TCF20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCF20_HUMAN
• UniProt AC: Q9UGU0
• Protein Name: Transcription factor 20
• Gene Name: TCF20
• Organism: Homo sapiens (Human).
• Sequence Length: 1960
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator..
• Protein Sequence: MQSFREQSSYHGNQQSYPQEVHGSSRLEEFSPRQAQMFQNFGGTGGSSGSSGSGSGGGRRGAAAAAAAMASETSGHQGYQGFRKEAGDFYYMAGNKDPVTTGTPQPPQRRPSGPVQSYGPPQGSSFGNQYGSEGHVGQFQAQHSGLGGVSHYQQDYTGPFSPGSAQYQQQASSQQQQQQVQQLRQQLYQSHQPLPQATGQPASSSSHLQPMQRPSTLPSSAAGYQLRVGQFGQHYQSSASSSSSSSFPSPQRFSQSGQSYDGSYNVNAGSQYEGHNVGSNAQAYGTQSNYSYQPQSMKNFEQAKIPQGTQQGQQQQQPQQQQHPSQHVMQYTNAATKLPLQSQVGQYNQPEVPVRSPMQFHQNFSPISNPSPAASVVQSPSCSSTPSPLMQTGENLQCGQGSVPMGSRNRILQLMPQLSPTPSMMPSPNSHAAGFKGFGLEGVPEKRLTDPGLSSLSALSTQVANLPNTVQHMLLSDALTPQKKTSKRPSSSKKADSCTNSEGSSQPEEQLKSPMAESLDGGCSSSSEDQGERVRQLSGQSTSSDTTYKGGASEKAGSSPAQGAQNEPPRLNASPAAREEATSPGAKDMPLSSDGNPKVNEKTVGVIVSREAMTGRVEKPGGQDKGSQEDDPAATQRPPSNGGAKETSHASLPQPEPPGGGGSKGNKNGDNNSNHNGEGNGQSGHSAAGPGFTSRTEPSKSPGSLRYSYKDSFGSAVPRNVSGFPQYPTGQEKGDFTGHGERKGRNEKFPSLLQEVLQGYHHHPDRRYSRSTQEHQGMAGSLEGTTRPNVLVSQTNELASRGLLNKSIGSLLENPHWGPWERKSSSTAPEMKQINLTDYPIPRKFEIEPQSSAHEPGGSLSERRSVICDISPLRQIVRDPGAHSLGHMSADTRIGRNDRLNPTLSQSVILPGGLVSMETKLKSQSGQIKEEDFEQSKSQASFNNKKSGDHCHPPSIKHESYRGNASPGAATHDSLSDYGPQDSRPTPMRRVPGRVGGREGMRGRSPSQYHDFAEKLKMSPGRSRGPGGDPHHMNPHMTFSERANRSSLHTPFSPNSETLASAYHANTRAHAYGDPNAGLNSQLHYKRQMYQQQPEEYKDWSSGSAQGVIAAAQHRQEGPRKSPRQQQFLDRVRSPLKNDKDGMMYGPPVGTYHDPSAQEAGRCLMSSDGLPNKGMELKHGSQKLQESCWDLSRQTSPAKSSGPPGMSSQKRYGPPHETDGHGLAEATQSSKPGSVMLRLPGQEDHSSQNPLIMRRRVRSFISPIPSKRQSQDVKNSSTEDKGRLLHSSKEGADKAFNSYAHLSHSQDIKSIPKRDSSKDLPSPDSRNCPAVTLTSPAKTKILPPRKGRGLKLEAIVQKITSPNIRRSASSNSAEAGGDTVTLDDILSLKSGPPEGGSVAVQDADIEKRKGEVASDLVSPANQELHVEKPLPRSSEEWRGSVDDKVKTETHAETVTAGKEPPGAMTSTTSQKPGSNQGRPDGSLGGTAPLIFPDSKNVPPVGILAPEANPKAEEKENDTVTISPKQEGFPPKGYFPSGKKKGRPIGSVNKQKKQQQPPPPPPQPPQIPEGSADGEPKPKKQRQRRERRKPGAQPRKRKTKQAVPIVEPQEPEIKLKYATQPLDKTDAKNKSFYPYIHVVNKCELGAVCTIINAEEEEQTKLVRGRKGQRSLTPPPSSTESKALPASSFMLQGPVVTESSVMGHLVCCLCGKWASYRNMGDLFGPFYPQDYAATLPKNPPPKRATEMQSKVKVRHKSASNGSKTDTEEEEEQQQQQKEQRSLAAHPRFKRRHRSEDCGGGPRSLSRGLPCKKAATEGSSEKTVLDSKPSVPTTSEGGPELELQIPELPLDSNEFWVHEGCILWANGIYLVCGRLYGLQEALEIAREMKCSHCQEAGATLGCYNKGCSFRYHYPCAIDADCLLHEENFSVRCPKHKPPLPCPLPPLQNKTAKGSLSTEQSERG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MQSFREQSSY -----CCCHHHCCCC	37.82	22468782
8	Phosphorylation	MQSFREQSSYHGNQQ CCCHHHCCCCCCCCC	28.28	23401153
9	Phosphorylation	QSFREQSSYHGNQQS CCHHHCCCCCCCCCC	22.35	28555341
10	Phosphorylation	SFREQSSYHGNQQSY CHHHCCCCCCCCCCC	20.99	30576142
16	Phosphorylation	SYHGNQQSYPQEVHG CCCCCCCCCCCCCCC	29.08	30576142
17	Phosphorylation	YHGNQQSYPQEVHGS CCCCCCCCCCCCCCC	12.47	26552605
24	Phosphorylation	YPQEVHGSSRLEEFS CCCCCCCCCCCCCCC	9.45	30576142
25	Phosphorylation	PQEVHGSSRLEEFSP CCCCCCCCCCCCCCH	45.54	26552605
31	Phosphorylation	SSRLEEFSPRQAQMF CCCCCCCCHHHHHHH	23.58	23401153
31 (in isoform 2)	Phosphorylation	-	23.58	-
44	Phosphorylation	MFQNFGGTGGSSGSS HHHHCCCCCCCCCCC	38.46	24043423
47	Phosphorylation	NFGGTGGSSGSSGSG HCCCCCCCCCCCCCC	32.63	24043423
48	Phosphorylation	FGGTGGSSGSSGSGS CCCCCCCCCCCCCCC	46.07	24043423
50	Phosphorylation	GTGGSSGSSGSGSGG CCCCCCCCCCCCCCC	33.21	24043423
