URB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: URB2_HUMAN
• UniProt AC: Q14146
• Protein Name: Unhealthy ribosome biogenesis protein 2 homolog
• Gene Name: URB2
• Organism: Homo sapiens (Human).
• Sequence Length: 1524
• Subcellular Localization: Nucleus, nucleolus .
• Protein Sequence: MAAVYSGISLKLKSKTTSWEDKLKLAHFAWISHQCFLPNKEQVLLDWARQSLVAFYKKKLELKEDIVERLWIYIDNILHSRKLQNLLKNGKTINLQISLVKIINERVAEFSLSGSQRNICAVLRCCQGILSTPALAVIYTAKQELMVALLSQLCWSACRQPEGAVVAQLFEVIHLALGHYLLILQQQVNPRRAFGDVTAHLLQPCLVLRHLLSGGTWTQAGQGQLRQVLSRDIRSQIEAMFRGGIFQPELLSSYKEGLLDQQQGDVKTGAMKNLLAPMDTVLNRLVDAGYCAASLHTSVVANSVALLYKLFLDSYFKEGNQLLCFQVLPRLFGCLKISHLQEEQSKALSTSDWTTELLVVEQLLNSVANNNIYNIAADRIRHEEAQFRFYRHVAELLINHAQAPIPAWFRCLKTLISLNHLILEPDLDDLLASAWIDAEVTEFRTKKAQEALIRTVFQTYAKLRQVPRLFEEVLGVICRPAAEALRQPVLASGPSTVLSACLLELPPSQILDTWSLVLEKFQSLVLPYLQSDADMALKSLSLSLLLHCIMFNMRSLDSSTPLPIVRRTQCMMERMMRELVQPLLALLPDTPGPEPELWLQKVSDSVLLLSYTWAQVDAMFSLNCSQYHSMSGPLIGVALEISNLPSLLPGVKTQHWKKIEKFTAQFSSLGTYCLEQLYLQKMKRTLMQTSFRSEGAIQSLRCDAAFIIGSGRKSLNQRTTASWDGQVGMVSGLTYPVAHWHLIVSNLTILISYLCPDDVGYLASVLLRTLPMGKAQEVSIDEEAYITLEKISKAFLHSPLFPEMQSLHSAFLTCVTTSCSSILCSGAQRDSGLVSQQLPWLFEKDHMVVGHWENRFAKAGPEGIEPRGEIAQNLLSLVKSDFPIQLEGEQLESILGLLEVISALQLDSLLPPYHVHYFLVLLSMAVTKLGCSCSSSLALKFLTTCYQLLGYLQKGKSARSVFKIMYGSDIFEVVLTSLFRASSRFLIEMDDPAWLEFLQVIGTFLEELMQMLIQMKLSLVLNFRKITAFLSSSKPYTEAASSKQLENQNPQGRQLLLVSLTRLCHVLGPFLKEQKLGQEAPAALSELLQQVVLQTGAVLQLCSVPGARGWRLPSVLISSVSTLLEADLGQHCRDGGADISQGSDRTLLSHVALYQGVYSQILLELPALAGHDQSFQAALQFLTLFFLAPELHPKKDSVFTSMFHSVRRVLADPEIPVQVTQDIEPHLGALFTQMLEVGTTEDLRLVMQCILQGLDVSNMWKADVQAVVSAVTLLRLLLNCPLSGEKASLLWRACPQIVTALTLLNREASQEQPVSLTVVGPVLDVLAALLRQGEEAIGNPHHVSLAFSILLTVPLDHLKPLEYGSVFPRLHNVLFSILQCHPKVMLKAIPSFLNSFNRLVFSVMREGRQKDKGSIDDLPTVLKCARLVERMYSHIAARAEEFAVFSPFMVAQYVLEVQKVTLYPAVKSLLQEGIYLILDLCIEPDVQFLRASLQPGMRDIFKELYNDYLKYHKAKHEGEKRYTA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAAVYSGISLKL ---CCCEECCEEEEE	9.10	29116813
6	Phosphorylation	--MAAVYSGISLKLK --CCCEECCEEEEEE	24.05	21406692
9	Phosphorylation	AAVYSGISLKLKSKT CCEECCEEEEEECCC	23.99	21406692
22	Ubiquitination	KTTSWEDKLKLAHFA CCCCHHHHHHHHHHH	35.69	29967540
51	Phosphorylation	LLDWARQSLVAFYKK HHHHHHHHHHHHHHH	21.18	20068231
56	Phosphorylation	RQSLVAFYKKKLELK HHHHHHHHHHHCCCC	16.50	20068231
57	Acetylation	QSLVAFYKKKLELKE HHHHHHHHHHCCCCH	36.66	26051181
