dbPTM

PHF14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PHF14_HUMAN
UniProt AC	O94880
Protein Name	PHD finger protein 14
Gene Name	PHF14
Organism	Homo sapiens (Human).
Sequence Length	888
Subcellular Localization
Protein Description
Protein Sequence	MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNLNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKTSTLPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEADMAMETLPDGTKRSRRQIKEPVKFVPQDVPPEPKKIPIRNTRTRGRKRSFVPEEEKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRYPS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	QVKPLAASLLEALDY HHHHHHHHHHHHHCC	28.07	21406692
23	Phosphorylation	SLLEALDYDSSDDSD HHHHHHCCCCCCCCC	20.69	17081983
23 (in isoform 2)	Phosphorylation	-	20.69	25849741
25	Phosphorylation	LEALDYDSSDDSDFK HHHHCCCCCCCCCCC	29.45	21712546
26	Phosphorylation	EALDYDSSDDSDFKV HHHCCCCCCCCCCCC	42.41	21712546
29	Phosphorylation	DYDSSDDSDFKVGDA CCCCCCCCCCCCCCC	50.35	30631047
37	Phosphorylation	DFKVGDASDSEGSGN CCCCCCCCCCCCCCC	46.54	25849741
39	Phosphorylation	KVGDASDSEGSGNGS CCCCCCCCCCCCCCC	41.17	29255136
42	Phosphorylation	DASDSEGSGNGSEDA CCCCCCCCCCCCCCC	25.65	28348404
46	Phosphorylation	SEGSGNGSEDASKDS CCCCCCCCCCCCCCC	35.98	20873877
50	Phosphorylation	GNGSEDASKDSGEGS CCCCCCCCCCCCCCC	49.68	20873877
53	Phosphorylation	SEDASKDSGEGSCSD CCCCCCCCCCCCCCH	42.34	25850435
57	Phosphorylation	SKDSGEGSCSDSEEN CCCCCCCCCCHHHHH	13.22	30576142
59	Phosphorylation	DSGEGSCSDSEENIL CCCCCCCCHHHHHHH	45.96	25849741
61	Phosphorylation	GEGSCSDSEENILEE CCCCCCHHHHHHHHH	30.43	25850435
77	Sumoylation	LNEDIKVKEEQLKNS HHHHHCCCHHHHHCH	51.00	-
77	Sumoylation	LNEDIKVKEEQLKNS HHHHHCCCHHHHHCH	51.00	-
84	Phosphorylation	KEEQLKNSAEEEVLS CHHHHHCHHHHHHHH	35.15	23401153
91	Phosphorylation	SAEEEVLSSEKQLIK HHHHHHHHHHHHHHH	41.44	25159151
92	Phosphorylation	AEEEVLSSEKQLIKM HHHHHHHHHHHHHHH	44.65	21815630
94	Acetylation	EEVLSSEKQLIKMEK HHHHHHHHHHHHHHH	52.96	26051181
94	Ubiquitination	EEVLSSEKQLIKMEK HHHHHHHHHHHHHHH	52.96	-
98	Sumoylation	SSEKQLIKMEKKEEE HHHHHHHHHHHHHHH	49.99	-
98	Sumoylation	SSEKQLIKMEKKEEE HHHHHHHHHHHHHHH	49.99	-
117	Acetylation	RPRKKKEKEKEKEKE CCCHHHHHHHHHHHH	80.91	18527635
119	Acetylation	RKKKEKEKEKEKEKE CHHHHHHHHHHHHHH	82.33	18527641
139	Phosphorylation	EKEKEKATVSENVAA HHHHHHHHHCHHHHH	35.32	30108239
141	Phosphorylation	EKEKATVSENVAASA HHHHHHHCHHHHHHH	21.06	30108239
147	Phosphorylation	VSENVAASAAATTPA HCHHHHHHHHCCCCC	14.54	27251275
150 (in isoform 2)	Ubiquitination	-	16.24	21890473
151	Phosphorylation	VAASAAATTPATSPP HHHHHHCCCCCCCCC	28.69	30108239
152	Phosphorylation	AASAAATTPATSPPA HHHHHCCCCCCCCCC	13.24	30108239
155	Phosphorylation	AAATTPATSPPAVNT HHCCCCCCCCCCCCC	42.86	30108239
156	Phosphorylation	AATTPATSPPAVNTS HCCCCCCCCCCCCCC	30.87	30108239
162	Phosphorylation	TSPPAVNTSPSVPTT CCCCCCCCCCCCCCC	35.10	30108239
163	Phosphorylation	SPPAVNTSPSVPTTT CCCCCCCCCCCCCCC	15.24	30108239
165	Phosphorylation	PAVNTSPSVPTTTTA CCCCCCCCCCCCCCC	40.26	30108239
168	Phosphorylation	NTSPSVPTTTTATEE CCCCCCCCCCCCCHH	34.32	30108239
169	Phosphorylation	TSPSVPTTTTATEEQ CCCCCCCCCCCCHHH	18.97	30108239
170	Phosphorylation	SPSVPTTTTATEEQV CCCCCCCCCCCHHHC	19.53	30108239
171	Phosphorylation	PSVPTTTTATEEQVS CCCCCCCCCCHHHCC	29.50	30108239