51	Phosphorylation	TGGSSGSSGSGSGGG CCCCCCCCCCCCCCC	40.27	24043423
53	Phosphorylation	GSSGSSGSGSGGGRR CCCCCCCCCCCCCHH	31.56	24043423
55	Phosphorylation	SGSSGSGSGGGRRGA CCCCCCCCCCCHHHH	35.64	24043423
60	Methylation	SGSGGGRRGAAAAAA CCCCCCHHHHHHHHH	42.23	24129315
79	Phosphorylation	ETSGHQGYQGFRKEA HCCCCCCCCCHHHCC	10.01	27642862
90	Phosphorylation	RKEAGDFYYMAGNKD HHCCCCEEEECCCCC	9.32	27642862
100	Phosphorylation	AGNKDPVTTGTPQPP CCCCCCCCCCCCCCC	25.54	21406692
101	Phosphorylation	GNKDPVTTGTPQPPQ CCCCCCCCCCCCCCC	39.01	21406692
103	Phosphorylation	KDPVTTGTPQPPQRR CCCCCCCCCCCCCCC	19.36	21815630
112	Phosphorylation	QPPQRRPSGPVQSYG CCCCCCCCCCCCCCC	54.65	-
117	Phosphorylation	RPSGPVQSYGPPQGS CCCCCCCCCCCCCCC	32.08	-
237	O-linked_Glycosylation	QFGQHYQSSASSSSS ECHHHCCCCCCCCCC	22.24	30059200
238	O-linked_Glycosylation	FGQHYQSSASSSSSS CHHHCCCCCCCCCCC	19.35	30059200
240	O-linked_Glycosylation	QHYQSSASSSSSSSF HHCCCCCCCCCCCCC	32.47	30059200
240	Phosphorylation	QHYQSSASSSSSSSF HHCCCCCCCCCCCCC	32.47	30576142
241	O-linked_Glycosylation	HYQSSASSSSSSSFP HCCCCCCCCCCCCCC	33.68	30059200
241	Phosphorylation	HYQSSASSSSSSSFP HCCCCCCCCCCCCCC	33.68	27732954
242	Phosphorylation	YQSSASSSSSSSFPS CCCCCCCCCCCCCCC	31.57	27732954
243	O-linked_Glycosylation	QSSASSSSSSSFPSP CCCCCCCCCCCCCCC	35.87	30059200
243	Phosphorylation	QSSASSSSSSSFPSP CCCCCCCCCCCCCCC	35.87	28450419
244	Phosphorylation	SSASSSSSSSFPSPQ CCCCCCCCCCCCCCC	31.76	28450419
245	Phosphorylation	SASSSSSSSFPSPQR CCCCCCCCCCCCCCC	37.64	28450419
246	O-linked_Glycosylation	ASSSSSSSFPSPQRF CCCCCCCCCCCCCCC	43.03	30059200
246	Phosphorylation	ASSSSSSSFPSPQRF CCCCCCCCCCCCCCC	43.03	28450419
249	Phosphorylation	SSSSSFPSPQRFSQS CCCCCCCCCCCCCCC	31.49	26055452
304	Sumoylation	MKNFEQAKIPQGTQQ CCCHHHCCCCCCHHH	55.39	28112733
336	O-linked_Glycosylation	MQYTNAATKLPLQSQ HHHHCCHHHCCCHHC	30.61	30059200
347	Phosphorylation	LQSQVGQYNQPEVPV CHHCCCCCCCCCCCC	15.16	27642862
356	Phosphorylation	QPEVPVRSPMQFHQN CCCCCCCCCCCCCCC	25.59	26074081
368	O-linked_Glycosylation	HQNFSPISNPSPAAS CCCCCCCCCCCCCCC	46.18	30059200
385	O-linked_Glycosylation	QSPSCSSTPSPLMQT CCCCCCCCCCCCCCC	16.11	30059200
419	Phosphorylation	LQLMPQLSPTPSMMP HHHCCCCCCCCCCCC	22.83	26055452
419 (in isoform 2)	Phosphorylation	-	22.83	-
421	Phosphorylation	LMPQLSPTPSMMPSP HCCCCCCCCCCCCCC	25.31	21712546
421 (in isoform 2)	Phosphorylation	-	25.31	-
423	Phosphorylation	PQLSPTPSMMPSPNS CCCCCCCCCCCCCCC	30.14	21712546
427	Phosphorylation	PTPSMMPSPNSHAAG CCCCCCCCCCCCCCC	20.86	26055452
427 (in isoform 2)	Phosphorylation	-	20.86	-
430	Phosphorylation	SMMPSPNSHAAGFKG CCCCCCCCCCCCCCC	20.21	26055452
430 (in isoform 2)	Phosphorylation	-	20.21	-
446	Acetylation	GLEGVPEKRLTDPGL CCCCCCHHHCCCCCH	46.79	25953088
446	Ubiquitination	GLEGVPEKRLTDPGL CCCCCCHHHCCCCCH	46.79	-
449	Phosphorylation	GVPEKRLTDPGLSSL CCCHHHCCCCCHHHH	44.15	18669648
449 (in isoform 2)	Phosphorylation	-	44.15	-
454	Phosphorylation	RLTDPGLSSLSALST HCCCCCHHHHHHHHH	34.84	23898821
460	Phosphorylation	LSSLSALSTQVANLP HHHHHHHHHHHHCCC	19.26	23898821
461	Phosphorylation	SSLSALSTQVANLPN HHHHHHHHHHHCCCH	28.10	23898821
469	Phosphorylation	QVANLPNTVQHMLLS HHHCCCHHHHHHHHH	21.43	23898821
476	Phosphorylation	TVQHMLLSDALTPQK HHHHHHHHHCCCCCC	19.51	25159151
480	Phosphorylation	MLLSDALTPQKKTSK HHHHHCCCCCCCCCC	25.95	29496963