57	Ubiquitination	QSLVAFYKKKLELKE HHHHHHHHHHCCCCH	36.66	21963094
58	Ubiquitination	SLVAFYKKKLELKED HHHHHHHHHCCCCHH	51.73	22817900
59	Ubiquitination	LVAFYKKKLELKEDI HHHHHHHHCCCCHHH	42.94	22817900
59	Acetylation	LVAFYKKKLELKEDI HHHHHHHHCCCCHHH	42.94	20167786
92	Phosphorylation	NLLKNGKTINLQISL HHHHCCCEEEEEEEH	19.25	27174698
98	Phosphorylation	KTINLQISLVKIINE CEEEEEEEHHHHHHH	17.72	27174698
111	Phosphorylation	NERVAEFSLSGSQRN HHHHHEECCCCCHHH	17.09	27174698
113	Phosphorylation	RVAEFSLSGSQRNIC HHHEECCCCCHHHHH	34.89	27174698
115	Phosphorylation	AEFSLSGSQRNICAV HEECCCCCHHHHHHH	23.69	27174698
255	Ubiquitination	PELLSSYKEGLLDQQ HHHHHHHHHCCCCCC	47.45	21906983
267	Ubiquitination	DQQQGDVKTGAMKNL CCCCCCHHHCHHHHH	46.08	21906983
272	Ubiquitination	DVKTGAMKNLLAPMD CHHHCHHHHHHHHHH	43.86	21906983
280	Phosphorylation	NLLAPMDTVLNRLVD HHHHHHHHHHHHHHH	22.20	21406692
314	Phosphorylation	LYKLFLDSYFKEGNQ HHHHHHHHHHHCCCE	34.32	20068231
336	Acetylation	PRLFGCLKISHLQEE HHHHCHHHHHHCHHH	46.36	26051181
336	Ubiquitination	PRLFGCLKISHLQEE HHHHCHHHHHHCHHH	46.36	21963094
447	Ubiquitination	VTEFRTKKAQEALIR HHHHCCHHHHHHHHH	55.48	29967540
447	Acetylation	VTEFRTKKAQEALIR HHHHCCHHHHHHHHH	55.48	11688261
462	Ubiquitination	TVFQTYAKLRQVPRL HHHHHHHHHCCCHHH	33.51	21963094
672	Phosphorylation	QFSSLGTYCLEQLYL HHHHHHHHHHHHHHH	8.01	-
685	Phosphorylation	YLQKMKRTLMQTSFR HHHHHHHHHHHHCCC	22.51	20068231
689	Phosphorylation	MKRTLMQTSFRSEGA HHHHHHHHCCCCCCH	18.83	20068231
690	Phosphorylation	KRTLMQTSFRSEGAI HHHHHHHCCCCCCHH	11.19	20068231
693	Phosphorylation	LMQTSFRSEGAIQSL HHHHCCCCCCHHHHH	38.07	20860994
790	Ubiquitination	EAYITLEKISKAFLH HHHHHHHHHHHHHHC	56.23	29967540
844	Ubiquitination	QLPWLFEKDHMVVGH CCCCHHCCCCEEEEH	45.67	21963094
858	Ubiquitination	HWENRFAKAGPEGIE HHHHHHHHCCCCCCC	51.68	21906983
876	Phosphorylation	EIAQNLLSLVKSDFP HHHHHHHHHHHCCCC	33.99	24719451
977	Phosphorylation	IFEVVLTSLFRASSR HHHHHHHHHHHHHCC	22.73	24719451
1025	Ubiquitination	SLVLNFRKITAFLSS HHHHCHHHHHHHHHC	40.03	27667366
1027	Phosphorylation	VLNFRKITAFLSSSK HHCHHHHHHHHHCCC	17.87	23663014
1031	Phosphorylation	RKITAFLSSSKPYTE HHHHHHHHCCCCCCH	26.55	23663014
1032	Phosphorylation	KITAFLSSSKPYTEA HHHHHHHCCCCCCHH	44.52	23663014
1033	Phosphorylation	ITAFLSSSKPYTEAA HHHHHHCCCCCCHHH	33.98	23663014
1034	Ubiquitination	TAFLSSSKPYTEAAS HHHHHCCCCCCHHHH	43.95	21906983