173	Phosphorylation	VPTTTTATEEQVSEP CCCCCCCCHHHCCCC	37.65	27251275
196	Phosphorylation	RPLLDFVSMEELNDM CCCCCCCCHHHHCCC	22.07	21406692
206	Phosphorylation	ELNDMDDYDSEDDND HHCCCCCCCCCCCCC	19.66	22115753
208	Phosphorylation	NDMDDYDSEDDNDWR CCCCCCCCCCCCCCC	36.37	22617229
217	Phosphorylation	DDNDWRPTVVKRKGR CCCCCCCCCCEECCC	29.38	22496350
232	Phosphorylation	SASQKEGSDGDNEDD CCCCCCCCCCCCCCC	39.24	30177828
244	Phosphorylation	EDDEDEGSGSDEDEN CCCCCCCCCCCCCCC	32.83	30177828
246	Phosphorylation	DEDEGSGSDEDENDE CCCCCCCCCCCCCCC	39.25	30177828
277	Phosphorylation	KKKSKVLSRNSADDE HHHHHCCCCCCCCCH	32.19	30266825
280	Phosphorylation	SKVLSRNSADDEELT HHCCCCCCCCCHHHC	31.78	30266825
287	Phosphorylation	SADDEELTNDSLTLS CCCCHHHCCCCCEEC	40.01	29255136
290	Phosphorylation	DEELTNDSLTLSQSK CHHHCCCCCEECCCC	25.89	29255136
292	Phosphorylation	ELTNDSLTLSQSKSN HHCCCCCEECCCCCC	28.45	29255136
294	Phosphorylation	TNDSLTLSQSKSNED CCCCCEECCCCCCCC	27.46	29255136
296	Phosphorylation	DSLTLSQSKSNEDSL CCCEECCCCCCCCCE	34.37	29255136
298	Phosphorylation	LTLSQSKSNEDSLIL CEECCCCCCCCCEEE	51.18	29255136
302	Phosphorylation	QSKSNEDSLILEKSQ CCCCCCCCEEEECCC	15.90	29255136
307	Ubiquitination	EDSLILEKSQNWSSQ CCCEEEECCCCCCCC	54.63	-
307 (in isoform 1)	Ubiquitination	-	54.63	21890473
308	Phosphorylation	DSLILEKSQNWSSQK CCEEEECCCCCCCCC	21.26	25159151
312	Phosphorylation	LEKSQNWSSQKMDHI EECCCCCCCCCCCEE	30.36	23186163
313	Phosphorylation	EKSQNWSSQKMDHIL ECCCCCCCCCCCEEE	25.99	23186163
351	Phosphorylation	ITVHEGCYGVDGESD CEEECCCCCCCCCCC	30.92	24275569
356 (in isoform 2)	Ubiquitination	-	47.08	21890473
359	Phosphorylation	GVDGESDSIMSSASE CCCCCCCCHHCCCCC	29.48	24275569
362	Phosphorylation	GESDSIMSSASENST CCCCCHHCCCCCCCC	22.53	24275569
363	Phosphorylation	ESDSIMSSASENSTE CCCCHHCCCCCCCCC	20.59	24275569
365	Phosphorylation	DSIMSSASENSTEPW CCHHCCCCCCCCCCC	38.98	24275569
396	Ubiquitination	PNQDGIFKETDAGRW CCCCCCCCCCCCCCC	58.76	-
398	Phosphorylation	QDGIFKETDAGRWVH CCCCCCCCCCCCCEE	31.57	-
427	Phosphorylation	IDKLRPVTLTEMNYS HHHCCCEEEEECCHH	30.55	20068231
429	Phosphorylation	KLRPVTLTEMNYSKY HCCCEEEEECCHHHC	24.67	25137130
433	Phosphorylation	VTLTEMNYSKYGAKE EEEEECCHHHCCCCC	12.77	20068231
434	Phosphorylation	TLTEMNYSKYGAKEC EEEECCHHHCCCCCC	17.88	20068231
435	Acetylation	LTEMNYSKYGAKECS EEECCHHHCCCCCCC	37.03	23749302
435	Ubiquitination	LTEMNYSKYGAKECS EEECCHHHCCCCCCC	37.03	-
435 (in isoform 1)	Ubiquitination	-	37.03	21890473
439	Acetylation	NYSKYGAKECSFCED CHHHCCCCCCCCCCC	55.69	26051181
439	Ubiquitination	NYSKYGAKECSFCED CHHHCCCCCCCCCCC	55.69	-
457	Phosphorylation	ARTGVCISCDAGMCR CCCCEEEECCCCCCE	10.79	-
496	Ubiquitination	DPFFAYCKQHADRLD CHHHHHHHHHHHHHC	32.23	-
527	Ubiquitination	MSLQEREKQLSPEAQ CHHHHHHHHCCHHHH	63.86	-
530	Phosphorylation	QEREKQLSPEAQARI HHHHHHCCHHHHHHH	20.42	23401153
547	Acetylation	RLQQYRAKAELARST HHHHHHHHHHHHHCC	33.14	25953088
553	Phosphorylation	AKAELARSTRPQAWV HHHHHHHCCCCCCCC	24.14	20068231
554	Phosphorylation	KAELARSTRPQAWVP HHHHHHCCCCCCCCC	40.59	20068231
570	Phosphorylation	EKLPRPLTSSASAIR HHCCCCCCCCHHHHH	24.26	25159151
571	Phosphorylation	KLPRPLTSSASAIRK HCCCCCCCCHHHHHH	31.43	20068231
572	Phosphorylation	LPRPLTSSASAIRKL CCCCCCCCHHHHHHH	22.47	20068231