480 (in isoform 2)	Phosphorylation	-	25.95	-
497	Phosphorylation	SSSKKADSCTNSEGS CCCCCCCCCCCCCCC	27.92	-
499	Phosphorylation	SKKADSCTNSEGSSQ CCCCCCCCCCCCCCC	45.81	-
501	Phosphorylation	KADSCTNSEGSSQPE CCCCCCCCCCCCCHH	25.77	27251275
504	Phosphorylation	SCTNSEGSSQPEEQL CCCCCCCCCCHHHHH	23.04	21815630
505	Phosphorylation	CTNSEGSSQPEEQLK CCCCCCCCCHHHHHH	61.69	17525332
505 (in isoform 2)	Phosphorylation	-	61.69	-
513	Phosphorylation	QPEEQLKSPMAESLD CHHHHHHCCCCHHCC	28.62	30576142
518	Phosphorylation	LKSPMAESLDGGCSS HHCCCCHHCCCCCCC	23.40	27732954
524	Phosphorylation	ESLDGGCSSSSEDQG HHCCCCCCCCCHHHH	36.21	30108239
525	Phosphorylation	SLDGGCSSSSEDQGE HCCCCCCCCCHHHHH	41.79	30108239
526	Phosphorylation	LDGGCSSSSEDQGER CCCCCCCCCHHHHHH	22.81	27732954
527	Phosphorylation	DGGCSSSSEDQGERV CCCCCCCCHHHHHHH	47.33	27732954
538	Phosphorylation	GERVRQLSGQSTSSD HHHHHHHCCCCCCCC	26.84	27273156
538 (in isoform 2)	Phosphorylation	-	26.84	-
541	Phosphorylation	VRQLSGQSTSSDTTY HHHHCCCCCCCCCCC	33.51	25159151
541 (in isoform 2)	Phosphorylation	-	33.51	-
542	Phosphorylation	RQLSGQSTSSDTTYK HHHCCCCCCCCCCCC	25.10	27794612
543	Phosphorylation	QLSGQSTSSDTTYKG HHCCCCCCCCCCCCC	31.31	25159151
544	Phosphorylation	LSGQSTSSDTTYKGG HCCCCCCCCCCCCCC	38.78	25159151
544 (in isoform 2)	Phosphorylation	-	38.78	-
546	Phosphorylation	GQSTSSDTTYKGGAS CCCCCCCCCCCCCCC	33.69	28450419
547	Phosphorylation	QSTSSDTTYKGGASE CCCCCCCCCCCCCCC	28.38	28450419
548	Phosphorylation	STSSDTTYKGGASEK CCCCCCCCCCCCCCC	15.10	28450419
548 (in isoform 2)	Phosphorylation	-	15.10	-
549	Acetylation	TSSDTTYKGGASEKA CCCCCCCCCCCCCCC	49.10	26051181
553	Phosphorylation	TTYKGGASEKAGSSP CCCCCCCCCCCCCCC	42.79	30108239
558	Phosphorylation	GASEKAGSSPAQGAQ CCCCCCCCCCCCCCC	37.70	29255136
558 (in isoform 2)	Phosphorylation	-	37.70	-
559	O-linked_Glycosylation	ASEKAGSSPAQGAQN CCCCCCCCCCCCCCC	24.28	30059200
559	Phosphorylation	ASEKAGSSPAQGAQN CCCCCCCCCCCCCCC	24.28	29255136
559 (in isoform 2)	Phosphorylation	-	24.28	-
574	Phosphorylation	EPPRLNASPAAREEA CCCCCCCCHHHHHHC	17.63	29255136
574 (in isoform 2)	Phosphorylation	-	17.63	-
582	Phosphorylation	PAAREEATSPGAKDM HHHHHHCCCCCCCCC	38.44	22167270
582 (in isoform 2)	Phosphorylation	-	38.44	-
583	Phosphorylation	AAREEATSPGAKDMP HHHHHCCCCCCCCCC	28.52	22167270
583 (in isoform 2)	Phosphorylation	-	28.52	-
587	Acetylation	EATSPGAKDMPLSSD HCCCCCCCCCCCCCC	61.55	26051181
592	Phosphorylation	GAKDMPLSSDGNPKV CCCCCCCCCCCCCCC	22.10	21815630
593	Phosphorylation	AKDMPLSSDGNPKVN CCCCCCCCCCCCCCC	58.16	23927012
598	Acetylation	LSSDGNPKVNEKTVG CCCCCCCCCCCCEEE	62.79	26051181
602	Acetylation	GNPKVNEKTVGVIVS CCCCCCCCEEEEEEE	43.22	25953088
603	Phosphorylation	NPKVNEKTVGVIVSR CCCCCCCEEEEEEEC	19.13	21406692
609	Phosphorylation	KTVGVIVSREAMTGR CEEEEEEECCHHCCC	17.18	21406692
614	Phosphorylation	IVSREAMTGRVEKPG EEECCHHCCCCCCCC	28.96	26714015
627	Phosphorylation	PGGQDKGSQEDDPAA CCCCCCCCCCCCHHH	35.82	17525332
627 (in isoform 2)	Phosphorylation	-	35.82	-
635	Phosphorylation	QEDDPAATQRPPSNG CCCCHHHHCCCCCCC	27.50	30266825
635 (in isoform 2)	Phosphorylation	-	27.50	-
640	Phosphorylation	AATQRPPSNGGAKET HHHCCCCCCCCCCCC	51.28	23401153
640 (in isoform 2)	Phosphorylation	-	51.28	-
