Phosphorylation	NGKLEVVSFCDSGDK CCEEEEEEEECCCCC	25.90	25849741
1298	Phosphorylation	EVVSFCDSGDKCSSE EEEEEECCCCCCCHH	50.50	21815630
1314	Phosphorylation	KILLEDQSKEKPETS EEECCCCCCCCCCCC	55.92	25849741
1320	Phosphorylation	QSKEKPETSTENHGD CCCCCCCCCCCCCCC	49.85	25159151
1321	Phosphorylation	SKEKPETSTENHGDD CCCCCCCCCCCCCCC	31.87	25849741
1322	Phosphorylation	KEKPETSTENHGDDL CCCCCCCCCCCCCCH	48.50	20873877
1338	Phosphorylation	KLEALECSNNEKLEP HHHHHCCCCCCCCCC	33.06	25159151
1347	Phosphorylation	NEKLEPGSDVEVKDA CCCCCCCCCCEEEHH	49.55	23401153
1363	Acetylation	LDKEGASKVKKYRKL CCHHHHHHHHHHHHH	58.50	25953088
1377	Phosphorylation	LILEQAKTTSLELVP HHHHHHCCCCCCCCC	25.32	26657352
1378	Phosphorylation	ILEQAKTTSLELVPE HHHHHCCCCCCCCCC	30.52	28450419
1379	Phosphorylation	LEQAKTTSLELVPEE HHHHCCCCCCCCCCC	25.69	28450419
1438	Phosphorylation	IYRHRKDYDKSQLVE HHHCCCCCCHHHHHH	28.45	24905233

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ATD2B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ATD2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATD2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ATD2B_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATD2B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1338, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, AND MASSSPECTROMETRY.	19007248 [Abstract]