574	Phosphorylation	RPLTSSASAIRKLMR CCCCCCHHHHHHHHH	26.61	20068231
582	Ubiquitination	AIRKLMRKAELMGIS HHHHHHHHHHHCCCC	32.04	-
589	Phosphorylation	KAELMGISTDIFPVD HHHHCCCCCCEEECC	17.82	20873877
590	Phosphorylation	AELMGISTDIFPVDN HHHCCCCCCEEECCC	31.06	20873877
598	O-linked_Glycosylation	DIFPVDNSDTSSSVD CEEECCCCCCCCCCC	37.49	29351928
598	Phosphorylation	DIFPVDNSDTSSSVD CEEECCCCCCCCCCC	37.49	23898821
600	Phosphorylation	FPVDNSDTSSSVDGR EECCCCCCCCCCCCC	30.26	21712546
601	Phosphorylation	PVDNSDTSSSVDGRR ECCCCCCCCCCCCCH	26.13	21712546
602	Phosphorylation	VDNSDTSSSVDGRRK CCCCCCCCCCCCCHH	36.15	21712546
603	Phosphorylation	DNSDTSSSVDGRRKH CCCCCCCCCCCCHHC	24.80	22617229
620 (in isoform 2)	Phosphorylation	-	4.66	28450419
624 (in isoform 2)	Phosphorylation	-	5.12	27732954
626 (in isoform 2)	Phosphorylation	-	32.14	27732954
635 (in isoform 2)	Phosphorylation	-	51.07	23663014
636 (in isoform 2)	Phosphorylation	-	20.70	23663014
637 (in isoform 2)	Phosphorylation	-	4.23	25849741
638 (in isoform 2)	Phosphorylation	-	27.87	23663014
641	Ubiquitination	QENMAEQKNIKDKLE HHHHHHHHCHHHHHH	52.74	-
641 (in isoform 1)	Ubiquitination	-	52.74	21890473
651 (in isoform 2)	Phosphorylation	-	65.78	25159151
653	Ubiquitination	KLENEQEKLHVEYNK HHHHHHHHHHHHHHH	43.52	-
660	Ubiquitination	KLHVEYNKLCESLEE HHHHHHHHHHHHHHH	54.32	-
664	Phosphorylation	EYNKLCESLEELQNL HHHHHHHHHHHHHHC	39.83	28348404
674	Ubiquitination	ELQNLNGKLRSEGQG HHHHCCHHHCCHHCC	39.39	-
693	Ubiquitination	LGRITGQKLNIPAIL HHHHHCCCCCHHHHH	44.86	-
715	Phosphorylation	PSKKEGGTQKTSTLP CCCCCCCCCCCCCCC	37.44	-
769	Phosphorylation	MPRKTKNSYWQCSEC CCCCCCCCCCCCCCC	29.33	30576142
770	Phosphorylation	PRKTKNSYWQCSECD CCCCCCCCCCCCCCC	14.64	30576142
774	Phosphorylation	KNSYWQCSECDQAGS CCCCCCCCCCCCCCC	26.59	30576142
781	Phosphorylation	SECDQAGSSDMEADM CCCCCCCCCCHHHHH	26.61	23401153
782	Phosphorylation	ECDQAGSSDMEADMA CCCCCCCCCHHHHHH	39.81	22617229
792	Phosphorylation	EADMAMETLPDGTKR HHHHHHHHCCCCCHH	30.42	21406692
797	Phosphorylation	METLPDGTKRSRRQI HHHCCCCCHHHHHHC	30.57	21406692
835	Phosphorylation	RTRGRKRSFVPEEEK CCCCCCCCCCCHHHH	33.36	29255136
856	Phosphorylation	RERRQRQSVLQKKPK HHHHHHHHHHHHCCC	27.30	26546556
877	Phosphorylation	ECATCKGTGDNENLV HHHHCCCCCCCCCCE	27.19	25599653

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
294	S	Phosphorylation	Kinase	ATR	Q13535	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PHF14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PHF14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PHS2_HUMAN	PCBD2	physical	20211142

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PHF14_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-287; SER-290 ANDSER-302, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-287 AND SER-290, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208; SER-280; THR-287;SER-290 AND SER-294, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-651(ISOFORM 2), AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91 AND SER-530, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-287; SER-290; SER-298;SER-302; SER-553 AND SER-835, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290, AND MASSSPECTROMETRY.	15302935 [Abstract]