651	Phosphorylation	AKETSHASLPQPEPP CCCCCCCCCCCCCCC	34.85	28555341
693	O-linked_Glycosylation	SAAGPGFTSRTEPSK CCCCCCCCCCCCCCC	24.18	30059200
694	O-linked_Glycosylation	AAGPGFTSRTEPSKS CCCCCCCCCCCCCCC	34.64	30059200
696	O-linked_Glycosylation	GPGFTSRTEPSKSPG CCCCCCCCCCCCCCC	52.60	30059200
696	Phosphorylation	GPGFTSRTEPSKSPG CCCCCCCCCCCCCCC	52.60	27251275
699	O-linked_Glycosylation	FTSRTEPSKSPGSLR CCCCCCCCCCCCCCC	39.26	30059200
699	Phosphorylation	FTSRTEPSKSPGSLR CCCCCCCCCCCCCCC	39.26	22817900
701	O-linked_Glycosylation	SRTEPSKSPGSLRYS CCCCCCCCCCCCCEE	38.54	30059200
701	Phosphorylation	SRTEPSKSPGSLRYS CCCCCCCCCCCCCEE	38.54	25056879
704	O-linked_Glycosylation	EPSKSPGSLRYSYKD CCCCCCCCCCEEEEC	17.04	30059200
704	Phosphorylation	EPSKSPGSLRYSYKD CCCCCCCCCCEEEEC	17.04	23312004
707	Phosphorylation	KSPGSLRYSYKDSFG CCCCCCCEEEECCCC	22.96	29438985
708	Phosphorylation	SPGSLRYSYKDSFGS CCCCCCEEEECCCCC	21.19	22817900
710	Sumoylation	GSLRYSYKDSFGSAV CCCCEEEECCCCCCC	40.74	28112733
710	Ubiquitination	GSLRYSYKDSFGSAV CCCCEEEECCCCCCC	40.74	-
712	Phosphorylation	LRYSYKDSFGSAVPR CCEEEECCCCCCCCC	27.62	21815630
733	Sumoylation	QYPTGQEKGDFTGHG CCCCCCCCCCCCCCC	56.76	28112733
748	Sumoylation	ERKGRNEKFPSLLQE CCCCCCCCCHHHHHH	67.15	28112733
781	Phosphorylation	EHQGMAGSLEGTTRP HHHCCCCCCCCCCCC	17.45	28555341
807	Phosphorylation	SRGLLNKSIGSLLEN HHCCCCHHHHHHHHC	30.98	25159151
810	Phosphorylation	LLNKSIGSLLENPHW CCCHHHHHHHHCCCC	28.28	27732954
823	Sumoylation	HWGPWERKSSSTAPE CCCCCCCCCCCCCCC	43.08	-
823	Sumoylation	HWGPWERKSSSTAPE CCCCCCCCCCCCCCC	43.08	28112733
824	Phosphorylation	WGPWERKSSSTAPEM CCCCCCCCCCCCCCH	35.42	28348404
825	Phosphorylation	GPWERKSSSTAPEMK CCCCCCCCCCCCCHH	34.44	28348404
826	Phosphorylation	PWERKSSSTAPEMKQ CCCCCCCCCCCCHHC	35.36	24719451
827	Phosphorylation	WERKSSSTAPEMKQI CCCCCCCCCCCHHCC	48.45	28348404
832	Sumoylation	SSTAPEMKQINLTDY CCCCCCHHCCCCCCC	46.49	28112733
837	Phosphorylation	EMKQINLTDYPIPRK CHHCCCCCCCCCCCC	29.06	-
839	Phosphorylation	KQINLTDYPIPRKFE HCCCCCCCCCCCCEE	9.60	17360941
844	Sumoylation	TDYPIPRKFEIEPQS CCCCCCCCEEECCCC	41.83	-
844	Acetylation	TDYPIPRKFEIEPQS CCCCCCCCEEECCCC	41.83	26051181
844	Sumoylation	TDYPIPRKFEIEPQS CCCCCCCCEEECCCC	41.83	28112733
844	Ubiquitination	TDYPIPRKFEIEPQS CCCCCCCCEEECCCC	41.83	21890473
844 (in isoform 1)	Ubiquitination	-	41.83	21890473
844 (in isoform 2)	Ubiquitination	-	41.83	21890473
852	Phosphorylation	FEIEPQSSAHEPGGS EEECCCCCCCCCCCC	28.53	28555341
859	Phosphorylation	SAHEPGGSLSERRSV CCCCCCCCHHHCCEE	34.34	28555341
861	Phosphorylation	HEPGGSLSERRSVIC CCCCCCHHHCCEEEE	30.65	26714015
865	Phosphorylation	GSLSERRSVICDISP CCHHHCCEEEEECHH	23.27	25159151
865 (in isoform 2)	Phosphorylation	-	23.27	-
871	Phosphorylation	RSVICDISPLRQIVR CEEEEECHHHHHHHC	12.48	30266825
871 (in isoform 2)	Phosphorylation	-	12.48	-
884	Phosphorylation	VRDPGAHSLGHMSAD HCCCCCHHHCCCCCC	35.20	25159151
889	Phosphorylation	AHSLGHMSADTRIGR CHHHCCCCCCCCCCC	19.81	25627689
903	Phosphorylation	RNDRLNPTLSQSVIL CCCCCCCCCCCEEEE	37.66	20068231
903 (in isoform 2)	Phosphorylation	-	37.66	-
905	Phosphorylation	DRLNPTLSQSVILPG CCCCCCCCCEEEECC	23.92	20068231
905 (in isoform 2)	Phosphorylation	-	23.92	-
907	Phosphorylation	LNPTLSQSVILPGGL CCCCCCCEEEECCCE	14.03	28348404