1036	Phosphorylation	FLSSSKPYTEAASSK HHHCCCCCCHHHHCH	22.43	23663014
1037	Phosphorylation	LSSSKPYTEAASSKQ HHCCCCCCHHHHCHH	27.89	23663014
1041	Phosphorylation	KPYTEAASSKQLENQ CCCCHHHHCHHHHHC	45.15	23663014
1042	Phosphorylation	PYTEAASSKQLENQN CCCHHHHCHHHHHCC	21.50	23663014
1043	Ubiquitination	YTEAASSKQLENQNP CCHHHHCHHHHHCCC	57.30	21963094
1072	Acetylation	HVLGPFLKEQKLGQE HHHHHHHHHHHCCCH	59.48	23749302
1072	Ubiquitination	HVLGPFLKEQKLGQE HHHHHHHHHHHCCCH	59.48	21963094
1075	Ubiquitination	GPFLKEQKLGQEAPA HHHHHHHHCCCHHHH	56.53	22817900
1140	Phosphorylation	RDGGADISQGSDRTL CCCCCCCCCCCCHHH	29.09	-
1143	Phosphorylation	GADISQGSDRTLLSH CCCCCCCCCHHHHHH	19.11	-
1194	Ubiquitination	LAPELHPKKDSVFTS HCHHCCCCCCHHHHH	59.47	22817900
1195	Ubiquitination	APELHPKKDSVFTSM CHHCCCCCCHHHHHH	60.74	21963094
1207	Methylation	TSMFHSVRRVLADPE HHHHHHHHHHHCCCC	26.46	24383539
1286	Ubiquitination	NCPLSGEKASLLWRA CCCCCCHHHHHHHHH	46.96	21963094
1346	Ubiquitination	NPHHVSLAFSILLTV CCHHHHHHHHHHHCC	6.66	22817900
1350	Ubiquitination	VSLAFSILLTVPLDH HHHHHHHHHCCCHHH	2.96	21890473
1373	Ubiquitination	VFPRLHNVLFSILQC CHHHHHHHHHHHHHH	3.88	22817900
1375	Ubiquitination	PRLHNVLFSILQCHP HHHHHHHHHHHHHCH	3.58	22817900
1383	Ubiquitination	SILQCHPKVMLKAIP HHHHHCHHHHHHHHH	19.33	22817900
1386	Ubiquitination	QCHPKVMLKAIPSFL HHCHHHHHHHHHHHH	3.67	21963094
1387	Acetylation	CHPKVMLKAIPSFLN HCHHHHHHHHHHHHH	26.61	26051181
1387	Ubiquitination	CHPKVMLKAIPSFLN HCHHHHHHHHHHHHH	26.61	21963094
1402	Phosphorylation	SFNRLVFSVMREGRQ HHHHHHHHHHHCCCC	13.92	23909892
1410	Ubiquitination	VMREGRQKDKGSIDD HHHCCCCCCCCCCCH	61.11	22817900
1412	Ubiquitination	REGRQKDKGSIDDLP HCCCCCCCCCCCHHH	62.69	21906983
1414	Phosphorylation	GRQKDKGSIDDLPTV CCCCCCCCCCHHHHH	28.69	27050516
1423	Ubiquitination	DDLPTVLKCARLVER CHHHHHHHHHHHHHH	22.85	21963094
1465	Ubiquitination	QKVTLYPAVKSLLQE HHCCCHHHHHHHHHC	14.07	22817900
1502	Ubiquitination	PGMRDIFKELYNDYL CCHHHHHHHHHHHHH	47.33	21906983
1510	Ubiquitination	ELYNDYLKYHKAKHE HHHHHHHHHHHHCCC	38.79	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of URB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of URB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of URB2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of URB2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.