916	Phosphorylation	ILPGGLVSMETKLKS EECCCEEEHHHHHHH	18.88	20068231
916 (in isoform 2)	Phosphorylation	-	18.88	-
919	Phosphorylation	GGLVSMETKLKSQSG CCEEEHHHHHHHCCC	32.79	20068231
920	Sumoylation	GLVSMETKLKSQSGQ CEEEHHHHHHHCCCC	40.38	28112733
922	Sumoylation	VSMETKLKSQSGQIK EEHHHHHHHCCCCCC	48.26	28112733
929	Sumoylation	KSQSGQIKEEDFEQS HHCCCCCCHHHHHHH	47.35	-
929	Sumoylation	KSQSGQIKEEDFEQS HHCCCCCCHHHHHHH	47.35	25114211
955	Phosphorylation	GDHCHPPSIKHESYR CCCCCCCCCCCCCCC	49.04	23401153
957	Sumoylation	HCHPPSIKHESYRGN CCCCCCCCCCCCCCC	45.73	28112733
966	Phosphorylation	ESYRGNASPGAATHD CCCCCCCCCCCCCCC	28.06	23401153
966 (in isoform 2)	Phosphorylation	-	28.06	-
971	Phosphorylation	NASPGAATHDSLSDY CCCCCCCCCCCHHHC	26.19	29255136
974	Phosphorylation	PGAATHDSLSDYGPQ CCCCCCCCHHHCCCC	23.36	23403867
976	Phosphorylation	AATHDSLSDYGPQDS CCCCCCHHHCCCCCC	32.51	24732914
978	Phosphorylation	THDSLSDYGPQDSRP CCCCHHHCCCCCCCC	27.59	23403867
983	Phosphorylation	SDYGPQDSRPTPMRR HHCCCCCCCCCCCCC	34.61	23403867
986	Phosphorylation	GPQDSRPTPMRRVPG CCCCCCCCCCCCCCC	28.71	23927012
990	Methylation	SRPTPMRRVPGRVGG CCCCCCCCCCCCCCC	32.50	115389129
994	Methylation	PMRRVPGRVGGREGM CCCCCCCCCCCCCCC	20.17	115389137
998	Methylation	VPGRVGGREGMRGRS CCCCCCCCCCCCCCC	31.22	115389145
1005	Phosphorylation	REGMRGRSPSQYHDF CCCCCCCCHHHHHHH	31.56	22167270
1005 (in isoform 2)	Phosphorylation	-	31.56	-
1007	Phosphorylation	GMRGRSPSQYHDFAE CCCCCCHHHHHHHHH	44.62	30266825
1009	Phosphorylation	RGRSPSQYHDFAEKL CCCCHHHHHHHHHHH	14.01	30266825
1015	Acetylation	QYHDFAEKLKMSPGR HHHHHHHHHCCCCCC	50.40	26051181
1015	Sumoylation	QYHDFAEKLKMSPGR HHHHHHHHHCCCCCC	50.40	28112733
1019	Phosphorylation	FAEKLKMSPGRSRGP HHHHHCCCCCCCCCC	23.71	23401153
1019 (in isoform 2)	Phosphorylation	-	23.71	-
1024	Methylation	KMSPGRSRGPGGDPH CCCCCCCCCCCCCCC	54.70	24129315
1046	Phosphorylation	FSERANRSSLHTPFS HHHHCCCCCCCCCCC	36.74	23401153
1047	Phosphorylation	SERANRSSLHTPFSP HHHCCCCCCCCCCCC	22.41	24732914
1050	Phosphorylation	ANRSSLHTPFSPNSE CCCCCCCCCCCCCHH	31.18	24732914
1053	Phosphorylation	SSLHTPFSPNSETLA CCCCCCCCCCHHHHH	25.11	25159151
1053 (in isoform 2)	Phosphorylation	-	25.11	-
1056	Phosphorylation	HTPFSPNSETLASAY CCCCCCCHHHHHHHH	35.03	24732914
1058	Phosphorylation	PFSPNSETLASAYHA CCCCCHHHHHHHHHH	27.69	24732914
1061	Phosphorylation	PNSETLASAYHANTR CCHHHHHHHHHHCCC	32.26	24732914
1063	Phosphorylation	SETLASAYHANTRAH HHHHHHHHHHCCCCH	10.04	24732914
1067	Phosphorylation	ASAYHANTRAHAYGD HHHHHHCCCCHHHCC	29.98	24732914
1072	Phosphorylation	ANTRAHAYGDPNAGL HCCCCHHHCCCCCCH	16.52	27642862
1081	Phosphorylation	DPNAGLNSQLHYKRQ CCCCCHHHHHHHHHH	38.88	28555341
1086	Sumoylation	LNSQLHYKRQMYQQQ HHHHHHHHHHHHHHC	25.96	28112733
1086	Ubiquitination	LNSQLHYKRQMYQQQ HHHHHHHHHHHHHHC	25.96	21890473
1086 (in isoform 1)	Ubiquitination	-	25.96	21890473
1086 (in isoform 2)	Ubiquitination	-	25.96	21890473
1098	Sumoylation	QQQPEEYKDWSSGSA HHCCHHHCCCCCCCH	56.87	28112733
1101	Phosphorylation	PEEYKDWSSGSAQGV CHHHCCCCCCCHHHH	34.65	28348404
1102	Phosphorylation	EEYKDWSSGSAQGVI HHHCCCCCCCHHHHH	32.29	28348404
1104	Phosphorylation	YKDWSSGSAQGVIAA HCCCCCCCHHHHHHH	21.26	28348404
1122	Phosphorylation	RQEGPRKSPRQQQFL HCCCCCCCHHHHHHH	26.96	25056879
1122 (in isoform 2)	Phosphorylation	-	26.96	-
1134	Phosphorylation	QFLDRVRSPLKNDKD HHHHHHHCCCCCCCC	31.56	29496963
1137	Sumoylation	DRVRSPLKNDKDGMM HHHHCCCCCCCCCCC	67.49	25755297
1167	Phosphorylation	AGRCLMSSDGLPNKG HHHHCCCCCCCCCCC	23.02	25627689
1173	Acetylation	SSDGLPNKGMELKHG CCCCCCCCCCCCCCH	58.66	26051181
1173	Sumoylation	SSDGLPNKGMELKHG CCCCCCCCCCCCCCH	58.66	28112733
1178	Sumoylation	PNKGMELKHGSQKLQ CCCCCCCCCHHHHHH	32.39	28112733
1181	Phosphorylation	GMELKHGSQKLQESC CCCCCCHHHHHHHHH	24.70	26714015
1183	Sumoylation	ELKHGSQKLQESCWD CCCCHHHHHHHHHHH	54.56	28112733
1187	Phosphorylation	GSQKLQESCWDLSRQ HHHHHHHHHHHHHHC	13.93	26074081
1192	Phosphorylation	QESCWDLSRQTSPAK HHHHHHHHHCCCCCH	21.62	26074081
1195	Phosphorylation	CWDLSRQTSPAKSSG HHHHHHCCCCCHHCC	35.25	25159151
1196	Phosphorylation	WDLSRQTSPAKSSGP HHHHHCCCCCHHCCC	17.96	28985074
1200	Phosphorylation	RQTSPAKSSGPPGMS HCCCCCHHCCCCCCC	42.50	26074081
1201	Phosphorylation	QTSPAKSSGPPGMSS CCCCCHHCCCCCCCC	55.39	26074081
1207	Phosphorylation	SSGPPGMSSQKRYGP HCCCCCCCCCCCCCC	35.22	26074081
1208	Phosphorylation	SGPPGMSSQKRYGPP CCCCCCCCCCCCCCC	30.72	26074081
1210	Sumoylation	PPGMSSQKRYGPPHE CCCCCCCCCCCCCCC	49.92	28112733
1212	Phosphorylation	GMSSQKRYGPPHETD CCCCCCCCCCCCCCC	40.81	26074081
1218	Phosphorylation	RYGPPHETDGHGLAE CCCCCCCCCCCCHHH	44.22	26074081
1231	Acetylation	AEATQSSKPGSVMLR HHHHCCCCCCCEEEE	59.66	26051181
1231	Sumoylation	AEATQSSKPGSVMLR HHHHCCCCCCCEEEE	59.66	28112733
1234	Phosphorylation	TQSSKPGSVMLRLPG HCCCCCCCEEEECCC	16.93	-
1259	Phosphorylation	IMRRRVRSFISPIPS HHHHHHHHHHCCCCC	24.87	22617229
1262	Phosphorylation	RRVRSFISPIPSKRQ HHHHHHHCCCCCCCC	18.11	21712546
1266	Phosphorylation	SFISPIPSKRQSQDV HHHCCCCCCCCCCCC	40.99	29396449
1267	Acetylation	FISPIPSKRQSQDVK HHCCCCCCCCCCCCC	49.45	25953088
1267	Sumoylation	FISPIPSKRQSQDVK HHCCCCCCCCCCCCC	49.45	28112733
1267	Ubiquitination	FISPIPSKRQSQDVK HHCCCCCCCCCCCCC	49.45	21890473
1267 (in isoform 1)	Ubiquitination	-	49.45	21890473
1267 (in isoform 2)	Ubiquitination	-	49.45	21890473
1270	Phosphorylation	PIPSKRQSQDVKNSS CCCCCCCCCCCCCCC	32.17	22817900
1274	Sumoylation	KRQSQDVKNSSTEDK CCCCCCCCCCCCHHH	60.44	28112733
1278	Phosphorylation	QDVKNSSTEDKGRLL CCCCCCCCHHHHHHH	48.28	22817900
1287	Phosphorylation	DKGRLLHSSKEGADK HHHHHHHCCHHHHHH	42.97	26714015
1288	Phosphorylation	KGRLLHSSKEGADKA HHHHHHCCHHHHHHH	24.79	26714015
1294	Ubiquitination	SSKEGADKAFNSYAH CCHHHHHHHHHHHHH	55.11	-
1298	Phosphorylation	GADKAFNSYAHLSHS HHHHHHHHHHHHHCC	19.76	27251275
1299	Phosphorylation	ADKAFNSYAHLSHSQ HHHHHHHHHHHHCCC	10.11	27251275
1303	Phosphorylation	FNSYAHLSHSQDIKS HHHHHHHHCCCCHHC	15.95	23312004
1305	Phosphorylation	SYAHLSHSQDIKSIP HHHHHHCCCCHHCCC	26.60	29214152
1309	Sumoylation	LSHSQDIKSIPKRDS HHCCCCHHCCCCCCC	51.09	28112733
1316	Phosphorylation	KSIPKRDSSKDLPSP HCCCCCCCCCCCCCC	43.23	23312004
1317	Phosphorylation	SIPKRDSSKDLPSPD CCCCCCCCCCCCCCC	34.18	20873877
1318	Acetylation	IPKRDSSKDLPSPDS CCCCCCCCCCCCCCC	68.20	26051181
1322	Phosphorylation	DSSKDLPSPDSRNCP CCCCCCCCCCCCCCC	48.95	29255136
1322 (in isoform 2)	Phosphorylation	-	48.95	-
1325	Phosphorylation	KDLPSPDSRNCPAVT CCCCCCCCCCCCCEE	28.86	22167270
1325 (in isoform 2)	Phosphorylation	-	28.86	-
1332	Phosphorylation	SRNCPAVTLTSPAKT CCCCCCEEECCCCCC	26.82	30266825
1332 (in isoform 2)	Phosphorylation	-	26.82	-
1334	Phosphorylation	NCPAVTLTSPAKTKI CCCCEEECCCCCCCC	24.25	30266825
1335	Phosphorylation	CPAVTLTSPAKTKIL CCCEEECCCCCCCCC	26.44	29255136
1335 (in isoform 2)	Phosphorylation	-	26.44	-
1338	Sumoylation	VTLTSPAKTKILPPR EEECCCCCCCCCCCC	54.45	28112733
1339	Phosphorylation	TLTSPAKTKILPPRK EECCCCCCCCCCCCC	25.98	24732914
1351	Sumoylation	PRKGRGLKLEAIVQK CCCCCCCCHHHHHHH	47.29	-
1351	Sumoylation	PRKGRGLKLEAIVQK CCCCCCCCHHHHHHH	47.29	-
1360	Phosphorylation	EAIVQKITSPNIRRS HHHHHHHCCCCHHHC	45.21	30266825
1361	Phosphorylation	AIVQKITSPNIRRSA HHHHHHCCCCHHHCC	21.30	30266825
1361 (in isoform 2)	Phosphorylation	-	21.30	-
1367	Phosphorylation	TSPNIRRSASSNSAE CCCCHHHCCCCCCCC	23.74	25159151
1367 (in isoform 2)	Phosphorylation	-	23.74	-
1369	Phosphorylation	PNIRRSASSNSAEAG CCHHHCCCCCCCCCC	31.16	21712546
1370	Phosphorylation	NIRRSASSNSAEAGG CHHHCCCCCCCCCCC	34.22	21712546
1370 (in isoform 2)	Phosphorylation	-	34.22	-
1372	Phosphorylation	RRSASSNSAEAGGDT HHCCCCCCCCCCCCE	29.45	21712546
1379	Phosphorylation	SAEAGGDTVTLDDIL CCCCCCCEEEHHHHH	20.75	30108239
1379 (in isoform 2)	Phosphorylation	-	20.75	-
1387	Phosphorylation	VTLDDILSLKSGPPE EEHHHHHHCCCCCCC	33.80	24719451
1389	Sumoylation	LDDILSLKSGPPEGG HHHHHHCCCCCCCCC	50.41	28112733
1407	Acetylation	VQDADIEKRKGEVAS EECCCHHHHCCCCHH	60.80	26051181
1409	Sumoylation	DADIEKRKGEVASDL CCCHHHHCCCCHHHH	71.18	28112733
1414	Phosphorylation	KRKGEVASDLVSPAN HHCCCCHHHHCCCCH	36.33	30108239
1418	Phosphorylation	EVASDLVSPANQELH CCHHHHCCCCHHCEE	26.12	25849741
1428	Acetylation	NQELHVEKPLPRSSE HHCEECCCCCCCCCH	51.25	26051181
1428	Sumoylation	NQELHVEKPLPRSSE HHCEECCCCCCCCCH	51.25	28112733
1440	Phosphorylation	SSEEWRGSVDDKVKT CCHHHHCCCCCCCCC	17.50	24719451
1446	Sumoylation	GSVDDKVKTETHAET CCCCCCCCCEEECEE	46.51	-
1446	Sumoylation	GSVDDKVKTETHAET CCCCCCCCCEEECEE	46.51	28112733
1446	Ubiquitination	GSVDDKVKTETHAET CCCCCCCCCEEECEE	46.51	-
1458	Ubiquitination	AETVTAGKEPPGAMT CEEECCCCCCCCCCC	65.66	-
1467	Phosphorylation	PPGAMTSTTSQKPGS CCCCCCCCCCCCCCC	22.69	22210691
1474	O-linked_Glycosylation	TTSQKPGSNQGRPDG CCCCCCCCCCCCCCC	34.21	30059200
1474	Phosphorylation	TTSQKPGSNQGRPDG CCCCCCCCCCCCCCC	34.21	22210691
1482	Phosphorylation	NQGRPDGSLGGTAPL CCCCCCCCCCCCCCE	31.08	25159151
1486	Phosphorylation	PDGSLGGTAPLIFPD CCCCCCCCCCEECCC	24.25	28555341
1510	Sumoylation	LAPEANPKAEEKEND ECCCCCCCHHHCCCC	69.14	28112733
1518	Phosphorylation	AEEKENDTVTISPKQ HHHCCCCCEEECCCC	31.00	23927012
1520	Phosphorylation	EKENDTVTISPKQEG HCCCCCEEECCCCCC	20.17	30266825
1522	Phosphorylation	ENDTVTISPKQEGFP CCCCEEECCCCCCCC	19.38	29255136
1522 (in isoform 2)	Phosphorylation	-	19.38	-
1524	Sumoylation	DTVTISPKQEGFPPK CCEEECCCCCCCCCC	54.94	28112733
1536	Phosphorylation	PPKGYFPSGKKKGRP CCCCCCCCCCCCCCC	54.03	29396449
1570	Phosphorylation	PPQIPEGSADGEPKP CCCCCCCCCCCCCCC	22.86	20873877
1613	Sumoylation	EPQEPEIKLKYATQP CCCCCCEEEEEECCC	36.95	28112733
1613	Ubiquitination	EPQEPEIKLKYATQP CCCCCCEEEEEECCC	36.95	-
1615	Ubiquitination	QEPEIKLKYATQPLD CCCCEEEEEECCCCC	28.04	-
1616	Phosphorylation	EPEIKLKYATQPLDK CCCEEEEEECCCCCC	25.89	-
1630	Phosphorylation	KTDAKNKSFYPYIHV CCCCCCCCCCCEEEE	39.13	26074081
1632	Phosphorylation	DAKNKSFYPYIHVVN CCCCCCCCCEEEEEC	11.39	26074081
1634	Phosphorylation	KNKSFYPYIHVVNKC CCCCCCCEEEEECCC	7.71	26074081
1669	Phosphorylation	RGRKGQRSLTPPPSS CCCCCCCCCCCCCCC	28.80	30266825
1669 (in isoform 2)	Phosphorylation	-	28.80	-
1671	Phosphorylation	RKGQRSLTPPPSSTE CCCCCCCCCCCCCCC	34.69	29255136
1671 (in isoform 2)	Phosphorylation	-	34.69	-
1675	Phosphorylation	RSLTPPPSSTESKAL CCCCCCCCCCCCCCC	56.52	19691289
1676	Phosphorylation	SLTPPPSSTESKALP CCCCCCCCCCCCCCC	41.80	23403867
1677	Phosphorylation	LTPPPSSTESKALPA CCCCCCCCCCCCCCC	48.92	23403867
1679	Phosphorylation	PPPSSTESKALPASS CCCCCCCCCCCCCHH	24.26	23403867
1713	Phosphorylation	CLCGKWASYRNMGDL HHHHCHHHHCCHHHH	24.42	24719451
1748	Acetylation	RATEMQSKVKVRHKS CCCHHHHHHEEEECC	29.23	25953088
1755	Phosphorylation	KVKVRHKSASNGSKT HHEEEECCCCCCCCC	30.70	21712546
1757	Phosphorylation	KVRHKSASNGSKTDT EEEECCCCCCCCCCC	49.14	25159151
1760	Phosphorylation	HKSASNGSKTDTEEE ECCCCCCCCCCCHHH	36.31	25159151
1762	Phosphorylation	SASNGSKTDTEEEEE CCCCCCCCCCHHHHH	50.26	25159151
1764	Phosphorylation	SNGSKTDTEEEEEQQ CCCCCCCCHHHHHHH	50.99	25159151
1764 (in isoform 2)	Phosphorylation	-	50.99	-
1792	Phosphorylation	RFKRRHRSEDCGGGP HHHHHHCCCCCCCCC	31.49	20164059
1900	Phosphorylation	AGATLGCYNKGCSFR CCCCEECCCCCCCEE	20.36	-
1951	Phosphorylation	QNKTAKGSLSTEQSE CCCCCCCCCCHHHHC	20.59	23403867
1953	Phosphorylation	KTAKGSLSTEQSERG CCCCCCCCHHHHCCC	31.43	24719451
1957	Phosphorylation	GSLSTEQSERG---- CCCCHHHHCCC----	24.03	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCF20_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCF20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCF20_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RNF4_HUMAN	RNF4	physical	10849425
RED1_HUMAN	ADARB1	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
COPB_HUMAN	COPB1	physical	26496610
TF3B_HUMAN	BRF1	physical	26496610
RBBP7_HUMAN	RBBP7	physical	26496610
TRI27_HUMAN	TRIM27	physical	26496610
UBP7_HUMAN	USP7	physical	26496610
MTA2_HUMAN	MTA2	physical	26496610
PHF14_HUMAN	PHF14	physical	26496610
HM20A_HUMAN	HMG20A	physical	26496610
RAI1_HUMAN	RAI1	physical	26496610
SIN3A_HUMAN	SIN3A	physical	26496610
P66A_HUMAN	GATAD2A	physical	26496610
S39AA_HUMAN	SLC39A10	physical	26496610
P66B_HUMAN	GATAD2B	physical	26496610
MTA3_HUMAN	MTA3	physical	26496610
ACTL8_HUMAN	ACTL8	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-419; SER-574 ANDTHR-1671, AND MASS SPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538; SER-559; THR-635;SER-640; SER-1335; SER-1522 AND THR-1671, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-419; SER-430;SER-574; SER-583; SER-871; SER-1335; SER-1361; SER-1522; SER-1669 ANDTHR-1671, AND MASS SPECTROMETRY.
PubMed: 18669648

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1522, AND MASSSPECTROMETRY.
PubMed: 19007248

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-505; SER-627 ANDSER-640, AND MASS SPECTROMETRY.
PubMed: 17525332

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1005 AND SER-1122, ANDMASS SPECTROMETRY.
PubMed: 17081983

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538; SER-559; SER-574;SER-583 AND THR-1671, AND MASS SPECTROMETRY.
PubMed: 15302935

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-548, AND MASSSPECTROMETRY.
PubMed: 15592455